Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion by Mirjana Babić Leko, Vera Župunski, Jason Kirincich, Dinko Smilović, Tibor Hortobágyi, Patrick R. Hof, Goran Šimić

“…In this review, we critically discuss each proposed mechanism and provide insight into the most recent studies aiming to elucidate the molecular underpinnings of C9FTD/ALS.…”
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<i>‘Changing the Focus’</i>: Co-Design of a Novel Approach for Engaging People with Dementia in Physical Activity by Claudia Meyer, Den-Ching A. Lee, Michele Callisaya, Morag E. Taylor, Katherine Lawler, Pazit Levinger, Susan Hunter, Dawn C. Mackey, Elissa Burton, Natasha Brusco, Terry Haines, Christina L. Ekegren, Amelia Crabtree, Keith D. Hill

“…Background: Promoting physical activity among people living with dementia is critical to maximise physical, cognitive and social benefits; yet the lack of knowledge, skills and confidence among health professionals, informal care partners and people with dementia deters participation. …”
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Improving the integrity and reproducibility of research that uses antibodies: a technical, data sharing, behavioral and policy challenge by M. Biddle, P. Stylianou, M. Rekas, A. Wright, J. Sousa, D. Ruddy, M. I. Stefana, K. Kmiecik, A. Bandrowski, R.A. Kahn, C. Laflamme, E. M. Krockow, H.S. Virk

“…Here we argue that the determinants of end-user antibody choice and use are critical, and under-addressed, behavioral drivers of this problem. …”
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Harnessing defects in Ag/CeO2 for enhanced photocatalytic degradation of antibiotic in water: Structural characteristics, in-depth insights on mechanism, degradation pathway by Ajit Kumar Dhanka, Emerson C. Kohlrausch, Raghabendra Samantray, Vinod Kumar, Balaram Pani, Nityananda Agasti

“…A plausible mechanism is proposed based on critical analysis of the results from the characterization techniques of the nanocomposites and photocatalytic experiments. …”
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Revealing the core suppression effects of various Di (2-ethylhexyl) phthalate exposure on early meiosis progression in postnatal male mice via single-cell RNA sequencing by Baoquan Han, Lei Hua, Shuai Yu, Wei Ge, Cong Huang, Yu Tian, Chunxiao Li, Jiamao Yan, Tian Qiao, Jiachen Guo, Dongliang Lu, Bin Wang, Diya Cai, Yunqi Zhang, Shaolin Liang, Jianjuan Zhao, Qi Hou, Wei Shen, Zhongyi Sun

“…DEHP exposure resulted in a substantial decrease in the expression of the Trp53 gene, which in turn down-regulated three critical downstream genes (Stmn1, Tubb5, and Ccnb1) that are implicated in spindle organization from a mechanistic perspective. …”
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Health Risk Assessment of Chemicals: From Bulk to Nano by Soqrat Omari Shekaftik, Jamal Biganeh, Maedeh Hosseinzadeh, Hamidreza Jafari Nodoushan, Neda Mehrparvar

“…Results: Both quantitative and qualitative health risk assessments play critical roles in occupational health, with each method providing different levels of depth and accuracy depending on the situation. …”
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Genomic scans for selection and runs of homozygosity in southern Italian turkey populations by Medhat S. Saleh, Vincenzo Landi, Martijn F.L. Derks, Gerardo Centoducati, Martien A.M. Groenen, Pasquale De Palo, Elena Ciani, Nicola Pugliese, Elena Circella, Antonio Camarda

“…Understanding the genomic patterns of BAS-APU turkeys is critical for effective breeding and preservation strategies. …”
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Global, regional and national epidemiological trends of multiple myeloma from 1990 to 2021: a systematic analysis of the Global Burden of Disease study 2021 by Linmin Zhuge, Xiaowu Lin, Ziwei Fan, Mengxian Jia, Chaowei Lin, Minyu Zhu, Honglin Teng, Guoliang Chen

“…Targeted preventive interventions and improvements in diagnosis, treatment, and care are critical, especially in underdeveloped regions, to address the growing global burden of MM.…”
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Analyzing the rainfed wheat yield gap in Northwest Iran by Arash Mohammadzadeh, Yaser Azimzadeh, Ramin Lotfi, Esmail Zadhasan, Khoshnood Alizadeh, Hamid Hassaneian Khoshro

“…Additionally, the pronounced differences in crop yield across various rotation systems and varieties highlight their critical role in realizing crop attainable yield as the qualitative independent variables. …”
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Trends in incidence, mortality, and DALYs of cystic echinococcosis in Central Asia from 1992 to 2021: an age-period-cohort analysis by Wulan Talafuhan, Kaibinuer Tuoheti, Ye Lixia, Qi Shuang, Mieyier Yeerjiang, Guzalinuer Aizezi, Wei Jingjing, Peierdun Mijiti, Peierdun Mijiti

“…This study analyzed trends in CE incidence, mortality, and disability-adjusted life years (DALYs) from 1992 to 2021 in Central Asia; compared them with global data; and explored variations by gender, age group, and country to identify critical factors in disease control.MethodsUsing data from the Global Burden of Disease Study 2021 (GBD 2021), we analyzed long-term trends in the incidence, mortality, and DALY rates of CE in Central Asia. …”
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Transcription Factor E2F-1 Is Upregulated in Human Gastric Cancer Tissues and Its Overexpression Suppresses Gastric Tumor Cell Proliferation by Qiang Xiao, Lei Li, Yubo Xie, Ning Tan, Changqing Wang, Junyi Xu, Keyi Xia, Kevin Gardner, Qingdi Q. Li

“…The E2F family members play a critical role in cell cycle regulation and other biological processes in the cell. …”
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Executive function, limbic circuit dynamics and repetitive and restricted behaviors in children with autism spectrum disorder by Xiangyu Zheng, Xinyue Wang, Ruochen Song, Junbin Tian, Li Yang

“…Regression analyses revealed that increased variance of this FC and EF significantly impacted RRBs, with inhibition, emotional control, and monitor showing strong associations (standardized β = 0.60 to 0.62, p &lt; 0.01), which also had significant indirect effects on the relationship between the above dynamic FC and RRBs, which accounted for 59% of the total effect.ConclusionThis study highlights the critical role of EFs as a key mechanism in addressing RRBs in ASD. …”
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Effect of potato glycoside alkaloids on mitochondria energy metabolism of Fusarium solani, the root rot pathogen of Lycium barbarum by Ruiyun Li, Bin Wang, Wei Chen, Chongqing Zhang, Nan Li, Yupeng Wang, Yuke Yan, Yuyan Sun, Jing He, Jing He

“…Furthermore, a total of 195 pathways were identified through KEGG analysis, with significant enrichment in critical pathways including pentose and glucuronate interconversions, propanoate metabolism, various types of N-glycan biosynthesis, the pentose phosphate pathway, and carbon fixation in photosynthetic organisms. …”
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MAMMOTH-Subaru. II. Diverse Populations of Circumgalactic Lyα Nebulae at Cosmic Noon by Mingyu Li, Haibin Zhang, Zheng Cai, Yongming Liang, Nobunari Kashikawa, Ke Ma, Xiaohui Fan, J. Xavier Prochaska, Bjorn H. C. Emonts, Xin Wang, Yunjing Wu, Shiwu Zhang, Qiong Li, Sean D. Johnson, Minghao Yue, Fabrizio Arrigoni Battaia, Sebastiano Cantalupo, Joseph F. Hennawi, Satoshi Kikuta, Yuanhang Ning, Masami Ouchi, Rhythm Shimakawa, Ben Wang, Weichen Wang, Zheng Zheng, Zhen-Ya Zheng

“…Ly α nebulae provide critical insights into the formation and evolution of today’s massive cluster galaxies at cosmic noon.…”
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Channel Coding Toward 6G: Technical Overview and Outlook by Mohammad Rowshan, Min Qiu, Yixuan Xie, Xinyi Gu, Jinhong Yuan

“…Furthermore, minimizing decoding latency is crucial for critical-mission applications, while optimizing energy efficiency is paramount for mobile and the Internet of Things (IoT) communications. …”
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The short-, medium-, and long-term prevalence of physical health comorbidities in first-episode psychosis: a systematic review and meta-analysis protocol [version 2; peer review: 3... by Michael Norton, Brian O'Donoghue, Mary Clarke, Karen O'Connor, Jennifer Murphy, Anna Zierotin

“…Risk of bias will be assessed using the Joanna Briggs Institute Critical Appraisal Checklist. A meta-analysis of the short-, medium-, and long-term prevalence of cardiovascular, metabolic, cancer, and respiratory outcomes and a narrative synthesis will be conducted. …”
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Enhanced AC/DC optimal power flow via nested distributed optimization for AC/VSC-MTDC hybrid power systems by Haixiao Li, Pedro P. Vergara, Robert Dimitrovski, Hongjin Du, Aleksandra Lekić

“…However, significant challenges exist in exploiting coordinated operations for such AC/VSC-MTDC hybrid power systems. One of the most critical issues is how to achieve the optimal operation of such wide-area systems involving several power entities with as minimal communication burden as possible. …”
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Mechanism of Threshold Voltage Instability in Double Gate &#x03B1;-IGZO Nanosheet TFT Under Bias and Temperature Stress by Muhammad Aslam, Shu-Wei Chang, Yi-Ho Chen, Yao-Jen Lee, Yiming Li, Wen-Hsi Lee

“…The reliably reported double gate IGZO nanosheet TFTs (DG-IGZO-NS-TFTs) are tested under positive and negative bias stress at variant temperatures, and the resulting modulations are analyzed critically. The reported DG-IGZO-NSTFTs exhibit a negative side threshold voltage shift (<inline-formula> <tex-math notation="LaTeX">$\Delta$ </tex-math></inline-formula>Vth) accompanied by an increase in Ion/Ion(0) under negative bias temperature stress (NBTS) at elevated temperatures, which indicates the presence of additional charges. …”
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Archeohandi: protocol for a national disabilities database in archaeology in France by Rozenn Colleter, Valérie Delattre, Cyrille Le Forestier, Alex Baiet, Philippe Blanchard, Fanny Chenal, Anne-Sophie Coupey, Stéphanie Desbrosse-Degobertière, Sylvie Duchesne, Cécile Durin, Jean-Luc Gisclon, Noémie Gryspeirt, Fanny La Rocca, Raphaëlle Lefebvre, Jérôme Livet, Cécile Paresys, Mikaël Rouzic, Isabelle Souquet, Florence Tane, Aminte Thomann, Ivy Thomson, Émilie Trébuchet, Marie-Cécile Truc, Jean-Baptiste Barreau

“…This list has been critically reviewed by experts in the field; it will evolve in a somewhat Darwinian fashion. …”
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Epidemiological features and risk factors of human psittacosis in Hangzhou City, eastern China by Zhou Sun, Ke Xu, Liangliang Huo, Xingliang Zhang, Yi Wang, Yonghui Gong, Bingbing Chen

“…A community-based 1:3 matched case-control study was performed to investigate the risk factors associated with Chlamydia psittaci infection.ResultsDuring the study period, 137 confirmed cases of human psittacosis were identified through laboratory tests, of which 24 (17.52%) were classified as critical cases, including one fatality. The epidemic curve indicated that the majority of cases occurred between October and March. …”
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