Immunosuppression and Outcomes in Patients with Cutaneous Squamous Cell Carcinoma of the Head and Neck by Doriana Iancu, Ana Fulga, Doina Vesa, Iuliu Fulga, Dana Tutunaru, Andrei Zenovia, Alin Ionut Piraianu, Elena Stamate, Corina Sterian, Florentin Dimofte, Mihail Alexandru Badea, Alin Laurentiu Tatu

“…The median survival time for immunosuppressed individuals ranged from 11 to 21 months, varying based on their particular characteristics, and most critically, on the presence of other malignancies, while that of immunocompetent patients ranged from 18 to 51 months. …”
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NLRP3: a key regulator of skin wound healing and macrophage-fibroblast interactions in mice by Jiamin Zhao, Shuangyi Zhang, Zhiguo Gong, Wei Mao, Wenhui Bao, Qianru Li, Yunjie Bai, Feifei Gao, Shuang Feng

“…Deficiencies in apoptosis were evident through altered expression of cysteine-aspartic acid protease 3 (Caspase-3), P53, and B-cell lymphoma-2 (Bcl-2). Furthermore, critical growth factors such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and matrix metalloproteinase-9 (MMP-9) were significantly decreased at the excisional skin wound sites. …”
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Sharing of cmeRABC alleles between C. coli and C. jejuni associated with extensive drug resistance in Campylobacter isolates from infants and poultry in the Peruvian Amazon by Kerry K. Cooper, Evangelos Mourkas, Francesca Schiaffino, Craig T. Parker, Tackeshy N. Pinedo Vasquez, Paul F. Garcia Bardales, Pablo Peñataro Yori, Maribel Paredes Olortegui, Katia Manzanares Villanueva, Lucero Romaina Cachique, Hermann Silva Delgado, Matthew D. Hitchings, Steven Huynh, Samuel K. Sheppard, Ben Pascoe, Margaret N. Kosek

“…This research underscores the critical role of genomic epidemiology in understanding the origins, evolution, and dissemination of antimicrobial resistance and highlights the need to address poultry as a reservoir for resistant Campylobacter.…”
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Prevalence and risk factors for long COVID among cancer patients: a systematic review and meta-analysis by Hongkun Xu, Hongkun Xu, Tingting Lu, Yajie Liu, Jingqi Yang, Simeng Ren, Baojin Han, Honghao Lai, Long Ge, Jie Liu

“…Methodological quality was assessed using the “Joannagen Briggs Institute (JBI) Critical Appraisal Checklist for Studies Reporting Prevalence Data”.ResultsA total of 13 studies involving 6,653 patients were included. …”
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Optimization of exogenous CeO2 nanoparticles on Pak choi (Brassica rapa L. var. chinensis) to alleviate arsenic stress by Rohina Tabassam, Shoaib Ahmad, Adiba Khan Sehrish, Azeem Ahmad, Sarah Owdah Alomrani, Abdul Ghafoor, Tahira Akram, Muhammad Ali Alshehri, Sumaira Noor, Shafaqat Ali, Shafaqat Ali

“…This article is intended to present critical issues of As contamination in agricultural soils, which imposes substantial risks to crop productivity and food security.…”
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Transmission Failure Prediction Using AI and Structural Modeling Informed by Distribution Outages by Sita Nyame, William O. Taylor, William Hughes, Mingguo Hong, Marika Koukoula, Feifei Yang, Aaron Spaulding, Xiaochuan Luo, Slava Maslennikov, Diego Cerrai

“…With an estimate of the probability of failure of transmission lines ahead of storms, power system planning and maintenance engineers will have critical information to make informed decisions, to create better mitigation plans and minimize power disruptions. …”
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One Health interventions and challenges under rural African smallholder farmer settings: A scoping review by Evanson R. Omuse, Honest Machekano, Bonoukpoè M. Sokame, Daniel M. Mutyambai, Thomas Dubois, Sevgan Subramanian, Frank Chidawanyika

“…Thus, this study was conducted to critically map the available evidence of OH initiatives in the lens of African smallholder settings and identify gaps and opportunities for optimally targeted interventions. …”
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Achieving 32.9% efficiency in Pb-Based quantum dot solar cells via SCAPS-1D simulation optimization by Md Hasnain, Abdul Wahed, Joyonta Das, Bassim Arkook, Moussab Harb, Nasim Mia

“…We found that lower defect densities ( $1 \times 10^{14}$ cm ^−3 ) critically improve PCE and fill factor across all materials. …”
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Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

“…Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with limited treatment options and a poor prognosis. The critical role of epigenetic alterations such as changes in DNA methylation, histones modifications, and chromatin remodeling, in pancreatic tumors progression is becoming increasingly recognized. …”
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Heatwave warnings mitigate long-term cardiovascular diseases risk from heat-related illness: a real-world prospective cohort studyResearch in context by Qi Huang, Limei Ke, Linfeng Liu, Yuyang Liu, Yanjun Li, Guoqing Feng, Bo Yin, Wenxin Xiang, Jiarun Li, Keyi Lyu, Miao Wang, Qiannan Tian, Liqun Wu, Xiaofeng He, Wannian Liang, Huatang Zeng, Jiming Zhu, Kuiying Gu, Qian Di

“…Heat-related illness, a critical risk during heatwaves, significantly impacts public health, yet its long-term health effects remain poorly understood. …”
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A Program for Master of Science in Environment and Natural Resources (MENR) by Kabale University

“…According to UN Sustainable Development Goals (SDG), the Goals and targets will stimulate action over the next 15 years in areas of critical importance for humanity and the planet. It states, “We are determined to end poverty and hunger, in all their forms and dimensions, and to ensure that all human beings can fulfil their potential in dignity and equality and in a healthy environment and determined to protect the planet from degradation, including through sustainable consumption and production, sustainably managing its natural resources and taking urgent action on climate change, so that it can support the need of the present and future generations” Goal 15 is to protect, restore and promote sustainable use of terrestrial ecosystems, sustainably manage forests, combat desertification, and halt and reverse land degradation and halt biodiversity loss. …”
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Designing the alignment model of petrochemical projects with the country's industrial strategies in the Ministry of Petroleum by Abdolrasoul Shojaeian, ghanbar abbaspour esfadan, Changiz Valmohammadi, Aboutorab Alirezaei

“…The proposed framework supports the alignment of project success with organizational goals through critical success factors. Primasari (2022) investigated strategy formulation to achieve alignment between information technology and business in game companies. …”
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Impact of COVID-19 on Corporate Cash Holdings and Speed of Adjustment by Abbas Aflatooni, Mohammad Khatiri, Farzad Eivani

“…Cash management is critical for firm value as both cash surpluses and deficits can diminish value. …”
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Training Psychological Skills: Efficacy and Assessment of a Nonclinical Psychological Sports Coaching E-Intervention for Young Elite Athletes by Raphaël Bonetti, Fabienne Crettaz von Rotten, Denis Hauw

“…However, their effectiveness remains uncertain, as scientific validation of these interventions is lacking. Given the critical role of psychological skills in the development of young athletes and the current emphasis on digital and sustainable innovations, the rise of accessible e-interventions is unsurprising. …”
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Editorial by Joanna Krasodomska, Nadia Albu, Anna Szychta

“…Halabi, Alan Labas, and Craig Hurley explores whether introducing a transformative subject on sustainability, the environment, and the SDGs into a master’s accounting course can foster critical thinking and shift student attitudes. Using qualitative data from student reflective journals, analyzed thematically through NVIVO software, the findings reveal transformative outcomes, including changed atti-tudes, increased self-efficacy to drive positive change, enhanced critical thinking, and a deeper understanding of business impacts on the environ-ment. …”
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High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa by Yan Yang, Xue Li, Lang Sun, Xiu-Kun Wang, You-Wen Zhang, Jing Pang, Guo-Qing Li, Xin-Xin Hu, Tong-Ying Nie, Xin-Yi Yang, Jian-Hua Liu, Gerrit Brandis, Xue-Fu You, Cong-Ran Li

“…Understanding the mechanisms behind non-carbapenemase carbapenem resistance is critical for developing effective therapeutic strategies. …”
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Advancements and opportunities to improve bottom–up estimates of global wetland methane emissions by Qing Zhu, Daniel J Jacob, Kunxiaojia Yuan, Fa Li, Benjamin R K Runkle, Min Chen, A Anthony Bloom, Benjamin Poulter, James D East, William J Riley, Gavin McNicol, John Worden, Christian Frankenberg, Meghan Halabisky

“…In fact, there are large disagreements between bottom–up estimates versus top–down estimates inferred from inversion of atmospheric CH _4 concentrations. To address these critical gaps, we review recent development, validation, and applications of bottom–up estimates of global wetland CH _4 emissions, as well as how they are used in top–down inversions. …”
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Urban ozone formation and sensitivities to volatile chemical products, cooking emissions, and NO_<i>x</i> upwind of and within two Los Angeles Basin cities by C. E. Stockwell, M. M. Coggon, R. H. Schwantes, C. Harkins, C. Harkins, B. Verreyken, B. Verreyken, B. Verreyken, C. Lyu, C. Lyu, Q. Zhu, Q. Zhu, Q. Zhu, L. Xu, L. Xu, L. Xu, J. B. Gilman, A. Lamplugh, A. Lamplugh, A. Lamplugh, J. Peischl, J. Peischl, J. Peischl, M. A. Robinson, M. A. Robinson, P. R. Veres, P. R. Veres, M. Li, M. Li, A. W. Rollins, K. Zuraski, K. Zuraski, S. Baidar, S. Baidar, S. Liu, T. Kuwayama, S. S. Brown, B. C. McDonald, C. Warneke

“…Further sensitivity analyses show that using VOCs represented by a separate state inventory requires steeper NO<span class="inline-formula">_<i>x</i></span> reductions to transition to NO<span class="inline-formula">_<i>x</i></span> sensitivity, further suggesting that accurately representing VOC reactivity in inventories is critical to determining the effectiveness of future NO<span class="inline-formula">_<i>x</i></span> reduction policies.…”
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The association between physician sex and patient outcomes: a systematic review and meta-analysis by Kiyan Heybati, Ashton Chang, Hodan Mohamud, Raj Satkunasivam, Natalie Coburn, Arghavan Salles, Yusuke Tsugawa, Ryo Ikesu, Natsumi Saka, Allan S. Detsky, Dennis T. Ko, Heather Ross, Mamas A. Mamas, Angela Jerath, Christopher J. D. Wallis

“…Fifteen studies were rated as having a moderate risk of bias, with 15 as severe, and 5 as critical. Mortality was significantly lower among patients of female versus male physicians (OR 0.95; 95% CI: 0.93 to 0.97; PQ = 0.13; I2 = 26%), which remained consistent among surgeon and non-surgeon physicians (Pinteraction = 0.60). …”
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Gully mitigation and rehabilitation measures have varying effects on soil macrofauna abundance and diversity in semi-arid lands by Harrison Churu, Solomon Kamau, Wilson Ng’etich, Keziah Magiroi, Bonface Alkamoi, James Mutio, Syphyline Kebeney, Fred Wamalwa

“…Nonetheless, there is limited understanding on how such gullies, their management or rehabilitation measures influence soil macrofauna, despite being a critical component of soil ecosystems. Thus, this study evaluated the influence of gully erosion mitigation and rehabilitation measures on soil macrofauna abundance, diversity and species richness in semi-arid lands with severe degradation and where restoration efforts are being put in place. …”
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