N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1 by Toru Miwa, Toru Miwa, Akihito Tarui, Akihito Tarui, Teppei Kouga, Yasunori Asai, Yasunori Asai, Hideaki Ogita, Hideaki Ogita, Taro Fujikawa, Nobuhiro Hakuba, Nobuhiro Hakuba

“…Sirtuins, particularly SIRT1, are NAD-dependent protein deacetylases critical to aging and stress responses. SIRT1 is modulated by nicotinamide N-methyltransferase (NNMT) and its product, N1-methylnicotinamide (MNAM), which influence ARHL progression. …”
Get full text

Estimation of chlorophyll-a in uncrewed aircraft systems imagery using autonomous surface vessel data with machine learning algorithms and feature selection techniques by Mohammad Shakiul Islam, Padmanava Dash, Abduselam M. Nur, Hafez Ahmad, Rajendra M. Panda, Jessica S. Wolfe, Gray Turnage, Lee Hathcock, Gary D. Chesser, Jr, Robert J. Moorhead

“…Chlorophyll-a (Chl-a) is a critical biological indicator of the eutrophic state of water bodies, emphasizing the importance of its detailed characterization and continuous monitoring. …”
Get full text

Spatiotemporal discrepancies and risk assessment of toxic heavy metals in surface water of Shitalakhya River around Narayanganj port in Bangladesh by Shahrina Sultana, Md. Sirajul Islam, Md. Humayun Kabir, Rima Sarker, Tanmoy Roy Tusher, Mir Md. Mozammal Hoque, Nowara Tamanna Meghla

“…The comparative analysis exhibited that the water quality of Shitalakhya River is deteriorating day by day at an alarming rate. HPI showed a critical pollution index value (drinking) for all three seasons, whereas HEI revealed low heavy metal contamination for all sampling stations. …”
Get full text

Synergy of Remote Sensing and Geospatial Technologies to Advance Sustainable Development Goals for Future Coastal Urbanization and Environmental Challenges in a Riverine Megacity by Minza Mumtaz, Syed Humayoun Jahanzaib, Waqar Hussain, Sadia Khan, Youssef M. Youssef, Saleh Qaysi, Abdalla Abdelnabi, Nassir Alarifi, Mahmoud E. Abd-Elmaboud

“…While previous studies have examined urban growth patterns or environmental impacts independently, there remains a critical gap in understanding the integrated impacts of land use/land cover (LULC) changes on both ecosystem vulnerability and sustainable development achievements. …”
Get full text

Significance of KLK7 expression, polymorphisms, and function in sheep horn growth by Mingzhu Shan, Hao Li, Xinyue Li, Guoqing Zhang, Jianxin Shi, Pingjie Feng, Lisheng Zhou, Zhangyuan Pan, Mingxing Chu

“…Abstract Background Sheep horns play a critical role in the survival and reproduction of sheep. …”
Get full text

How learning to read Braille in visual and tactile domains reorganizes the sighted brain by Maciej Gaca, Alicja M. Olszewska, Dawid Droździel, Agnieszka Kulesza, Małgorzata Paplińska, Bartosz Kossowski, Katarzyna Jednoróg, Jacek Matuszewski, Aleksandra M. Herman, Artur Marchewka

“…Since neuroplasticity can occur within days, understanding neural reorganization during early learning stages is critical. Moreover, such activation was not tested in visual and tactile domains using comparable tasks. …”
Get full text

Dual disease co-expression analysis reveals potential roles of estrogen-related genes in postmenopausal osteoporosis and Parkinson’s disease by Dongdong Yu, Dongdong Yu, Jian Kang, Chengguo Ju, Qingyan Wang, Ye Qiao, Ye Qiao, Long Qiao, Long Qiao, Dongxiang Yang

“…The objective of this study was to identify critical genes and potential mechanisms associated with PMO by examining co-expressed genes linked to PD.MethodsInitially, pertinent data concerning PMO and PD were obtained from the GWAS database, followed by conducting a Bayesian colocalization analysis. …”
Get full text

Integrated metabolome and transcriptome analysis reveals key genes and pathways associated with egg yolk percentage in chicken by Wen Li, Yuxing Luo, Shoujia Zhu, Mengyuan Wang, Xuli Zhao, Zhonghua Ning

“…Yolk percentage is a critical index in the egg product industry, reflecting both nutritional value and economic benefits. …”
Get full text

An outbreak within an outbreak: The impact of Infection Prevention and Control strategies on hospital-acquired infections and the occurrence of multi-drug resistant organisms durin... by B Mashigo, A Parker, U Lalla, B W Allwood, M S Moolla, T Lovelock, C F N Koegelenberg

“…The outbreak of both CRE and A. baumannii, and the fact that many patients cultured the same CRE organism and A. baumannii, strongly suggests that a critical breakdown in IPC measures had occurred. …”
Get full text

Spatiotemporal analysis of surface Urban Heat Island intensity and the role of vegetation in six major Pakistani cities by Shoaib Ahmad Anees, Kaleem Mehmood, Syed Imran Haider Raza, Sebastian Pfautsch, Munawar Shah, Punyawi Jamjareegulgarn, Fahad Shahzad, Abdullah A. Alarfaj, Sulaiman Ali Alharbi, Waseem Razzaq Khan, Timothy Dube

“…To quantify SUHII dynamics, the impact of urban sprawl and vegetation changes was analyzed. The study offers critical insights into the implications for urban planning and policymaking in Pakistan. …”
Get full text

A General Framework for Closed Loop Negative Feedback Multivariable Physiological Control Systems: Existence, Uniqueness, and Stability of Homeostatic Equilibrium Points by Anna Procopio, Annarita Tedesco, Fabrizio Lo Regio, Giuseppe Cesarelli, Leandro Donisi, Carlo Ricciardi, Alessio Merola, Alfonso Maria Ponsiglione, Maria Romano, Francesco Montefusco, Carlo Cosentino, Francesco Amato

“…To this regard, in this paper, the existence, possible uniqueness and stability properties of the homeostatic equilibrium points of the general model are investigated; the theoretical framework is then illustrated through two real-world case-studies: (i) the PI3K/AKT/mTOR pathway nonlinear dynamics, a critical regulator of cellular growth, proliferation, and survival; (ii) the control mechanism of the neuromuscular stretch reflex, among the prime triggers implicated in postural control. …”
Get full text

Biochar Application and Mowing Independently and Interactively Influence Soil Enzyme Activity and Carbon Sequestration in Karst and Red Soils in Southern China by Wenjia Luo, Daniel F. Petticord, Shiwen Zhu, Shaowu Zhu, Yuanlong Wu, Xun Yi, Xinyue Wang, Yili Guo, Xuxin Song

“…Soil organic carbon (SOC), a critical component of the global carbon cycle, represents the largest terrestrial carbon reservoir, and is thus a major component of influencing climate regulation and ecosystem health. …”
Get full text

Metabolic profiling of Perilla leaves of different colors: insights into metabolite variation and bioactive compound distribution by Senouwa Segla Koffi Dossou, Qianchun Deng, Feng Li, Lei Wang, Nanjun Jiang, Habtamu Kefale, Rong Zhou, Donghua Li, Meilian Tan, Linhai Wang

“…Three types of Perilla leaves, including green, green/purple and purple, are mainly found, and the leaf color is a critical attribute for consumer preferences. However, the extent of diversity and variability of metabolites in Perilla leaves of different colors remain elusive. …”
Get full text

A lightweight wheat ear counting model in UAV images based on improved YOLOv8 by Ruofan Li, Xiaohua Sun, Kun Yang, Zhenxue He, Zhenxue He, Xinxin Wang, Xinxin Wang, Chao Wang, Chao Wang, Bin Wang, Fushun Wang, Fushun Wang, Hongquan Liu, Hongquan Liu

“…Wheat (Triticum aestivum L.) is one of the significant food crops in the world, and the number of wheat ears serves as a critical indicator of wheat yield. Accurate quantification of wheat ear counts is crucial for effective scientific management of wheat fields. …”
Get full text

Patient-reported quality of life and adherence outcomes after integrating exclusive liquid meal replacement in patients with head and neck cancer undergoing chemoradiation: results... by Luca F. Valle, Fang-I Chu, Xiaoyan Wang, Andrew Erman, Jackie Hernandez, Elizabeth Kaoh, Nicolas Edgar, Ann C. Raldow, Deborah J. Wong, Michael L. Steinberg, Amar U. Kishan, Robert K. Chin, John V. Hegde

“…ObjectivesPreventing malnutrition during chemoradiation (CRT) for head and neck cancer is critical maximizing quality of life (QOL). We sought to assess patient-reported QOL outcomes after integrating exclusive liquid meal replacement with Soylent, a novel meal replacement agent, in patients with head and neck cancer undergoing CRT.MethodsPatients undergoing definitive or adjuvant concurrent CRT for locally advanced head and neck cancer enrolled on our single-institution, prospective phase II protocol evaluating nutritional replacement with Soylent. …”
Get full text

Surgery for Patients With cT3/4N2M0, Stage IIIB NSCLC. Is It Time to Redefine Resectability? by J. Humberto Rodriguez-Quintero, MD, MPH, Rajika Jindani, MD, MPH, MS, Roger Zhu, MD, Isaac Loh, Mohamed K. Kamel, MD, Anne Montal, MD, Marc Vimolratana, MD, MS, Neel P. Chudgar, MD, Nitin Ohri, MD, MS, Balazs Halmos, MD, MS, Brendon M. Stiles, MD

“…Careful patient selection is undoubtedly critical, but stage IIIB designation alone should not exclude patients from surgical consideration.…”
Get full text

Preparedness, prevention and control related to zoonotic avian influenza by EFSA Panel on Animal Health and Animal Welfare (AHAW), ECDC, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S. Herskin, Virginie Michel, Miguel Ángel Miranda Chueca, Eleonora Nannoni, Søren Saxmose Nielsen, Romolo Nonno, Anja B. Riber, Jan Arend Stegeman, Karl Ståhl, Hans‐Hermann Thulke, Frank Tuyttens, Christoph Winckler, Claire Brugerolles, Thorsten Wolff, Anna Parys, Erika Lindh, Neus Latorre‐Margalef, Marie‐Anne Rameix Welti, Ralf Dürrwald, Ramona Trebbien, Sylvie Van der Werf, Magnus Gisslén, Isabella Monne, Alice Fusaro, Claire Guinat, Alessio Bortolami, Leonidas Alexakis, Theresa Enkirch, Olov Svartstrom, Katriina Willgert, Francesca Baldinelli, Ludovica Preite, Malin Grant, Alessandro Broglia, Angeliki Melidou

“…All preparedness, preventive and control measures must be implemented under a One Health framework and tailored to the setting and the epidemiological situation; in particular, enhanced monitoring, biosecurity, genomic surveillance and global collaboration are critical for mitigating the zoonotic risks of AIV.…”
Get full text

Ice-proximal sea ice reconstruction in the Powell Basin, Antarctica, since the Last Interglacial by W. W. Khoo, J. Müller, J. Müller, J. Müller, O. Esper, W. Xiao, C. Stepanek, P. Gierz, G. Lohmann, G. Lohmann, G. Lohmann, W. Geibert, J. Hefter, G. Mollenhauer, G. Mollenhauer, G. Mollenhauer

“…<p>In Antarctica, the presence of sea ice not only plays a critical role in the climate system but also contributes to enhancing the stability of the floating ice shelves. …”
Get full text

Comprehensive analysis of antimicrobial resistance dynamics among broiler and duck intensive production systems by Zsombor Szoke, Peter Fauszt, Maja Mikolas, Peter David, Emese Szilagyi-Tolnai, Georgina Pesti-Asboth, Judit Rita Homoki, Ildiko Kovacs-Forgacs, Ferenc Gal, Laszlo Stundl, Levente Czegledi, Aniko Stagel, Sandor Biro, Judit Remenyik, Melinda Paholcsek

“…The grower phase emerged as a critical intervention point. In farm environments 15 broiler-specific and 9 duck-specific biomarker species were identified, each strongly correlated with poultry-core HRCs (correlation coefficient > 0.7). …”
Get full text

Functional near-infrared spectroscopy for the assessment and treatment of patients with disorders of consciousness by Nan Wang, Nan Wang, Nan Wang, Yifang He, Sipeng Zhu, Dongsheng Liu, Xiaoke Chai, Xiaoke Chai, Qiheng He, Tianqing Cao, Jianghong He, Jingqi Li, Juanning Si, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Jizong Zhao, Jizong Zhao

“…BackgroundAdvances in neuroimaging have significantly enhanced our understanding of brain function, providing critical insights into the diagnosis and management of disorders of consciousness (DoC). …”
Get full text