Mid-Infrared High-Power InGaAsSb/AlGaInAsSb Multiple-Quantum-Well Laser Diodes Around 2.9 μm by Hongguang Yu, Chengao Yang, Yihang Chen, Jianmei Shi, Juntian Cao, Zhengqi Geng, Zhiyuan Wang, Haoran Wen, Enquan Zhang, Yu Zhang, Hao Tan, Donghai Wu, Yingqiang Xu, Haiqiao Ni, Zhichuan Niu

“…The miscibility gap of the InGaAsSb alloy was systematically investigated by calculating the critical temperatures based on the delta lattice parameter model. …”
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Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial–Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cel... by David A. Bunsick, Leili Baghaie, Yunfan Li, Abdulrahman M. Yaish, Emilyn B. Aucoin, Elizabeth Skapinker, Rashelle Aldbai, Myron R. Szewczuk

“…To assess the key survival pathways critical for pancreatic cancer progression, we used the AlamarBlue assay to determine synthetic CB1 cannabinoids to induce the cell’s metabolic viability drivers to stage migratory intercellular communication. …”
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Antibiotic Susceptibility Patterns and Virulence Profiles of Classical and Hypervirulent <i>Klebsiella pneumoniae</i> Strains Isolated from Clinical Samples in Khyber Pakhtunkhwa,... by Azra, Taj Ali Khan, Ihtisham Ul Haq, Woranich Hinthong, Susana Campino, Aisha Gohar, Noman Khan, Muhammad Kashif, Ihsan Ullah, Taane G. Clark

“…The findings of this study underscore the critical need for the active surveillance of antimicrobial resistance and virulence determinants in <i>K. pneumoniae</i>. …”
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Genotype by environment interactions and phenotypic traits stability of the EUCLEG faba bean collection by Dejan Sokolović, Snežana Babić, Mirjana Petrović, Ignacio Solís, Mathias Cougnon, Natalia Gutierrez, Pertti Pärssinen, Dirk Reheul, Jasmina Radović, Ana M. Torres

“…The information derived from this study provides a chance for breeding new resilient faba bean cultivars adapted to different agroecological European regions, a critical point for addressing Europe’s reliance on protein imports and enhancing sustainable agriculture practices.…”
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Quantifying the potential of using Soil Moisture Active Passive (SMAP) soil moisture variability to predict subsurface water dynamics by A. K. Nayak, X. Xu, X. Xu, S. K. Frey, S. K. Frey, O. Khader, O. Khader, A. R. Erler, D. R. Lapen, H. A. J. Russell, E. A. Sudicky, E. A. Sudicky

“…<p>Advances in satellite Earth observation have opened up new opportunities for global monitoring of soil moisture (SM) at fine to medium resolution, but satellite remote sensing can only measure the near-surface soil moisture (SSM). As such, it is critically important to examine the potential of satellite SSM measurements to derive the water resource variations in deeper subsurface. …”
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Comparative analysis of the human microbiome from four different regions of China and machine learning-based geographical inference by Yinlei Lei, Min Li, Han Zhang, Yu Deng, Xinyu Dong, Pengyu Chen, Ye Li, Suhua Zhang, Chengtao Li, Shouyu Wang, Ruiyang Tao

“…ABSTRACT The human microbiome, the community of microorganisms that reside on and inside the human body, is critically important for health and disease. However, it is influenced by various factors and may vary among individuals residing in distinct geographic regions. …”
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Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiments by Bowen Yin, Jingyi Ren, Xuanyi Liu, Yadong Zhang, Jinshi Zuo, Rui Wen, Huanting Pei, Miaomiao Lu, Siqi Zhu, Zhenao Zhang, Ziyi Wang, Yanyi Zhai, Yuxia Ma

“…Additionally, ASX enhances the expression of P62 and decreases levels of Beclin1 and microtubule-associated proteins light chain 3 (LC3).ConclusionOur results indicate that ferroptosis and autophagy are critical factors influencing the occurrence and progression of DOX-induced cardiotoxicity. …”
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Prevalence of Preoperative Anxiety and Associated Factors Among Surgical Patients: Systematic Review and Meta-Analysis in Ethiopia by Magarsa Lami, Abraham Negash, Jerman Dereje, Ahmed Hiko, Sinetibeb Mesfin, Arsema Gebreyesus, Nano Belama, Nesredin Ahmed Omer, Bikila Balis, Usmael Jibro

“…Methods: In this study, all observational study designs conducted in Ethiopia were included while studies that did not report our main outcome of interest or did not meet the quality criteria by Joanna Briggs Institute (JBI) critical appraisal techniques were excluded. Electronic databases (PubMed, SCOPUS, Web of Science Core Collection, CAB Abstract, EMBASE, and CINHAL (EBSCO)), Google Scholar, and lists of references were used to search works of literature in Ethiopia. …”
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Special aspects of the clinical course and replacement therapy peculiarities in a patient with autoimmune polyglandular syndrome type 1: a clinical case by Maria G. Pavlova, Olga O. Golounina, Tatyana B. Morgunova, Natalya V. Likhodey, Marina F. Kalashnikova, Aleksandr G. Farmanov, Tamriko D. Khazaliya, Valentin V. Fadeev

“…Due to abnormalities of cellular and humoral immunity, APS-1 patients are at an extremely high risk for a critical course of COVID-associated pneumonia. In 2020, the patient contracted the coronavirus infection complicated by bilateral pneumonia, followed by respiratory failure, bacterial sepsis and acute renal failure. …”
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Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP by Song Guo, Song Guo, Qihao Pan, Qihao Pan, Baokang Chen, Baokang Chen, Yijuan Huang, Yijuan Huang, Si Li, Si Li, Chenyu Gou, Chenyu Gou, Yu Gao, Yu Gao

“…YAP (Yes-associated protein) was reported to play a critical role in regulation of aging and resisting oxidative damage, yet these roles had not been elucidated in the placenta. …”
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Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury by Fei Yuan, Jie Liu, Liang Zhong, Pengtao Liu, Ting Li, Kexin Yang, Wei Gao, Guangyuan Zhang, Jie Sun, Xiangyu Zou

“…The antioxidant stress effect induced by GSTO1 is identified as one of the most critical underlying mechanisms. Our findings highlight that hypoxia-pretreated MSC-EVs represent a novel and promising therapeutic strategy for renal IRI. …”
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Frequency and accuracy of intraoperative bone margin sampling for T4a cancers of the head and neck at the QEII Health Sciences Centre: a retrospective chart review by Anna-Claire Lamport, Colin A. MacKay, Martin J. Bullock, S. Mark Taylor, Jonathan R. Trites, Martin Corsten, Matthew H. Rigby

“…Adequate resection of these tumors is a critical factor in maximizing survival. Tumors invading bone pose a unique challenge to intraoperative bone margin assessment. …”
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Early prediction of in-hospital mortality in patients with congestive heart failure in intensive care unit: a retrospective observational cohort study by Tao Huang, Rui Yang, Jun Lyu, Didi Han, Fengshuo Xu, Shuai Zheng, Luming Zhang, Haiyan Yin

“…Early diagnosis and risk assessment of death of patients with CHF are critical to prognosis and treatment. The purpose of this study was to establish a nomogram that predicts the in-hospital death of patients with CHF in the intensive care unit (ICU).Design A retrospective observational cohort study.Setting and participants Data for the study were from 30 411 patients with CHF in the Medical Information Mart for Intensive Care database and the eICU Collaborative Research Database (eICU-CRD).Primary outcome In-hospital mortality.Methods Univariate logistic regression analysis was used to select risk factors associated with in-hospital mortality of patients with CHF, and multivariate logistic regression was used to build the prediction model. …”
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PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation by Yin-Li Zhang, Zhanhong Hu, Huifang Jiang, Jiamin Jin, Yan Zhou, Mengru Lai, Peipei Ren, Siya Liu, Ying-Yi Zhang, Yan Rong, Wei Zheng, Shen Zhang, Xiaomei Tong, Songying Zhang

“…Conclusion PATL2 plays a critical role in regulating mRNA accumulation and decay in human oocytes, potentially through interactions with CPEB1 and TUT7, respectively. …”
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Inducible engineering precursor metabolic flux for synthesizing hyaluronic acid of customized molecular weight in Streptococcus zooepidemicus by Rui Zhao, Jun Li, Yingtian Li, Xujuan Pei, Jingyi Di, Zhoujie Xie, Hao Liu, Weixia Gao

“…The ratio of HA’s precursors, UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-glucuronic acid (UDP-GlcA), is critical for the extension and release of HA. An imbalance in the precursor proportions for HA synthesis leads to a significant decrease in HA MW, indicating that controlling the precursor ratio may serve as a potential method for regulating HA MW. …”
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Peripheral blood cell counts as predictors of immune-related adverse events in cancer patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis by Xinyu Zhang, Bei Zhang, Danfei Li, Yunchao Yang, Sen Lin, Ruiqi Zhao, Yijia Li, Lisheng Peng

“…Predicting and preventing irAEs during the early stages of treatment has become a critical research focus in cancer immunotherapy. This study aims to evaluate the predictive value of peripheral blood cell counts for irAEs.MethodsStudies meeting the inclusion criteria were identified through database searches. …”
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Development and usability testing of a multifaceted intervention to reduce low-value injury care by Mélanie Bérubé, Alexandra Lapierre, Michael Sykes, Jeremy Grimshaw, Alexis F. Turgeon, François Lauzier, Monica Taljaard, Henry Thomas Stelfox, Holly Witteman, Simon Berthelot, Éric Mercier, Catherine Gonthier, Jérôme Paquet, Robert Fowler, Natalie Yanchar, Barbara Haas, Paule Lessard-Bonaventure, Patrick Archambault, Belinda Gabbe, Jason R. Guertin, Yougdong Ouyang, Lynne Moore, the Canadian Traumatic Brain Injury Research Consortium

“…A total of 61 issues were identified during the usability testing, of which eight were critical, 33 were moderately important, and 18 were minor. …”
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Ethanolamine-induced assembly of microcompartments is required for Fusobacterium nucleatum virulence by Dana S. Franklin, Yi-Wei Chen, Yimin Chen, Manuel Wittchen, Angela Agnew, Alexis Luu, Julian P. Whitelegge, Z. Hong Zhou, Andreas Tauch, Asis Das, Hung Ton-That

“…Together, these results establish that the BMC-mediated metabolism of ethanolamine is critical for fusobacterial virulence.IMPORTANCEThe oral anaerobe Fusobacterium nucleatum can spread to distal internal organs, such as the colon and placenta, thereby promoting the development of colorectal cancer and inducing preterm birth, respectively. …”
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Integrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression of athe... by Yifeng Zhang, Yifeng Zhang, Shuxian Lu, Shuxian Lu, Liang Qiu, Liang Qiu, Manman Qin, Manman Qin, Dan Shan, Lianhua Xie, Yao Yi, Yao Yi, Jun Yu

“…Therefore, this study aimed to identify critical target genes and pathways of Tregs associated with the progression of AS.MethodsThe gene expression data and single cell RNA-seq data of AS were downloaded from the Gene Expression Omnibus (GEO) database. …”
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Knowledge, attitude, and perception of Pakistani populations toward monkeypox: a cross-section study by Humayun Yousaf, Abdul Qadeer, Muhammad Sohail, Maqbool Khan, Muhammad Farooq, Zakir Khan, Dalia Fouad, Yu-Chia Liu, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen

“…ObjectiveThe reappearance of monkeypox in non-endemic countries has preceded critical public health concerns. The public’s adherence to preventative measures is influenced by their understanding of the infectious monkeypox virus (Mpox), attitude toward it, and perceptions of it. …”
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