Towards a net-zero healthcare system in Kenya: Stakeholder perspectives on opportunities, challenges and priorities by Iris Martine Blom, Melvine Anyango Otieno, Susannah Mayhew, Neil Spicer, Andy Haines, Sarah Whitmee

“…Results: Stakeholders identified and validated 14 process components crucial for this transformation, ranging from leadership and financing to behavioral change and monitoring. Critical barriers, such as infrastructure limitations, competing health priorities, financial constraints, and gaps in strategy coordination, were highlighted. …”
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Cardiovascular Disease Detection through Innovative Imbalanced Learning and AUC Optimization by Karthikeyan Palanisamy, Krishnaveni Krishnasamy, Praba Venkadasamy

“…The performance of this model was rigorously evaluated using comprehensive data from a medical survey conducted in 2012, which included an extensive cohort of 26,002 athletes. Critical parameters such as height, weight, age, gender, blood pressure, and resting heart rate were meticulously documented. …”
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Adjuvanted subunit intranasal vaccine reduces SARS-CoV-2 onward transmission in hamsters by Yongjun Sui, Swagata Kar, Bhavna Chawla, Tanya Hoang, YuanKai Yu, Shannon M. Wallace, Hanne Andersen, Jay A. Berzofsky

“…IntroductionMost COVID-19 vaccine trials have focused on recipient protection, not protection of their contacts, a critical need. As a subunit intranasal COVID-19 vaccine reduced nasopharyngeal virus more than did an intramuscular (IM) vaccine, we hypothesized that this vaccine might reduce onward transmission to others.MethodsWe vaccinated hamsters with either the IM-administrated licensed mRNA vaccine twice or one dose of mRNA IM followed by adjuvanted subunit intranasal vaccine. 24 hours after SARS-CoV-2 challenge, these animals were housed with naïve recipients in a contactless chamber that allows airborne transmission.ResultsOnward airborne transmission was profoundly blocked: the donor and recipients of the intranasal vaccine-boosted group had lower oral and lung viral loads (VL), which correlated with mucosal ACE2 inhibition activity. …”
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Impact of resin tapping on the radial growth and climate sensitivity of naturally- regenerated Pinus roxburghii (Chir pine) in Western Nepal by Bipin Bhattarai, Narayan Prasad Gaire, Tek Maraseni, Bishnu Prasad Devkota, Badri Bhattarai, Shankar Tripathi, Kamal Raj Aryal, Hari Adhikari

“…Furthermore, both tapped and untapped trees exhibited a positive correlation between radial growth and temperatures in May, June, July and August suggesting critical role of temperature in influencing the growth of Pinus roxburghii trees whether they have been tapped for resin or not. …”
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Iron(III) edta-accelerated growth of gold/silver core/shell nanoparticles for wide-range colorimetric detection of hydrogen peroxide by Mahdi Hemmati, Amir Hossein Q. Selakjan, Forough Ghasemi

“…The nanorods distinguished color in a rainbow manner for higher concentrations of H2O2, and spherical nanoparticles were critical in the sensitive detection of lower concentrations of H2O2. …”
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Edaravone dexborneol alleviates pericyte-mediated fibrosis depositing extracellular matrix through TGF-β1/IL-11 in cerebral small vessel disease by Qingrui Duan, Zhiyang Liu, Yuxuan Xing, Haifeng Huang, Lin Zhu, Jiaxuan Liu, Peikun He, Guixian Ma, Yuhu Zhang, Kun Nie, Yuyuan Gao, Lijuan Wang

“…Abstract Background Chronic cerebral hypoperfusion (CCH) is a critical pathophysiological mechanism underlying cerebral small vessel disease (CSVD). …”
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Improving Telemedicine through IoT and Cloud Computing: Opportunities and Challenges by M. Sunil Kumar, D. Ganesh

“…Real-world case studies outline successful implementations of these methods, which result in decreased hospital readmissions, improved patient engagement in health management, and centralized critical care expertise. However, significant challenges are addressed, including data security, interoperability, and reliable internet connectivity in various healthcare settings. …”
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Real-time detection of road surface friction coefficient: A new framework integrating diffusion model and Transformer in Transformer algorithms by Zhangcun Yan, Lishengsa Yue, Wang Luo, Jian Sun

“…The real-time road surface friction coefficient (RSFC) is a critical parameter for evaluating skid resistance and making safe driving decisions in driver assistance systems and autonomous vehicles, especially under adverse weather conditions. …”
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Impact of invasive and noninvasive pneumococcal diseases on adult populations: risk factors and vaccination status by Hasip Kahraman, Pınar Yıldız, Şenay Yılmaz, Gül Durmaz, Muzaffer Bilgin, Derya Çağlayan

“…Our findings highlight the critical role of comorbidities and intensive care unit admissions in affecting patient outcomes, stressing the importance of timely interventions and enhanced health strategies to improve vaccination rates and overall outcomes in high-risk populations.…”
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Cell-free osteoarthritis treatment with dual-engineered chondrocyte-targeted extracellular vesicles derived from mechanical loading primed mesenchymal stem cells by Peng Wang, Haiyue Zhao, Wei Chen, Yuhui Guo, Shuo Zhang, Xin Xing, Shuai Yang, Fengkun Wang, Juan Wang, Zengwu Shao, Yingze Zhang

“…In conclusion, this study underscores the critical role of mechanical loading in augmenting effectiveness of EVs in mitigating OA and introduces dual-engineered EVs that specifically target chondrocytes, providing a promising therapeutic strategy for OA.…”
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Defining the sensitivity of cosmic ray muons to groundwater storage changes by Tramontini, Matías, Rosas-Carbajal, Marina, Zyserman, Fabio Iván,  Longuevergne, Laurent, Nussbaum, Christophe, Marteau, Jacques

“…Quantifying groundwater storage variations is key for sustainable water resource management, estimating droughts and climate change impacts, and the environmental protection of the Critical Zone. Despite the many geophysical methods traditionally used to indirectly infer groundwater storage, there is still a gap in the spatial and temporal scales covered. …”
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Membrane-bound model of the ternary complex between factor VIIa/tissue factor and factor X by Melanie P. Muller, Alex Mortenson, Josepha C. Sedzro, Po-Chao Wen, James H. Morrissey, Emad Tajkhorshid

“…These findings underscore the substrate-binding exosite of TF as being pivotal in the formation of the EC, serving as a critical interface linking the GLA domains of both FVIIa and FX.…”
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Partitioning the phenotypic and genetic variances of reaction norms by de Villemereuil, Pierre, Chevin, Luis-Miguel

“…In addition, the evolutionary potential of phenotypic traits and their plasticity in heterogeneous environments critically depends on how reaction norms vary genetically, but there is no consensus on how this should be quantified. …”
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Yiqi Juanshen decoction alleviates renal interstitial fibrosis by targeting the LOXL2/PI3K/AKT pathway to suppress EMT and inflammation by Kaiyue Tan, Jingwei Deng, Yi Liu, Yudi Zhang, Yu Xiong, Su Yuan, Jun Liu, Zhiwei Chen, Yuanyuan Liu, Wenfu Cao

“…This modulation of the LOXL2/PI3K/AKT pathway contributes to the inhibition of both EMT and inflammation, highlighting a critical role in the therapeutic intervention against RIF. …”
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Divergent thinking in groups during cold-water immersion is impaired by cold stress not the cold shock response by Max Kailler Smith, Max Kailler Smith, Rebecca Weller, Rebecca Weller, Tony Duong, Tony Duong, Rebecca McClintock, Rebecca McClintock, Matthew Peterson, Nathaniel Barr, Douglas M. Jones, Timothy L. Dunn

“…However, results indicated that those with lower skin temperatures performed worse on the DAT.DiscussionResults suggest that the ability to engage in divergent thinking is relatively preserved in the critical ~10-min window although skin cooling may bias attention toward the cold stress impacting task performance. …”
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DEVELOPMENT OF MEDIA LITERACY AND COMMUNICATION SKILLS BY MEANS OF DIGITAL STORYTELLING IN JAPAN by Lyubov V. Gutor, Pavlo A. Sodomora, Oleh H. Vasylenko, Halyna I. Zalutska

“…Famous universities of Japan initiate and realize scientific and academic projects, extending communication connections of Japanese population, improving their skills of critical thinking and argumentation, developing desires and abilities to communicate freely, fluently, confidently and persuasively.    …”
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Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats by Hong Yang, Cheng Zhang, Woonghee Kim, Mengnan Shi, Metin Kiliclioglu, Cemil Bayram, Ismail Bolar, Özlem Özdemir Tozlu, Cem Baba, Nursena Yuksel, Serkan Yildirim, Shazia Iqbal, Jihad Sebhaoui, Ahmet Hacımuftuoglu, Matthias Uhlen, Jan Boren, Hasan Turkez, Adil Mardinoglu

“…Furthermore, our findings underpin the critical role of extrahepatic metabolism in the development of diet-induced steatosis, offering valuable guidance for future studies focused on JNK-targeting for effective treatment of MAFLD.…”
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Progress Analysis and Development Prospects of Soil Ecological and Environmental Effects of Interlayer Construction by JIA Zhenjiang, WU Yangyang, LI Wangcheng, MA Dongxiang, CHEN Jihong, GAO Susu, NIU Xiaoxiao, XU Tianyuan

“…[Results] Interlayer construction could improve soil structure, nutrient content, ecosystem service functions, and agricultural production efficiency, but the responses process to interlayer mode selection and farmland management measures have shown differences. [Conclusion] The critical scientific problems and future development directions that need to be solved in the process of agricultural development and ecological governance were provided. …”
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Beyond buzzwords: fostering interdisciplinary and collaborative global health research in Germany and beyond by Maeve Cook-Deegan, Kerem Böge, Walter Bruchhausen, Mizeck Chagunda, Medha Chaturvedi, Meral Esen, Johanna Hanefeld, Beate Kampmann, Carsten Köhler, Charlotte Köhler, Francis Osei, Clarissa Prazeres da Costa, Eva Rehfuess, Thirumalaisamy P. Velavan, Nora Anton, on behalf of the GLOHRA Steering Committee**

“…Insights indicate that highly interdisciplinary and diverse governance structures and seed-funding for interdisciplinary and cross-sector research with appropriate review processes represent a critical step for achieving these aims. Additionally, inclusive training sessions and networking events help to bridge disciplinary boundaries, equipping researchers to envision the broader context of their work. …”
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Implementing an environmental DNA/RNA-based approach to non-invasively investigate disease caused by Ichthyophthirius multifiliis by Yajiao Duan, Moonika Haahr Marana, Hannah Malene Jensen, Cyril Henard, Louise von Gersdorff Jørgensen

“…This study provides an insight into the pathogen eNA dynamics where a Ct value of 18–25 of iag52a indicated critical disease outbreak.…”
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