Inequalities in children’s tooth decay requiring dental extraction under general anaesthetic: a longitudinal study using linked electronic health records by Carol Dezateux, Nicola Firman, Vanessa Muirhead

“…We linked 120 985 EHRs to school weight records and estimated HRs (95% CI) for DGA by excess weight (body mass index ≥91st centile) using Cox’s proportional regression.Results 3034 children had at least one DGA (0.50%; 95% CI 0.48 to 0.52). …”
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Impact of multimorbidity and complex multimorbidity on mortality among older Australians aged 45 years and over: a large population-based record linkage study by Alamgir Kabir, An Tran, Sameera Ansari, Damian P Conway, Margo Barr

“…Eleven self-reported chronic conditions (cancer, heart disease, diabetes, stroke, Parkinson’s disease, depression/anxiety, asthma, allergic rhinitis, hypertension, thrombosis and musculoskeletal conditions) from the baseline survey were included in the MM and CMM classifications. Cox proportional hazard models were used to estimate adjusted and unadjusted 8-year mortality hazard ratios (HRs).Results Of 251 689 people (53% female and 54% aged ≥60 years) in the cohort, 111 084 (44.1%) were classified as having MM and 39 478 (15.7%) as having CMM. …”
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Longitudinal changes in remnant cholesterol and the risk of cardiovascular disease by Yijun Zhang, Qin Xu, Xue Tian, Xue Xia, Shuohua Chen, Fen Liu, Shouling Wu, Anxin Wang

“…The RC long-term change pattern was defined as the RC trajectories from 2006 to 2010. Multivariate Cox proportion models were used to calculate hazard ratios (HRs) and their 95% confidence intervals (CIs). …”
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Development of a prognostic nomogram for ocular melanoma: a SEER population-based study (2000–2021) by Miyun Zheng, Miyun Zheng, Maodong Xu, Maodong Xu, Mengxing You, Mengxing You, Zhiqing Huang, Zhiqing Huang

“…This study develops a prognostic nomogram for OM using machine learning and internal validation techniques, aiming to improve prognosis prediction and clinical decision-making.MethodsIndependent prognostic variables were identified using univariate and multivariate COX proportional hazard regression models. Significant variables were then incorporated into the nomogram. …”
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Determining timeframes to death for imminently dying patients: a retrospective cohort study by Tricia O’Connor, Wai-Man Liu, Juliane Samara, Joanne Lewis, Karen Strickland, Catherine Paterson

“…Method This is a large retrospective cohort study of 2,438 patients, 18 years and over, cared for as hospice inpatients or by community palliative care services, died between January 2017 and December 2021, and who collectively had 49,842 AKPS data points. An Interval-Censored Cox Proportional Hazards regression model was used. …”
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The Relationship between Red Blood Cell Distribution Width and Incident Diabetes in Chinese Adults: A Cohort Study by Jialu Wang, Yanan Zhang, Yanping Wan, Zhuping Fan, Renying Xu

“…Diabetes was diagnosed if either FBG≥7.0 mmol/L or HbA1c≥6.5%. We used the Cox proportional hazards regression model to evaluate the association between baseline RDW and incident diabetes. …”
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Incidence and predictors of mortality among HIV positive children on anti-retroviral therapy in the selected health facilities of West Wollega Zone, Western Ethiopia: Retrospective... by Gelane Gurmu, Emiru Merdassa, Gemechu Tiruneh, Keneni Efrem, Firezer Belay, Lalisa Mekonnen, Jira Wakoya Feyisa, Matiyos Lema, Adisu Tafari Shama, Markos Desalegn

“…A Kaplan-Meir survival curve and Long Rank test were used to estimate survival probability and assess statistical differences. The Cox regression model was used to determine independent predictors of mortality.…”
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Prognostic implications of system inflammation response index in atrial fibrillation patients with type 2 diabetes mellitus by Yang Chen, Bin Zhou, Chaoquan Peng, Yong Liu, Weiyan Lai

“…A cohort of 2054 AF and T2DM patients participated. COX regression analysis revealed elevated SIRI levels as an independent risk factor for both in-hospital and 1-year mortality. 192 patients died during hospitalization, and 265 died during the follow-up of 1 year. …”
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Identification of a Ferroptosis-Related Signature Associated with Prognosis and Immune Infiltration in Adrenocortical Carcinoma by Xi Chen, Lijun Yan, Feng Jiang, Yu Lu, Ni Zeng, Shufang Yang, Xianghua Ma

“…Genes included in ferroptosis risk signature were assessed by univariable and multivariable Cox regression analysis as well as lasso regression analysis. …”
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Mediation of the effect of prenatal maternal smoking on time to natural menopause in daughters by birthweight-for-gestational-age z-score and breastfeeding duration: analysis of tw... by Darina Peycheva, Leah Li, Mary Fewtrell, Richard Silverwood, Rebecca Hardy

“…Methods Using pooled data from two prospective birth cohort studies – the 1970 British Cohort Study (n = 3,878) followed-up to age 46 years and the 1958 National Child Development Study (n = 4,822) followed-up to age 50 years – we perform mediation analysis with inverse odds weighting implemented in Cox proportional-hazards models. Results Prenatal maternal smoking was associated with lower birthweight z-scores [β: -0.29; 95% CI -0.34, -0.24] and reduced breastfeeding duration [RRR< 1month: 0.90; 95% CI 0.79, 1.02; RRR≥ 1 month: 0.66; 95% CI 0.59, 0.73 relative to women who were never breastfed]. …”
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Acute Kidney Injury, Mild Cognitive Impairment, and Dementia: A Cohort Study of Patients from SPRINT by Kristen L. Nowak, Anna Ostrow, Ester S. Oh, Zhiying You, Michel Chonchol

“…Outcomes: Incident mild cognitive impairment (MCI), probable dementia, and their composite. Analytical Approach: Cox proportional hazard models. Results: Participants were 68 ± 9 years, 65% male, 28% with prevalent chronic kidney disease), with a median (interquartile range) follow-up time for the composite of 4.0 (2.1-5.4) and 4.6 (3.6-5.9) years in the AKI and non-AKI groups, respectively. …”
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Early, Noninvasive Clinical Indicators of Kidney Prognosis in Primary Nephrotic Syndrome: A Retrospective Exploratory Study by Keiji Fujimoto, Takatoshi Haraguchi, Sho Kumano, Keita Yamazaki, Nobuhiko Miyatake, Kanae Nomura, Kiyotaka Mukai, Kazuaki Okino, Norifumi Hayashi, Hiroki Adachi, Hitoshi Yokoyama, Yasuo Iida, Kengo Furuichi

“…This retrospective exploratory study aimed to identify early clinical indicators of kidney prognosis in primary nephrotic syndrome (NS). Univariate Cox proportional hazards regression analysis identified clinical parameters in the 2-month period after initiating immunosuppressive therapy (IST); it predicted 40% reduction in the estimated glomerular filtration rate (eGFR) in 36 patients with primary NS. …”
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The link between smoking, emphysema, and fibrosis: A retrospective cohort study by Liying Zhai, Haihong Gong, Wencheng Yu

“…Kaplan-Meier survival analysis with log-rank testing and multivariable Cox proportional hazards regression analysis were used to compare all-cause mortality. …”
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Within-hospital Temporal Clustering of Postoperative Complications and Implications for Safety Monitoring and Benchmarking Using ACS-NSQIP Data by Mark E. Cohen, PhD, Yaoming Liu, PhD, Clifford Y. Ko, MD, MS, MSHS, FACS, Bruce L. Hall, MD, PhD, MBA, FACS

“…ACS-NSQIP data from 1,547,440 patients, in 425 hospitals, over a 2-year period was examined. Hospital-specific Cox proportional hazards regression was used to estimate the incidence of mortality, morbidity, and surgical site infection (SSI) over a 30-day postoperative period, with risk adjustment for patient and procedure and with additional adjustments for linear trend, day-of-week, and season. …”
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Time to neonatal mortality and its predictors among preterm neonates admitted to the neonatal intensive care unit in northern Ethiopia, 2023/2024: a retrospective cohort study by Brhanu Fisseha, Eskedar Berhanie Gidey, Berhe Gebrehiwot Tewele, Teklehaimanot Gereziher Haile

“…Kaplan-Meier analysis, life table, and log rank were computed. Cox proportional hazards models were fitted to identify independent predictors of preterm mortality. …”
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Prognosis and cardiotoxicity associated to adjuvant trastuzumab for breast cancer: real world study in a public health system by Ana Elisa Ribeiro da Silva Cabello, César Cabello, Susana Oliveira Botelho Ramalho, Otávio Rizzi Coelho, Otávio Rizzi Coelho-Filho, Helymar da Costa Machado, Délio Marques Conde, Luiz Carlos Zeferino

“…The Kaplan-Meier method, the log-rank test, and the Cox proportional hazards model were used. Results: In all, 15.3% (39/255) of patients presented with cardiotoxicity. …”
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Long-term prognostic impact of glucagon-like peptide-1 receptor agonist before ST-segment elevation myocardial infarction in patients with type 2 diabetes: a nationwide cohort stud... by Jasmine Melissa Madsen, Alexander Krüger Kjaer, Jacob Thomsen Lønborg, Lars Køber, Charlotte Glinge, Reza Jabbari, Thomas Engstrøm

“…During 8.4 years, 36% patients treated with GLP-1RA died whereas 52% died in the no GLP-1RA group (p = 0.002). In adjusted Cox analysis, GLP-1RA was associated with lower long-term mortality (hazard ratio (HR) 0.60, 95% confidence interval (CI) 0.43–0.84). …”
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Insulin secretion, sensitivity, and clearance in normoglycemic Black and White adults with parental type 2 diabetes: association with incident dysglycemia by Samuel Dagogo-Jack, Jim Wan, Chimaroke Edeoga, Peace Asuzu

“…During 5.5 years of follow-up, 91 of 268 participants developed incident dysglycemia and 177 maintained normoglycemia. In Cox proportional hazards models, insulin secretion (HR 0.997 (95% CI 0.996 to 0.999), p=0.005), insulin sensitivity (HR 0.948 (95% CI 0.913 to 0.984), p=0.005), DI (HR 0.945 (95% CI 0.909 to 0.983), p=0.005) and basal insulin clearance (HR 1.030 (95% CI 1.005 to 1.056), p=0.018) significantly predicted incident dysglycemia.Conclusions Insulin sensitivity, secretion, and clearance differ significantly in normoglycemic African American versus European American offspring of parents with type 2 diabetes and are associated with the risk of incident dysglycemia.…”
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The Combination of D-TACE-HAIC, Lenvatinib, and PD-1 Inhibitors Shows Significant Clinical Efficacy in Patients with Unresectable Hepatocellular Carcinoma by Wu Y, Zhu J, Zhang H, Xia N

“…The median progression-free and overall survival (PFS and OS) of patients in Group A were 13.2 and 28.8 months, with both being significantly higher than the corresponding intervals in Group B (5.7 and 10.8 months, respectively). Cox multivariate analyses identified combination D-TACE-HAIC + lenvatinib+ PD-1 inhibitor treatment as being independently associated with patient PFS and OS.Conclusion: In summary, D-TACE-HAIC + lenvatinib + PD-1 inhibitor treatment exhibits a favorable safety profile, outperforming TACE + sorafenib treatment for unresectable HCC patients while improving overall rates of translational efficacy, increasing rates of surgical conversion, prolonging patient survival, and conferring long-term survival benefits.Keywords: unresectable hepatocellular carcinomas, drug-eluting beads-transarterial chemoembolization-hepatic arterial infusion chemotherapy, clinical efficacy, prognosis…”
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Moderate-severe aortic arch calcification and high serum alkaline phosphatase co-modify the risk of cardiovascular events and mortality among chronic hemodialysis patients by Cheng-Hao Chang, Hung-Hsiang Liou, Chung-Kuan Wu

“…Patients were categorized into four groups: non-to-mild AoAC/low Alk-P, non-to-mild AoAC/high Alk-P, moderate-to-severe AoAC/low Alk-P, and moderate-to-severe AoAC/high Alk-P. The Cox proportional hazard model and Kaplan–Meier analysis were used to evaluate the risks of major adverse cardiovascular effects (MACEs) and cardiovascular and all-cause mortality after multivariate adjustment.Results Among 376 chronic HD patients recruited, 125 (33%) had non-to-mild AoAC/low Alk-P, 76 (20%) had non-to-mild AoAC/high Alk-P, 89 (24%) had moderate-to-severe AoAC/low Alk-P, and 86 (23%) had moderate-to-severe AoAC/high Alk-P. …”
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