The neutrophil–lymphocyte ratio as a risk factor for all-cause mortality among individuals with resolved HBV infection: evidence from the NHANES 1999–2018 by Chen Qiu, Chaojie Yu, Lanlan Yang, Siqi Liu, Qian Zhang, Shengnan Jia, Wenrui Wang, Zhenjing Jin, Dongdong Yu

“…BackgroundInflammation is a critical component in the process of resolved hepatitis B virus (HBV) infection. …”
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Identification and expression analysis of the heat shock proteins Hsp70, Hsp90, and Hsp90b in Litopenaeus vannamei under low-temperature stress by Min Peng, Hui Wang, Shuiping Wen, Zheng Liang, Zheng Huang, Bin Zhang, Tianchong Chen, Qingyun Liu, Qiangyong Li, Yuan Meng, Yuliu Huang, Chunling Yang, Digang Zeng, Manyuan Li, Weilin Zhu, Yongzhen Zhao

“…These findings highlight the critical role of heat shock proteins in the low-temperature response of L. vannamei and provide valuable insights into understanding the mechanisms of shrimp cold tolerance and the development of cold-tolerant varieties.…”
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Development of a pandemic-related core set of quality indicators for quality and patient safety in University Hospitals in Germany by Janis Evers, Natalie Altschuck, Claudia Mehl, Lilly Rüthrich, Lorenz Harst, Felix Walther, Oliver Steidle, Arnt Suckow, Ruth Hecker, Jochen Schmitt, Max Geraedts

“…Results The comprehensive evaluation identified two primary strands: organizational/management indicators (Strand A, 60 indicators) and disease-specific clinical quality and patient safety indicators (Strand B, 20 indicators for critical conditions like stroke, myocardial infarction, and cancer.) …”
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MSCPNet: A Multi-Scale Convolutional Pooling Network for Maize Disease Classification by Mehdhar S. A. M. Al-Gaashani, Reem Alkanhel, Muthana Ali Salem Ali, Mohammed Saleh Ali Muthanna, Ahmed Aziz, Ammar Muthanna

“…Maize (Zea mays) is a critical crop for global food security and economic stability. …”
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Enhanced photocatalytic degradation of Rhodamine B using polyaniline-coated XTiO3(X = Co, Ni) nanocomposites by Mariyem Abouri, Abdellah Benzaouak, Mohamed Elouardi, Lahcen El Hamdaoui, Fatima Zaaboul, Khalil Azzaoui, Belkheir Hammouti, Rachid Sabbahi, Shehdeh Jodeh, Mohammed Alaoui El Belghiti, Adnane El Hamidi

“…The study elucidates the degradation mechanism through intermediate identification via HPLC-MS analysis, highlighting N-de-ethylation, aromatic ring cleavage and eventual mineralization into CO2 and H2O as critical pathways. Furthermore, the 1wt.%PANI@NiTiO3 nanocomposite demonstrated excellent stability and recyclability, maintaining its degradation efficiency over four consecutive cycles with minimal change. …”
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Association between estimated glucose disposal rate and cardiovascular diseases in patients with diabetes or prediabetes: a cross-sectional study by Jinhao Liao, Linjie Wang, Lian Duan, Fengying Gong, Huijuan Zhu, Hui Pan, Hongbo Yang

“…Three machine learning methods (SVM-RFE, XGBoost, and Boruta algorithms) were employed to select the most critical variables. Logistic regression models were established to evaluate the association between eGDR and CVD. …”
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Deficiency of ATF3 facilitates both angiotensin II‐induced and spontaneously formed aortic aneurysm and dissection development by activating cGAS–STING pathway by Yifan Du, Poyi Hu, Xiangchao Ding, Dashuai Wang, Jingjing Luo, Sheng Le, Lingyun Ren, Manhua Chen, Ping Ye, Jiahong Xia

“…Abstract Background Sporadic aortic aneurysm and dissection (AAD) is a critical condition characterised by the progressive loss of vascular smooth muscle cells (VSMCs) and the breakdown of the extracellular matrix. …”
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Characterization of NOD-like receptor-based molecular heterogeneity in glioma and its association with immune micro-environment and metabolism reprogramming by Chunlin Lu, Huihao Ma, Jie Wang, Fei Sun, Fei Sun, Mingyang Fei, Ying Li, Jing Liu, Bin Dong

“…Knockdown of TRIP6 gene can significantly inhibit the proliferation and migration ability of GBM cells.ConclusionThe NLR signaling pathway plays a critical role in regulating immune microenvironment and metabolism reprogramming of GBM. …”
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Development of a Recombinant Fusion Vaccine Candidate Against Lethal <i>Clostridium botulinum</i> Neurotoxin Types A and B by Eun-Sun Choi, Seong-Wook Pyo, So-Hyeon Kim, Jun-Ho Jeon, Gi-Eun Rhie, Mi-Ran Yun, Hwajung Yi, Yoon-Seok Chung

“…The HC_C domain is critical for binding to neuronal cell membrane receptors and facilitating BoNT internalization via endocytosis. …”
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Hu-lu-su-pian ameliorates hepatic steatosis by regulating CIDEA expression in AKT-driven MASLD mice by Rumeng Ren, Rumeng Ren, Qi Wang, Qi Wang, Dongjie Deng, Dongjie Deng, Aoao Guo, Aoao Guo, Xin Chen, Xin Chen, Yan Meng, Yan Meng, Ying Fang, Ying Fang, Guohua Zheng, Guohua Zheng, Zhong Xu, Zhong Xu, Man Li, Junjie Hu, Junjie Hu

“…In addition, HLSP significantly reduced lipid accumulation and expression of critical genes for de novo fatty acid synthesis in HepG2 and Huh-7 cells overexpressing CIDEA.DiscussionThe present study preliminarily suggests that HLSP can ameliorate hepatic steatosis by inhibiting CIDEA-mediated de novo fatty acid synthesis and LD formation, which may offer a potential strategy for treating MASLD.…”
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Impact of gut microbial diversity on egg production performance in chickens by Liping Wu, Tao Zhang, Zhihua Luo, Huiyuan Xiao, Di Wang, Cailong Wu, Xinyan Fang, Jiawei Li, Jing Zhou, Junjie Miao, Hongli Tan, Yanan Wang, Qing Liu, Jianhua Huang

“…This study provides a scientific basis and intestinal microbiome data for selecting probiotics related to high egg production in chickens.IMPORTANCEThis study elucidates the critical role of gut microbiota in the egg-laying performance of chickens, a key economic indicator in the poultry industry. …”
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Preparation Methods and Perceived Risk of Foodborne Illness Among Consumers of Prepackaged Frozen Vegetables – United States, September 2022 by Michelle Canning, Michael Ablan, Tamara N. Crawford, Amanda Conrad, Alexandra Busbee, Misha Robyn, Katherine E. Marshall

“…Both findings highlight the critical importance of preventive controls in the production of frozen vegetables prior to reaching the consumer.…”
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Early risk assessment in paediatric and adult household contacts of confirmed tuberculosis cases by novel diagnostic tests (ERASE-TB): protocol for a prospective, non-interventiona... by Ursula Panzner, Katharina Kranzer, Tsitsi Bandason, Kuda Mutasa, Sandra Rukobo, Charles Sandy, Bariki Mtafya, Andrea Rachow, Norbert Heinrich, Michael Hoelscher, Judith Bruchfeld, Olena Ivanova, Nyanda Elias Ntinginya, Doreen Pamba, Laura Olbrich, Issa Sabi, Simeon Mwanyonga, Elmar Saathoff, Willyhelmina Olomi, Junior Mutsvangwa, Hazel M Dockrell, Edson Tawanda Marambire, Denise Banze, Alfred Mfinanga, Theodora D Mbunda, Khosa Celso, Gunilla Kallenius, Claire J Calderwood, Christof Geldmacher, Kathrin Held, Tejaswi Appalarowthu, Friedrich Rieß, Anna Shepherd, Christopher Sundling, Mishelle Mugava, Martha Chipinduro, Lwitiho Sudi, Antelmo Haule, Emmanuel Sichone, Paschal Qwaray, Harrieth Mwambola, Lilian Minja, Peter Edwin, Dogo Ngalison, Stella Luswema, Celina Nhamuave, António Machiana, Carla Madeira, Emelva Manhiça, Nádia Sitoe, Jorge Ribeiro

“…Better diagnostics, together with tools to predict disease progression, are critical for achieving WHO End-TB targets. The Early Risk Assessment in TB Contacts by new diagnoStic tEsts (ERASE-TB) study aims to evaluate novel diagnostics and testing algorithms for early TB diagnosis and accurate prediction of disease progression among household contacts (HHCs) exposed to confirmed index cases in Mozambique, Tanzania and Zimbabwe.Methods and analysis A total of 2100 HHCs (aged ≥10 years) of adults with microbiologically-confirmed pulmonary TB will be recruited and followed up at 6-month intervals for 18–24 months. …”
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Screening potential diagnostic biomarkers for PLA2R‑associated idiopathic membranous nephropathy by WGCNA analysis and LASSO algorithm by Jinxu Huang, Yaqing Huang, Xiaoling Zeng, Yuhong Zhang, Junneng Zhang, Qingchu Hong, Yongtiao Peng

“…The onset of phospholipase A2 receptor (PLA2R1)-associated IMN is critically linked to M-type PLA2R1 exposure, yet the mechanism underlying glomerular injury remains unclear. …”
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Molecular evidence of the inhibitory potential of melatonin against sodium arsenite toxicity by Ramtin Farhadi, Marzieh Daniali, Maryam Baeeri, Reza Khorasani, Hamed Haghi-Aminjan, Mahdi Gholami, Mahban Rahimifard, Mona Navaei-Nigjeh, Mohammad Abdollahi

“…Mitigating different harms and toxicities through different mechanisms, such as antioxidant properties, anti-inflammatory effects, and critical gene regulation, is essential. Due to these findings, this study aimed to evaluate the hypothesis that MLT may ameliorate pancreatic damage caused by exposure to SA. …”
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‘I no longer worry about money for transport to the health centre’ - economic empowerment of caregivers of children living with HIV through Village Savings and Loan Associations: e... by Joseph Rujumba, Carmen Roebersen, Susan Namara, Richard Ochen, Sharon Eva Ahumuza, Allen Tushabe, Mathias Akugizibwe, David Bitira, Innocent Mwesigye, Stella Kentusi, Henry Zakumumpa, Japheth Kwiringira, Merian Natukwatsa Musinguzi

“…Group training, integration of expert clients in VSLA groups, provision of VSLA kits, provision of financial top-up and linking groups to other service providers were critical success factors. However, poverty, poor leadership characterised by domination by select individuals in decision making, favoritism in giving out loans and lack of transparency in handling group activities as well as the COVID-19 were key challenges. …”
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Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy by Miaomiao Mao, Nikola Jancovski, Yafit Kushner, Lucas Teasdale, Phan Truong, Kun Zhou, Samuel Reid, Linghan Jia, Ye Htet Aung, Melody Li, Christopher A. Reid, Sean Byars, Ingrid Scheffer, Steven Petrou, Snezana Maljevic

“…KCNQ2 encodes a voltage-gated potassium channel KV7.2 widely expressed in the central nervous system and critically involved in the regulation of neuronal excitability. …”
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Physiological accumulation of lipid droplets in the newborn liver during breastfeeding is driven by TLR4 ligands by Wanderson Ferreira da Silva Júnior, Karen Marques de Oliveira Costa, Hortência Maciel Castro Oliveira, Maísa Mota Antunes, Kassiana Mafra, Brenda Naemi Nakagaki, Pedro Sérgio Corradi da Silva, Júlia Duarte Megale, Sarah Campos de Sales, Douglas Carvalho Caixeta, Mário Machado Martins, Robinson Sabino-Silva, Cristina Maria Pinto de Paula, Luiz Ricardo Goulart, Rafael Machado Rezende, Gustavo Batista Menezes

“…Subsequent studies using TLR4-deficient mice and cell-specific deletion revealed that TLR4 signaling, particularly within hepatocytes, plays a critical role in driving fat storage within the newborn liver. …”
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Clinical validation of an artificial intelligence algorithm for classifying tuberculosis and pulmonary findings in chest radiographs by Thiago Fellipe Ortiz de Camargo, Thiago Fellipe Ortiz de Camargo, Guilherme Alberto Sousa Ribeiro, Guilherme Alberto Sousa Ribeiro, Maria Carolina Bueno da Silva, Luan Oliveira da Silva, Pedro Paulo Teixeira e Silva Torres, Denise do Socorro Rodrigues da Silva, Mayler Olombrada Nunes de Santos, William Salibe Filho, Marcela Emer Egypto Rosa, Magdala de Araujo Novaes, Thiago Augusto Massarutto, Osvaldo Landi Junior, Elaine Yanata, Marcio Rodrigues da Cunha Reis, Gilberto Szarf, Pedro Vieira Santana Netto, Joselisa Peres Queiroz de Paiva

“…BackgroundChest X-ray (CXR) interpretation is critical in diagnosing various lung diseases. However, physicians, not specialists, are often the first ones to read them, frequently facing challenges in accurate interpretation. …”
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Interprofessional collaborative practice in health and social care for people living with multimorbidity: a scoping review protocol by Josephine-L. K. Murray, Virginia Hernandez-Santiago, Frank Sullivan, Joanna Hornal, Farhana Badshah, Ben Keatley, Jillian Galbraith, Pam Channer, Anne Fearfull, Anne Haddow, Eleanor Johnston, Maureen Ward, Veronica O’Carroll

“…Hand searching will be performed on all included full-text articles for any articles missing from the two steps above. Critical data will be extracted by adapting existing data abstraction forms based on the needs of the research objectives. …”
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