Presynaptic CRF1 Receptors Mediate the Ethanol Enhancement of GABAergic Transmission in the Mouse Central Amygdala by Zhiguo Nie, Eric P. Zorrilla, Samuel G. Madamba, Kenner C. Rice, Marissa Roberto, George Robert Siggins

“…These data indicate that presynaptic CRF1 receptors play a critical role in permitting or mediating ethanol enhancement of GABAergic synaptic transmission in CeA, via increased vesicular GABA release, and thus may be a rational target for the treatment of alcohol abuse and alcoholism.…”
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Comparative efficacy of neuroprotective agents for improving neurological function and prognosis in acute ischemic stroke: a network meta-analysis by Yuchen Wang, Yuchen Wang, Mengqi Li, Mengqi Li, Yuye Jiang, Yuye Jiang, Qiuhong Ji

“…While reperfusion therapies play a critical role in the management of acute ischemic stroke (AIS), their applicability is limited, leaving many patients with significant neurological deficits and poor prognoses. …”
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Reflections by a member of the Editorial Board by Kevin T. Smith

“…I’m excited at the prospect of Les/Wood extending its traditional strengths to meet the critical need for wood science to optimize wood utilization, ecological understanding, and cultural patrimony. …”
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Pelvic Floor Muscle Training vs. Vaginal Vibration Cone Therapy for Postpartum Dyspareunia and Vaginal Laxity by Federico Villani, Izabella Petre, Florina Buleu, Stela Iurciuc, Luciana Marc, Adrian Apostol, Chiara Valentini, Elisabetta Donati, Tommaso Simoncini, Ion Petre, Cristian Furau

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Gcn2 rescues reprogramming in the absence of Hog1/p38 signaling in C. neoformans during thermal stress by David Goich, Amanda L. M. Bloom, Sean R. Duffy, Maritza N. Ventura, John C. Panepinto

“…When left untreated, cryptococcal meningitis is uniformly fatal, and in patients receiving the most effective antifungal regimens, mortality remains high. Thus, there is a critical need to identify additional targets that play a role in the adaptation to the human host and virulence. …”
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Exploring the potential benefits of areca nut extract in animal production: a review by Zhuying Liu, Zhuying Liu, Xiaolong Wang, Lixin Wen, Lixin Wen

“…Globally, the issue of antibiotic residues in agricultural products and their environments is increasingly critical, with the spread of microbial resistance becoming an urgent international challenge. …”
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CLEC11A-Driven Molecular Mechanisms in Intervertebral Disc Degeneration: A Comprehensive Multi-Omics Study by Jiang N, Wang Q, Hu Z, Tian X

“…Finally, we validated these findings through in vitro experiments, confirming the regulatory roles of these critical genes in the progression of IVDD.Results: Transcriptomic and MR analyses identified six candidate pathogenic genes (AEN, CLEC11A, HMGN1, LRRC25, TAF7, and TREM1) significantly associated with IVDD. …”
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An exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer: looking into the relationship with body composition by Cong Chen, Xin Luo, Xianchao Lin, Ronggui Lin, Yuanyuan Yang, Congfei Wang, Haizong Fang, Tianhong Teng, Heguang Huang, Fengchun Lu

“…Abstract Background Among cancer patients, pancreatic cancer patients have the highest rate of sarcopenia, which is a critical prognostic factor. Serum creatine kinase (CK) is closely related to skeletal muscle mass and has been reported to decline with the progression of cancer. …”
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Exploring public perceptions and awareness of Parkinson's disease: A scoping review. by Sophie Crooks, Gillian Carter, Christine Brown Wilson, Lisa Wynne, Patrick Stark, Michail Doumas, Matthew Rodger, Emma O'Shea, Gary Mitchell

“…The Joanna Briggs Institute Critical Appraisal Tools (JBI) were used to assess the quality of primary studies, however, all relevant studies were considered regardless of their methodological quality. …”
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Petrophysical assessment of the Hammam Faraun, Matulla and Nubia Reservoirs in the Ashrafi Oil Field, Gulf of Suez by Mohammed Amer, Walid M. Mabrouk, Amr M. Eid, Ahmed Metwally

“…Integrating this structures with petrophysical parameters such as shale volume, effective porosity, and hydrocarbon saturation provides critical insights into reservoir quality, informing future exploration and production strategies. …”
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Construction of a novel radioresistance-related signature for prediction of prognosis, immune microenvironment and anti-tumour drug sensitivity in non-small cell lung cancer by Yanliang Chen, Chan Zhou, Xiaoqiao Zhang, Min Chen, Meifang Wang, Lisha Zhang, Yanhui Chen, Litao Huang, Junjun Sun, Dandan Wang, Yong Chen

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Selective dorsal rhizotomy long-term effects on functional motility in Jordanian children with spastic cerebral palsy by Yazan E. Al-kharabsheh, Anas Said, Ismail A. Ismaiel, Issam Khawaja, Marwan Altaher, Ali Bani-Ahmed, Carmen M. Cirstea, Carmen M. Cirstea

“…These findings provide critical information that may aid in identifying “the best” therapeutic window and “the best” candidate for SDR in Jordan.…”
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Assessing Mean Glandular Dose in Mammography in Jordan According to American College of Radiology (ACR) Standards by Al Hrout R, Ayasrah M, Noor Azman NZ

“…Higher MGD values were particularly common in non-accredited facilities, where the average MGD reached 2.7 mGy, compared to 1.6 mGy in accredited units, suggesting gaps in quality control and adherence to best practices in non-accredited centers.Conclusion: This study emphasizes the critical role of accreditation and adherence to quality standards in maintaining safe and effective mammography practices. …”
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A noninvasive method for the detection of foetal DNA in early pregnancy based on differential methylation pattern of Ras association domain family member 1A by Yulin Sha, Wei Liu, Jiongzhi Hong, Yan Yang, Jian Yu, Xiaodong Fu

“…After digestion of the cell samples using a methylation-sensitive restriction enzyme cocktail, a critical step to differentiate between maternal and foetal DNA, the quantitative polymerase chain reaction (qPCR) of RASSF1A and β-actin (ACTB) were employed to measure foetal DNA and cell concentrations. …”
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Owners’ perceptions of dog treat management in Western Romania by Sorana Daina, Anamaria Blaga-Petrean, Silvana Popescu, Ioana Delia Pop, Daniel Mierlita, Adrian Macri

“…Veterinarians play a critical role in guiding owners toward balanced feeding strategies that incorporate treats into comprehensive dietary plans. …”
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Comparative evaluation of non-contrast MRI versus gadoxetic acid-enhanced abbreviated protocols in detecting colorectal liver metastases by Haoran Dai, Cheng Yan, Xi Jia, Yuyao Xiao, Xinyue Liang, Chun Yang, Kai Liu, Mengsu Zeng

“…The proposed Ab-MRI approach may be a viable alternative for CRLM surveillance. Critical relevance statement The non-enhanced abbreviated MRI (Ab-MRI) protocol is as effective as the gadoxetic acid-enhanced protocol in identifying colorectal liver metastasis (CRLM). …”
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Thyroid function during COVID-19 and post-COVID complications in adults: a systematic review by Anisha Panesar, Palma Gharanei, Natasha Khovanova, Lawrence Young, Dimitris Grammatopoulos, Dimitris Grammatopoulos

“…Study quality was assessed using the Critical Appraisal Skills Programme (CASP). A total of 53 studies met the inclusion criteria. …”
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Evaluating Reaction Videos of Young People Watching Edutainment Media (MTV Shuga): Qualitative Observational Study by Venetia Baker, Sarah Mulwa, David Khanyile, Georgia Arnold, Simon Cousens, Cherie Cawood, Isolde Birdthistle

“… BackgroundMass media campaigns, particularly edutainment, are critical in disseminating sexual health information to young people. …”
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The relationship between activities of daily living and speech impediments based on evidence from statistical and machine learning analyses by Liu Jun, Hongguo Li, Yu Mao, Lan Hu, Dan Wu

“…Early detection of potential SI in this demographic is critical. This study investigates the potential of Activities of Daily Living (ADL) as a predictive marker for SI, utilizing data from the 2018 China Health and Retirement Longitudinal Study (CHARLS), which includes 10,136 individuals aged 45 and above. …”
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Prevalence and spatial distribution of workplace violence against emergency medical staff in China: a cross-sectional study by Ruofan ZHANG, Jing FENG, Ge QU, Xinyan LI, Zihui LEI, Yuchao SUN, Aoqi SHEN, Chuanzhu LV, Xingyue SONG, Yong GAN

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