Mild ultrasound-assisted alkali de-esterification modified pectins: Characterization and structure–activity relationships in immunomodulatory effects by Huan Guo, Dong Li, Baohe Miao, Kanglin Feng, Guijing Chen, Renyou Gan, Zhiliang Kang, Hong Gao

“…Additionally, AP-E3 significantly upregulated the expression of key immune response genes (tnf-α, il-1β, il-6, cox-2, inos, and nf-κb) and restored the gut microbiota composition and abundance in chloramphenicol-induced immunocompromised zebrafish. …”
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Butyrylcholinesterase Levels on Admission Predict Severity and 12-Month Mortality in Hospitalized AIDS Patients by Lijun Xu, Biao Zhu, Ying Huang, Zongxing Yang, Jia Sun, Yan Xu, Jinlei Zheng, Sabine Kinloch, Michael T. Yin, Honglei Weng, Nanping Wu

“…Kaplan–Meier curves and Cox proportional hazards model were used to assess associations between low BChE levels and mortality, after adjustment for age, CD4 count, WHO stage, and laboratory parameters. …”
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Online tools to predict individualised survival for primary oesophageal cancer patients with and without pathological complete response after neoadjuvant therapy followed by oesoph... by Jie Zhang, Xiang Chen, Dong Dong, Lijie Tan, Yajie Zhang, Hecheng Li, Yuqin Cao, Binhao Huang, Han Tang, Tianzheng Shen, Xijia Feng, Jiahao Zhang, Liqiang Shi, Chengqiang Li, Heng Jiao

“…Two distinct multivariable Cox models of overall survival (OS) were constructed for pCR and non-pCR patients, respectively, and were presented using web-based dynamic nomograms (graphical representation of predicted OS based on the clinical characteristics that a patient could input into the website). …”
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Partial weight bearing and long-term survival outcomes in extracapsular hip fractures treated with trochanteric Gamma3 nails by Carlos Hernández-Pascual, José Ángel Santos-Sánchez, Jorge Hernández-Rodríguez, Carlos Fernando Silva-Viamonte, Carmen Pablos-Hernández, Pablo Alonso-Rodríguez, José Antonio Mirón-Canelo

“…EPWB and Not-EPWB were comparable, except for hospital stay and dependence. We used the Cox method for mortality. < 0.05 p-values were significant. …”
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Pre-diagnostic risk factors for brain cancer incidence and survival: insights from the Golestan Cohort Study by Parisa Rezanejad-Asl, Peyvand Parhizkar Roudsari, Negar Rezaei, Maryam Sharafkhah, Gholamreza Roshandel, Hossein Poustchi, Sadaf Sepanlou, Reza Malekzadeh

“…Minimally adjusted and multiple Cox proportional hazards models were used to investigate the association of demographic and behavioral risk factors with brain cancer incidence and survival. …”
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The effect of miR-381 on proliferation and prognosis of breast cancer by altering CCNA2 expression by Ming-Gang Cao, Yan Wang, Zhi-Min Yang, Yang Wang, Mei-Qing Wang, Shuai Zhuo, Yan Yang, Chun-Sheng Liu

“…The area under curves (AUCs) of miRNA-381 and CCNA2 for predicting PFS and OS were 0.711, 0.695, 0.694 and 0.675 respectively. Cox regression analysis showed that miRNA-381 ≥ 1.65 2−ΔΔCt and CCNA ≥ 2.95 2−ΔΔCt were the influence factors of PFS and OS, the hazard ratio (HR) values were 0.553, 2.075, 0.462 and 2.089, respectively.Conclusion miR-381 inhibitors breast cancer cells proliferation and migration by down-regulating the expression of CCNA2, both of them can predict the prognosis of breast cancer.…”
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The association between estimated pulse wave velocity and cardio-cerebrovascular disease risk: a cohort study by Guangyan Liu, Wenyue Sha, Yueying Wu, Jinhua Luo, Yuying Cai, Tuming Zhang, Yu Yang

“…Clinical and demographic characteristics were collected. A Cox proportional hazards model was used to explore the relationship between ePWV and the risk of cardiovascular disease. …”
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Proteinuria and the risk of Incident atrial fibrillation according to glycemic stages: a nationwide population-based cohort study by Muhan Yeo, So-Ryoung Lee, Eue-Keun Choi, JungMin Choi, Kyung-Yeon Lee, Soonil Kwon, Hyo-Jeong Ahn, Bong-Seong Kim, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip

“…Incidence rates increased from 2.46 to 8.18 per 1000 person-years with increasing proteinuria (p < 0.001). Adjusted Cox regression models revealed a heightened AF risk with higher proteinuria across all glycemic stages (adjusted hazard ratios for urine dipstick 3+/4+: 1.58, 1.64, 2.39, 2.12, and 2.53 for normal, prediabetes, new-onset DM, early DM, and late DM, respectively). …”
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Characteristics of subacute stroke patients who achieve earlier independence in real-life walking performance during hospitalization by Kenji Kawakami, Shigeo Tanabe, Daiki Kinoshita, Ryo Kitabatake, Hiroo Koshisaki, Kenta Fujimura, Yoshikiyo Kanada, Hiroaki Sakurai

“…Hazard ratios were calculated via multivariable Cox proportional hazard models. Results: The median time to independence was 4 weeks, with significant differences (p < 0.05) by age, FIM-M, FIM-C, and FAC stratification. …”
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Transfer from long-term care to acute care and risk of new permanent cognitive or physical disability among long-term care residents in Canada: protocol for a retrospective cohort... by Sharon Kaasalainen, Daniel I McIsaac, Steven Hawken, Daniel Kobewka, Peter Tanuseputro, Amy Hsu, Robert Talarico, Colleen Webber, Ramtin Hakimjavadi, Celeste Fung, Mary M Scott, Doug Manuel, Christina Y Yin, Jackie Kierulf, Frank Molnar, Sandy Shamon, Aliza Moledina

“…Due to the time-varying nature of the exposure and confounders, we will use an extended cause-specific Cox regression model to explore this relationship. …”
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Comparisons of risk factors and outcomes between abdominal aortic aneurysm and peripheral arterial disease: a case-control study by Ian Beeton, Jay Acharya, Bengisu Kesin Meric, James Hobden, Tahir Ali, Thang S. Han

“…Methods: Group differences were examined by Fisher's exact tests with Bonferroni correction, postoperative complications (including delirium and pneumonia) and LOS by logistic regression, and mortality by Cox regression, adjusted for age, sex, smoking, co-morbidities and medications. …”
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Joint association of sleep patterns and oxidative balance score with all-cause and cardiovascular mortality among the general population by Chen Chen, Hanzhang Wu, Hanzhang Wu, Hongyu Jin, Zhiping Jiang, Wei Wang, Xiao Tan, Xiao Tan, Wen-Yang Li

“…OBS was calculated based on twenty oxidative stress-related exposures to dietary and lifestyle factors. Cox proportional hazards model was conducted to evaluate the association between sleep patterns or OBS alone and combined with all-cause and CVD mortality.ResultsPoor sleep patterns and pro-oxidant OBS (Q1 &amp; Q2) were identified as risk factors for mortality. …”
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Assessing microvascular dysfunction and predicting long-term prognosis in patients with cardiac amyloidosis by cardiovascular magnetic resonance quantitative stress perfusion by Leting Tang, Wenjin Zhao, Kang Li, Lin Tian, Xiaoyue Zhou, Hu Guo, Mu Zeng

“…Mortality-associated markers were analyzed by univariate and multivariable Cox regression. Results: The median follow-up time was 37 (33.6–40.4) months, and 62 patients died. …”
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New prognostic model in patients with advanced urothelial carcinoma treated with second-line immune checkpoint inhibitors by Ernest Choy, Yohann Loriot, Fabio Calabrò, Cora N Sternberg, Guillermo De Velasco, Daniel Castellano, Roubini Zakopoulou, Aristotelis Bamias, Nicholas James, Axel Merseburger, F Lopez-Rios, Mario Kramer, Kimon Tzannis

“…The development and internal validation of a prognostic model for overall survival (OS) was performed using Cox regression analyses, bootstrapping methods and calibration.Results In 936 patients, ECOG PS, alkaline phosphatase, hemoglobin, neutrophil-to-lymphocyte ratio, liver metastases, bone metastases and time from last chemotherapy were identified as independent prognostic factors. …”
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Tumour DNA methylation markers associated with breast cancer survival: a replication study by Elaheh Zarean, Shuai Li, Ee Ming Wong, Enes Makalic, Roger L. Milne, Graham G. Giles, Catriona McLean, Melissa C. Southey, Pierre-Antoine Dugué

“…Candidate methylation sites (N = 22) and signatures (N = 3) potentially associated with breast cancer survival were identified from five prior studies that used The Cancer Genome Atlas (TCGA) methylation dataset, which shares key characteristics with the MCCS: comparable sample size, tissue type (formalin-fixed paraffin-embedded; FFPE), technology (Illumina HumanMethylation450 array), and participant characteristics (age, ancestry, and disease subtype and severity). Cox proportional hazard regression analyses were conducted to assess associations between these markers and both breast cancer-specific survival and overall survival, adjusting for relevant participant characteristics. …”
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The performance status gap in immunotherapy for frail patients with advanced non-small cell lung cancer by Julie Tsu-Yu Wu, June Corrigan, Chloe Su, Clark Dumontier, Jennifer La, Aparjita Khan, Shipra Arya, Alex H. S. Harris, Leah Backhus, Millie Das, Nhan V. Do, Mary T. Brophy, Summer S. Han, Michael Kelley, Nathanael R. Fillmore

“…We also examined overall survival (OS) on intensive treatment using Cox regression stratified by PS. Intensive treatment was defined as concurrent use of platinum-doublet chemotherapy and/or dual checkpoint blockade and non-intensive as ICI monotherapy. …”
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Changes in Phenylacetylglutamine Levels Provide Add-On Value in Risk Stratification of Hypertensive Patients: A Longitudinal Cohort Study by Xuan Xu, Lixin Jia, Bokang Qiao, Yanyan Gong, Shan Gao, Yuan Wang, Jie Du

“…After follow-up, the Kaplan–Meier curve and the Cox regression model were utilized to determine the correlation between PAGln and MACEs (death, non-fatal ischemic stroke and hemorrhagic stroke, non-fatal acute coronary syndrome and unplanned revascularization). …”
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Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis by Georgios K. Vasileiadis, Yuan Zhang, Tahzeeb Fatima, Ronald van Vollenhoven, Jon Lampa, Bjorn Gudbjornsson, Espen A. Haavardsholm, Dan Nordström, Gerdur Grondal, Kim Hørslev‐Petersen, Kristina Lend, Marte S. Heiberg, Merete Lund Hetland, Michael Nurmohamed, Till Uhlig, Tuulikki Sokka‐Isler, Anna Rudin, Cristina Maglio

“…Overall, participants with baseline adipokine levels above the median and those with adipokine levels below the median had similar mean CDAI and changes in CDAI throughout follow‐up for up to 48 weeks. Adjusted Cox proportional hazards models did not show any effect of baseline adiponectin, leptin, and resistin levels on the likelihood of achieving CDAI remission (adiponectin: hazard ratio [HR] 1.08, 95% confidence interval [CI] 0.80–1.45, P = 0.62; leptin: HR 0.89, 95% CI 0.64–1.26, P = 0.52; resistin: HR 0.86, 95% CI 0.65–1.13, P = 0.26). …”
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Development of a prognostic nomogram and risk stratification system for elderly patients with esophageal squamous cell carcinoma undergoing definitive radiotherapy: a multicenter r... by Yuanji Xu, Chuyan Lin, Chun Han, Xin Wang, Yidian Zhao, Qingsong Pang, Xinchen Sun, Gaofeng Li, Kaixian Zhang, Ling Li, Xueying Qiao, Yu Lin, Zefen Xiao, Junqiang Chen

“…We identified independent prognostic factors using univariate and multifactorial Cox regression to construct a nomogram model. Its effectiveness was evaluated using concordance statistics (C-index), area under the curve (AUC), net reclassification index (NRI), and integrated discrimination improvement (IDI), and compared against the AJCC staging. …”
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Survival and prognostic factors for primary lung extranodal NK/T-cell lymphoma: a retrospective study of data from China and the SEER database by Qiuyu Li, Haoyu Zuo, Chengyang Liu, Jing Yang, Nini Dai

“…Clinical characteristics, treatment modalities, and survival data were collected and analyzed using Kaplan–Meier and Cox regression models to identify potential prognostic factors.ResultsThe study cohort included 13 male (65%) and 7 female (35%) patients with a median age of 57 years. …”
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