Formulation development and evaluation, in silico PBPK modeling and in vivo pharmacodynamic studies of clozapine matrix type transdermal patches by Abdul Qadir, Syed Umer Jan, Muhammad Harris Shoaib, Muhammad Sikandar, Rabia Ismail Yousuf, Fatima Ramzan Ali, Fahad Siddiqui, Abdul Jabbar Magsi, Ghulam Mustafa, Muhammad Talha Saleem, Shafi Mohammad, Mohammad Younis, Muhammad Arsalan

“…The numerical and graphical optimization was based on the desirability function and the optimized formulation obtained from the polynomial equation was further validated and evaluated for the targeted critical attributes. The optimized patch was further evaluated for skin irritation, in vivo pharmacodynamics, in silico prediction, and simulation using the GastroPlus TCAT® model and stability. …”
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Effects of permafrost stability changes on vegetation dynamics in the middle part of the Greater Khingan Mountains by Jiaman Sun, Wei Shan, Chengcheng Zhang

“…These research findings underscore the critical role of changes in permafrost stability in shaping vegetation dynamics, which has significant implications for the carbon budget and ecological stability in the context of future climate warming.…”
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Extreme drought-heatwave exacerbates water quality deterioration in China by Jie Jiang, Zhaoli Wang, Zhenxing Zhang, Xushu Wu, Chengguang Lai, Zhaoyang Zeng, Xiaohong Chen

“…This study revealed that extreme drought-heatwave event critically deteriorate river water quality in China, highlighting the urgent need for adaptive strategies to protect and restore water quality during extreme drought-heatwave events.…”
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Gualou Guizhi Granule inhibits microglia-mediated neuroinflammation to protect against neuronal apoptosis in vitro and in vivo by Xuezhen Li, Han Huang, Yanan Li, Yi Feng, Jinxuan Wang, Shuping Luo, Yaping Chen, Yuqin Zhang, Guohong Yan, Lihong Nan

“…ObjectNeuroinflammation mediated by microglia has emerged as a critical factor in ischemic stroke and neuronal damage. …”
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“I Desire to Have an HIV‐Free Baby”: Pregnant and Breastfeeding Mothers’ Perceptions of Viral Load Testing and Suppression in HIV Care in Southwestern Uganda. by Kabami, Jane, Akatukwasa, Cecilia, Kabageni, Stella, Nangendo, Joanita, Byamukama, Ambrose, Atwiine, Fredrick, Mftumukiza, Valence, Tamu, Munezero John Bosco, Arinaitwe, Elizabeth, Mutabazi, Andrew, Ssebutinde, Peter, Musoke, Phillipa, Kamya, Moses R., Katahoire, Anne R.

“…Introduction Viral suppression is a critical component for preventing mother-to-child transmission of HIV(MTCT). …”
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Construction of the cancer patients’ database based on the US National Health and Nutrition Examination Survey (NHANES) datasets for cancer epidemiology research by Jinyoung Moon, Yongseok Mun

“…The US NHANES provides a wealth of critical data on environmental toxicant exposures. …”
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Risk Factors of Hemophagocytic Lymphohistiocytosis in Adults with Fever of Unknown Origin: A Retrospective Study by Tian F, Xie N, Sun W, Zhang W, Zhang W, Chen J, Ruan Q, Song J

“…Fangbing Tian,1 Nana Xie,1 Wenjin Sun,2 Wencong Zhang,1 Wenyuan Zhang,1 Jia Chen,1 Qiurong Ruan,3,* Jianxin Song1,* 1Department of Infectious Diseases, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Department of Infectious Diseases, Ezhou Central Hospital, Ezhou, People’s Republic of China; 3Institute of Pathology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianxin Song, Department of Infectious Diseases, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China, Email songsingsjx@sina.com Qiurong Ruan, Institute of Pathology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China, Email ruanqiurong@sina.comPurpose: Hemophagocytic lymphohistiocytosis (HLH) is a critical syndrome with a high mortality rate. In clinical practice, some patients with fever of unknown origin (FUO) can develop HLH, further complicating the diagnosis and treatment. …”
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Inhibiting HnRNP L-mediated alternative splicing of EIF4G1 counteracts immune checkpoint blockade resistance in Castration-resistant prostate Cancer by Xumin Zhou, Shilong Cheng, Zhongjie Chen, Jinming Zhang, Jiaqi Wang, Qiang Li, Xumin Zhou

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M-Mode in grade 3 dyspneic patients assessment by Ravikanti Karthik, Yerramsetty Venu Sashank, Kumar Ranjith K., Haward Raymond

“…Introduction/Objective Respiratory distress is a serious condition that can develop in the critically ill or those who have significant injuries. …”
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Root and mycorrhizal nutrient acquisition strategies in the succession of subtropical forests under N and P limitation by Xue Wu, Yueming Liang, Wenwu Zhao, Fujing Pan

“…Root and mycorrhizal are critical to plant nutrient absorption in nutrient-limited ecosystems. …”
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Sexual Abuse as a Cause of Sexually Transmitted Infections (STI) and Human Immunodeficiency Virus (HIV) in a Bisexual Adolescent Indonesian: A Case Report by Achdiat PA, Wibowo RG, Larasati R, Rowawi R, Usman HA, Maharani RH

“…Syphilis and HIV are the predominant infections, showing the critical necessity of administering appropriate medical treatment, such as antiretroviral therapy and comprehensive STI management, with psychological assessment and management to enhance the psychological well-being of sexually abused individuals.Keywords: bisexual, human immunodeficiency virus, Indonesian, men sex with men, secondary syphilis, sexual abuse…”
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A mixed methods exploration of self-presentation, authenticity, and role model function on Instagram: perspectives from female influencers in Germany by Daniel Zimmermann, Colleen Schneider, Kai Kaspar

“…Nevertheless, they are criticized for their potential negative influence on their followers' physical and mental health due to their potentially biased self-presentation. …”
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Quantitative Characterization of Pore Connectivity and Movable Fluid Distribution of Tight Sandstones: A Case Study of the Upper Triassic Chang 7 Member, Yanchang Formation in Ordo... by Boli Wang, Xisen Zhao, Wen Zhou, Bin Chang, Hao Xu

“…The pore connectivity and distribution of moveable fluids, which determines fluid movability and recoverable reserves, are critical for enhancing oil/gas recovery in tight sandstone reservoirs. …”
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Optimising patient engagement for assessing total joint arthroplasty outcomes – a randomised controlled trial by Wyatt Tyndall, Nebojsa Kuljic, Michael Thatcher, Michaela Nickol, Johannes M. van der Merwe

“…Abstract Introduction Patient satisfaction is a critical outcome in total joint arthroplasty (TJA), yet assessing it effectively remains a challenge due to limitations in patient-reported outcome measures (PROMS). …”
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Identification of mitophagy-related key genes and their correlation with immune cell infiltration in acute myocardial infarction via bioinformatics analysis by Zulong Sheng, Rui Zhang, Zhenjun Ji, Zhuyuan Liu, Yaqing Zhou

“…Mitochondrial dysfunction is critically involved in AMI progression, and mitophagy plays a vital role in eliminating damaged mitochondria. …”
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A Multi-Branch Convolution and Dynamic Weighting Method for Bearing Fault Diagnosis Based on Acoustic–Vibration Information Fusion by Xianming Sun, Yuhang Yang, Changzheng Chen, Miao Tian, Shengnan Du, Zhengqi Wang

“…Rolling bearings, as critical components of rotating machinery, directly affect the reliability and efficiency of the system. …”
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Determination of the Hydration Damage Instability Period in a Shale Borehole Wall and Its Application to a Fuling Shale Gas Reservoir in China by Haicheng She, Zaiqiang Hu, Zhan Qu, Yao Zhang, Hu Guo

“…In reviewing Chinese shale gas reserves and national policies regarding shale gas exploitation, shale gas will be of critical importance in providing clean natural gas to China. …”
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USE OF INFORMATION AND SOFTWARE IN THE MANAGEMENT SYSTEM OF INTERNATIONAL ENTERPRISES by Maryna V. Kovbatiuk, Ivanna I. Strilok, Viktoriya V. Shklyar, George O. Kovbatiuk

“…As modern international businesses continue to evolve and adapt to change, the use of information and software is becoming a critical success factor. High-tech management solutions allow companies to respond effectively to global market challenges and remain competitive in an ever-changing business environment.…”
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Response mechanism of heat-sensitive neurons under combined noise stimulation by Yunhai Wang, Guodong Huang, Rui Zhu, Shu Zhou, Yuan Chai

“…Patients with congenital analgesia who lack the ability to sense temperature generally face low survival rates, highlighting a critical need to understand the underlying mechanisms of heat sensation. …”
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Associations of neutrophil/high-density lipoprotein cholesterol ratio with frailty and its mortality by Jianqiang Zhang, Jianqiang Zhang

“…BackgroundFrailty is an increasingly important determinant in the field of health, and its identification has important clinical significance in the field of critical care medicine. However, there are still a large number of challenges in quick and accurate identification of frailty. …”
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