An Independent Prognostic Model Based on Ten Autophagy-Related Long Noncoding RNAs in Pancreatic Cancer Patients by Jiahui Tian, Chunyan Fu, Xuan Zeng, Xiaoxiao Fan, Yi Wu

“…The prognostic model, generated through univariate and multivariate Cox regression analyses, included 10 autophagy-related lncRNAs. …”
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The Peroxisome Proliferator-Activated Receptor Gamma System Regulates Ultraviolet B-Induced Prostaglandin E2 Production in Human Epidermal Keratinocytes by Raymond L. Konger, Kellie Clay Martel, Danielle Jernigan, Qiwei Zhang, Jeffrey B. Travers

“…UVB is also a potent inducer of prostaglandin E2  (PGE2) production and COX-2 expression in keratinocytes and PPARγ is coupled to increased PGE2 production in other cell lines. …”
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The Mechanisms of Action of Interleukin-1 on Rabbit Intestinal Epithelial Cells by Fadia R. Homaidan, Liming Zhao, Iman Chakroun, Carla A. Martin, Robert Burakoff

“…IL-1 caused concentrationand time-dependent increases in the levels of PLA2 activity, and/or in the levels of PLAP, COX-2 and PGE2. The IL-induced increase in PGE2 levels was biphasic, with the first peak due to the increase in PLAP levels, and the second peak due to the increase in COX-2 levels. …”
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İngilis Toyları ilə Bağlı İnanclar by Vefa İbrahim

“…Mərasimlər qədim dövrlərdə daha çox dini-magik funksiya daşıyırdısa, sonrakı dövrlərdə onların əksəriyyəti öz funksiyasını itirərək sadəcə əyləncə və ya oyun kimi qeyd olunur. …”
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Regulator of Calcineurin 1 in Periodontal Disease by Ulrike Peters, Eleni Solominidou, Yüksel Korkmaz, Stefan Rüttermann, Astrid Klocke, Thomas Frank Flemmig, Thomas Beikler

“…Expression analysis of rcan1 and cox2 was done by real time PCR using specific primers for rcan1.4 and cox2. …”
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Selective mPGES-1 Inhibitor Ameliorated Adjuvant-Induced Arthritis in the Rat Model by Min Ji Kim, Hwi-Ho Lee, Choi Kim, Ja Yeon Lee, Kyung-Sook Chung, Kyung-Tae Lee, Jae Yeol Lee

“…As our continuous research for the discovery of novel mPGES-1 inhibitors, we have characterized MPO-0144 as a selective mPGES-1 inhibitor with a selectivity index of >270 over COX-1 and >25 over COX-2, respectively. Herein, we evaluated the anti-inflammatory effect of MPO-0144 in an adjuvant-induced arthritis rat model. …”
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Canine Mammary Tumors as a Potential Model for Human Breast Cancer in Comparative Oncology by Amirhossein Razavirad, Sanaz Rismanchi, Pejman Mortazavi, Ahad Muhammadnejad

“…Moreover, univariate and multivariable Cox proportional hazard analyses were applied to estimate hazard ratios (HRs). …”
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To construct and validate a risk score model of angiogenesis-related genes to predict the prognosis of hepatocellular carcinoma by Duangui Gao, Yuan Lu, Tianpeng Jiang, Qinghong Duan, Zhi Huang

“…We established a prognostic risk assessment model based on 13 significant genes associated with HCC prognosis by Cox analysis and LASSO-Cox regression analysis. …”
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Exploration of analgesic and anthelmintic activities of Artocarpus chaplasha ROXB. leaves supported by in silico molecular docking by S M Sohag, Sharmin Nur Toma, Md. Niaj Morshed, Md. Al Imran Imon, Md. Monirul Islam, Md. Ibnul Piash, Naznin Shahria, Imran Mahmud

“…ADMET properties and molecular docking analysis were performed using the identified compounds and analgesic targets COX-1 and COX-2 and the anthelmintic target tubulin-colchicine. …”
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Multipotent Effect of Clozapine on Lipopolysaccharide-Induced Acetylcholinesterase, Cyclooxygenase-2,5-Lipoxygenase, and Caspase-3: In Vivo and Molecular Modeling Studies by Minhajul Arfeen, Devendra Kumar Dhaked, Vasudevan Mani

“…The results demonstrated modulation of COX-2, 5-LOX, AChE, Caspase-3, and MDA in LPS-induced brains. …”
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Self-reported reproductive morbidity and healthcare-seeking practices of adolescent girls in migrant Rohingya community in Bangladesh by Rejoana Karim, Rupam Mitra, Md. Hafizul Islam, S.M. Symon Bappy, Khaleda Islam, Md. Mohsin Hossain

“…A total of 406 Rohingya adolescent girls in Ukhiya, Cox's Bazar, Bangladesh, were interviewed to collect relevant information. …”
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髓核源性坐骨神经痛大鼠背根神经节磷酸化 p38MAPK表达的变化

“…【目的】 观察髓核源性坐骨神经痛大鼠模型中背根神经节磷酸化p38丝裂原活化蛋白激酶(p-p38MAPK)表达的变化及其与炎性反应和机械痛敏的关系,以探讨腰椎间盘突出症的病理机制65377; 【方法】 选择成年SD雄性大鼠66只随机分为空白组(12只)65380;假手术组(18只)和模型组(36只)65377;模型组在左腰5神经背根神经节(L5DRG)自体髓核移植以建立大鼠非压迫性腰椎间盘突出模型,假手术组自体肌肉移植65377;空白组不进行手术65377;测量各组大鼠术前至术后21 d的左后肢50%机械性撤足阈值(50%PWT)以测定机械痛敏的变化,空白组65380;假手术组术后7 d及模型组术后765380;1465380;21 d各12只大鼠取左腰5DRG用免疫组化法测定环氧化酶-2(COX-2)与p-p38MAPK的阳性细胞比率65377; 【结果】 假手术组50%PWT术后无明显变化,模型组术后7 d出现明显的50%PWT下降损伤,术后14 d达最低值,术后21 d部分恢复;空白组65380;假手术组术后7 d DRG 的 COX-2和p-p38MAPK微弱表达,模型组术后7 d DRG的COX-2和p-p38MAPK高表达,模型组术后14 d DRG的COX-2和p-p38MAPK表达更高,模型组术后21 d DRG的COX-2和p-p38MAPK表达减弱65377;【结论】 背根神经节的p-p38MAPK的表达与非压迫性髓核所致炎性反应和坐骨神经病理性神经痛的变化密切相关65377;…”
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Ge-gen decoction alleviates primary dysmenorrhoea symptoms in a rat model by Yazhen Xie, Haifeng Xu, Zhijuan Gu

“…Additionally, GGD increased β-EP content and inhibited ERK1/2 activation and ERα expression in uterine tissues.Conclusions The results of this study suggest that GGD alleviates PD in rats by suppressing the COX-2-mediated release of PGE2 and PGF2α, modulating the ERα/ERK1/2/COX-2 pathway, and increasing β-EP content. …”
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Crotalus durissus ruruima Snake Venom and a Phospholipase A2 Isolated from This Venom Elicit Macrophages to Form Lipid Droplets and Synthesize Inflammatory Lipid Mediators by Ana Eduarda Zulim de Carvalho, Karina Giannotti, Elbio Leiguez Junior, Márcio Matsubara, Maria Cristina Dos Santos, Consuelo Latorre Fortes-Dias, Catarina Teixeira

“…Neither CdrV nor CBr induced the expression of COX-1 and COX-2 by macrophages. LDs induced by both CdrV and CBr are associated to PLIN2 recruitment and expression and were shown to be dependent on COX-1, but not COX-2 activity. …”
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Diethylcarbamazine Reduces Chronic Inflammation and Fibrosis in Carbon Tetrachloride- (CCl4-) Induced Liver Injury in Mice by Sura Wanessa Santos Rocha, Maria Eduarda Rocha de França, Gabriel Barros Rodrigues, Karla Patrícia Sousa Barbosa, Ana Karolina Santana Nunes, André Filipe Pastor, Anne Gabrielle Vasconcelos Oliveira, Wilma Helena Oliveira, Rayana Leal Almeida Luna, Christina Alves Peixoto

“…Immunohistochemical and immunofluorescence analyses of the DEC-treated group showed reduced COX-2, IL1β, MDA, TGF-β, and αSMA immunopositivity, besides exhibiting decreased IL1β, COX-2, NFκB, IFNγ, and TGFβ expressions in the western blot analysis. …”
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Liposome-Encapsulated Bioactive Guttiferone E Exhibits Anti-Inflammatory Effect in Lipopolysaccharide-Stimulated MH-S Macrophages and Cytotoxicity against Human Cancer Cells by Jean Paul Dzoyem, Shashank Reddy Pinnapireddy, Hugues Fouotsa, Jana Brüßler, Frank Runkel, Udo Bakowsky

“…The fluorometric cyclooxygenase (COX) activity assay kit was used to assess the COX activity while the nitric oxide production was evaluated by the Griess reagent method. …”
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A Novel 8-Gene Prognostic Signature for Survival Prediction of Uveal Melanoma by Zhongjun Tang, Kebo Cai

“…The Least Absolute Shrinkage and Selection Operator (Lasso) Cox regression was used to select candidate genes and build a gene expression signature. …”
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Improvement of the Nonparametric Estimation of Functional Stationary Time Series Using Yeo-Johnson Transformation with Application to Temperature Curves by Sameera Abdulsalam Othman, Haithem Taha Mohammed Ali

“…In this article, Box-Cox and Yeo-Johnson transformation models are applied to two time series datasets of monthly temperature averages to improve the forecast ability. …”
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Synthesis and biological evaluation of new tri-heterocyclic derivatives as anti-colorectal cancer agents by Benjamin Victoir, Océane Pertegaz, Elfi Ducrocq, Marion Polomski, Maxime Guéguinou, William Raoul, Cécile Croix, Gildas Prié

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Therapy with Interleukin-22 Alleviates Hepatic Injury and Hemostasis Dysregulation in Rat Model of Acute Liver Failure by Tariq Helal Ashour

“…Furthermore, IL-22 treatment decreased the hepatic contents of TNF-α and COX-2. The histopathological findings also supported the hepatoprotective effect of IL-22. …”
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