Angiotensin Inhibition Reduces the Risk of Subarachnoid Hemorrhage in Patients With Hypertension by Mohammad Hossein Abbasi, Colleen M. Brensinger, Emily K. Acton, Christopher G. Favilla, Jan‐Karl Burkhardt, Scott E. Kasner

“…The primary outcome was the subsequent development of nontraumatic SAH. Cox proportional hazard regression models were used to compare the time to SAH by type of antihypertensive treatment. …”
Get full text

First report of non-marine ostracods (Crustacea, Ostracoda) from the Dahlak Archipelago (Eritrea), with the description of two new species by Giampaolo Rossetti, Ilaria Mazzini, Giorgio Chiozzi, Luca Vecchioni, Federico Marrone

“…A detailed description of the morphology of valves and soft parts is given, and COX1 sequences were obtained for four species. Cypris galefensis was so far only known for its type locality in Somalia with a population containing both males and females, whereas our samples consisted exclusively of females. …”
Get full text

Prehospital care for ovarian cancer in Catalonia: could we do better in primary care? Retrospective cohort study by Mercè Marzo-Castillejo, Josep M Borras, Carmen Vela-Vallespín, Paula Manchon‐Walsh, Luisa Aliste

“…Diagnostic process intervals were based on the Aarhus statement. 1-year and 5-year survival analysis was undertaken.Results Of the 513 patients included in the cohort, 67.2% initially consulted their family physician, while 36.4% were diagnosed through emergency services. In the Cox models, survival was influenced by advanced stage at 1 year (HR 3.84, 95% CI 1.23 to 12.02) and 5 years (HR 5.36, 95% CI 3.07 to 9.36), as was the type of treatment received, although this association was attenuated over follow-up. …”
Get full text

Short- and long-term survival after ST-elevation myocardial infarction treated with pharmacoinvasive versus primary percutaneous coronary intervention strategy: a prospective cohor... by Sigrun Halvorsen, Jon Michael Gran, Kristin Kvakkestad

“…Adjusted effect of PI versus pPCI strategy on survival was estimated using logistic and Cox regression and propensity score weighting.Setting Single-centre registry in Norway during 2005–2011, within a regional STEMI network allocating patients to a PI strategy if estimated time to PCI >120 min.Primary outcomes 30-day mortality and survival during follow-up.Secondary outcome Incidence of CV death during follow-up.Results 4061 STEMI patients <80 years were included, 527 (13%) treated with a PI strategy and 3534 (87%) with a pPCI strategy. …”
Get full text

Green space is associated with new-onset stroke among Chinese middle-aged and older adults: data from China Health and Retirement Longitudinal Study (CHARLS) by Qiong Lu, Qiong Lu, Cheng Lian, Xinglin Chen, Xinglin Chen

“…Baseline data were collected in 2011 and new-onset stroke data were gathered during follow-up in 2013, 2015, 2018, and 2020. Multivariate Cox regression models were constructed to investigate the association between green space and stroke risk. …”
Get full text

The protective role of SGLT2 inhibitors on aortic aneurysm mediated by oxidative stress and inflammation in type 2 diabetes mellitus by Rujie Zheng, Wenjuan Song, Jie Lu, Mingyue Yuan, Xiaotong Sun, Chengzhi Lu

“…Methods We extracted and analyzed the data of 4964 patients with T2DM from the First Affiliated Hospital of Zhengzhou University during July 2017 to January 2023. Multivariate Cox models, interaction analysis and Kaplan–Meier curves were performed to approximate the associations of SGLT2i therapy on the risk of AA. …”
Get full text

Identification of Hepatocellular Carcinoma Subtypes Based on Global Gene Expression Profiling to Predict the Prognosis and Potential Therapeutic Drugs by Cunzhen Zhang, Jiyao Wang, Lin Jia, Qiang Wen, Na Gao, Hailing Qiao

“…Survival-related genes were identified using Cox regression, and their expression and function were validated via qPCR and gene interference. …”
Get full text

Age-dependent differences in the association between blood interleukin-6 levels and mortality in patients with sepsis: a retrospective observational study by Takashi Shimazui, Takehiko Oami, Tadanaga Shimada, Keisuke Tomita, Taka-aki Nakada

“…In the non-elderly group, univariate Cox regression analysis showed a significant association between IL-6 levels and mortality (hazard ratio [HR] 1.71, 95% confidence interval [CI] 1.25–2.37, P < 0.001). …”
Get full text

Trends in motives for trying to stop smoking: a population study in England, 2018–2023 by Sarah E Jackson, Jamie Brown, Sharon Cox, Vera Buss

Get full text

Daily iron supplementation does not impact on prevalence of exclusive breastfeeding or growth in young breastfed Gambian infants by Sophie Moore, Carla Cerami, Isabella Stelle, Mamadou Bah, Hans Verhoef

“…There was no evidence that iron supplementation reduced the time to cessation of exclusive breastfeeding (median: 70 days (range: 7–105 days), iron: 67 days; placebo 71 days; Kaplan-Meier, log-rank test: p=0.15; Cox regression, crude HR: 1.42, 95% CI: 0.86 to 2.34, p=0.17; HR adjusting for infant age and sex: 1.40, 95% CI: 0.85 to 2.31, p=0.19) or age at cessation of exclusive breastfeeding (median time: 18 weeks (range:1–24 weeks), iron: 16 weeks; placebo 18 weeks; Kaplan-Meier, log-rank test: p=0.13; crude HR=1.47, 95% CI: 0.89, 2.43; p=0.13; HR adjusting for infant age and sex=1.44, 95% CI: 0.87, 2.39 p=0.16) There was no evidence that iron supplementation affected infant weight (p=0.79) or length (p=0.64) at endline or change in z-scores during the intervention period for weight-for-age (p=0.99), length-for-age (p=0.70) and weight-for-length (p=0.89). …”
Get full text

Surgical Outcomes Following Neoadjuvant Treatment for Locally Advanced and Borderline Resectable Pancreatic Ductal Adenocarcinoma by Kai Tai Derek Yeung, PhD, FRCS, Sacheen Kumar, PhD, FRCS, David Cunningham, MD, FRCP, FMedSci, OBE, Long R. Jiao, MD, FRCS, Ricky Harminder Bhogal, PhD, FRCS

“…Similarly, 9 versus 18 versus 42 versus 41 months for N1 chemo, N1 chemo and CRT, N0 chemo and N0 chemo, and CRT groups, respectively, P = 0.0026. Multivariable Cox regression model demonstrated that perineural invasion (hazard ratio: 2.88, 95% confidence interval: 1.06–7.81; P = 0.038) and perivascular invasion (PVI) (HR: 2.76, 95% CI: 1.24–6.13; P = 0.013) were associated with significantly worse OS. …”
Get full text

术前CA 15-3和CEA水平在接受托瑞米芬治疗的管腔型可手术乳腺癌患者中的预后价值 by 夏雯

“…使用卡方检验或Fisher检验进行分类变量的比较，使用Kaplan-Meier曲线描述无病生存期（DFS）和总生存期（OS），同时应用log-rank检验比较差异，并使用单因素及多因素Cox回归分析和分层分析法来寻找和DFS及OS相关的预后指标。【结果】在这368例患者中，分别有29和47例患者术前检查发现CEA和CA15-3的升高。…”
Get full text

Simple hypertrophic tonsils have more active innate immune and inflammatory responses than hypertrophic tonsils with recurrent inflammation in children by Qun Huang, Hu Hua, Wei Li, Xi Chen, Lei Cheng

“…Consistent with the innate immune profile, the expression of inflammatory markers (IL-1β, NF-κB and IL-7) was also significantly elevated in TH group. Meanwhile, the COX-2/PGE2/EP4 signaling pathway was found to be involved in the inflammatory response and the formation of fibroblasts. …”
Get full text

Inflammation and Immune Escape in Ovarian Cancer: Pathways and Therapeutic Opportunities by Liu C, Yin Q, Wu Z, Li W, Huang J, Chen B, Yang Y, Zheng X, Zeng L, Wang J

“…Targeting these inflammatory and immune evasion mechanisms offers promising therapeutic strategies. COX-2 inhibitors, Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway blockers, and NF-kB inhibitors have shown potential in preclinical studies, while immune checkpoint inhibitors targeting PD-1/PD-L1 and CTLA-4 have been explored with mixed results in OC. …”
Get full text

Capecitabine enhances sensitivity to oxaliplatin in advanced gastric cancer and the effects on patients’ FOXP1 and GGT levels by Xinyu Guo, Yi Liu

“…The prognostic factors were analyzed by the COX regression model. The Kaplan–Meier survival curve was used to analyze the survival of gastric cancer. …”
Get full text

Survival Status and Predictors of Mortality among Newborns Admitted with Neonatal Sepsis at Public Hospitals in Ethiopia by Samuel Dessu, Aklilu Habte, Tamirat Melis, Mesfin Gebremedhin

“…Variables which had p value < 0.05 in multivariable analysis using the cox proportional hazard model were declared as statistically significant predictors of mortality. …”
Get full text

Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy by Cui-qin Huang, Wen-tao Xiao, Xiang-rong Yao, Zhi-min Li, Jun-yan He

“…Additionally, multivariate Cox regression analysis identified POSTN as an independent prognostic factor for CC patients undergoing radical radiotherapy. …”
Get full text

Association between systemic immune-inflammation index and the risk of all-cause, cancer and non-cancer mortality in the general population: results from national health and nutrit... by Siyu Wu, Zhao Liu, Xing Li, Shan Gao, Peng Xia

“…Methods 25,955 participants (≥ 20 years) were included from 2005 to 2018 National Health and Nutrition Examination Survey (NHANES) and were divided into four groups according to the SII quartiles. Weighted multivariate Cox regression was used to assess the correlation between SII and mortality. …”
Get full text

Association between phase angle and all-cause mortality in adults aged 18–49 years: NHANES 1999–2004 by Xian-xin Xia, Chuan-xiang Li, Xin-xin Xue, Ya-jun Chen, Fang He, Hong-rong Guo

“…Kaplan-Meier (KM) curve, multiple Cox regression and stratified analyses were performed. …”
Get full text

Health and economic impact of oral PrEP provision across subgroups in western Kenya: a modelling analysis by Linxuan Wu, Sarah Cox, Monisha Sharma, Brian Pfau, Rachel Wittenauer

Get full text