Assessing water demand and supply in the Upper Indus Basin using integrated hydrological modeling under varied socioeconomic scenarios by Sareer Ahmad, Muhammad Waseem, Hira Wahab, Abdul Qadeer Khan, Zulqarnain Jehan, Izhar Ahmad, Megersa Kebede Leta

“…The study highlights the critical role of technology and farmer awareness in achieving these reductions, despite current irrigation scheme losses of 20%. …”
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Low-exhaustion peripheral circulating γδ T cells serve as a biomarker for predicting the clinical benefit rate of non-small cell lung cancer (NSCLC) patients to chemotherapy or tar... by Dongdong Zhang, Guichao Liu, Jinhui Ye, Ke Li, Guojun Zhang, Qiang Quan, Xinhai Zhu, Peng Li

“…Conclusions These findings collectively suggest that circulating Vδ2 T cells with low levels of immune exhaustion are critical contributors to the effectiveness of chemotherapy and targeted therapies in NSCLC. …”
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Construction of a novel cuproptosis-related gene signature and integrative analyses in cholangiocarcinoma by Liye Wang, Pan Li, Shuai Gong, Lina Pang, Mingyu Li, Chi Zhang, Shengli Zhang, Xiaoke Zhang, Guozhong Jiang, Wei He

“…In contrast, a high-risk score was associated with cancer and metastasis-related pathways, high infiltration of M2 macrophages, high expression of immune checkpoint genes, suppressive immunity and more aggressive phenotypes, and less benefit from chemotherapeutic and immunotherapy. In addition, the critical CRGs were further validated through qRT-PCR and WB. …”
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Transcriptome analysis reveals potential regulatory mechanism of genes and pathways following Aeromonas veronii infection and hypoxic stress in Chinese mitten crab, Eriocheir sinen... by Gang Jiang, Fengyuan Yan, Yuanfeng Xu, Jianlin Li, Wenrong Feng, Guo an Hua, Wen jing Li, Jun Zhou, Yongkai Tang

“…Finally, 29 DEGs were identified as critical in responding to hypoxia stress and A. veronii infection. …”
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Effects of Immune System-Related Medications on COVID-19 Outcome in a Cohort of Iranian Patients: Preliminary Report of a Data Mining Study by Ehsan Bitaraf, Seyyed Amir Yasin Ahmadi, Alireza Gandomi-Mohammadabadi, Zahra Noorani Mejareh, Bahare Abdollahi, Javad Balasi, Farzan Moodi, Nima Hemmati, Ali Kabir

“…Regulation of the immune system is critical for fighting against viral infections. Both suppression and hyperactivity of the immune system result in failure of treatment. …”
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Tracking the Prevalence of Antibiotic Resistance in <i>Enterococcus</i> Within the Spanish Poultry Industry: Insights from a One Health Approach by Josep Garcia-Llorens, Isaac Monroy, Jan Torres-Boncompte, Jose M. Soriano, Pablo Catalá-Gregori, Sandra Sevilla-Navarro

“…<b>Conclusions</b>: These findings highlight the critical need for targeted surveillance and intervention strategies in poultry production to mitigate the risks posed by MDR <i>Enterococcus</i> to public health.…”
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Enhancing collaborative clinical reasoning among multidisciplinary healthcare teams in a neurosurgery ICU: insights from video-reflexive ethnography by Ching-Yi Lee, Ching-Hsin Lee, Sze-Yuen Yau, Hung-Yi Lai, Po-Jui Chen, Mi-Mi Chen

“…Abstract Background Clinical reasoning is a critical skill for healthcare professionals, vital for making accurate diagnoses and effective treatment decisions. …”
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Recent Developments to the ANSWERS® Monte Carlo Codes MONK® and MCBEND® by Fildes Jessica, Richards Simon, Bird Adam, Cox Andrew, Fry Timothy, Hanlon David, Jones Brian, Long David, Tantillo Francesco, Wright George, Hiles Richard

“…MONK® and MCBEND® are two advanced Monte Carlo codes developed by the ANSWERS® Software Service, which have been used in over 30 countries worldwide for a range of applications, and have been well-established in the UK criticality and shielding communities respectively over the course of several decades. …”
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Evaluation of S100A8/A9 and neutrophils as prognostic markers in metastatic melanoma patients under immune-checkpoint inhibition by Yasmin F Melzer, Nadine L Fergen, Christian Mess, Julia-Christina Stadler, Glenn Geidel, Ysabel A Schwietzer, Julian Kött, Klaus Pantel, Stefan W Schneider, Jochen Utikal, Ewa Wladykowski, Sabine Vidal-y-Sy, Alexander T Bauer, Christoffer Gebhardt

“…Significance: These findings underscore the critical need for reliable biomarkers in melanoma research, particularly for predicting responses to immune-checkpoint inhibitors (ICIs). …”
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OSBPL3 modulates the immunosuppressive microenvironment and predicts therapeutic outcomes in pancreatic cancer by Qihui Sun, Xiaoqi Zhu, Qi Zou, Yang Chen, Tingting Wen, Tingting Jiang, Xiaojia Li, Fang Wei, Keping Xie, Jia Liu

“…Conclusions Our study reveals OSBPL3 as a critical regulator of the immunosuppressive microenvironment in pancreatic cancer and a potential therapeutic target. …”
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Exploring the heterogeneity of HER2 gene status and expression in non-positive breast cancer patients: insights from immunohistochemistry and fluorescence in situ hybridization by Jingmin Zhong, Beibei Gao, Qingjie Wang, Jun He, Danjv Luo, Chen Zhang, Jun Fan, Xiu Nie

“…Abstract Breast cancer became the most prevalent malignancy among women, and HER2 expression status is critical for treatment decisions. With the emergence of ADC drugs, HER2 low-expressing patients who previously did not respond well to traditional anti-HER2 therapies may now benefit. …”
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A Series of Novel Alleles of <i>Ehd2</i> Modulating Heading and Salt Tolerance in Rice by Peng Xu, Shulei Hao, Xiaoxia Wen, Guifang Ma, Qinqin Yang, Ling Liu, Galal Bakr Anis, Yingxin Zhang, Lianping Sun, Xihong Shen, Qunen Liu, Daibo Chen, Yongbo Hong, Yuyu Chen, Xiaodeng Zhan, Shihua Cheng, Liyong Cao, Weixun Wu

“…Rice (<i>Oryza sativa</i> L.) is a staple crop for nearly half of the global population and one of China’s most extensively cultivated cereals. Heading date, a critical agronomic trait, determines the regional and seasonal adaptability of rice varieties. …”
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Taking a partnership approach to embed physical activity in local policy and practice: a Bradford District case study by Jennifer Hall, Elliot Lever, Nathan Dawkins, Emma Young, Jamie Crowther, Rachel Williams, John Pickavance, Sally Barber, Andy Daly-Smith, Anna Chalkley, On behalf of the wider JU:MP team

“…Results Four themes were identified which embody conditions that appear to be critical for working towards physical activity being embedded in local policy & practice within the Bradford District. …”
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Assessing the detection and interaction of Lawsonia intracellularis and porcine circovirus 2 in low and high-performance wean-to-finish pig groups in different porcine reproductive... by Guilherme Cezar, Fernando L. Leite, Eduardo Fano, Reid Phillips, John Waddell, Kate Dion, Edison Magalhães, Giovani Trevisan, Gustavo Silva, Daniel C. Linhares

“…Thus, understanding factors that lead to more or less severe disease are critically important. Porcine circovirus type 2 (PCV2) and Lawsonia intracellularis (L. intracellularis) are endemic pathogens in the U.S., affecting herds with varying degrees of subclinical and clinical disease and impact on performance. …”
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Association between poor drug adherence and undernutrition among adult HIV patients in southern Ethiopia: an institution based cross sectional study by Muluken Bekele Sorrie, Nigus Kabtu Belete, Tesfaye Feleke Gadore, Darik Temesgen Assefa, Manaye Yihune Teshale, Eshetu Zerihun Tariku

“…Therefore, effectively managing poor drug adherence, nutritional supplements and communicating behavioural change implications are critical for successfully preventing undernutrition.…”
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Genome-wide identification of MGT gene family in soybean (Glycine max) and their expression analyses under magnesium stress conditions by Ammar Anwar, Junaid Akhtar, Saba Aleem, Maida Aleem, Muhammad Khuram Razzaq, Saud Alamri, Qasim Raza, Iram Sharif, Arooj Iftikhar, Shehreen Naseer, Zaheer Ahmed, Iqrar Ahmed Rana, Waheed Arshad, Muhammad Imran Khan, Javaid Akhter Bhat, Muqadas Aleem, Abdel-Rhman Z. Gaafar, Mohamed S. Hodhod

“…Abstract Background Magnesium (Mg) is essential for plant growth and development and plays critical roles in physiological and biochemical processes. …”
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Transcriptional landscape and predictive potential of long noncoding RNAs in peritoneal recurrence of gastric cancer by Xiao-Xia Cai, Guo-Ming Chen, Zi-Qi Zheng, Yi-Xin Yin, Shuang Wang, Li Qiao, Xiao-Jiang Chen, Bai-Wei Zhao, Jin-Ling Duan, Cheng-Cai Liang, Ruo-Peng Zhang, Cheng-Zhi Wei, Fei-Yang Zhang, Bo-Wen Huang, Ze-Xian Liu, Zhi-Wei Zhou, Dan Xie, Mu-Yan Cai, Shu-Qiang Yuan, Yuan-Fang Li, Run-Cong Nie

“…Abstract Background Long noncoding RNAs (lncRNAs) play a critical role in gastric cancer (GC) progression and metastasis. …”
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ILN-YOLOv8: A Lightweight Image Recognition Model for Crimped Wire Connectors by Xiaojian Zhou, Jicheng Kan, Nur Fatin Liyana Mohd Rosely, Xu Duan, Jiajing Cai, Zihan Zhou

“…With the rapid growth of China&#x2019;s new energy vehicle industry, the quality of crimped wire connectors directly impacts the performance of wiring harnesses, which are critical to the overall vehicle quality. At present, reliable methods for inspecting crimped wire connectors are still primarily based on image recognition evaluations. …”
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Self-Assembled Peptide Hydrogels PPI45 and PPI47: Novel Drug Candidates for <i>Staphylococcus aureus</i> Infection Treatment by Quanlong Wu, Mengyin Deng, Ruoyu Mao, Na Yang, Ya Hao, Manli Cao, Da Teng, Jianhua Wang

“…The high-level preparation of PPI45 and PPI47 was achieved with yields of 1.82 g/L and 2.13 g/L, which are 2.19 and 2.60 times the yield of PPI42. Additionally, the critical micelle concentrations (CMCs) of the peptides at pH 7.4 for PPI42, PPI45, and PPI47 were determined to be 245 µg/mL, 973 µg/mL, and 1016 µg/mL, respectively. …”
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REGENERATIVE MEDICINE IN BURN INJURY: A BIBLIOMETRIC ANALYSIS AND LITERATURE REVIEW by Naufal Aminur Rahman, Santi Devina, Muhammad Yusuf Billiant Pradana, Godwin Emeka Ozokolie, Lanre Peter Daodu, Shreya Pandey

“…Highlights: • This research analyzes regenerative medicine trends for burn injuries, providing valuable insights into focal points and article characteristics, enhancing understanding of this critical healthcare issue. • This research analyzes trends in regenerative medicine for burn injuries, highlighting emerging areas like 3D printing, nanotechnology, and photothermal therapy as promising future research directions. …”
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