Effect of primary tumor volume on survival of concurrent chemoradiotherapy in stage IV non‐small cell lung cancer by Xiaxia Chen, Wei Zhang, Lan Luo, Shimei Fu, Dongdong Cao, Shengfa Su, Qingsong Li, Wengang Yang, Yichao Geng, Bing Lu, Weiwei Ouyang

“…Results The survival rate of patients with GTV <150 cm3 is better than patients with GTV ≥150 cm3. Multivariate Cox regression analyses suggested that peripheral lung cancer, radiation dose ≥63 Gy, GTV <150 cm3, 4–6 cycles of chemotherapy, and CR + PR are good prognostic factors for patients with stage IV non‐small cell lung cancer. …”
Get full text

Impact of same-day ART initiation on medical care and medication discontinuation among patients with incident HIV infection or AIDS in Taiwan: A population-based cohort study by Chen-Han Chueh, Hsiao-Jou Yu, Yu-Wen Wen, Ming-Neng Shiu, Yi-Ying Chen, Shao-Chin Chiang, Yi-Wen Tsai

“…We used a doubly robust weighted Cox regression model to estimate the average hazard ratio for same-day ART initiation compared to rapid ART initiation within 7 days over a 12-month care- and medication-discontinuation risk horizon. …”
Get full text

Association of thoracic aortic calcium with incident cardiovascular disease and all-cause mortality across the spectrum of coronary artery calcium burden by Alexander C. Razavi, Omar Dzaye, Miguel Cainzos-Achirica, Zeina Dardari, Marly Van Assen, Arshed A. Quyyumi, Khurram Nasir, J. Jeffrey Carr, Matthew J. Budoff, Roger S. Blumenthal, Paolo Raggi, Carlo N. De Cecco, Laurence S. Sperling, Michael J. Blaha, Seamus P. Whelton

“…Methods: Cardiac CT was performed among 6,783 asymptomatic Multi-Ethnic Study of Atherosclerosis participants at baseline. Cox proportional hazards regression assessed the association of TAC with incident CVD and all-cause mortality over a median follow-up of 17.7 years, adjusting for CVD risk factors and CAC. …”
Get full text

Association of Cardiovascular Autonomic Neuropathy and Distal Symmetric Polyneuropathy with All-Cause Mortality: A Retrospective Cohort Study by Orsolya E. Vági, Márk M. Svébis, Beatrix A. Domján, Anna E. Körei, Ildikó Istenes, Zsuzsanna Putz, Szilvia Mészáros, Noémi Hajdú, Magdolna Békeffy, Solomon Tesfaye, Péter Kempler, Viktor J. Horváth, Adam G. Tabák

“…We investigated the association of CAN (Ewing tests) and DSPN (Neurometer) with all-cause mortality using Cox models stratified by diabetes type. Results. …”
Get full text

Assessing the Comparative Efficacy and Safety of Warfarin and Rivaroxaban for Cancer Associated Thrombosis: Experience From a Resource Limited Setting by Abel Tenaw Tasamma, Tsegab Alemayehu Bukate, Abdulrahim Mehadi, Bereket Tagesse Handiso, Beniam Yohannes Kassa, Eman Omer Hassen, Zekarias Seifu Ayalew, Dawit Habtie Tegegne, Gebeyehu Tessema Azibte, Tigest Abebaw Zewdie, Tinsaye Zergaw Shihur, Yonas Degelo Geremamo, Yeabsira Dessalegne Mesfin, Rediet M. Alemayehu, Amanuel Kassu Asefa, Fozia Abdela, Addisu Melkie

“…The primary endpoint was a composite of recurrence of venous thromboembolism (VTE), major bleeding event, or all‐cause mortality. The Cox regression model was used to compare the outcome of the two groups. …”
Get full text

Model for End-Stage Liver Disease and Sodium Velocity Predicts Overall Survival in Nonmetastatic Hepatocellular Carcinoma Patients by Justin Y. Tang, Nitin Ohri, Rafi Kabarriti, Santiago Aparo, Jennifer Chuy, Sanjay Goel, Jonathan M. Schwartz, Milan Kinkhabwala, Andreas Kaubisch, Chandan Guha

“…The median changes in percentage of MELD-Na over 90 days were an increase of 9% (IQR -4% to 55%). Multivariable Cox proportional hazards modeling demonstrated that both baseline MELD-Na (HR=1.07 per unit increase, 95% CI 1.03 to 1.11, p<0.001) and changes in MELD-Na exceeding 40% (HR=3.69, 95% CI 2.39 to 5.69, p<0.001) were independently associated with increased mortality risk. …”
Get full text

Prognostic model and immune-infiltrating cell landscape based on differentially expressed autophagy-related genes in TP53-mutated multiple myeloma by Yan-Hua Zheng, Hong-Yuan Shen, Xiang Chen, Juan Feng, Guang-Xun Gao

“…Material and methods Information about MM patients with TP53 mutations was downloaded from the Gene Expression Omnibus (GEO) database. Cox proportional hazard regression was employed to determine the independent prognostic ARG and construct a risk signature. …”
Get full text

Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disorders by David Mataix-Cols, Christian Rück, Lorena Fernández de la Cruz, Kayoko Isomura, Henrik Larsson, Paul Lichtenstein, Brian M D’Onofrio, Anna Sidorchuk, Zheng Chang, James J Crowley, Ralf Kuja-Halkola, Isabell Brikell, Josep Pol-Fuster, Anna Holmberg, Lina Martinsson

“…We estimated the risk of cardiovascular diseases (CVD) and metabolic disorders (including obesity, type 2 diabetes and hyperlipidaemia), comparing the relatives of probands with and without OCD. Cox proportional hazards regression models, incorporating time-varying exposures, estimated HRs.Results OCD was associated with an increased risk of CVD (HR 1.47; 95% CI 1.43 to 1.51), obesity (HR 1.69; 95% CI 1.63 to 1.74), type 2 diabetes (HR 2.01; 95% CI 1.90 to 2.12) and hyperlipidaemia (HR 1.42; 95% CI 1.33 to 1.52). …”
Get full text

Cell-free DNA predicts all-cause mortality of sepsis-induced acute kidney injury by Feixiang Xu, Xiao Tan, Jianli Wang, Su Lu, Hailin Ding, Mingming Xue, Yumei Chen, Sheng Wang, Jie Teng, Yiqin Shi, Zhenju Song

“…CfDNA was extracted from serum and quantified using Quant-iT PicoGreen dsDNA Reagent.Results Overall survival was significantly lower in the high cfDNA group than in the low cfDNA group (Log-Rank p = 0.012). Univariate Cox proportional hazard model showed that cfDNA was significantly associated with all-cause mortality (HR [hazard ratio] 2.505, 95% CI [95% confidence interval] 1.184–5.298, p = 0.016). …”
Get full text

Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus... by Minrui Xu, Mingtao Huang, Deren Qiang, Jianxin Gu, Yong Li, Yingzi Pan, Xingjuan Yao, Wenchao Xu, Yuan Tao, Yihong Zhou, Hongxia Ma

“…A total of 15,717 eligible participants without baseline T2DM and aged 35 and over were included from a Chinese rural cohort. Cox proportional hazards regression models were used to estimate the association of HTGW and LAP with the incidence of T2DM, and the restricted cubic spline model was used to evaluate the dose-response association. …”
Get full text

Cytoplasmic genetic diversity of potato varieties bred in Russia and FSU countries by Т. A. Gavrilenko, N. S. Klimenko, N. V. Alpatieva, L. I. Kostina, V. A. Lebedeva, Z. Z. Evdokimova, O. V. Apalikova, L. Y. Novikova, O. Yu. Antonova

“…Fragments of the  nad2, nad7, cox2, atp6 and  CcmFc genes  were identical  in all 15 selected genotypes. …”
Get full text

Metabolic dysfunction-associated steatotic liver disease and risk of four intrahepatic and extrahepatic diseases by Yiyuan Xiao, Sihua Xu, Wenyan Hu, Jiapeng Huang, Deke Jiang, Rong Na, Zhaoqing Yin, Jingjing Zhang, Haitao Chen

“…The odd ratio (OR) and the hazard ratio (HR) were calculated using the logistic regression modals and Cox regression models, respectively. Results: Among 39,230 eligible individuals, 6,865 MASLD subjects, 2,379 MetALD subjects and 884 ALD subjects were diagnosed. …”
Get full text

Impact of exercise-based cardiac rehabilitation on cardiopulmonary function and prognosis in ST elevation myocardial infarction after PCI patients in extremely cold regions by Shenglong Hou, Li Liu, Jing Yao, Qi Zhao, Wei Feng, Qingqing Liu, Mou Zou, Ruoxi Zhang, Hongtao Yin, Huimin Xian

“…The cardiopulmonary test indicators for patients in CR group showed significant improvement over one year, including Power, HR, VCO₂, VO₂, VE, VD/VT, PetCO₂, CHO, CO, and SV, all with statistical significance. Multivariate COX regression analysis showed that CR was independently associated with heart failure in follow up. …”
Get full text

The relation of radiological tumor volume response to histological response and outcome in patients with localized Ewing Sarcoma by Lianne M. Haveman, Andreas Ranft, Henk vd Berg, Anne Smets, Jarmila Kruseova, Ruth Ladenstein, Benedicte Brichard, Michael Paulussen, Thomas Kuehne, Heribert Juergens, Stephanie Klco‐Brosius, Uta Dirksen, Johannes H.M. Merks

“…Correlations between TVR, HisRes, event free survival (EFS), and overall survival (OS) were analyzed using chi‐square tests, log‐rank tests, and the Cox‐regression model. Results Early adequate TVR, noted in 41% of patients, did not correlate with EFS (P = 0.92) or OS (P = 0.38). …”
Get full text

Machine learning identification of a novel vasculogenic mimicry-related signature and FOXM1’s role in promoting vasculogenic mimicry in clear cell renal cell carcinoma by Chao Xu, Sujing Zhang, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Shengtao Dai, Bowei Zhang, Meng Zhu, Yuepeng Liu, Junfei Gu

“…A consensus VRG_score was formulated using a machine learning computational framework and Cox regression, displaying strong predictive power for prognosis and clinical translation. …”
Get full text

Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas by Yanguo Li, Jiawei Fan, Zhuo Shen, Jun Zhang, Xuemei Yin, Fang Han, Wenfei Li

“…Univariate and multivariate Cox analyses were used to identify independent prognostic factors associated with survival. …”
Get full text

Metabolic Syndrome and Its Components Predict the Risk of Type 2 Diabetes Mellitus in the Mainland Chinese: A 3-Year Cohort Study by Kun Wang, Qun-Fang Yang, Xing-Lin Chen, Yu-Wei Liu, Sheng-Shuai Shan, Hua-Bo Zheng, Xiao-Fang Zhao, Chang-Zhong Chen, Cheng-Yun Liu

“…MetS and its components were assessed by multivariable analysis using Cox regression. Prediction models were developed. …”
Get full text

Effect of Prehospital Epinephrine on Outcomes of Out-of-Hospital Cardiac Arrest: A Bayesian Network Approach by Joonghee Kim, Yu Jin Kim, Sangsoo Han, Han Joo Choi, Hyungjun Moon, Giwoon Kim

“…The effect of epinephrine and SALS program was modelled based on the structure using extended Cox-regression and logistic regression, respectively. …”
Get full text

Seasonal trends of pyogenic spondylodiscitis in Japan: a nationwide inpatient database study by Takayuki Motoyoshi, Takahisa Ogawa, Kazuyuki Fukushima, Satoshi Kutsuna, Haggai Schermann, Kiyohide Fushimi, Toshitaka Yoshii

“…Risk factors for in-hospital death were evaluated using multivariable Cox proportional hazards regression models. Results: A total of 71,134 patients with pyogenic spondylodiscitis were identified, with 11.9 % (n = 8446) exhibiting MRSA infection. …”
Get full text

Physical vs. multidimensional frailty in older adults with and without heart failure by Gianluca Testa, Francesco Curcio, Ilaria Liguori, Claudia Basile, Martina Papillo, Carlo Gabriele Tocchetti, Gianlugi Galizia, David Della‐Morte, Gaetano Gargiulo, Francesco Cacciatore, Domenico Bonaduce, Pasquale Abete

“…Mortality, disability, and hospitalizations were assessed at baseline and after a 24 month follow‐up. Cox regression analysis demonstrated that, compared with phy‐Fi score, m‐Fi score was more predictive of mortality [hazard ratio (HR) = 1.05 vs. 0.66], disability (HR = 1.02 vs. 0.89), and hospitalization (HR = 1.03 vs. 0.96) in the absence and even more in the presence of HF (HR = 1.11 vs. 0.63, 1.06 vs. 0.98, and 1.14 vs. 1.03, respectively). …”
Get full text