Hematopoietic stem cell discovery: unveiling the historical and future perspective of colony-forming units assay by Nur Afizah Yusoff, Zariyantey Abd Hamid, Siti Balkis Budin, Izatus Shima Taib

“…The outcomes of such studies are crucial in providing critical insights into hematopoiesis. In this review, we explore the fundamental discoveries concerning the CFUs assay by covering the following aspects: (i) the historical overview of the CFUs assay for the study of clonal hematopoiesis involving multilineage potential of HSPCs, (ii) its use in various experimental models comprising humans, mice/rodents, zebrafish and induced pluripotent stem cells (iPSCs) and (iii) research gaps and future direction concerning the role of CFUs assay in clinical and basic sciences. …”
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Polyunsaturated Fatty Acid and S-Adenosylmethionine Supplementation in Predementia Syndromes and Alzheimer's Disease: A Review by Francesco Panza, Vincenza Frisardi, Cristiano Capurso, Alessia D'Introno, Anna M. Colacicco, Alessandra Di Palo, Bruno P. Imbimbo, Gianluigi Vendemiale, Antonio Capurso, Vincenzo Solfrizzi

“…Therefore, these findings underscored the critical role of SAM in maintenance of neuronal health, suggesting a possible role of SAM as a neuroprotective dietary supplement for AD patients. …”
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Risk Factor Analysis of Ski and Snowboard Injuries During the 2023/2024 Winter Season: A Single, High-Volume Trauma Center Database Analysis by Michele Paolo Festini Capello, Pieralberto Valpiana, Giuseppe Aloisi, Giovanni Cristofolini, Svea Caren Misselwitz, Giuseppe Petralia, Mario Muselli, Salvatore Gioitta Iachino, Christian Schaller, Pier Francesco Indelli

“…Additionally, the absence of significant correlations between weather conditions, snow quality, equipment type, and the difficulty of the slope with injury risk suggests that individual factors such as age and skill level are more critical determinants of injury risk than environmental or equipment-related factors.…”
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Applying ‘cultural humility’ to occupational therapy practice: a scoping review protocol by Hardeep Singh, Michelle L A Nelson, Heather Colquhoun, Kristina Marie Kokorelias, Tram Nguyen, Ruheena Sangrar, Sachindri Wijekoon, Erica Nekolaichuk, Sofia Mirzazada, Holly Assaf

“…Recognition of power imbalances between clients and healthcare providers is critical to enhancing cross-cultural interactions in healthcare delivery. …”
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An Approach to Refining MODIS LAI Data Using a Fitting Scale Factor Time Series by Junxian Tang, Peijuan Wang, Rui Feng, Yang Li, Qing Li

“…Although the remote sensing LAI data provide a critical foundation for monitoring crop growth and estimating yields, the existing datasets often exhibit notable errors due to the pixel-level heterogeneity. …”
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As-cast microstructure characteristics of K439B nickel-based superalloy thin- walled castings of different thickness by ZHOU Depeng, SUI Dashan, MA Jinyuan, GUI Daxing, DONG Anping, SUN Baode

“…Combined with numerical simulation analysis， it is shown that the relationship trend between dendrite arm spacings， temperature gradient， and cooling rate basically matches the existing empirical formula， but the relationship between PDAS and temperature gradient and cooling rate no longer simply matches the formula when the wall thickness is reduced to a certain critical thickness. These results of the experimental and simulation analysis could provide a reference to rationally design the casting process for the K439B nickel-based superalloy thin-walled casting crafts.…”
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Chloroquine and Rapamycin Augment Interleukin-37 Expression via the LC3, ERK, and AP-1 Axis in the Presence of Lipopolysaccharides by Xiaoyi Shi, Chunhui Lai, Lianyu Zhao, Mingying Zhang, Xi Liu, Shanqin Peng, Weizhong Guo, Qiuying Xu, Song Chen, Guang-xing Chen

“…IL-37 is a cytokine that plays critical protective roles in many metabolic inflammatory diseases, and its therapeutic potential has been confirmed by exogenous IL-37 administration. …”
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Factors influencing choice of residency program among medical intern doctors and medical students: a cross-sectional survey by Ali Al Ajmi, Masoud Kashoub, Ibrahim S. Al-Busaidi, Mohammed Al Rashdi, Moza AlHussaini, Arwa Alsaidi, Mohammed Al Rawahi, Abdullah M. Al Alawi

“…Abstract Introduction The global shortage of healthcare professionals is a critical concern, with an estimated deficit of 18 million workers by 2030, particularly in low- and middle-income countries. …”
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Barriers to orthodox medical care of prostate cancer in Ghana by Patrick Opoku Manu Maison, Prince Arkoh, Ahmed Sani, Emmanuel Ekow Mensah-Baidoo, Gifty Owusu, Esther Yeboah Danso, Nana Benyin Koufie, Susanna Andzie, Perez Gyamfi, Emmanuel Omane, Sylvester Antwi, Nallasivam Palanisamy, Clara Hwang, Eleanor Walker, Valerie Ofori Aboah, Evelyn Mawunyo Jiagge

“…The study highlights significant cultural and economic barriers that lead to the late-stage presentation of PCa among men in Ghana’s Central region. There is a critical need for a culturally sensitive, multi-pronged strategy that enhances public education about the benefits of early diagnosis and fosters collaboration between traditional healers and orthodox healthcare providers to improve prostate cancer outcomes in Ghana.…”
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Response of the germinable soil seed bank of temperate Leymus chinensis meadows to mowing regimes by Zhitao Zhang, Zhitao Zhang, Tianqi Yu, Xiaoping Xin, Hongmei Liu, Shijie Lv, Zhijun Wei, Guodong Han, Ruirui Yan

“…Thus, germinable soil seed banks are critical for restoring overexploited meadows. In this study, we conducted germination experiments on 135 soil samples from various depths to comprehensively analyze the germinable seed bank under different mowing regimes. …”
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Nitrate–Nitrite–Nitric Oxide Pathway, Oxidative Stress, and Fertility Outcomes in Morbidly Obese Women Following Bariatric Surgery: A Systematic Review by Charalampos Voros, Despoina Mavrogianni, Aspasia Minaoglou, Alexios Karakasis, Anthi-Maria Papahliou, Vasileios Topalis, Antonia Varthaliti, Raphail Mantzioros, Panagiota Kondili, Menelaos Darlas, Regina Sotiropoulou, Diamantis Athanasiou, Dimitrios Loutradis, Georgios Daskalakis

“…The NO₃-NO₂-NO route is critical in compensating for lower NO generation under oxidative stress and hypoxia, and bariatric surgery significantly improves this pathway to optimize blood flow, mitochondrial function, and reproductive results.…”
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Impacts of coal fracture roughness and aperture on the seepage of injected water: An experimental study by Gang WANG, Xuechang CHEN, Hao CHEN, Qingming LONG, Yixin LIU

“…ObjectiveWater injection into coal seams is recognized as a critical technical measure for dust removal and the prevention and control of coal and gas outbursts and rock bursts in coal mines. …”
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Study of antifungal susceptibility pattern of various Candida species with reference to conventional and automated methods in a tertiary care hospital by Paulami De, Rehena Sarkar, Raja Ray, Kumkum Bhattacharyya, Hasina Banu, Hirak Jyoti Raj

“…Result: Total Candida isolates were 100, among them near about half (43%) of the isolates were obtained from critical care unit followed by thoracic unit (17%), Ward (16%), trauma centre (15%), high dependency (7%) and 2% from outdoor. …”
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Therapeutic effects of cyclophosphamide, dsDNA preparations and combinations thereof against Krebs-2 ascites cancer cells and various cancer transplants by E. A. Potter, E. V. Dolgova, A. M. Minkevich, Ya. R. Efremov, O. S. Taranov, V. V. Omigov, V. P. Nikolin, N. A. Popova, A. S. Proskurina, E. I. Vereschagin, A. V. Kozel, V. A. Rogachev, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…Next, we show that the timepoint 18 hrs post CP treatment is critical to the ongoing repair process in that it divides the repair into two phases: nucleotide excision repair + dsDNA break repair and homologous recombination. …”
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Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy by Rebecca F. Slykerman, Naomi Davies, Klara Vlckova, Kenneth J. O'Riordan, Shalome A. Bassett, James Dekker, Harriët Schellekens, Niall P. Hyland, Gerard Clarke, Elaine Patterson

“…ABSTRACT Advancing microbiome–gut–brain axis science requires systematic, rational and translational approaches to bridge the critical knowledge gaps currently preventing full exploitation of the gut microbiome as a tractable therapeutic target for gastrointestinal, mental and brain health. …”
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Perceptions of swine euthanasia among Brazilian caretakers from non-integrated swine farms by Laya Kannan Silva Alves, Laya Kannan Silva Alves, Monique Danielle Pairis-Garcia, Andréia Gonçalves Arruda, Cecília Archangelo Ferreira de Melo, Nadia de Almeida Ciriaco Gomes, Roberta Yukari Hoshino, Cesar Augusto Pospissil Garbossa

“…This study highlights the variability in caretaker experience and attitudes toward euthanasia, suggesting a critical need for targeted training programs and euthanasia protocols that address both emotional and practical aspects. …”
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Evaluating implementation of a hospital‐based cancer registry to improve childhood cancer care in low‐ and middle‐income countries by Melissa R. Maas, Allison Yang, Michele A. Muir, James B. Collins IV, Courtney Canter, Gevorg Tamamyan, Inam Chitsike, Francine Kouya, Kim Hoa Nguyen, Alia Ahmad, Ana Patricia Alcasabas, Yi‐Jin Gao, Kimberly J. Johnson, Gia Ferrara, Nickhill Bhakta, Benyam Muluneh

“…Hospital‐based cancer registries (HBCRs) collect detailed patient information to critically evaluate and evolve care. The St. Jude Global Childhood Cancer Analytics Resource and Epidemiological Surveillance System (SJCARES) is a cloud‐based HBCR network facilitating quality data collection of pediatric cancer. …”
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Case report: Atypical young case of MV1 Creutzfeldt-Jakob disease with unusually long survival by Lucie Yeongran Ahn, Mark L. Cohen, Mark L. Cohen, Ignazio Cali, Ignazio Cali, Tia Russell, Jessica Ludwig, Xun Jia, Alberto Bizzi, Lawrence B. Schonberger, Ryan A. Maddox, Rohini Paul, Tania C. Ghazarian, Jaspreet Garcha, Mostafa Hammoudi, Brian Stephen Appleby, Brian Stephen Appleby, Brian Stephen Appleby, Brian Stephen Appleby

“…Very young onset sCJD often has atypical clinical presentations and disease progression, neuropathological examination results, and/or laboratory test results that may confound diagnosis. It is critical to perform thorough, comprehensive evaluations to make an accurate diagnosis, which includes autopsy confirmation with histology, prion protein typing and prion gene sequencing.…”
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Understanding regular exercise behavior in frail older adults: a structural equation model based on social-cognitive variables by Shiqi Yu, Jie Lin, Siping Song, Shuqi Huang, Fan Liu, Mingzhao Xiao

“…Integrating self-efficacy and outcome expectations into further exercise promotion is critical. Patient-centered approach is essential for developing more effective and sustainable exercise interventions.…”
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Multimodal strategies to hand hygiene in Ghanaian hospitals: a cross-sectional study in the Eastern Region of Ghana by Angela Ackon, Sofonias Asrat, Stephen Dajaan Dubik, Winfred Ofosu, Sally-Ann Ohene, Kingsly E Amegah, Ama Akyampomaa Owusu-Asare, Akosua Takyiwa Kwakye, Christiana Akufo, Joyce Amponsah, Hectoria Awekeya, Leslie Vander Puije, Jocelyn Asibey, Seth Twum, Francis Mensa Akwetey, Portia Sam, Hedidor George Kwesi

“…Background Hand hygiene (HH) is one of the core components of infection prevention and control and is critical for a high quality of care. Multimodal approaches are recommended to strengthen and drive HH systems in healthcare facilities (HCFs). …”
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