Downregulation of hnRNPA1 inhibits hepatocellular carcinoma cell progression by modulating alternative splicing of ZNF207 exon 9 by Qi Ouyang, Qi Ouyang, Wenhui He, Yiping Guo, Lin Li, Ying Mao, Xiang Li, Shuanglin Xiang, Xiang Hu, Jun He

“…Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) plays a critical role in RNA metabolism, including alternative splicing, which is linked to cancer progression. …”
Get full text

Nonlinear relationship between hepatic steatosis index and reversion to normal glucose regulation in Chinese adults with prediabetes by Haiyong Zeng, Fei Yu, Haofei Hu, Yong Han, Ruixue Ye, Changchun Cao

“…Furthermore, a nonlinear relationship was identified between HSI levels and the reversion to NGR, with a critical threshold at an HSI value of 43.08. Below this threshold, a strong negative association was observed, markedly enhancing the probability of returning to normoglycemic status (HR = 0.91, 95% CI: 0.88–0.94, P < 0.0001). …”
Get full text

Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK-PGC-1α pathway by Baolong Li, Kaiming Yu, Xiongyao Zhou, Jialu Sun, Le Qi, Weiye Li, Tuo Yang, Weizhen Li, Ningning Wang, Xiaosong Gu, Shusen Cui, Rangjuan Cao

“…Bioinformatics analysis revealed that pyroptosis and inflammatory responses induced by spared nerve injury (SNI) in the spinal dorsal horn play a critical role in the initiation and persistence of neuropathic pain. …”
Get full text

Exploring the Connectivity Between Education 4.0 and Classroom 4.0: Technologies, Student Perspectives, and Engagement in the Digital Era by Kapil Joshi, Rajesh Kumar, Salil Bharany, Dilip Kumar Jang Bahadur Saini, Rajiv Kumar, Ashraf Osman Ibrahim, Abdelzahir Abdelmaboud, Wamda Nagmeldin, Mohammad Awad Medani

“…In the future, it is critical to investigate and build creative instructional practices that effectively synergize with Classroom 4.0. …”
Get full text

Comprehensive Analysis of <i>blaCTX-M1</i> Gene Expression Alongside <i>iutA</i>, <i>csgA</i>, and <i>kpsMII</i> Virulence Genes in Septicemic <i>Escherichia coli</i> Using Real-Ti... by Mohsen Karbalaei, Mojgan Esmailpour, Valentyn Oksenych, Majid Eslami

“…Monitoring of these genes is critical for developing effective therapeutic strategies. …”
Get full text

Mindfulness-based retreat for mothers of paediatric heart transplant recipients: protocol for a pilot intervention study by Sara Ahola Kohut, Joanna Mitchell, Samantha J Anthony, Taylor Robertson, Heather Telfer, Mirna Seifert-Hansen

“…Given that a mother’s ability to successfully cope with the demands of her caregiving role may be predictive of positive familial psychosocial outcomes, it is critical that maternal coping is assessed and supported in paediatric healthcare. …”
Get full text

The Addis Declaration on Immunization: Assessing the Effectiveness and Efficiency of Immunization Service Delivery Systems in Africa as of the End of 2023 by Franck Mboussou, Charles Shey Wiysonge, Bridget Farham, Ado Bwaka, Sarah Wanyoike, Amos Petu, Sidy Ndiaye, Andre Bita Fouda, Johnson Muluh Ticha, Adidja Amani, Regis Obiang, Magaran Monzon Bagayoko, Benido Impouma

“…<b>Conclusions</b>: It is critical, as a follow up to this study, to document best practices from the seven countries that achieved the fourth ADI commitment. …”
Get full text

Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy by Yu Chen, Mingyuan Jiang, Liping Li, Shanshan Yang, Zuimeng Liu, Shiwen Lin, Wanxiao Wang, Jinyang Li, Feng Chen, Qiang Hou, Xiaoyin Ma, Ling Hou

“…Abstract Epithelial-to-mesenchymal transition (EMT) is a critical and complex process involved in normal embryonic development, tissue regeneration, and tumor progression. …”
Get full text

YOLOv8-LCNET: An Improved YOLOv8 Automatic Crater Detection Algorithm and Application in the Chang’e-6 Landing Area by Jing Nan, Yexin Wang, Kaichang Di, Bin Xie, Chenxu Zhao, Biao Wang, Shujuan Sun, Xiangjin Deng, Hong Zhang, Ruiqing Sheng

“…The analysis of this impact crater catalogue has provided critical support for landing site selection and characterization of the CE-6 mission and lays the foundation for future lunar geological studies.…”
Get full text

The Solar and Geomagnetic Storms in 2024 May: A Flash Data Report by Hisashi Hayakawa, Yusuke Ebihara, Alexander Mishev, Sergey Koldobskiy, Kanya Kusano, Sabrina Bechet, Seiji Yashiro, Kazumasa Iwai, Atsuki Shinbori, Kalevi Mursula, Fusa Miyake, Daikou Shiota, Marcos V. D. Silveira, Robert Stuart, Denny M. Oliveira, Sachiko Akiyama, Kouji Ohnishi, Vincent Ledvina, Yoshizumi Miyoshi

“…We compared naked-eye and camera auroral visibility, providing critical caveats on their difference. We also confirmed global disturbances of the storm-enhanced density of the ionosphere.…”
Get full text

Determinants of outcomes in patients with hepatitis B virus-decompensated cirrhosis by Yi-Jie Huang, Jun-Sing Wang, Cheng-Hsu Chen, Shou-Wu Lee, Chung-Hsin Chang, Szu-Chia Liao, Yen-Chun Peng, Teng-Yu Lee, Tsai-Chung Li

“…Liver functional reserve and age played a critical role in the prognosis of CHB patients with decompensated cirrhosis. …”
Get full text

External validation of AI-based scoring systems in the ICU: a systematic review and meta-analysis by Patrick Rockenschaub, Ela Marie Akay, Benjamin Gregory Carlisle, Adam Hilbert, Joshua Wendland, Falk Meyer-Eschenbach, Anatol-Fiete Näher, Dietmar Frey, Vince Istvan Madai

“…Thus, external validation is a critical – but frequently overlooked – step to establish the reliability of predicted risk scores to translate them into clinical practice. …”
Get full text

Development of a novel strategy for the quantification of ultra-trace impurity elements in high-purity magnesium using inductively coupled plasma tandem mass spectrometry by Liang Fu, Guangsheng Huang, Yaobo Hu, Xianhua Chen, Jingfeng Wang, Fusheng Pan

“…Impurities in high-purity magnesium affect material properties, which has become the most critical factor restricting its application. However, accurate analysis of multiple ultra-trace impurity elements in high-purity magnesium is extremely challenging. …”
Get full text

Comparison of the Influence of Vegetarian and Mediterranean Diets on the Formation of Kidney Stones by Sebastian Samuła, Michał Mazur, Dorota Waz, Jakub Szarłowicz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak, Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski

“… Introduction and Purpose: Kidney stone disease is a significant global health concern with increasing prevalence worldwide. Diet plays a critical role in both the prevention and development of this condition. …”
Get full text

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19 by Yongzhi Lu, Qi Yang, Ting Ran, Guihua Zhang, Wenqi Li, Peiqi Zhou, Jielin Tang, Minxian Dai, Jinpeng Zhong, Hua Chen, Pan He, Anqi Zhou, Bao Xue, Jiayi Chen, Jiyun Zhang, Sidi Yang, Kunzhong Wu, Xinyu Wu, Miru Tang, Wei K. Zhang, Deyin Guo, Xinwen Chen, Hongming Chen, Jinsai Shang

“…The co-crystal structures of PLpro with lead compounds reveal that the residues D164 and Q269 around the S2 site are critical for improving the inhibitor’s potency. The lead compound GZNL-P36 not only inhibits SARS-CoV-2 and its variants at the cellular level with EC50 ranging from 58.2 nM to 306.2 nM, but also inhibits HCoV-NL63 and HCoV-229E with EC50 of 81.6 nM and 2.66 μM, respectively. …”
Get full text

Subtype-specific human endogenous retrovirus K102 envelope protein is a novel serum immunosuppressive biomarker of cancer by Qinyuan Gong, Qinyuan Gong, Rongzhen Xu, Rongzhen Xu

“…Immune dysfunction is one of the hallmarks of cancer and plays critical roles in immunotherapy resistance, but there is no serum biomarker that can be used to evaluate immune-dysfunction status of cancer patients. …”
Get full text

The Impact of Violations of Bicycles and Pedestrians on Vehicle Emissions at Signalized Intersections by Jianchang Huang, Guohua Song, Jianbo Zhang, Chenxu Li, Qiumei Liu, Lei Yu

“…And frequent violations such as running the red light have been a critical social problem at signalized intersections in developing countries. …”
Get full text

Influence of the polysaccharide capsule on virulence and fitness of Klebsiella pneumoniae by Lisa Zierke, Rodi Mourad, Thomas P. Kohler, Mathias Müsken, Sven Hammerschmidt

“…IntroductionThe capsular polysaccharide (CPS) of pathogenic bacteria is a critical virulence factor, often evading phagocytosis by host immune cells, while also interfering with the contact of the pathogen with host cells and contributing to biofilm formation. …”
Get full text

Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice by Parinda Jamrus, Nuttanan Pholngam, Benjaporn Kiatpakdee, Kittikun Viwatpinyo, Jim Vadolas, Sukonthar Ngampramuan, Saovaros Svasti, Pornthip Chaichompoo

“…These results underscore the critical role of iron overload in accelerating cognitive decline in β-thalassaemia and suggest that regular monitoring of iron levels and chelation therapy may help prevent early cognitive impairment, ultimately improving the quality of life for β-thalassaemia patients.…”
Get full text

An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing by Jacob W. Fleming, Molly C. McCloskey, Kevin Gray, David R. Nash, Vincent Leung, Christos Michas, Shawn M. Luttrell, Christopher Cavanaugh, Julie Mathieu, Shawn Mcquire, Mark Bothwell, David L. Mack, Nicholas A. Geisse, Alec S.T. Smith

“…Animal models of the neuromuscular junction (NMJ) have been widely studied but exhibit critical differences from human biology limiting utility in drug and disease modelling. …”
Get full text