Luteolin improves mitochondrial dynamics and function in ulcerative colitis via the miR-195-5p/Notch signalling pathway by Moxixuan Liu, Yuge Wang, Zhao Liu, Senxia Liu, Qian Yang, Bolin Li

“…Additionally, our findings corroborate the hypothesis that miR-195-5p plays a critical role as a mediator in the negative feedback regulation of the Notch signalling pathway. …”
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Migration of Health Workers and Its Impacts on the Nigerian Health Care Sector: Protocol for a Scoping Review by David Omiyi, Ebenezer Arubuola, Marcus Chilaka, Md Shafiqur Rahman Jabin

“…Understanding the factors driving migration, its effects on health care delivery, and potential policy interventions is critical for addressing this complex issue. …”
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Association between secondhand smoke exposure and hypertension in never smokers: a cross-sectional survey using data from Korean National Health and Nutritional Examination Survey... by Young Sik Park, Chang-Hoon Lee, Sang Haak Lee, Kwang-Ha Yoo, Yu-Il Kim, Chul Min Ahn, Ju Ock Kim, Ju-Heon Park, Jae Yeol Kim, Eun Mi Chun, Tae-Hoon Jung

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Experiments and Index Construction for Disaster Caused by Low Temperature Affecting Hetao Sunflower in Inner Mongolia by Duan Xiaofeng, Liu Wei, Bao Jiajing, Liu Yanli, Li Shuqi, Tang Hongyan

“…The variation in cold resistance among different parts is greater than the variation caused by different sowing methods. The critical freezing temperature of sunflower plants is -1 ℃. …”
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Portable UV-C device to treat high flow of infectious aerosols generated during clinical respiratory care by Richard Vincent, David Rapoport, Priti Balchandani, Joseph Borrello, Michael Schotsaert, Robert Karlicek, Gabriel Laghlali, Prajakta Warang, Seokchan Park, Gagandeep Singh, Isabella Morgan, James Paredes, Raveen Rathnasinghe, Jacob Wolf, Adolfo García-Sastre

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Physicians’, pharmacists’, and nurses’ education of patients about antibiotic use and antimicrobial resistance in primary care settings: a qualitative systematic literature review... by Lavinia Bianca Balea, Ragnhild J. A. Gulestø, Hongxuan Xu, Hongxuan Xu, Stinne Glasdam

“…Quality appraisal followed the Critical Appraisal Skills Program (CASP) qualitative study checklist. …”
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Antimicrobial resistance, virulence gene profiles, and molecular epidemiology of enterococcal isolates from patients with urinary tract infections in Shanghai, China by Weiyi Wu, Shuzhen Xiao, Lizhong Han, Qiong Wu

“…The prevalence of E. faecalis CC16 and E. faecium CC17 further complicates the treatment landscape for Enterococcal UTIs.IMPORTANCEThis study highlighted the critical need to understand Enterococcal strains causing UTIs in Shanghai, given their high prevalence. …”
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Identifying the Latitude and Longitude of ATMs in ATM Networks by Niloofar Haghjoo, Mohammad rahmati, Ali Zare Mirakabad

“…Objective The geographical positioning of Automated Teller Machines (ATMs) is a pivotal data point that significantly aids in the analytical process and decision-making for a multitude of critical banking and economic determinations. Given the constraints imposed by the insular viewpoint prevalent in the nation’s banking ecosystem, maintaining a consolidated perspective of all ATMs’ geographical locations is not feasible. …”
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A secure and energy-efficient routing using coupled ensemble selection approach and optimal type-2 fuzzy logic in WSN by S. Ambareesh, Pundalik Chavan, S. Supreeth, Rajesh Nandalike, P. Dayananda, S. Rohith

“…This research contributes significantly to the WSN field by providing a comprehensive routing solution that integrates energy conservation, security, and QoS, ultimately extending the lifespan of WSNs and boosting confidence in critical applications, paving the way for implementation scenarios that require secure, low-power, and real-time data transmission.…”
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Development and Validation of a Photoplethysmography System for Noninvasive Monitoring of Hemoglobin Concentration by Hongyun Liu, Fulai Peng, Minlu Hu, Jinlong Shi, Guojing Wang, Haiming Ai, Weidong Wang

“…Traditional invasive hemoglobin (Hb) detection led to delayed diagnosis, operational inefficiency, incorrect critical decision making, and uncomfortable patient experience. …”
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A quantitative PCR to detect non-toxigenic Clostridioides difficile by Khurshida Begum, Hubert C. Chua, M. Jahangir Alam, Kevin W. Garey, Jinhee Jo

“…Detecting these strains is critical as it underscores the importance of avoiding unnecessary antibiotic treatment in patients colonized with NTCD. …”
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Prescription pattern, glycemic control status, and predictors of poor glycemic control among diabetic patients with comorbid chronic kidney disease in Ethiopia: a facility-based cr... by Oumer Sada Muhammed, Minimize Hassen, Samuel Mamusha

“…With only 4.4% of participants achieving optimal HbA1c levels, the findings underscore a critical public health concern regarding the management of diabetes in this vulnerable population. …”
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Investigation of <i>ITGB3</i> Heterogeneity to Overcome Trastuzumab Resistance in HER2-Positive Breast Cancer by Asiye Busra Boz Er

“…<i>ITGB3</i> plays a critical role in Trastuzumab resistance through the modulation of TGF-β signalling, migration, and contributing to tumour heterogeneity. …”
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Function over form: The benefits of aspen as surrogate brood‐rearing habitat for greater sage‐grouse by Michel T. Kohl, Charles P. Sandford, Paul C. Rogers, Renee Chi, Terry A. Messmer, David K. Dahlgren

“…Here, we term these areas surrogate habitat, defined as vegetation communities or resource sites that provide similar critical resources as conventional sites, and assess their potential for conservation using a case study of greater sage‐grouse (Centrocercus urophasianus) on Parker Mountain, Utah (1998–2009). …”
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Development of a Web-Based Intervention for Middle Managers to Enhance Resilience at the Individual, Team, and Organizational Levels in Health Care Systems: Multiphase Study by Eva Gil-Hernández, Irene Carrillo, Jimmy Martin-Delgado, Daniel García-Torres, José Joaquín Mira

“…Phase 1 involved designing the content for the web-based tool based on a comprehensive review of critical elements around resilience. Phase 2 included validation by an international panel of experts who reviewed the tool and rated it according to a structured grid. …”
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Synthetic inhibition of SREBP2 and the mevalonate pathway blocks rhabdomyosarcoma tumor growth in vitro and in vivo and promotes chemosensitization by Silvia Codenotti, Michela Asperti, Maura Poli, Luisa Lorenzi, Alberto Pietrantoni, Matteo Cassandri, Francesco Marampon, Alessandro Fanzani

“…Conclusions: These data suggest that the Akt1, SREBP2 and MVP axis is critical for RMS tumor growth, migration, and oxidative stress protection primarily through maintaining adequate CHO levels that enable proper intracellular signaling. …”
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Severe pregnancy-associated atypical hemolytic uremia syndrome in the context of the COVID-19 pandemic: a novel survival case report by Yan Yang, Xiao-jin Li, Hua-Yan Yuan, Jing-Jing Xiong, Peng-Fei Li, Zhen Wang

“…Early recognition of aHUS is critical for effective treatment and improved prognosis. …”
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Evaluation of circadian rhythm and prognostic variability pre-and post-CEA or CAS treatment in patients with carotid artery stenosis by Yi Quan, Zhongzhu Wang, Tao Zhang, Yanyong Sui, Xin Zhang, Xueliang Ji, Ao-fei Liu, Weijian Jiang

“…Additionally, increased physical activity after treatment was linked to improved neurological recovery.ConclusionThis study highlights the critical role of circadian rhythm regulation and cardiovascular health in stroke recovery following CEA or CAS. …”
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PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway by Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen

“…This study highlights the critical role of PTEN in RCC progression and suggests potential therapeutic targets for intervention.…”
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Pharmacokinetics and Bioequivalence of Two Fixed-Dose Combination Tablets of Valsartan/Amlodipine (80/5 Mg) in Healthy Chinese Subjects by Tian M, Huang J, Chen Y, Jin Q, Jiang H, Shi C, Mei J, Xu M, Yu X, Yang S

“…The point estimates of the geometric mean ratios (GMRs) of Cmax, AUC0−t, and AUC0−∞ for valsartan were 1.0805, 1.0991, and 1.1015 respectively, and the critical bounds were all less than 0. The Swr of Cmax, AUC0−t, and AUC0−∞ for amlodipine were all < 0.294, and the 90% confidence intervals (CIs) of the GMRs fell within the bioequivalence range, as evaluated by the average bioequivalence (ABE) method. …”
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