Dual-Mechanism Gastroretentive Tablets with Encapsulated Gentian Root Extract by Jelena Mudrić, Ljiljana Đekić, Nemanja Krgović, Đorđe Medarević, Katarina Šavikin, Milica Radan, Nada Ćujić Nikolić, Tijana Ilić, Bojana Vidović, Jelena Đuriš

“…<b>Results:</b> The trehalose content and high-shear-homogenization (HSH) time of primary emulsion were critical factors. Trehalose content positively influenced emulsion viscosity, moisture content, floating lag time, encapsulation efficiency, and the release rate of gentiopicroside. …”
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Proteomics and metabolomics analyses of mechanism underlying bovine sperm cryoinjury by Renzheng Zhang, Xiuyuan Wang, Ruili Liu, Yanfang Mei, Xiuping Miao, Jiaxu Ma, Lei Zou, Qiuyue Zhao, Xuejin Bai, Yajuan Dong

“…Results The results indicate that low levels of ROS and high degrees of MMP and ATP play a critical role in the survival of HMS during the freezing process. …”
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Pre-diabetes and cardiovascular risk factors in NAFLD patients: a retrospective comparative analysis by Azam Teimouri, Zahra Ebrahimpour, Awat Feizi, Bijan Iraj, Elahe Saffari, Mojtaba Akbari, Mozhgan Karimifar

“…ObjectivesInsulin resistance plays a critical role in the pathophysiology of diabetes mellitus and non-alcoholic fatty liver disease (NAFLD). …”
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Exosomes Derived from Schistosoma japonicum Cystatin-Treated Macrophages Attenuated CLP-Induced Sepsis in Mice by Feifei Huang, Yayun Qian, Huihui Li, Liang Chu, Chen Wan, Qili Shen, Qianqian Li, Xiuxiu Li, Xinyue Wu, Bin Zhan, Rui Zhou, Xiaodi Yang

“…Exosomes derived from Sj-Cys-treated macrophages exhibited significant therapeutic effect on CLP-induced sepsis in mice with prolonged survival rate and less damage of critical organs by downregulating the proinflammatory factors TNF-α and IL-6 and upregulating the anti-inflammatory factor TGF-β. …”
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Transcriptomic and proteomic analysis of the jejunum revealed the effects and mechanism of protocatechuic acid on alleviating Salmonella typhimurium infection in chickens by Sheng Zhang, Qin Wang, Xiangtian Yao, Jingjing Dong, Guanhuo Li, Yingan Zang, Shouqun Jiang, Yibing Wang

“…Results of proteomic showed that protocatechuic acid inhibited the positive regulation of dendritic cell cytokine production and I-κB kinase/NF-κB signaling, as well as cytokine-cytokine receptor interaction and MAPK signaling pathways, and activated the mTOR signaling pathways. These results were critical to both suppressing the secretion of inflammatory cytokines and restoring the intestinal function. …”
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A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's disease by Zhongying Gong, Dan Guo, Yufeng Lin, Zhiwei Liu, Mengdi Lv, Xinxin Liu, Yang Yao, Sijia Wang, Yuan Wang, Zhiyun Wang

“…It has been reported that astrocytes play a critical role in the pathogenesis and progression of PD. …”
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Antibiotic-induced changes in the human gut microbiota for the most commonly prescribed antibiotics in primary care in the UK: a systematic review by Alastair D Hay, Alyson L Huntley, Karen T Elvers, Esther T van der Werf, Victoria J Wilson, Ashley Hammond, Lorna Duncan

“…Risk of bias was evaluated using the Critical Appraisal Skills Programme. Narrative synthesis was used to report the themes emerging from the data.Main outcome measures Primary outcomes were antibiotic-induced changes in the composition and/or diversity of the gut microbiota. …”
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Using a participatory approach to identify priorities to advance LHS implementation at an academic medical center by Reid M. Eagleson, Madeline Gibson, Carletta Dobbins, Frederick Van Pelt, Allyson Hall, Larry Hearld, Andrea L. Cherrington, Jacob McMahon, Keith Tony Jones, Michael J. Mugavero

“…Of the eight major themes, “Creating a Structure for Aligned and Informed Prioritization” and “Right Data, Right Time, Improved Performance” ranked in the top three most important themes across all focus groups and became the critical priorities as UAB enhances its LHS. A task force comprised of diverse constituents from across UAB's academic medical center is taking first steps toward addressing these priority areas. …”
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Thin film sputter-deposition of AlN crystals in oxygenated chamber: a pilot study by Muhammad Izzuddin Abd Samad, Syazwani Izrah Badrudin, Marwan Mansor, Nafarizal Nayan, Ahmad Shuhaimi Abu Bakar, Mohd Zamri Yusop, Rhonira Latif

“…A high degree of AlN〈002〉 crystallisation may suggest good electrical insulating properties in AlN thin film layer, which can be applied in electronic devices that critically require a low leakage current specification.…”
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Development, Optimization, and Stability Study of a Yataprasen Film-Forming Spray for Musculoskeletal Pain Management by Jaenjira Angsusing, Weerasak Samee, Sarin Tadtong, Supachoke Mangmool, Siriporn Okonogi, Nopparut Toolmal, Chuda Chittasupho

“…Despite its widespread use, the quality and stability of the YTPS formulation, critical to its efficacy, safety, and patient adherence, have not been comprehensively studied. …”
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Microscopic and Spectroscopic Investigation of (AlxGa1–X)2O3 Films: Unraveling the Impact of Growth Orientation and Aluminum Content by Jith Sarker, Prachi Garg, Abrar Rauf, Ahsiur Rahman Nirjhar, Hsien‐Lien Huang, Menglin Zhu, A. F. M. Anhar Uddin Bhuiyan, Lingyu Meng, Hongping Zhao, Jinwoo Hwang, Eric Osei‐Agyemang, Saquib Ahmed, Baishakhi Mazumder

“…Abstract (AlxGa1–x)2O3 is an ultrawide‐bandgap semiconductor with a high critical electric field for next‐generation high‐power transistors and deep‐ultraviolet photodetectors. …”
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MicroRNA-21 as a Regulator of Cancer Stem Cell Properties in Oral Cancer by Milica Jaksic Karisik, Milos Lazarevic, Dijana Mitic, Maja Milosevic Markovic, Nicole Riberti, Drago Jelovac, Jelena Milasin

“…In conclusion, miRNA-21 plays a critical role in the regulation of oral cancer CD44+ cells properties. …”
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Global terrestrial moisture recycling in Shared Socioeconomic Pathways by A. Staal, P. Meijer, P. Meijer, M. K. Nyasulu, M. K. Nyasulu, M. K. Nyasulu, O. A. Tuinenburg, S. C. Dekker

“…However, we find differences among regions and river basins in trends in precipitation recycling and whether projected drying or wetting is mainly contributed by land or ocean. Our results give critical insight into the relative contributions of global warming and land-use changes on global precipitation changes over the course of this century. …”
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Outcome and complications in postcardiotomy cardiogenic shock treated with extracorporeal life support – a systematic review and meta-analysis by Romana Maria Kienlein, Ralf Felix Trauzeddel, Nilufar Akbari, Leonello Avalli, Fausto Biancari, Carlotta Sorini Dini, Sabina Guenther, Christian Hagl, Matthias Heringlake, Jochen Kruppa, Timo Mäkikallio, Raphael Martins, Marc Pineton de Chambrun, Ardawan Julian Rastan, Antonio Rubino, Floris van den Brink, Michael Nordine, Sascha Treskatsch

“…Therefore, until future work has elucidated which patients benefit at all, the risks of ECLS-treatment must be critically weighed up against a possible benefit.…”
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Grid-Forming Inverters: A Comparative Study of Different Control Strategies in Frequency and Time Domains by Nabil Mohammed, Harith Udawatte, Weihua Zhou, David J. Hill, Behrooz Bahrani

“…Hence, they can not only stably operate in regions of the grid characterized by low strength but also provide critical ancillary services to power systems, including voltage, frequency, and inertia support. …”
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Effect of integrated case-based and problem-based learning on clinical thinking skills of assistant general practitioner trainees: a randomized controlled trial by Dingyuan Jiang, Danpei Huang, Hua Wan, Wuliang Fu, Weidong Shi, Jin Li, Huan Zou, Niannan Hou, Qing Li, Nani Li

“…Specifically, the mean scores for critical, systematic, and evidence-based thinking showed notable improvement in the CBL-PBL group. …”
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Toward Resilient Maternal, Neonatal and Child Health Care: A Qualitative Study Involving Afghan Refugee Women in Pakistan by Yasir Shafiq, Ameer Muhammad, Kantesh Kumar, Zabin Wajid Ali, Saba Noor, Zamir Hussain Suhag, Rehman Tahir, Abdullah Jan, Luca Ragazzoni, Francesco Barone-Adesi, Martina Valente

“…Conclusion: The findings highlight a critical need for comprehensive policy reforms, infrastructure enhancement, and community-centered approaches to address Afghan refugees’ health needs effectively. …”
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Outbreak of carbapenem resistant Klebsiella pneumoniae in a neurorehabilitation unit: Genomic epidemiology reveals complex transmission pattern in a tertiary care hospital by Maria Grazia Silvotti, Erika Scaltriti, Luca Bolzoni, Beatrice Zerbi, Gabriella Tocci, Andrea Zappavigna, Gianfranco Lamberti, Federico Donati, Franco Federici, Stefano Pongolini, Giuliana Lo Cascio

“…The study highlights the critical role of genomic epidemiology in hospital outbreaks. © 2025 The Author(s). …”
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Profiling gene alterations in striatonigral neurons associated with incubation of methamphetamine craving by cholera toxin subunit B-based fluorescence-activated cell sorting by Rachel D. Altshuler, Megan A. M. Burke, Kristine T. Garcia, Kenneth Class, Raffaello Cimbro, Xuan Li, Xuan Li

“…We previously demonstrated a critical role of dorsal striatum (DS) in this incubation in rats. …”
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Second Trimester Umbilical Cord Coiling Index and Perinatal Outcomes by Yusuf Aytaç Tohma, Mehmet Metin Altay, Derya Turgut, Selcan Coşkun, Eylem Ünlübilgin, Sertaç Esin, Orhan Gelişen, Okyar Erol

“… OBJECTIVE: Umbilical cord usually seems simple functionally and structurally but it's the life link between fetus and mother that was critically important for growing fetus. The aim of this study is to evaluate the effect of early umbilical cord coiling index on perinatal outcomes. …”
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