Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage by Ji Eon Kim, Hyun Su Kim, Wonsik Kim, Eun Hae Lee, Soyeon Kim, Taewoo Kim, Eun-Ae Shin, Kyung-hee Pyo, Haesong Lee, Seo Hee Jin, Jae-Ho Lee, Soo-Min Byeon, Dong Joo Kim, Jinwook Jeong, Jeongwon Lee, Minjae Ohn, Hyojung Lee, Su Jong Yu, Dongyun Shin, Semi Kim, Jun Yeob Yoo, Seung-Chul Lee, Young-Ger Suh, Jung Weon Lee

“…Abstract Dynamic communication between hepatocytes and the environment is critical in hepatocellular carcinoma (HCC) development. …”
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<i>Chlamydia trachomatis</i> Serovars from the C-Complex and the B- and C-Related Complexes Are Significantly More Pathogenic than Those from the B-Complex in C3H/HeN but Not in BA... by Sukumar Pal, Jennifer R. Carmichael, Delia F. Tifrea, Olga Tatarenkova, Luis M. de la Maza

“…These results support the findings in humans and emphasize the critical importance of the immunogenetic background of the host on the outcome of <i>C. trachomatis</i> infections. …”
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Decoding oral cancer: insights from miRNA expression profiles and their regulatory targets by Xin Wang, Xin Wang, Shuang Zhang, Shuang Zhang, Shuyi Wang, Tao Cao, Tao Cao, Hong Fan, Hong Fan

“…MicroRNAs (miRNAs), as critical regulators of gene expression, have emerged as key players in modulating plethora of cellular mechanisms. …”
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A flux tower site attribute dataset intended for land surface modeling by J. Shi, H. Yuan, W. Lin, W. Dong, H. Liang, Z. Liu, J. Zeng, H. Zhang, N. Wei, Z. Wei, S. Zhang, S. Liu, X. Lu, Y. Dai

“…Model simulations revealed substantial disparities in the output between the attribute data observed at the site and those commonly used by LSMs, underscoring the critical role of site-observed attribute data and increasing the emphasis on flux tower attribute data in the LSM community. …”
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Dynamic physiology and transcriptomics revealed the alleviation effect of melatonin on Reaumuria trigyna under continuous alkaline salt stress by Xuebo Li, Lei Wang, Heyi Wang, Rui Hao, Lunkai Gao, Hongbo Cui, Hai Wu, Xiaodong Wu, Tong Qiao, Weijie Bai, Liming Zhang

“…This study investigates the response mechanisms of melatonin on the dynamic physiology and transcriptomics of Reaumuria trigyna, a critical salt-tolerant plant species in Central Asian salt desert ecosystems. …”
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Exploring seasonal dynamics of sea spray aerosol bioactivity: Insights into molecular effects on human bronchial epithelial cells by Zixia Liu, Emmanuel Van Acker, Maarten De Rijcke, Filip Van Nieuwerburgh, Colin Janssen, Jana Asselman

“…We found that SSA exposure influenced the expression of genes involved in critical signaling pathways: mTOR, PI3K, Akt, and NF-κB were downregulated, while AMPK was upregulated. …”
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Effects of Lemon Beverage Containing Citric Acid with Calcium Supplementation on Bone Metabolism and Mineral Density in Postmenopausal Women: Double-Blind 11-Month Intervention Stu... by Hiromi Ikeda, Tadayuki Iida, Masanori Hiramitsu, Takashi Inoue, Satomi Aoi, Miho Kanazashi, Fumiko Ishizaki, Toshihide Harada

“…A critical factor for preventing osteoporosis after menopause is attenuation of the accelerated turnover rate of bone metabolism. …”
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A novel method for detecting intracranial pressure changes by monitoring cerebral perfusion via electrical impedance tomography by Ming-xu Zhu, Jun-yao Li, Zhan-xiu Cai, Yu Wang, Wei-ce Wang, Yi-tong Guo, Guo-bin Gao, Qing-dong Guo, Xue-tao Shi, Wei-chen Li

“…Abstract Background Acute and critical neurological diseases are often accompanied with elevated intracranial pressure (ICP), leading to insufficient cerebral perfusion, which may cause severe secondary lesion. …”
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The economic burden of post-endoscopic retrograde cholangiopancreatography (ERCP) procedure infections in Italy by Paolo Sciattella, Annarosa Fornero, Susanna Giordano, Claudio De Angelis, Francesco Cattel

“…Conclusion: Post-ERCP infections impose substantial financial burdens on the healthcare system, underscoring the critical importance of implementing cost-effective prevention strategies to mitigate this public health threat in Italy. …”
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Using group model building to frame the commercial determinants of dietary behaviour in adolescence – findings from online system mapping workshops with adolescents, policymakers a... by Yanaina Chavez-Ugalde, Frank De Vocht, Russell Jago, Martin White, Zoi Toumpakari

“…Conclusions This study highlights the need for public health policymaking processes to provide youth with a space to voice influential elements and consequences, thereby co-creating policies and designing interventions to buffer risk factors and increase well-being in this critical transitional stage.…”
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Exploring the functional diversity and metabolic activities of the human gut microbiome in Thai adults in response to a prebiotic diet by Amornthep Kingkaw, Preecha Patumcharoenpol, Narissara Suratannon, Massalin Nakphaichit, Sittiruk Roytrakul, Wanwipa Vongsangnak

“…However, as the field moves toward understanding the relationship between microbiome and diet in relation to gut health, it is critical to evaluate how changes in metabolic activities relate to cooperative metabolic routes in the gut microbiome for promoting human health. …”
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SFSCDNet: A Deep Learning Model With Spatial Flow-Based Semantic Change Detection From Bi-Temporal Satellite Images by K. S. Basavaraju, N. Sravya, Vibha Damodara Kevala, Shilpa Suresh, Shyam Lal

“…Experimental results of proposed network on the SECOND dataset demonstrate that the proposed model significantly improves the ability to localize critical changes and distinguish between change and no-change regions. …”
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Epidemiology and Resistance Profiles of Bacteria Isolated From Blood Samples in Septic Patients at Emergency Department Admission: A 6-Year Single Centre Retrospective Analysis Fro... by Valeria Cento, Sara Carloni, Riccardo Sarti, Linda Bussini, Zian Asif, Paola Morelli, Francesco De Fazio, Federica Maria Tordato, Maddalena Casana, Debora Mondatore, Antonio Desai, Elena Generali, Nicola Pugliese, Elena Costantini, Massimo Vanoni, Maurizio Cecconi, Stefano Aliberti, Giorgio Da Rin, Erminia Casari, Michele Bartoletti, Antonio Voza

“…Conclusions: Community-onset BSIs demonstrated substantial prevalence of resistant pathogens, including ESBL and MRSA, emphasizing the need for robust surveillance systems. Age is a critical factor in guiding empirical antibiotic therapy in the ED.…”
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Seasonal Variation in Antimicrobial Activity of Crude Extracts of Psammaplysilla sp. 1 from Phillips Reef, South Africa by Wasswa Cuthbert Kibungu, Justine Fri, Anna-Maria Clarke, Anthony Otigbu, Henry Akum Njom

“…Phytochemical screening was conducted to identify the presence of 7 critical phytochemical groups. During the four seasons, the mean water temperature was 17.35°C ± 2.06, with autumn recording the highest (20°C) temperature. …”
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Exploring manual therapy in the management of irritable bowel syndrome in adults: A scoping review by Natalia Płóciennik-Korycka, Sara Maria Pani, Bogumiła Bruc, Paolo Contu, Magdalena Wrzesińska

“…IBS contributes to substantial work absenteeism and economic burdens and often coexists with other somatic and psychiatric conditions, with psychological well-being being a critical determinant of QoL. IBS sufferers often turn to MT due to dissatisfaction with conventional treatments. …”
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Comparison of biochar and Poultry Litter Treatment (PLT) amendments on broiler litter quality and bird performance by Maryam K. Mohammadi-Aragh, Katie L. Norris, Gary D. Chesser, Jr., John W. Lowe, Jeffrey D. Evans, Joseph L. Purswell, John E. Linhoss

“…SUMMARY: Broiler litter management is critical for overall bird health and performance. Poor litter conditions can result in increased ammonia (NH3) volatilization and moisture, which negatively impact bird productivity and welfare. …”
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Drought-induced shifts in gross primary production pathways in Moso bamboo forests: Insights from improved BIOME-BGC and structural equation modeling by Zhaodong Zheng, Fangjie Mao, Huaqiang Du, Xuejian Li, Fengfeng Ye, Xianfeng Teng, Ningxin Yang, Jiacong Yu, Meixuan Song, Yinyin Zhao

“…Drought during different growing seasons (Rapid Growing Season, Main Growing Season, and Final Growing Season) led to decreases in daily GPP of 0.44, 0.52, and 0.28 g C m−2 day−1, respectively. (3) The combined analysis using RF and SEM reveals that temperature and stomatal conductance are the most critical environmental and physiological factors driving GPP variations. …”
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Two Cases of Composite Pheochromocytoma-Ganglioneuromas With Plasma Metanephrine Levels in the Subclinical Range Pheochromocytoma-Ganglioneuroma by Mayssam El Najjar, MD, Elie Naous, MD, Caroline Blake, Aysegul Bulut, MD, Alexander Perepletchikov, MD, Ann T. Sweeney, MD

“…As with isolated pheochromocytomas, lifetime surveillance is critical for composite pheochromocytoma-ganglioneuromas.…”
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Prolidase activity in women with polycystic ovarian syndrome undergoing assisted conception by Kadriye Erdoğan, Emine Utlu Özen, İnci Kahyaoğlu, Salim Neselioglu, Özcan Erel, Serra Akar, Özhan Özdemir, Cihangir Mutlu Ercan, Yaprak Engin Üstün

“…Prolidase recycling from imidodipeptides plays a critical role in collagen resynthesis and extracellular matrix (ECM) remodelling. …”
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Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with children by Steven M. Brunwasser, Tebeb Gebretsadik, Anisha Satish, Jennifer C. Cole, William D. Dupont, Christine Joseph, Casper G. Bendixsen, Agustin Calatroni, Samuel J. Arbes, Jr, Patricia C. Fulkerson, Joshua Sanders, Leonard B. Bacharier, Carlos A. Camargo, Jr, Christine Cole Johnson, Glenn T. Furuta, Rebecca S. Gruchalla, Ruchi S. Gupta, Gurjit K. Khurana Hershey, Daniel J. Jackson, Meyer Kattan, Andrew Liu, George T. O'Connor, Katherine Rivera-Spoljaric, Wanda Phipatanakul, Marc E. Rothenberg, Max A. Seibold, Christine M. Seroogy, Stephen J. Teach, Edward M. Zoratti, Alkis Togias, Tina V. Hartert

“…Objective: Understanding compliance with COVID-19 mitigation recommendations is critical for informing efforts to contain future infectious disease outbreaks. …”
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