Salmonella pathogenicity Island 1 undergoes decay in serovars adapted to swine and poultry by Martina Tambassi, Melissa Berni, Chiara Bracchi, Ilaria Menozzi, Alessandra Dodi, Laura Mazzera, Marina Morganti, Erika Scaltriti, Stefano Pongolini

“…Intensive farming with a high density of animals could be a possible driver of this evolution.IMPORTANCEThis study shows at the global population level of Salmonella that the main attenuated serovars adapted to food-producing animals are undergoing convergent evolution toward further attenuation through the decay of SPI-1, considered critically important for the intestinal phase of Salmonella infection. …”
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Diagnostic value of dual-layer spectral detector CT parameters for differentiating high- from low-grade bladder cancer by Li Chen, Lili Xu, Xiaoxiao Zhang, Jiahui Zhang, Xin Bai, Qianyu Peng, Erjia Guo, Xiaomei Lu, Shenghui Yu, Zhengyu Jin, Gumuyang Zhang, Yi Xie, Huadan Xue, Hao Sun

“…Conclusion Using DLCT AEF could help distinguish high-grade from low-grade BCa. Critical relevance statement This research demonstrates that the arterial enhancement fraction (AEF), a parameter derived from dual-layer spectral detector CT (DLCT), effectively distinguishes between high- and low-grade bladder cancer, thereby aiding in the selection of appropriate clinical treatment strategies. …”
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Distinguishable Immunologic Characteristics of COVID-19 Patients with Comorbid Type 2 Diabetes Compared with Nondiabetic Individuals by Ruxing Zhao, Yujing Sun, Yongyuan Zhang, Weili Wang, Shouyu Wang, Chuang Wang, Jinbo Liu, Ling Gao, Zhao Hu, Jianchun Fei, Xinguo Hou, Huizhen Zheng, Li Chen

“…The immune system poses the critical interactive chain between the human body and the virus. …”
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Evaluation of Root Canal Diameters and Radicular Wall Thickness of the Human Primary Molars by using Multidetector Computed Tomography: A Cross-sectional Study by Piyali Datta, Shabnam Zahir, Kaushik Dutta, Pratik Kumar Lahiri, Sudipta Kar, Biswaroop Chandra, Trishik Basak, Shreya Tripathi

“…Introduction: Paediatric endodontics is critical for preserving the primary tooth until its physiologic exfoliation and ensuring the child’s quality of life. …”
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Interventions for the management of post-COVID-19 condition (long COVID): protocol for a living systematic review and network meta-analysis by Paul Garner, Lawrence Mbuagbaw, Jason W Busse, Dena Zeraatkar, Thomas Agoritsas, Ariel Izcovich, Tari Turner, Lyn Turkstra, Roger S McIntyre, Rachel J Couban, Tyler Pitre, Sarah Kirsh, Tanvir Jassal, Michael Ling, Samantha Chakraborty, Signe A Flottorp

“…Trustworthy systematic reviews that clarify the benefits and harms of interventions are critical to promote evidence-based practice.Objective To create and maintain a living systematic review and network meta-analysis addressing the benefits and harms of pharmacologic and non-pharmacologic interventions for the treatment and management of long COVID.Methods Eligible trials will randomise adults with long COVID to pharmacologic or non-pharmacologic interventions, placebo, sham or usual care. …”
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Tangeretin alleviates sepsis-induced acute lung injury by inhibiting ferroptosis of macrophage via Nrf2 signaling pathway by Hui Zhang, Yan Wang, Shenghua Wang, Xiaomei Xue, Kai Huang, Dunfeng Xu, Lai Jiang, Siyuan Li, Yunqian Zhang

“…Conclusion We identified that ferroptosis as a critical mechanism contributing to sepsis-induced ALI. …”
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A randomised controlled implementation trial of the feasibility and effectiveness of school staff delivery of a selective substance use and mental health program during the COVID-1... by Lucinda Grummitt, Kirsty Rowlinson, Joanne Cassar, Chloe Conroy, Louise Birrell, Lexine Stapinski, Emma Louise Barrett, Julia Macauley, Maree Teesson, Nicola C. Newton, Erin V. Kelly

“…Alternative approaches, such as delivery by dedicated personnel within schools without a teaching load, may be critical in implementing such evidence-based interventions at scale. …”
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Comparative transcriptome analysis reveals molecular mechanisms of resistance in Chinese cabbage to Plasmodiophora brassicae pathotype 11 by Yue Qiu, Yue Qiu, Yue Qiu, Jinhao Zhang, Jinhao Zhang, Chunju Deng, Chunju Deng, Jiasheng Yuan, Jiasheng Yuan, Bowen Wang, Bowen Wang, Han Meng, Han Meng, Mohamed Mohany, Liting Zeng, Liting Zeng, Lanfang Wei, Lanfang Wei, Waqar Ahmed, Guanghai Ji, Guanghai Ji

“…Results demonstrated that 14 days after inoculation (dai) is a critical time point of the infection process for resistant variety to inhibit the proliferation of P. brassica. …”
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The value of MRI in differentiating ovarian clear cell carcinoma from other adnexal masses with O-RADS MRI scores of 4–5 by Lingling Lin, Le Fu, Huawei Wu, Saiming Cheng, Guangquan Chen, Lei Chen, Jun Zhu, Yu Wang, Jiejun Cheng

“…Conclusions The comprehensive model combining clinical and MRI features can effectively differentiate CCC from adnexal masses with O-RADS MRI scores of 4–5. Critical relevance statement CCC has a high incidence rate in Asians and has limited sensitivity to platinum chemotherapy. …”
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Feasibility of trancutaneous auricular vagus nerve stimulation in Black and Hispanic/Latino people with peripheral neuropathy by Marlon L. Wong, Eva Widerström-Noga, Jessica L. Bolanos, Gabriel Gonzalez, Frank J. Penedo, Peter J. Hosein, Melissa M. Tovin, Juan P. Gonzalez, Lisa M. McTeague

“…However, research is needed to determine the feasibility, acceptability, and effects of taVNS in people with PN. It is also critical that this research on taVNS include the perspectives of Black and Hispanic/Latino patients, who are often underrepresented in research.MethodsThis research was comprised of two consecutive studies: a survey and a pilot randomized sham-controlled trial (RCT). …”
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Spatial variations in the microbiota: comparative analysis of microbial composition and predicted functions across different intestinal segments and feces in donkeys by Yanwei Wang, Yanwei Wang, Yanwei Wang, Tong Hu, Tong Hu, Kaixuan Liang, Kaixuan Liang, Shinuo Li, Shinuo Li, Qiyue Zhang, Qiyue Zhang, Qiyue Zhang, Wenqiang Li, Honglei Qu, Honglei Qu, Boying Dong, Haihua Zhang, Qiugang Ma, Qiugang Ma, Ru Jia, Shimeng Huang, Shimeng Huang

“…This study provided critical primary data on the differences in donkey gut microbiota and the synergistic effects between gut microbiota and host functions. …”
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Elevations in D-dimer levels in patients with Plasmodium infections: a systematic review and meta-analysis by Suriyan Sukati, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay, Ching-Ping Tseng, Aongart Mahittikorn, Nsoh Godwin Anabire, Polrat Wilairatana, Kinley Wangdi, Hideyuki J Majima, Apiporn Thinkhamrop Suwannatrai, Wiyada Kwanhian Klangbud, Wanida Mala, Rujikorn Rattanatham, Manas Kotepui

“…The methodological quality of the included studies was assessed using the Joanna Briggs Institute critical appraisal tools. Thematic synthesis and meta-analysis were carried out to synthesize the findings of the included studies. …”
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Autologous osteoperiosteal transplantation achieves comparable repair effect and superior interface integration to autologous osteochondral transplantation in porcine osteochondral... by Shuai Yang, En Deng, Linxin Chen, Yanbin Pi, Anhong Wang, Linghui Dai, Hongjie Huang, Xiaoning Duan, Xin Fu, Jiying Zhang, Qinwei Guo, Weili Shi

“…Despite similar radiographic findings, mechanical performance and histological structure displayed in both grafted groups, AOPT exhibit superior interface integration, which is critical for effective tissue restoration. The translational potential of this article: As a recently developed procedure for treating osteochondral defects, AOPT has shown promising repair effect and is being increasingly adopted in clinical practice. …”
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Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD by Yao Xu, Tianxiao Hu, Peiwu Jiang, Xiujing Wang, Jiaqi Yao, Huiling Shen, Zhenying Zhang, Bojing Zheng, Ting Wang, Yanxia Ren, Jing Wang, Qingying Tan

“…IntroductionSirtuin 1, a class III histone deacetylase, plays a critical role in the pathophysiology of both diabetes mellitus and bone metabolism by promoting osteoblast differentiation and inhibiting osteoclast maturation. …”
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Non Linear Thermal Radiation Analysis of Electromagnetic Chemically Reacting Ternary Nanofluid Flow over a Bilinear Stretching Surface by Shobha V, Hasan Mulki, Baskar P, S. Suresh Kumar Raju, Saleh Mahmoud, Mostafa Abdrabboh, S.V.K. Varma

“…This study aims to contribute to this growing field by analyzing the combined effects of magnetic fields, rotation, and thermal radiation on the flow and heat transfer behavior in nano materials. These insights are critical for optimizing heat transfer systems in energy, manufacturing, and engineering sectors. …”
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First report of serological, molecular detection, and characterization of human parvovirus B19 infections among sickle cell anaemia patients in Khartoum State, Sudan by Khalid Salman, Sittna Hayder El Nagar, Abdel Rahim M. El Hussein, Mohammed A. El Hussein, Hadi M. Yassine, Hebah A. Al Khatib, Mashael Ali Al- Badr, Ibrahim Farah, Khalid A. Enan

“…Screening for parvovirus B19 is critical for patients requiring blood transfusions, particularly those with haematological disorders. …”
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3D-AttenNet model can predict clinically significant prostate cancer in PI-RADS category 3 patients: a retrospective multicenter study by Jie Bao, Litao Zhao, Xiaomeng Qiao, Zhenkai Li, Yanting Ji, Yueting Su, Libiao Ji, Junkang Shen, Jiangang Liu, Jie Tian, Ximing Wang, Hailin Shen, Chunhong Hu

“…Conclusions Our model offers a noninvasive screening clinical tool to re-stratify risks in PI-RADS 3 patients, thereby reducing unnecessary invasive biopsies and improving the effectiveness of biopsies. Critical relevance statement The deep learning model with MRI can help to screen out csPCa in PI-RADS category 3. …”
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Exploring the relationships between self-efficacy, self-care, and glycaemic control in primary care diabetes management by Le Ho Thi Quynh Anh, Nguyen Vu Quoc Huy, Nguyen Minh Tam, Johan Wens, Anselme Derese, Wim Peersman, Vo Ngoc Ha My, Tran Binh Thang, Nguyen Thi Phuong Anh, Tran Thi Truc Ly, Peter Pype

“…Conclusions: Our study highlights the critical role of self-efficacy in diabetes primary care. …”
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Ultra-low dose dual-layer detector spectral CT for pulmonary nodule screening: image quality and diagnostic performance by Li Ding, Mingwang Chen, Xiaomei Li, Yuting Wu, Jingxu Li, Shuting Deng, Yikai Xu, Zhao Chen, Chenggong Yan

“…Conclusion Ultra-low dose dual-layer detector CT with 91.2% radiation dose reduction achieves sufficient image quality and diagnostic performance of pulmonary nodules. Critical relevance statement Dual-layer detector spectral CT enables substantial radiation dose reduction without impairing image quality for the follow-up of pulmonary nodules or lung cancer screening. …”
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Evaluating the Impacts of Procedural and Patient-Specific Factors on the Outcomes of Transcatheter Aortic Valve Implantation (TAVI) by Abilkhair Kurmanaliyev, Rima Braukylienė, Ali Aldujeli, Rassul Zhumagaliyev, Serik Aitaliyev, Ramunas Unikas

“…<i>Conclusions</i>: Procedural factors such as fluoroscopy duration and contrast volume, along with patient-specific attributes including age, left ventricular function, and valve calcification patterns, critically influence TAVI outcomes. These findings emphasize the need for tailored procedural strategies and patient management protocols to mitigate risks and enhance the efficacy of TAVI interventions.…”
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