Whole exome sequencing-based homologous recombination deficiency test for epithelial ovarian cancer by Ying-Cheng Chiang, Hsien-Neng Huang, Kuan-Ting Kuo, Wuh-Liang Hwu, Po-Han Lin

“…Patients with positive HRD status defined by WES-based scarHRD test and Myriad MyChoice® CDx test were both highly associated with platinum sensitive response (both Fisher’s exact test, p = 0.002) as well as the superior progression-free survival (both log-rank p = 0.002). The multi-variate Cox regression model incorporated with optimal debulking surgery showed that the recurrence risk was decreased in the patients with positive HRD status, either defined by Myriad MyChoice® CDx test (Hazard ratio (HR) 0.33, 95% confidence interval (CI) 0.14–0.79, p = 0.013) or WES-based test Myriad MyChoice® CDx test (HR 0.34, 95% CI 0.14–0.80, p = 0.014). …”
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Are psychological attitudes towards vaccination an expression of personality? A cross-sectional study on COVID-19 vaccination in France by Gaëlle Lièvre, Jonathan Sicsic, Simon Galmiche, Tiffany Charmet, Arnaud Fontanet, Judith Mueller

“…Multivariable logistic regressions and Cox models predicting vaccine behaviours were run with the 7C antecedents, both with and without personality traits. …”
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Outcomes of coronary artery aneurysms: insights from the Coronary Artery Ectasia and Aneurysm Registry (CAESAR) by Alessandro Candreva, Jessica Huwiler, Diego Gallo, Victor Schweiger, Thomas Gilhofer, Roberta Leone, Michael Würdinger, Maurizio Lodi Rizzini, Claudio Chiastra, Julia Stehli, Jonathan Michel, Alexander Gotschy, Barbara E. Stähli, Frank Ruschitzka, Umberto Morbiducci, Christian Templin

“…Time-dependent event risks for the CAE and CAA groups were assessed using Cox regression models and Kaplan-Meier curves. …”
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Intensive Blood Pressure Control and Diabetes Mellitus Incidence for Patients with Impaired Fasting Glucose: A Secondary Analysis of SPRINT by Beiru Lin, Xiaochuan Liu, Sichen Yao, Zhigang Pan

“…The secondary outcome was incident IFG reversion (IFGR), defined as the time to first FBG back to normoglycemia (<100 mg/dl) among participants without incident T2D. Cox proportional hazards models were used to compare the cumulative incidence of outcomes between the two BP control groups. …”
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A beneficial levels of 25-hydroxyvitamin D for a decrease in thyrotropin receptor antibody (TRAB) in patients with Graves’ disease: a real-world study by Xide Chen, Yongze Zhang, Luxi Lin, Yuxia Chen, Ximei Shen, Lingning Huang, Fengying Zhao, Sunjie Yan

“…Results There was a higher TSH and lower TRAB titer in the 20–29 ng/mL group at initial diagnosis. Cox regression analysis suggested that 20–29 ng/mL group had significantly higher remission rates [RR; 95% CI: 7.505 (1.401–40.201), 8.975 (2.759–29.196),6.853(2.206–21.285), respectively] and negative conversion rates [RR; 95% CI: 7.835 (1.468–41.804),7.189(1.393–37.092), 8.122(1.621–40.688)] at the 6-, 12-, and 24-month follow-up, respectively . …”
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The simpler modified fried frailty scale predicts 2-year mortality in older adults with heart failure: a pilot study by Celalettin Küçük, Serdar Özkök, Gülistan Bahat, Ekrem Bilal Karaayvaz, Mustafa Altınkaynak, Alpay Medetalibeyoğlu, Mehmet Akif Karan

“…FRAIL scale, the Study of Osteoporosis Fractures (SOF) index, and Edmonton Frailty Scale (EFS) were alternatively used to study the correlation of SMFFS with different scales. Cox-regression analysis was performed to identify whether SMFFS-defined frailty could predict mortality in follow-up, with adjusting for a list of clinical characteristics and geriatric syndromes. …”
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Mortality-related risk factors of carbapenem-resistant Enterobacteriaceae infection with focus on antimicrobial regimens optimization: a real-world retrospective study in China by Sheng Deng, Jinglan Chen, Pengxiang Zhou, Qin Hu

“…Mortality-related risk factors were analyzed by the Cox proportional regression model for multivariate analysis. …”
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Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study by Ming-Ju Wu, Chew-Teng Kor, Chia-Chu Chang, Shuo-Chun Weng, Chia-Lin Wu, Ping-Fang Chiu, Der-Cherng Tarng

“…All the participants were registered in the National Health Insurance Research Database.Participants Finally, data from 7156 subjects with migraine and 7156 propensity-score-matched control subjects were analysed.Primary outcome measure We used Cox proportional hazards regression to estimate adjusted HRs for incident CKD; subgroup analyses were performed to assess the interactive effects of migraine with demographics, comorbidities and long-term medications.Results The incidence of CKD was higher in the migraine group than in the control group. …”
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SARS-CoV-2 infection rates and associated risk factors in healthcare workers: systematic review and meta-analysis by Amit Bansal, Mai-Chi Trieu, Emily M. Eriksson, Fan Zhou, Jodie McVernon, Karl Albert Brokstad, Rebecca Jane Cox

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初治转移性鼻咽癌预后因素及治疗模式探讨

“…肺(15.7%)等,全部患者至少接受1个疗程的以铂类为基础的联合化疗,中位化疗周期为5个,将预后不利因素纳入多因素Cox比例风险回归模型中分析? 【结果】 全组中位随访时间为21个月,中位生存时间为24个月,3年?…”
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The role of gut microbiota in disease management: Ayurvedic perspectives on metabolic diseases and health by Bhawana Jangra, Shreyanshi Kulshreshtha, Alok Goyal, Sanjay M. Jachak

“…These plants possess incredible therapeutic properties and are able to inhibit TNF-α, NF-κB, COX, LOX, α-amylase, α-glucosidase, etc. They are well documented and used for treating conditions like IBS, chronic diarrhoea, constipation, ulcerative colitis, Agnimandya (digestive impairment), Mandagni (impaired digestive fire) and other gut-related diseases. …”
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Rechallenge therapy versus tyrosine kinase inhibitor (TKI) for advanced metastatic colorectal cancer: a retrospective study by Chenming Liu, Jintao Chen, Yuxing Liu

“…After 1:1 matching, there were 34 patients in both the TKI and rechallenge groups. Cox regression analysis was performed to identify independent predictive factors. …”
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A novel mitochondrial-related risk model for predicting prognosis and immune checkpoint blockade therapy response in uterine corpus endometrial carcinoma by Ru-Gen Liao, Jin-Hong Wang, Fan Zhang, Yu-Tong Fang, Li Zhou, Yong-Qu Zhang

“…In the training cohort, a risk model based on DEMRGs was developed using Lasso Cox regression analysis. Subsequently, patients in both cohorts were stratified into high-risk and low-risk groups based on their median risk scores. …”
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Assessment of Tumor Burden Score as a Feasible and Reliable Tool for Prognosis Prediction for Hepatocellular Carcinoma Undergoing Hepatectomy: A Multicenter, Retrospective Study by Guan R, Zheng Z, Deng M, Mei J, Lin Y

“…Finally, univariate and multivariate cox analysis was used to determine independent prognostic predictors.Results: About 44.2% (n=1343) of patients had low TBS, 38.8% (n=1182) had intermediate TBS and 17% (n=519) had high TBS. …”
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Study on postoperative survival prediction model for non-small cell lung cancer: application of radiomics technology workflow based on multi-organ imaging features and various mach... by Hanlin Wang, Yuan Hong, Zimo Zhang, Kang Cheng, Bo Chen, Renquan Zhang

“…Subsequently, the classification performance of all constructed models was compared to select the optimal prediction model.ResultsUnivariate Cox regression analysis showed no significant correlation between the collected clinical factors and patient survival time. …”
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Changes in sarcopenia and incident cardiovascular disease in prospective cohorts by Qingyue Zeng, Lijun Zhao, Qian Zhong, Zhenmei An, Shuangqing Li

“…CVD was identified through self-reported physician diagnoses of heart disease, including angina, myocardial infarction, congestive heart failure, and other heart problems, or stroke. Cox proportional hazards models were employed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for potential confounding factors. …”
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Relationship between Obesity and Cognitive Function in Young Women: The Food, Mood and Mind Study by Rebecca L. Cook, Nicholas J. O’Dwyer, Cheyne E. Donges, Helen M. Parker, Hoi Lun Cheng, Katharine S. Steinbeck, Eka P. Cox, Janet L. Franklin, Manohar L. Garg, Kieron B. Rooney, Helen T. O’Connor

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Risk, incidence and predictors of venous thromboembolism among patients attending the emergency department of tertiary care hospitals in Addis Ababa city, Ethiopia: a multicentre p... by Desalew Mekonnen, Alemseged Beyene Berha, Worku Degefa, Minyahil Alebachew Woldu

“…Eighteen patients (4.3%) were diagnosed with VTE during their emergency stay. Multivariate Cox regression analysis revealed that patients who were physically active prior to admission (adjusted hazard ratio (AHR)=0.67, 95% CI 0.082 to 1.579, p=0.014) and those receiving pharmacological prophylaxis (AHR=0.167, 95% CI 0.037 to 0.768, p=0.021) were found to have a protective effect against the risk of developing VTE. …”
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Real-World Analysis of Weight Gain and Body Mass Index Increase Among Patients with HIV-1 Using Antiretroviral Regimen Containing Tenofovir Alafenamide, Tenofovir Disoproxil Fumara... by Bruno Emond, Carmine Rossi, Rachel Rogers, Patrick Lefebvre, Marie-Hélène Lafeuille, Prina Donga

“…Time-to-weight and BMI increase ≥5% were compared using Cox models adjusted for baseline characteristics. …”
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初治急性早幼粒细胞白血病缓解后三氧化二砷和常规化疗巩固治疗疗效分析

“…【目的】 探讨初治急性早幼粒细胞白血病(APL)缓解后三氧化二砷(ATO)和常规化疗交替巩固治疗的长期疗效和安全性【方法】 自2003年5月至2009年12月,初治APL患者完全缓解(CR)后采用ATO和常规化疗交替巩固治疗方案:ATO 10 mg/d每周5 d × 4周或连续20 d为1疗程,化疗为常规剂量蒽环类药物-阿糖胞苷“3+7”方案【结果】 54例初治APL患者CR后采用ATO和常规化疗交替巩固治疗方案,男29例,女25例,中位年龄31岁,ATO和化疗巩固中位疗程数各4(2 ~ 8)个,ATO总剂量中位数15.1(5.9 ~ 34.8)mg/kgATO巩固治疗结束阶段常出现3/4级中性粒细胞减少,但不增加细菌感染率,其它毒副作用轻微可逆巩固治疗期间无治疗相关死亡,所有患者在巩固治疗期间获分子生物学完全缓解中位随访39(12 ~ 91)个月,复发2例,其CR期分别为25和46个月;3年5年无白血病生存率(LFS)和累积复发风险分别为(97.7 ± 2.3) %(93.4 ± 4.7) % 和(2.4 ± 2.3)%(6.8 ± 4.7) %,其中CR > 5年17例(占31%)> 3年29例(占54%),无ATO慢性蓄积中毒和继发第二恶性肿瘤的发生COX回归模型单因素分析表明患者年龄性别病初WBCHbPLTLDH值外周血和骨髓异常早幼粒细胞比例以及诱导治疗方案中维甲酸是否联合ATO与LFS均无显著相关(P > 0.05)【结论】 初治APL缓解后采用ATO联合常规化疗安全有效,可获得更高的长期无病生存率…”
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