Association between body mass index and chronic obstructive pulmonary disease in young individuals: a nationwide population‑based cohort study by Chiwook Chung, Hajeong Kim, Kyu Na Lee, Dong Wook Shin, Sei Won Lee, Kyungdo Han

“…We performed multivariate Cox proportional hazards models to estimate the adjusted hazard ratio (aHR) of risk factors for COPD development. …”
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Association between neutrophil-to-eosinophil ratio and efficacy outcomes with avelumab plus axitinib or sunitinib in patients with advanced renal cell carcinoma: post hoc analyses... by Brian Rini, Mariangela Mariani, Alessandra di Pietro, Paul Nathan, Christian Kollmannsberger, Marc-Oliver Grimm, Martin H Voss, Bradley A McGregor, Mehmet A Bilen, Yoshihiko Tomita, Bo Huang, Robert Amezquita, Matthew Tucker, Yu-Wei Chen

“…Objective We report post hoc analyses of efficacy with first-line avelumab plus axitinib or sunitinib according to baseline neutrophil-to-eosinophil ratio (NER) in patients with advanced renal cell carcinoma (aRCC) from the JAVELIN Renal 101 phase 3 trial.Methods and analysis Progression-free survival (PFS), overall survival (OS) and objective response per baseline NER were analysed in the overall population and in patients with programmed death ligand 1 (PD-L1+) tumours. Multivariable Cox regression analyses to assess the effect of NER after adjustment for other baseline variables were conducted.Results In NER <median versus ≥median subgroups of the avelumab plus axitinib arm, HRs for PFS and OS were 0.81 (95% CI 0.630 to 1.035) and 0.67 (95% CI 0.481 to 0.940), and objective response rates (ORRs) were 63.9% vs 55.2%, respectively. …”
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The combined impact of BMI and ABSI on all-cause mortality among American adults with diabetes by Shuwu Wei, Weimin Jiang, Huijuan Zheng, Jiale Zhang, Jie Yang, Yaoxian Wang, Yang Liu, Liqiao Sun, Xinrong Li, Junping Wei, Weiwei Sun

“…Methods A nationally representative cohort study was conducted using NHANES data (2005–2018), including 6,572 diabetic adults. Weighted Cox proportional hazards models and restricted cubic splines were applied to evaluate the independent and combined associations of anthropometric indices (BMI, ABSI, WHtR, BRI, and Conicity Index) with all-cause mortality. …”
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Effect of antiretroviral therapy on the mortality of HIV-1 infection long-term non-progressors: a cohort study by Jinming Su, Jie Liu, Fengxiang Qin, Rongfeng Chen, Tongxue Qin, Xing Tao, Xiu Chen, Wen Hong, Bingyu Liang, Ping Cui, Li Ye, Junjun Jiang, Hao Liang

“…Multivariate logistic, Cox regression, and Kaplan-Meier method were employed to scrutinize associated factors and mortality risk of LTNP. …”
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Comparative Study on Associations Between Lung Cancer Prognosis and Diagnostic Criteria Set by the European Palliative Care Research Collaboration and the Asian Working Group for C... by Utae Katsushima, Takuya Fukushima, Jiro Nakano, Naoya Ogushi, Kazuki Fujii, Yutaro Nagata, Keisuke Kamisako, Yukiko Okuno, Yuta Okazaki, Kentaro Nakanishi, Kiyori Yoshida, Tatsuki Ikoma, Yuki Takeyasu, Yuta Yamanaka, Hiroshige Yoshioka, Kimitaka Hase, Takayasu Kurata

“…The association between cachexia diagnosis and prognosis was examined for each set of criteria using a Cox proportional hazards model. C‐statistic analysis was performed to compare the discriminative power for prognosis. …”
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Association between the prognosis and comorbidity of active cancer in chronic thromboembolic pulmonary hypertension by Hiroyuki Fujii, Yu Taniguchi, Yuichi Tamura, Miki Sakamoto, Sachiyo Yoneda, Kenichi Yanaka, Noriaki Emoto, Ken-ichi Hirata, Hiromasa Otake

“…In the active cancer group, the 5-year survival rate was also lower than that in the non-active cancer and non-cancer groups (52.0% vs. 99.5%, p < 0.001 and 52.0% vs. 92.3%, p < 0.001, respectively). Multivariate Cox hazard analysis revealed that hemodialysis (p < 0.001) and cancer (p < 0.001) were independently associated with poor survival. …”
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Associations between mental illness, TB risk and migrant status by S.E. Hayward, K.L. Kristensen, A. Deal, J.H. Petersen, T. Lillebaek, S. Hargreaves, M. Norredam, J.S. Friedland

“…METHODS: A nationwide prospective cohort study was conducted in Denmark from 1994–2015, involving migrants matched 1:6 to Danish-born individuals. Cox regression models, adjusted for age, sex and migrant status, were used to assess the effect of mental disorders on TB risk. …”
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Elevated resting heart rate in adolescent men and risk of heart failure and cardiomyopathy by Martin Lindgren, Josefina Robertson, Martin Adiels, Maria Schaufelberger, Maria Åberg, Kjell Torén, Margda Waern, N. David Åberg, Annika Rosengren

“…Risk estimates were calculated by Cox‐proportional hazards models while adjusting for potential confounders. …”
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A combination of clinical, electrocardiographic, and echocardiographic parameters predicts pulmonary hypertension occurrence in patients with end-stage renal disease by Handong Ding, Handong Ding, Handong Ding, Fei Zhang, Fei Zhang, Fei Zhang, Jinbiao Zhong, Jinbiao Zhong, Jinbiao Zhong, Jiashan Pan, Jiashan Pan, Jiashan Pan, Yiding Chen, Yiding Chen, Yiding Chen, Ji Zhang, Ji Zhang, Ji Zhang, Qin Wang, Guiyi Liao, Guiyi Liao, Guiyi Liao, Zongyao Hao, Zongyao Hao, Zongyao Hao

“…Results of multivariate Cox analysis showed that LAD &gt;3.785 cm, IVSd &gt;1.165 cm, SV &gt;79.5 ml, QTc &gt;438.5 ms, and pericardial effusion were independent predictors of PH in patients with ESRD. …”
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Association between beta‐blocker atenolol use and prostate cancer upgrading in active surveillance1 by Ali H. Zahalka, Ethan Fram, Evan Garden, Lauren Howard, Emily Wiggins, Mustufa Babar, Jay Annam, Allison Reagan, Benjamin Eilender, Amanda deHoedt, Stephen J. Freedland, Ash Tewari, Kara L. Watts

“…Exposure was duration of atenolol use, and outcome was pathologic grade group upgrading (to GG ≥ 3) on final prostate biopsy. Cox proportional hazard regression models were used to determine the associations between atenolol use and risk of upgrading with time, on a per‐examination basis. …”
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Impact of duration of treatments with metformin and sulfonylureas, individually or in combination, on diabetic retinopathy among newly diagnosed type 2 diabetic patients: a pooled... by Mansour Bahardoust, Yadollah Mehrabi, Farzad Hadaegh, Davood Khalili, Ali Delpisheh

“…The cumulative exposure to metformin, SUs, aspirin, statin, and anti-hypertensive medication was also determined using the same approach. The Cox proportional hazards (CPH) model was used to calculate the hazard ratio (HR) (95% CI) for the outcomes while adjusting for confounding factors such as fasting Blood Sugar (FBS), age, statin, aspirin, and anti-hypertensive medications. …”
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Synovial sarcoma. Evaluation of Prognosis with Emphasis on the Study of DNA Ploidy and Proliferation (PCNA and Ki-67) Markers by José M. Lopes, Einar Hannisdal, Bodil Bjerkehagen, Øyvind S. Bruland, Håvard E. Danielsen, Erik O. Pettersend, Manuel Sobrinho-Simões, Jahn M. Nesland

“…The prognostic value of gender, age, duration of symptoms, location, compartmentalization, size, adequacy of surgical margins, residual tumor, adjuvant therapy, histologic subtype, extent of necrosis, glandular differentiation, calcification, and extent of hemangiopericytic areas, mitotic rate, amount of mast cells, blood vessel invasion, histologic (UICC and NCI) grades, DNA ploidy, percentage of cells in S and S+G2 phases, PCNA and Ki-67 labeling indices (LI), and TNM (UICC) stage of the tumors, were evaluated by univariate and multivariate (Cox hazard model) analyses. Short duration of symptoms (<12 months), biphasic SS, scarcity of mast cells (<10/10 HPF), high mitotic rate (≥10/10 HPF), high histologic grade (grade 3), high PCNA-LI (≥20%), high Ki-67-LI (≥10%), DNA aneuploidy, and advanced TNM stage (stage III) were features associated with significantly shorter relapse-free and overall 5-year survival rates in the univariate analyses. …”
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Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines by Alexandra Razumovskaya, Mariia Silkina, Mariia Silkina, Mariia Silkina, Andrey Poloznikov, Timur Kulagin, Maria Raigorodskaya, Nina Gorban, Anna Kudryavtseva, Maria Fedorova, Boris Alekseev, Alexander Tonevitsky, Alexander Tonevitsky, Alexander Tonevitsky, Sergey Nikulin, Sergey Nikulin, Sergey Nikulin

“…Prognostic performance was evaluated through Kaplan-Meier survival analysis and log-rank tests, while independent prognostic significance was assessed using multivariate Cox proportional hazards modeling.ResultsA small set of genes showed consistent correlation with resistance to chemotherapy across different datasets. …”
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Patterns and predictors of mortality in a semi-urban population-based cohort in Sri Lanka: findings from the Ragama Health Study by Anuradhani Kasturiratne, Dileepa Senajith Ediriweera, Madunil Anuk Niriella, Hithanadura Janaka de Silva, Arunasalam Pathmeswaran, Shamila Thivanshi De Silva, Uthuru Beddage Thulani, Anuradha Supun Dassanayake, Arjuna Priyadarsin De Silva, Sureka Chackrewarthy, Udaya Ranawaka, Norihiro Kato, Ananda Rajitha Wickremasinghe

“…We determined the survival probability of the cohort over 10 years and estimated Hazard ratios (HRs) for all-cause mortality (ACM), cardiovascular mortality (CVM) and cancer-related mortality (CRM) using Cox’s proportional hazards model. We also estimated the survival probabilities for men and women in each 10-year age group and standardised mortality ratio relative to the source population.Results There were 169 deaths over 10 years with standardised mortality rates of 5.3 and 2.4 per 1000 years of follow-up for men and women, respectively. …”
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Risk factors and outcomes in patients who switched from peritoneal dialysis to physician-oriented or patient-oriented kidney replacement therapy by Liu Zhang, Xu Guan, Liang Liu, Yinghui Huang, Jiachuan Xiong, Jinghong Zhao

“…The association of physician-oriented or patient-oriented KRT conversion with outcomes after the conversion was assessed by using Cox proportional hazards models.Results A total of 257 PD patients were included in the study. …”
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Use of disease modifying anti-rheumatic drugs and risk of multiple myeloma in US Veterans with rheumatoid arthritis by Kate Tokareva, Alexander C. Peterson, Aaron Baraff, Sarah P. Chung, Jennifer Barton, Joshua F. Baker, Bryant R. England, Ted R. Mikuls, Nicholas L. Smith, David G. Coffey, Noel S. Weiss, Namrata Singh

“…DMARD exposure was categorized as follows: conventional synthetic (cs)DMARDs; bDMARDs, which included tumor necrosis factor inhibitors (TNFi), non-TNFi; and a tsDMARD, tofacitinib. A Cox proportional hazards model with time-varying exposure was used to estimate the hazard ratio for developing MM among those who received b/tsDMARD medications relative to b/tsDMARD-naïve persons. …”
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Survival and risk factors for metastatic colorectal cancer patients with a history of prior malignancy by Yiwen Qiu, Nida Cao, Dan Meng, Jian Yuan, Yingjie Zhu

“…The Kaplan‒Meier method was used for survival analysis, as were the multivariate Cox proportional hazard model and multivariate competing risk model. …”
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Impact of vancomycin area under the curve in early or later phase on efficacy and nephrotoxicity in patients with enterococcal bloodstream infections: a multicenter study by Piyawadee Tangvichitrerk, Dhitiwat Changpradub, Jatapat Hemapanpairoa, Piraporn Juntanawiwat, Wichai Santimaleeworagun

“…In addition, patients receiving concomitant nephrotoxic drugs had an AUC cutoff value of 650 mg·h/l. Multivariate Cox regression analysis showed that vancomycin AUCss < 420 mg·h/l, unknown source of bacteremia, and acute kidney injury were significantly associated with 30-day mortality. …”
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A Metabolic Gene Signature to Predict Overall Survival in Head and Neck Squamous Cell Carcinoma by Zeng-Hong Wu, Yun Tang, Yue Zhou

“…Carbonic anhydrase 9 (CA9) and CA6 had the largest logFCs in the upregulated and downregulated genes, respectively. Our Cox regression model data showed 51 prognostic-related genes with lysocardiolipin acyltransferase 1 (LCLAT1) and choline dehydrogenase (CHDH) being associated with the highest risk (HR=1.144, 95% CI=1.044~1.251) and the lowest risk (HR=0.580, 95% CI=0.400~0.839) in HNSCC, respectively. …”
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Evaluating the effects of time-restricted eating on overweight and obese women with polycystic ovary syndrome: A randomized controlled trial study protocol. by Hui Liu, Fuliang Shangguan, Fen Liu, Yu Guo, Huixi Yu, Hanbing Li, Yinhua Su, Zhongyu Li

“…Statistical analysis will include the Anderson-Darling test for normality, T-test/Wilcoxon test based on distribution, mixed-effects models for assessing time/group effects, Cox model for time-to-event analysis, repeated ANOVA for change analysis, and sensitivity analysis. …”
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