Clinical characteristics, metastasis patterns, and treatment outcomes of HER2-low breast cancer by Maria Elena Lacruz, Saskia Thies, Andrea Schmidt-Pokrzywniak, Ian Wittenberg, Tobias Engler, Fabian Reinwald, Monika Klinkhammer-Schalke, Sylke Ruth Zeissig, Bianca Franke, Kerstin Weitmann, Atanas Ignatov

“…While metastatic behaviour, treatment and long-term response in HER2-low were comparable to HER2-zero, the hormone receptor status seems to play a critical role in these outcomes.…”
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SMR-guided molecular subtyping and machine learning model reveals novel prognostic biomarkers and therapeutic targets in non-small cell lung adenocarcinoma by Baozhen Wang, Yichen Yin, Anqi Wang, Weidi Liu, Jing Chen, Tao Li

“…This study offers fresh insights into the molecular subtyping, prognostic prediction, and personalized therapeutic decision-making in LUAD, laying a critical foundation for future clinical applications and targeted therapy research.…”
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Cryptic species and hybridisation in corals: challenges and opportunities for conservation and restoration by Riginos, Cynthia, Popovic, Iva, Meziere, Zoe, Garcia, Vhon, Byrne, Ilha, Howitt, Samantha M., Ishida, Hisatake, Bairos-Novak, Kevin, Humanes, Adriana, Scharfenstein, Hugo, Richards, Thomas, Briggs, Ethan, Clark, Vanessa, Lei, Chuan, Khan, Mariam, Prata, Katharine E.

“…Incorporating the expectation that coral cryptic taxa with incomplete species boundaries will frequently be encountered is critical to the long-term success of coral conservation and restoration programs. …”
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Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance by Tianming Qiu, Yu Zhi, Jingyuan Zhang, Ningning Wang, Xiaofeng Yao, Guang Yang, Liping Jiang, Li Lv, Xiance Sun

“…Sodium arsenite (NaAsO2), the most common form of inorganic arsenic prevalent in the environment, has been closely linked to islet β-cell dysfunction, a critical pathological hallmark of type 2 diabetes (T2D). …”
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Sustainable closed-loop supply chain network design: heuristic hybrid approach with considering inflation and carbon emission policies by Saeid Kalantari, Hamed Kazemipoor, Farzad Movahedi Sobhani, Seyyed Mohammad Hadji Molana

“…Purpose: Establishing the structure and expansion of sustainable closed-loop supply chains is critical to meeting environmental, economic, and social standards to strengthen their position in competitive markets. …”
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Targeting accuracy of neuronavigation: a comparative evaluation of an innovative wearable AR platform vs. traditional EM navigation by Marina Carbone, Marina Carbone, Nicola Montemurro, Nicola Montemurro, Nadia Cattari, Nadia Cattari, Martina Autelitano, Martina Autelitano, Fabrizio Cutolo, Fabrizio Cutolo, Vincenzo Ferrari, Vincenzo Ferrari, Emanuele Cigna, Emanuele Cigna, Sara Condino, Sara Condino

“…This ergonomic approach can facilitate a more intuitive understanding of spatial relationships and guidance cues, potentially reducing cognitive load and enhancing the accuracy of surgical gestures by aligning critical information with the actual anatomy in real-time. …”
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Optimizing Phaeodactylum tricornutum cultivation: integrated strategies for enhancing biomass, lipid, and fucoxanthin production by Mostafa E. Elshobary, Walaa A. Abo-Shanab, Stephan S. W. Ende, Mohammed Alquraishi, Rania A. El-Shenody

“…These findings demonstrate the critical role of precise cultivation conditions in optimizing microalgal metabolic performance for biotechnological applications.…”
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Cephalometric and Photographic Evaluation of the Nasolabial Angle in Orthodontically Treated Patients: An Observational Cohort Study by Silvia Izabella Pop, Eugen Bud, Krisztina Mártha, Izabella Éva Mureșan, Kinga Mária Jánosi, Boglárka Dósa, Bernadette Kerekes-Máthé

“…<b>Background:</b> The nasolabial angle (NLA) is one of the most critical parameters of the soft tissue profile when orthodontic treatment is required. …”
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Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease by Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge

“…The SARS-CoV-2 main protease (Mpro or Nsp5) is critical for production of viral proteins during infection and, like many viral proteases, also targets host proteins to subvert their cellular functions. …”
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Understanding the exodus: a 15-year retrospective cohort study on the pattern and determinants of migration among Nigerian doctors and dentists by Oghenebrume Wariri, Patience Toyin-Thomas, Itua C.G. Akhirevbulu, Oladapo Oladeinde, Oluchi Omogbai, Philippa Odika, John Osakue, Avwebo Ukueku, Efetobo Orikpete, Chinelo Iwegim, Efe E. Omoyibo, Jermaine Okpere, Uwaila Otakhoigbogie, Ekhosuehi T. Agho, Sunday C. Madubueze, Nnennaya C. Ugoji, Chukwunwike W. Ozegbe, Oti N. Aria, Paul Ikhurionan

“…Background Nigeria faces a critical shortage of healthcare professionals yet experiences a significant annual exodus of doctors and dentists. …”
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Multi-UE 5G RAN Measurements: A Gamut of Architectural Options by Andreas Ingo Grohmann, Mauri Seidel, Sebastian A. W. Itting, Ray-Guang Cheng, Martin Reisslein, Frank H. P. Fitzek

“…The Radio Access Network (RAN) of Fifth Generation (5G) communication systems critically influences the overall performance and cost of a 5G system. 5G RANs allow for a gamut of implementations ranging from closed (carrier-grade) implementations by traditional vendors that are expensive and configured by the vendor to RANs that are compliant with the specifications of the O-RAN ALLIANCE, i.e., to so-called O-RANs. …”
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Epidermal stem cell derived exosomes-induced dedifferentiation of myofibroblasts inhibits scarring via the miR-203a-3p/PIK3CA axis by Shixin Zhao, Haoran Kong, Dahu Qi, Yushuang Qiao, Yu Li, Zhiming Cao, Hanwen Wang, Xuefeng He, Hengdeng Liu, Hao Yang, Suyue Gao, Tao Liu, Julin Xie

“…The conversion of fibroblasts to myofibroblasts is known to play a critical role in HS formation, making it essential to identify molecules that promote myofibroblast dedifferentiation and to elucidate their underlying mechanisms. …”
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Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis by Yuan Liang, Mengni Liu, Bingyuan Liu, Benjamin Ziman, Guanjie Peng, Qiong Mao, Xingzhe Wang, Lizhen Jiang, De-Chen Lin, Yueyuan Zheng

“…Abstract Background Histone modification H3K27me3 plays a critical role in normal development and is associated with various diseases, including cancer. …”
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Selective engagement of long-latency reflexes in postural control through wobble board training by Theodore Deligiannis, Mahsa Barfi, Brian Schlattmann, Ken Kiyono, Damian G. Kelty-Stephen, Madhur Mangalam

“…Abstract Long-latency reflexes (LLRs) are critical precursors to intricate postural coordination of muscular adaptations that sustain equilibrium following abrupt disturbances. …”
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Effect of dietary starch inclusion, feeding level and their combination on nutrient digestibility, bile acid balance, faecal waste production and characteristics of yellowtail king... by Yaqing Zhang, Roel M. Maas, Peter Horstmann Zuther, Jeroen Kals, Satya Prakash, Thomas W.O. Staessen, Fotini Kokou, Johan W. Schrama

“…High dietary starch levels resulted in increased faecal waste production, and higher amounts of non-removed faeces by settling due to reduced faecal removal efficiency. The critical dietary starch content was estimated to be 6 %. …”
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Cross-sectional analysis of risk factors associated with the coexistence of three undernutrition indicators among children aged 0–23 months in Tanzania by Edgar Elirehema Pallangyo, Oliva Joseph Kimaro, Nsajigwa Reuben Mwalupani, George Stephen George, Doris Katana, Amina Suleiman Msengwa

“…Conclusion This study highlights critical risk factors, including maternal education, child age, and birth characteristics, for the coexistence of stunting, wasting, and underweight. …”
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Coronary Angiography Safety between Transradial and Transfemoral Access by Santosh Kumar Sinha, Vikas Mishra, Nasar Afdaali, Mukesh Jitendra Jha, Ashutosh Kumar, Mohammad Asif, Ramesh Thakur, Chandra Mohan Varma

“…The aim of study was to evaluate safety, feasibility, and procedural variables of transradial approach compared with transfemoral approach in a standard population of patients undergoing coronary catheterization as one of the major criticisms of the transradial approach is that it takes longer overall procedure and fluoroscopy time, thereby causing more radiation exposure. …”
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Multiple Dimensions Define Thresholds for Population Resilience of the Eastern Oyster, Crassostrea virginica by Megan K. La Peyre, Hongqing Wang, Shaye E. Sable, Wei Wu, Bin Li, Devin Comba, Carlos Perez, Melanie Bates, Lauren M. Swam

“…Two statistical approaches were applied, with each model highlighting a different operational definition of a threshold: random forest models identified a threshold as an abrupt change in the oyster abundance‐ salinity relationship, while Bayesian models identified an increased probability of oyster abundance dropping below a critical threshold, defined here as less than 50% of the 5‐year mean. …”
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High-level biosynthesis and purification of the antimicrobial peptide Kiadin based on non-chromatographic purification and acid cleavage methods by Liangjun Zheng, Fengyi Yang, Chen Wang, Muhammad Zafir, Zishuo Gao, Pilong Liu, Fatma A. El-Gohary, Xin Zhao, Huping Xue

“…Our optimization of acid cleavage temperature, duration, and isoelectric precipitation conditions proved critical for maximizing the purification efficiency and expression levels of Kiadin. …”
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Recommendations of the Russian Gastroenterological Association on Clinical Use of High-Resolution Manometry in Diagnosis of Esophageal Disorders by V. T. Ivashkin, I. V. Mayev, A. S. Trukhmanov, O. A. Storonova, S. A. Abdulkhakov, D. N. Andreev, D. S. Bordin, E. R. Valitova, I. L. Klyaritskaya, V. V. Krivoy, Yu. A. Kucheryavyi, T. L. Lapina, S. V. Morozov, O. A. Sablin, E. V. Semenikhina, Yu. P. Uspenskiy, A. A. Sheptulin

“…It enables a medical professional to obtain evidence that may critically affect the choice of optimal patient care strategy and effective treatment. …”
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