Engineering a live-attenuated porcine reproductive and respiratory syndrome virus vaccine to prevent RNA recombination by rewiring transcriptional regulatory sequences by Liwei Li, Jinxia Chen, Zhengda Cao, Ziqiang Guo, Jiachen Liu, Yanjun Zhou, Guangzhi Tong, Fei Gao

“…The results have enriched our understanding of the critical role of TRS circuits in PRRSV recombination mechanisms and indicate a successful redesign that can endow PRRSV live vaccines with recombination-resistant capabilities.IMPORTANCEPorcine reproductive and respiratory syndrome viruses (PRRSVs) are genetically diverse, and this is due in part to their extensive recombination. …”
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Skema Kredibilitas Sertifikat Berbasis Ilearning Gamifikasi Blockchain pada Kampus Merdeka by Qurotul Aini, Nur Azizah, Rahmat Salam, Nuke Puji Lestari Santoso, Fitra Putri Oganda

“…The final result of this research is to build new normality in the successful implementation of MBKM and create an ecosystem of interactive student activity hours, hone soft skills, and build critical thinking by carrying out the iLearning learning model based on Blockchain gamification techniques (iLearning Gamichain).  …”
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A Proposed mHealth Intervention to Address Patient Barriers to Colposcopy Attendance: Qualitative Interview Study of Clinic Staff and Patient Perspectives by Jennifer R Hemler, Rachel B Wagner, Brittany Sullivan, Myneka Macenat, Erin K Tagai, Jazmarie L Vega, Enrique Hernandez, Suzanne M Miller, Kuang-Yi Wen, Charletta A Ayers, Mark H Einstein, Shawna V Hudson, Racquel E Kohler

“…ConclusionsClinic staff members and patient perspectives are critical for designing appropriate and relevant interventions. …”
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LncRNA PTS-1 Protects Against Osteoarthritis Through the miR-8085/E2F2 Axis by Ma C, Chen Q, Wei YF, Chen SW, Liu H, Xin F, Ren YX

“…Emerging evidence highlights the critical role of long non-coding RNAs (lncRNAs) in OA pathogenesis. …”
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Associations between Prospective Memory, Executive Function and Physical Activity in Schoolchildren by Anouk Irina Glättli, Markus Gerber, Sebastian Ludyga

“…Those cognitive abilities are critical for successfully coping with everyday challenges from school age to late adulthood (Diamond, 2013). …”
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Value of Magnifying Chromoendoscopy and Magnifying Optical Enhancement Technology in Classifying Colorectal Polyps: A Prospective Controlled Study by Ying-Hao Song, Ruo-Xin Xu, Yong Zhang, Meng-Xuan Xing, Li-Dong Xu, Kun-Kun Li, Xing-Guo Xiao, Lu Li, Yan-Jing Xiao, Yu-Lei Qu, Ying-Jie Ma, Bao-Hui Jia, Hui-Li Wu

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Previous treatment with anthracycline does not affect the course of sepsis in cancer patients: Retrospective cohort study by Camille Windsor, Adrien Joseph, Stephanie Pons, Djamel Mokart, Frederic Pène, Achille Kouatchet, Alexandre Demoule, Fabrice Bruneel, Martine Nyunga, Edith Borcoman, Matthieu Legrand, Michael Darmon, Lara Zafrani, Elie Azoulay, Virginie Lemiale

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Surgical options for Evans-Jensen type IV intertrochanteric femur fractures in the elderly over 65: a comparison between total hip arthroplasty and proximal femoral nail antirotati... by Ming Sun, Hai-Rui Liang, He Zhang, Tong Bai, Rong-Da Xu, Si-Yu Duan, Zhen-Cun Cai, Zhen-Cun Cai

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Rapid identification and phenotyping of nonalcoholic fatty liver disease patients using a machine‐based approach in diverse healthcare systems by Anna O. Basile, Anurag Verma, Leigh Anne Tang, Marina Serper, Andrew Scanga, Ava Farrell, Brittney Destin, Rotonya M. Carr, Anuli Anyanwu‐Ofili, Gunaretnam Rajagopal, Abraham Krikhely, Marc Bessler, Muredach P. Reilly, Marylyn D. Ritchie, Nicholas P. Tatonetti, Julia Wattacheril

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Factors Influencing the Elastic Stiffness Factor in Reinforced Concrete Structures of Dual Systems Using Pushover Analysis by Shahram Jkhsi, Saya Abdullah Saber

“… Stiffness is one of the most critical characteristics of a building, which is considered for public safety against earthquake loads and refers to displacement resistance. …”
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USP22 inhibits microglial M1 polarization by regulating the PU.1/NLRP3 inflammasome pathway by Ming-chen Yu, Xiao-lin Li, Ming-liang Ning, Zhen-zhong Yan, Wan-tao Yu

“…The PU.1/NLRP3 inflammasome pathway may be a critical regulatory pathway of USP22 in BV-2 cell polarization.…”
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Trends in certifications of overall vision impairment and that due to diabetic retinopathy/maculopathy in England and Wales, 2009/2010 to 2019/2020: a retrospective database analys... by Catey Bunce, Gwyn Samuel Williams, David Owens, Wen Xing, Rhianon Reynolds, Antra Zekite, Declan Flanagan, RL Thomas, Rebecca John

“…Despite fluctuations in Wales, the overall reduction in certifications due to diabetic retinopathy in both regions suggests a critical need for ongoing public health initiatives aimed at preventing vision impairment linked to diabetes. …”
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Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling by Adolf Koudelka, Gregory J. Buchan, Veronika Cechova, James P. O’Brien, Emily R. Stevenson, Crystal E. Uvalle, Heng Liu, Steven R. Woodcock, Steven J. Mullett, Cheng Zhang, Bruce A. Freeman, Stacy L. Gelhaus

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Quantifying diversity and growth form distribution of scleractinian corals, in Mangrove Bay, El Qoseir, Egypt by Theres Koch, Angelina Ivkić, Lewis Jones, Victor Scharnhorst, Constanze Stix, Antonia Auer, Theda Schöchtner, Gözde Özer, Simon Steinwender, Joseph Wallace Daurella, Martin Zuschin

“…Millepora contributed the most at the exposed reef edge with nearly 28% cover, but was scarce elsewhere; soft corals exhibited their highest abundance on the deeper slope.Our observations serve as a critical baseline for future research and conservation efforts at Mangrove Bay by presenting an initial inventory of the local scleractinian communities and emphasise the importance of detailed species data in understanding and preserving coral reef ecosystems.…”
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Inflammatory Markers and Severity in COVID-19 Patients with Clostridioides Difficile Co-Infection: A Retrospective Analysis Including Subgroups with Diabetes, Cancer, and Elderly by Teodor Cerbulescu, Flavia Ignuta, Uma Shailendri Rayudu, Maliha Afra, Ovidiu Rosca, Adrian Vlad, Stana Loredana

“…Background and Objectives: The interplay of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and <i>Clostridioides difficile</i> infection (CDI) poses a critical clinical challenge. The resultant inflammatory milieu and its impact on outcomes remain incompletely understood, especially among vulnerable subgroups such as elderly patients, those with diabetes, and individuals with cancer. …”
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Performance evaluation of inset feed microstrip patch antenna parameters with different substrate materials for 5G wireless applications by Kebbekoppalu Shrinivasa Praveena, M Patil Chandrashekar

“…These findings provide critical insights into antenna design and material selection, emphasizing the significance of substrate choice in achieving desired performance metrics in modern RF 5G applications.…”
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30 Years of Research in Brand Personality: Mapping Knowledge and Analyzing the Thematic Structure by a Scientometrics Approach by Mohammad Rahim Esfidani, Mohsen Nazari, Shahriar Gharibzadeh, Nakisa Rezaie

“…Brand personality is considered a critical element in brand differentiation and positioning strategies. …”
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Cigarette Smoking Patterns Among Racial and Ethnic Groups With Chronic Lung Diseases During the COVID-19 Pandemic by Vijaya L. Seegulam, MPH, Caretia J. Washington, BS, Parvathy P. Surendran, BPT, Alyssa M. Falise, PhD, MSPH, Diana Gomez-Manjarres, MD, Catalina Lopez-Quintero, MD, MPH, PhD

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De la police coloniale française à la police nationale marocaine : décolonisation et héritages policiers (1953-1960) by Benjamin Badier

“…While the archives of the DGSN are not available, those of the Consultative National Assembly (1956-1959), held at the Archives of Morocco, provide valuable insights, along with the critical perspective of the Moroccan left. The first part examines the transformations of the Cherifian Police in the early 1950s, when it struggled to reorganize itself to confront the increasingly violent nationalist mobilizations. …”
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Rapid inference of antibiotic susceptibility phenotype of uropathogens using metagenomic sequencing with neighbor typing by Amanda C. Carroll, Leanne Mortimer, Hiren Ghosh, Sandra Reuter, Hajo Grundmann, Karel Brinda, William P. Hanage, Angel Li, Aimee Paterson, Andrew Purssell, Ashley Rooney, Noelle R. Yee, Bryan Coburn, Shola Able-Thomas, Martin Antonio, Allison McGeer, Derek R. MacFadden

“…We created resistance-associated sequence elements (RASE) databases for Escherichia coli and Klebsiella spp. and used them to predict antibiotic susceptibility in directly sequenced (Oxford Nanopore) urine specimens from critically ill patients. RASE analysis was performed on pathogen-specific reads from metagenomic sequencing. …”
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