Coupling genome-wide continuous perturbation with biosensor screening reveals the potential targets in yeast isopentanol synthesis network by Qi Xiao, Jingjing Shi, Lixian Wang, Guoping Zhao, Yanfei Zhang

“…Our results confirmed the critical roles of HOM3 and DIP5 in isopentanol production, along with genes associated with the aerobic respiratory chain (SDH3, CYT1, COX7, ROX1, and ATG41) and cofactor balance (BNA2 and NDE1). …”
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A Mitochondria‐Related Signature in Diffuse Large B‐Cell Lymphoma: Prognosis, Immune and Therapeutic Features by Zhen‐Zhong Zhou, Jia‐Chen Lu, Song‐Bin Guo, Xiao‐Peng Tian, Hai‐Long Li, Hui Zhou, Wei‐Juan Huang

“…Results Eighteen prognostic MRGs (DNM1L, PUSL1, CHCHD4, COX7A1, CPT1A, CYP27A1, POLDIP2, PCK2, MRPL2, PDK3, PDK4, MARC2, ACSM3, COA7, THNSL1, ATAD3B, C15orf48, TOMM70A) were identified to construct the risk model. …”
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Plasma IL-17A is increased in patients with critical MIS-C and associated to in-hospital mortality by Emmerson C. F. de Farias, Luciana M. P. P. do Nascimento, Manoel J. C. Pavão Junior, Dalila C. A. Pavão, Ana P. S. Pinheiro, Andreza H. O. Pinheiro, Marília C. B. Alves, Kíssila M. M. M. Ferraro, Larisse F. Q. Aires, Luana G. Dias, Mayara M. M. Machado, Michaelle J. D. Serrão, Raphaella R. Gomes, Sara M. P. de Moraes, Gabriela C. L. Pontes, Railana D. F. P. Carvalho, Cristiane T. C. Silva, Carla M. A. das Neves, Joyce C. L. dos Santos, Adriana M. B. de Sousa, Leda L. da Silva, Mary L. F. M. F. de Mello, Patricia B. Carvalho, Renata de B. Braga, Kathia de O. Harada, Maria C. A. Justino, Iran B. Costa, Igor Brasil-Costa, Marta C. Monteiro, Gleice Clemente, Maria Teresa Terreri

“…Univariate and multivariate Cox regression analyses were conducted. The ROC (Receiver Operating Characteristic) curve analysis was performed.Results and conclusionsA total of 41 patients out of 109 patients admitted at PICU with suspected MIS-C during the study period were included, of which 33 (80.5%) were male, 9 (22%) were under one year old, and 30 (73.2%) presented comorbidities. …”
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Utilization of cardiopulmonary bypass at radical nephrectomy for renal cell carcinoma with tumour thrombus by Chalairat Suk‐Ouichai, Mitchell M. Huang, Clayton Neill, Christopher K. Mehta, Ashley E. Ross, Shilajit D. Kundu, Kent T. Perry Jr, Duc T. Pham, Hiten D. Patel

“…Logistic regression assessed predictors for utilizing CPB, and Cox regression identified factors associated with survival. …”
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The prevalence and prognostic significance of Sarcopenia and Adipopenia in Pleural Mesothelioma by Andrew C. Kidd, Gordon W. Cowell, Geoffrey A. Martin, Jenny Ferguson, Dean A. Fennell, Matt Evison, Kevin G. Blyth

“…Overall survival associations were evaluated using Kaplan–Meier methodology ± Cox proportional hazards models. Results: T4 and L3 measurements were possible in 111/111 and 91/111 (82 %). …”
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An MRI radiomics model for predicting a prostate-specific antigen response following abiraterone treatment in patients with metastatic castration-resistant prostate cancer by Yi Wu, Xiang Liu, Shaoxian Chen, Fen Fang, Feng Shi, Yuwei Xia, Zehong Yang, Daiying Lin

“…Univariate and multivariate analyses were performed using Cox regression to identify significant predictors of the efficacy of abiraterone treatment in patients with mCRPC.ResultsThe integrated model was constructed from seven radiomics features extracted from the T2WI, DWI, and ADC sequence images of the training data. …”
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A novel nomogram to predict all‐cause readmission or death risk in Chinese elderly patients with heart failure by Mengxi Yang, Liyuan Tao, Hui An, Gang Liu, Qiang Tu, Hu Zhang, Li Qin, Zhu Xiao, Yu Wang, Jiaxai Fan, Dongping Feng, Yan Liang, Jingyi Ren

“…Demographic, co‐morbidity, laboratory, and medication data were collected. A Cox regression model was used to identify factors for the prediction of readmission or death at 30 days and 1 year. …”
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Prognostic Value of the Tricuspid Regurgitation Impact on Outcomes (TRIO) Score in Patients Undergoing Transcatheter Aortic Valve Implantation by Jizhong Wang, Yuanwei Chen, Xuxing Zhang, Songyuan Luo, Jie Li, Fang Pei, Jianfang Luo

“…Results: Over a mean follow-up period of 22 months, patients with a TRIO score >4 had significantly higher rates of mortality (11.5% vs. 3.1%, p < 0.001) and MACEs (14.9% vs. 3.6%, p < 0.001). Multivariable Cox regression analysis identified a TRIO score >4 as an independent risk factor for all-cause mortality (hazard ratio (HR): 2.41, 95% confidence interval (CI): 1.08–5.37, p = 0.032) and MACEs (HR: 2.78, 95% CI: 1.34–5.75, p = 0.006). …”
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Comprehensive analysis of the expression and prognostic value of ARMCs in pancreatic adenocarcinoma by Guanxiang Zhuo, Shengzhai Lin, Fei Yuan, Qiaoling Zheng, Yinpin Guo, Zuwei Wang, Jianfei Hu, Meihong Yao, Fuxiu Zhong, Shi Chen, Yanling Chen, Huixing Chen

“…In addition, ARMC5 and ARMC10 were independent prognostic factors in univariate and multivariate Cox regression analyses. Finally, through our confirmation experiment, it was found that the expression of ARMC1 and 10 in PAAD tissues was significantly increased compared with those in paracancer tissue. …”
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Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction by Aric A. Prather, PhD, Ying Gao, MS, Legna Betancourt, BS, Rose C. Kordahl, BS, Anya Sriram, BS, Chiung-Yu Huang, PhD, Steven R. Hays, MD, Jasleen Kukreja, MD, Daniel R. Calabrese, MD, Aida Venado, MD, Bhavya Kapse, PhD, John R. Greenland, MD, PhD, Jonathan P. Singer, MD, MS

“…We evaluated the associations between SPI and insomnia on time to chronic lung allograft dysfunction (CLAD) and death using Cox models, adjusting for age, sex, and transplant indication. …”
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Tuberculosis screening among cough suppressant buyers in pharmacies and drug outlets in Guinea: a cross-sectional study by Jonathon R Campbell, Vanessa Veronese, Aboubacar Sidiki Magassouba, Almamy Amara Toure, Boubacar Djelo Diallo, Gnoume Camara, Desire Lucien Dahourou, Aly Badara Nabe, Souleymane Camara, Adama Marie Bangoura, Hugues Asken Traore, Corinne Simone Collette Merle

“…We assessed factors associated with eventual TB diagnosis using logistic regression and time to TB diagnosis using cox regression and used microcosting to estimate the cost of the intervention in 2020 US$.Results From November 2019 to June 2020, we screened 916 people referred from pharmacies or drug outlets with TB symptoms, with median age of 31 years (54% male). …”
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Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma by Jian‐Hua Wang, Shu‐Ting Huang, Lan Zhang, Zi‐Gang Liu, Rong‐Xin Liang, Sen‐Wei Jiang, Yi‐Nan Jiang, Xing‐Juan Yu, Yu‐Chuan Jiang, Xi‐Zhao Li, Pei‐Fen Zhang, Zhe‐Sheng Wen, Min Zheng

“…Kaplan‐Meier analysis and Cox proportional hazards models were built for estimating the prognostic values of CD47 and CD133 expression and their combined stemness index. …”
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Impact of Clinical Characteristics and Treatment on Cholangiocarcinoma Prognosis in Southern Thailand by Chirawadee Sathitruangsak, Tanawat Pattarapuntakul, Apichat Kaewdech, Tortrakoon Thongkan, Apinya Prisutkul, Phatcharaporn Thongwatchara, Hutcha Sriplung, Chanon Kongkamol, Kanyanatt Kanokwiroon, Sumalee Obchoei, Pimsiri Sripongpun

“…Overall survivals (OS) were determined by Kaplan–Meier method and multivariable Cox regressions. Results The mean age was 63.9 years; 50.7% were men. …”
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Infection‐Related Hospitalization and Incident Heart Failure: The Atherosclerosis Risk in Communities Study by Rebecca L. Molinsky, Amil Shah, Melana Yuzefpolskaya, Bing Yu, Jeffrey R. Misialek, Bruno Bohn, David Vock, Richard MacLehose, Barry A. Borlaug, Paolo C. Colombo, Chiadi E. Ndumele, Junichi Ishigami, Kunihiro Matsushita, Pamela L. Lutsey, Ryan T. Demmer

“…We used multivariable‐adjusted Cox proportional hazards models to assess the association between IRH and incident HF, HF with reduced ejection fraction, and HF with preserved ejection fraction. …”
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Associations between degree of food processing and all-cause and cause-specific mortality: a multicentre prospective cohort analysis in 9 European countriesResearch in context by Esther M. González-Gil, Michèle Matta, Fernanda Morales Berstein, Manon Cairat, Geneviève Nicolas, Jessica Blanco, Nathalie Kliemann, Renata Bertazzi Levy, Fernanda Rauber, Inarie Jacobs, Aline Al Nahas, Emine Koc Cakmak, Eszter P. Vamos, Kiara Chang, Sahar G. Yammine, Christopher Millett, Mathilde Touvier, Maria Gabriela Matias Pinho, Konstantinos K. Tsilidis, Alicia K. Heath, Christina M. Lill, Valeria Pala, Conchi Moreno-Iribas, Maria Santucci De Magistris, Christina C. Dahm, Niels Bock, Anja Olsen, Anne Tjønneland, Yvonne T. van der Schouw, Pilar Amiano, Franziska Jannasch, Matthias B. Schulze, Francesca Romana Mancini, Chloé Marques, Claire Cadeau, Catalina Bonet, Daniel Redondo-Sánchez, Kristin Benjaminsen Borch, Magritt Brustad, Guri Skeie, Jesús Humberto-Gómez, Alessandra Macciotta, Pietro Ferrari, Laure Dossus, Marc J. Gunter, Inge Huybrechts

“…Hazard ratios (HRs) and 95% CIs were estimated using multivariable Cox proportional hazards regression models. Substitution analyses were also performed. …”
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The association between systemic inflammatory response index and contrast-associated acute kidney injury in patients undergoing elective percutaneous coronary intervention by Jun-Han Chen, Li-Wei Zhang, Wen-Jia Liang, Wei-ze Lin, Xiao-Fang Chen, Zhi-Jie Lin, Chang-Xi Wang, Kai-Yang Lin, Yan-Song Guo

“…After adjusting for potential confounders, multivariate analysis showed that the high SIRI group (SIRI > 1.39) was a strong independent predictor of CA-AKI in patients undergoing elective PCI compared with the low SIRI group (SIRI ≤ 1.39) (odds ratio = 1.642, 95% CI: 1.274–2.116, p < 0.001). Additionally, COX regression analysis showed that SIRI > 1.39 was significantly associated with long-term mortality at a median follow-up of 2.8 years. …”
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The systemic oxidative stress index predicts clinical outcomes of esophageal squamous cell carcinoma receiving neoadjuvant immunochemotherapy by Jifeng Feng, Jifeng Feng, Liang Wang, Xun Yang, Qixun Chen, Qixun Chen

“…Independent variable determination was executed using a cox regression analysis. For prognostic prediction, a risk categorization method based on recursive partitioning analysis (RPA) was also created.ResultsFour SOS-related indicators, including albumin, creatinine, blood urea nitrogen, and direct bilirubin, were used to establish the SOSI. …”
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The interaction between genetic predicted gut microbiome abundance and particulate matter on the risk of incident asthma in adults by Hehua Zhang, Yong Feng, Honghao Yang, Yuqian Li, Zheng Ma, Liuxin Li, Liangkai Chen, Yuhong Zhao, Lishen Shan, Yang Xia

“…Incident asthma was identified by linking with medical encounters or first occurrence source. Cox proportional hazards regression models were used to evaluate the associations. …”
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SLC1A5 is a key regulator of glutamine metabolism and a prognostic marker for aggressive luminal breast cancer by Lutfi H. Alfarsi, Rokaya El Ansari, Busra Erkan, Ali Fakroun, Madeleine L. Craze, Mohammed A. Aleskandarany, Kiu Wai Cheng, Ian O. Ellis, Emad A. Rakha, Andrew R. Green

“…Statistical analysis was performed using chi-squared tests, ANOVA, Spearman’s correlation, Kaplan–Meier analysis, and Cox regression. SLC1A5 mRNA and SLC1A5 protein expression were strongly correlated in luminal B, HER2 + and triple-negative BC (TNBC). …”
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Postoperative blood glucose increase can predict all-cause mortality within 3 months after successful interventional recanalization in patients with acute large vessel occlusion ce... by Wensheng Zhang, Yajie Liu, Hongxing Zhou, Jie Li, Weifang Xing, Kaifeng Li, Yudi Li, Xiongjun He, Li Ling, Jinzhao He

“…A retrospective analysis was conducted on the clinical data of patients with acute cerebral infarction due to anterior circulation large vessel occlusion in two centers from January 2019 to November 2023, who successfully underwent interventional recanalization. A multivariable Cox regression was performed to determine independent factors of all-cause mortality after successfully interventional recanalization. …”
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