The Application of Incretin-Based Pharmacotherapy in the Contemporary Management of Type 2 Diabetes: A Review of the Literature by Jakub Waszczyński, Wojciech Kulej, Wiktor Biesiada, Piotr Kulej, Justyna Woźniak, Justyna Weronika Kmieć, Anna Mariia Chernysh, Aleksandra Dusińska, Kamila Fuczyło, Karolina Stankević

“… Introduction Type 2 diabetes is a critical global health issue due to its rising prevalence and severe complications, including cardiovascular diseases, chronic kidney disease, and neuropathies, which reduce quality of life and increase mortality risk. …”
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Inhaled [D-Ala2]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung Injury by Vladislav N. Karkischenko, Veronika I. Skvortsova, Melik T. Gasanov, Yuriy V. Fokin, Maxim S. Nesterov, Nataliya V. Petrova, Oxana V. Alimkina, Igor A. Pomytkin

“…The mechanism of action involves preventing HMGB1’s hyperacetylation at critical lysine residues within nuclear localization sites, as well as promoting the expression of sirtuin 1 (SIRT1), an enzyme known to deacetylate HMGB1. …”
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In Silico Screening of Putative Corynebacterium pseudotuberculosis Antigens and Serological Diagnosis for Caseous Lymphadenitis in Sheep by Enzyme-Linked Immunosorbent Assay by Daniela Droppa-Almeida, Caroline de Santana Ferreira, Ioná Brito, Sibele Borsuk, Jorge Alberto López Rodríguez, Isabel Bezerra Lima-Verde, Francine Ferreira Padilha

“…Therefore, this study aimed to use bioinformatics software to evaluate the critical chemical characteristics of unknown proteins of C. pseudotuberculosis by selecting them for heterologous expression in Escherichia coli. …”
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Linking evidence for targeted blood biomarkers in post-stroke cognitive impairment and dementia by Jinny Hong, Katherine Mun, Katherine Mun, Kyle C. Kern, Kyle C. Kern, Marissa Thirion, Jason D. Hinman, Jason D. Hinman

“…Key biomarkers that have been proposed as relevant to PSCID include interleukin-6, C-reactive protein, β-amyloid 42:40 ratio, neurofilament light chain, and 10 angiogenic molecules. Critical to the assessment of prior studies includes defining the sample collection period and cognitive assessment period of prior studies to assess the temporal pattern of biomarker levels in relation to an incident stroke event. …”
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Interpretable machine learning-based prediction of 28-day mortality in ICU patients with sepsis: a multicenter retrospective study by Li Shen, Li Shen, Jiaqiang Wu, Jianger Lan, Chao Chen, Yi Wang, Zhiping Li

“…The top three risk predictors of mortality included APACHE score, serum lactate levels, and AST.ConclusionML models reliably predicted 28-day mortality in critically ill sepsis patients. Of the models evaluated, the XGBoost algorithm exhibited the most stable performance in identifying patients at elevated mortality risk. …”
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In Situ X-Ray Study During Thermal Cycle Treatment Combined with Complementary Ex Situ Investigation of InGaN Quantum Wells by Ewa Grzanka, Sondes Bauer, Artur Lachowski, Szymon Grzanka, Robert Czernecki, Byeongchan So, Tilo Baumbach, Mike Leszczyński

“…Furthermore, there is a critical temperature (<i>T</i> = 940 °C) at which the mean value of the indium concentration starts to decrease below 15% in 1. …”
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Explainable artificial intelligence with fusion-based transfer learning on adverse weather conditions detection using complex data for autonomous vehicles by Khaled Tarmissi, Hanan Abdullah Mengash, Noha Negm, Yahia Said, Ali M. Al-Sharafi

“…Nowadays, deep learning (DL) and machine learning (ML) models are critical to enhancing object detection in AVs, particularly in adversarial weather conditions. …”
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Anticancer activity of Ilex khasiana, a rare and endemic species of holly in Northeast India, against murine lymphoma by Charles Lalnunfela, Pawi Bawitlung Lalthanpuii, Hmar Tlawmte Lalremsanga, Zothansiama, Chhaihlo Lalmuansangi, Mary Zosangzuali, Nachimuthu Senthil Kumar, Tochhawng Lalhriatpuii, Kholhring Lalchhandama

“…Ilex khasiana Purkay. is a lesser-known species of holly (family Aquifoliaceae) that is endemic to Northeast India. Designated as critically endangered, the plant is used in the treatments of bacterial infections, cancer, intestinal helminthiasis, tuberculosis, and viral infections. …”
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Altered Atlas of Exercise-Responsive MicroRNAs Revealing miR-29a-3p Attacks Armored and Cold Tumors and Boosts Anti-B7-H3 Therapy by Jie Mei, Zhiwen Luo, Yun Cai, Renwen Wan, Zhiwen Qian, Jiahui Chu, Yaying Sun, Yuxin Shi, Ying Jiang, Yan Zhang, Yongmei Yin, Shiyi Chen

“…In conclusion, we uncovered that miR-29a-3p is a critical exercise-responsive miRNA, which attacked armored and cold tumors by inhibiting B7-H3 expression. …”
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Structural Vulnerability Factors and Gestational Weight Gain:  A Scoping Review on the Extent, Range, and Nature of the Literature by Labonté, Jocelyne M, Dumas, Alex, Clark, Emily, Savard, Claudia, Fournier, Karine, O’Connor, Sarah, Morisset, Anne-Sophie, Fontaine-Bisson, Bénédicte

“…This nuanced perspective is critical for informing future research and developing effective strategies to address the pervasive perinatal health challenges associated with inadequate and excessive GWG.…”
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Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α by Jie Yu, Haibin Liu, Shuli He, Pingping Li, Chunxiao Ma, Minglei Ma, Yiwen Liu, Lu Lv, Fan Ping, Huabing Zhang, Wei Li, Qi Sun, Lingling Xu, Yuxiu Li

“…Dietary magnesium intake may be a critical component of the cellular aging process, and its effect could be partly mediated by TNFα.…”
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Validation of Ionospheric Specifications During Geomagnetic Storms: TEC and foF2 During the 2013 March Storm Event‐II by J. S. Shim, I.‐S. Song, G. Jee, Y.‐S. Kwak, I. Tsagouri, L. Goncharenko, J. McInerney, A. Vitt, L. Rastaetter, J. Yue, M. Chou, M. Codrescu, A. J. Coster, M. Fedrizzi, T. J. Fuller‐Rowell, A. J. Ridley, S. C. Solomon, J. B. Habarulema

“…It is found that the models tend to underestimate the storm‐time enhancements of foF2 (F2‐layer critical frequency) and TEC (Total Electron Content) and to predict foF2 and/or TEC better in North America but worse in the Southern Hemisphere. …”
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Geographical feature and method factors significantly influence the reliability of ecological source information transmission at multi-scale by Kai Li, Wei Wu, Shiqi Tian, Linjuan Li, Zhe Li, Yue Cao

“…It also emphasizes that accurately identifying ecological sources is essential for determining critical biodiversity conservation areas and guiding decision-makers in formulating effective conservation strategies and land-use planning.…”
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Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review by Li Zhu, Mengchen Tang, Yinyin Cai, Yinyin Cai, Panpan Wang, Panpan Wang

“…Drawing on current evidence, it provides a comprehensive analysis of these associations, offering critical insights to guide the development of preventive strategies and public health interventions. …”
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Image-Based Detection and Classification of Malaria Parasites and Leukocytes with Quality Assessment of Romanowsky-Stained Blood Smears by Jhonathan Sora-Cardenas, Wendy M. Fong-Amaris, Cesar A. Salazar-Centeno, Alejandro Castañeda, Oscar D. Martínez-Bernal, Daniel R. Suárez, Carol Martínez

“…This study introduces a robust and scalable automated system that addresses critical challenges in malaria diagnosis by integrating advanced image quality assessment and deep learning techniques for parasite detection and classification. …”
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Annotated Checklist of Poroid Hymenochaetoid Fungi in Central Asia: Taxonomic Diversity, Ecological Roles, and Potential Distribution Patterns by Yusufjon Gafforov, Manzura Yarasheva, Xue-Wei Wang, Milena Rašeta, Yelena Rakhimova, Lyazzat Kyzmetova, Kanaim Bavlankulova, Sylvie Rapior, Jia-Jia Chen, Ewald Langer, Burkhon Munnavarov, Zafar Aslonov, Bobozoda Bakokhoja, Li-Wei Zhou

“…For the first time, we modelled the potential distribution patterns of Hymenochaetoid fungi in Central Asia, revealing that their distribution is strongly influenced by host plant availability and temperature-related factors. The three most critical variables were host plant density, annual temperature range (Bio7), and mean temperature of the warmest quarter (Bio10). …”
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Carbapenem resistance in the Dominican Republic: clinical characteristics, genotypic profiles, and risk factors by Ricardo Ernesto Hernández-Landa, Rita Rojas-Fermín, Anel Guzman-Marte, Katherine Peralta Agramonte, Missel María Jiménez Cedano, Surelly Alexandra Mora-Peralta, Patricia Sanrregré-Oven, Alfredo J. Mena Lora

“…Conclusions: CRE infections in the DR increased during the COVID-19 pandemic, associated with prolonged hospitalizations and critical care. Enhanced antimicrobial stewardship is essential to curb resistance. …”
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Optimization of fatigue life of the seismic vibrator baseplate considering the coupling effect of welding residual stress by Zhen Chen, Qiaomu Wang, Shulong Nie, Shuang Jing, Bo Kong, Nan Luan

“…WRS is identified as a critical factor influencing the fatigue life of SVB, and optimizing welding parameters can effectively reduce WRS, thus extending the service life. …”
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Fatigue characteristics of deep excavation-disturbed jinping marble by Anlin Zhang, Ru Zhang, Ting Ai, Li Ren, Zetian Zhang, Jing Xie, Chendi Lou, Kun Xiao, Zeqian Yang

“…Understanding the fatigue behavior of excavation-disturbed rocks in complex stress environments is critical for assessing the long-term stability of deep rock structures. …”
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C3-VQA: Cryogenic Counter-Based Coprocessor for Variational Quantum Algorithms by Yosuke Ueno, Satoshi Imamura, Yuna Tomida, Teruo Tanimoto, Masamitsu Tanaka, Yutaka Tabuchi, Koji Inoue, Hiroshi Nakamura

“…The sources of heat dissipation include passive inflow via intertemperature wires and the power consumption of components located in the cryostat, such as wire amplifiers and quantum&#x2013;classical interfaces. Thus, a critical challenge is to reduce the number of wires by reducing the required intertemperature bandwidth while maintaining minimal additional power consumption in the cryostat. …”
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