Effect of ubiquitin-specific proteinase 43 on ovarian serous adenocarcinoma and its clinical significance by Qin Li, Wenhao Li, Jiahao Wang, Wenjing Shi, Taorong Wang

“…WGCNA was employed to prioritise these genes, and Cox regression analysis and survival analysis based on disease-specific time were conducted to identify significant genes. …”
Get full text

Comprehensive analysis of heat shock protein 110, 90, 70, 60 families and tumor immune microenvironment characterization in clear cell renal cell carcinoma by Wenjing Liao, Mao Huang, Xiaoyi Du, Liangdan Tang, Junwu Li, Qin Tang

“…Survival analysis, receiver operating characteristic (ROC) curve, univariate and multivariate COX regression analysis demonstrated the accuracy and independence of signature. …”
Get full text

A Novel Prognostic Signature Revealed the Interaction of Immune Cells in Tumor Microenvironment Based on Single-Cell RNA Sequencing for Lung Adenocarcinoma by Xing Jin, Zhengyang Hu, Qihai Sui, Mengnan Zhao, Jiaqi Liang, Zhenyu Liao, Yuansheng Zheng, Hao Wang, Yu Shi

“…The overlap of the brown module gene, natural killer cell signature, and DEGs of tumor and adjacent normal samples was screened by LASSO Cox regression. The obtained 5-gene risk model showed an excellent prognostic performance in the validation dataset. …”
Get full text

Assessment of long-term changes in subvalvular aortic stenosis in patients following transcatheter aortic valve implantation by Vladlen V. Bazylev, Andrey B. Voevodin, Alexey S. Masyutin

“…Long-term outcomes of TAVI included a significant decrease in hypertrophy of IVS (p=0.031) IVS thicknesses mainly decreased over the period up to 24 months after surgery. Cox regression analysis found that each year of patient’s age increased the risk of no postoperative decrease in IVS thickness after surgery by 12% every month. …”
Get full text

Association of functional health literacy and cognitive ability with self-reported diabetes in the English Longitudinal Study of Ageing: a prospective cohort study by Ian J Deary, Chloe Fawns-Ritchie, Jackie Price

“…Adequate (compared with limited) functional health literacy (OR 0.71, 95% CI 0.61 to 0.84) and higher cognitive ability (OR per 1 SD=0.73, 95% CI 0.67 to 0.80) were associated with lower odds of self-reporting diabetes at wave 2. Cox regression was used to test the associations of functional health literacy and cognitive ability measured at wave 2 with self-reporting diabetes over a median of 9.5 years follow-up (n=6961). …”
Get full text

Histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine model by Yu Sato, Matthew Kutnya, Biniyam Abebe, Mohammed S. El Kurdi, Martijn Cox, Richard W. Bianco, Bart Meuris, Yoshinobu Onuma, Patrick W. Serruys, Renu Virmani

Get full text

Association between right atrial area measured by echocardiography and prognosis among pulmonary arterial hypertension: a systematic review and meta-analysis by Ke Liu, Chunhua Zhang, Bingyu Chen, Mingfeng Li, Peican Zhang

“…Objective The purpose of this meta-analysis was to evaluate the association between enlarged right atrial area (RAA), as measured by echocardiography, and prognosis of patients with pulmonary arterial hypertension (PAH).Design Systematic review and meta-analysis.Data sources To identify potential publications, a comprehensive literature search through MEDLINE, the Cochrane database and the Embase database was performed up to December 2019.Eligibility criteria for selecting studies Studies were included if they reported Cox regression based-HRs with 95% CIs for all-cause mortality or composite endpoint consisting of death and PAH-related events for echocardiography measurements of the RAA or the right atrial area index (RAAI) in patients with PAH.Data extraction and synthesis The unadjusted HR with 95% CI was extracted for the final pooled analysis. …”
Get full text

OpenWFS—a library for conducting and simulating wavefront shaping experiments by Jeroen H Doornbos, Daniël W S Cox, Tom Knop, Harish Sasikumar, Ivo M Vellekoop

Get full text

The Promising Key Factors Mediating Secondary Neuronal Damage in the Perihematomal Region of Intracerebellar Hemorrhage of Mice by Saandeep Bhatia, Ramissh Paramasivam, Mohd Khairul Izamil Bin Zolkefley, Regunath Kandasamy, Sangu Muthuraju, Jafri Malin Abdullah

“…The expressions of superoxide dismutase (SOD), catalase (CAT), neuronal nitric oxide synthases (nNOSs), glutathione peroxidase 1, and cyclooxygenase-2 (COX-2) were significantly increased on day 3. Morphological studies of the PH and tissue showed that neuronal damage occurred from day 1 onward and peaked on day 3, associated with alterations in NO, reactive astrocytes (GFAP), glutamate transport regulation (EAAT1), and GABA receptor. …”
Get full text

Characteristics and outcomes of secondary acute lymphoblastic leukemia (sALL) after multiple myeloma (MM): SEER data analysis in a single-center institution by Jing Jia, Jiahui Yin, Chuanying Geng, Aijun Liu

“…Methods: We conducted this population-based study using the Surveillance, Epidemiology, and End Results (SEER) database and retrospectively reviewed patients with sALL following MM treatment at our institution. Cox regression analysis was performed to investigate the prognostic factors for survival in patients with sALL. …”
Get full text

Programmed cell death 1 inhibitor alone or combined with chemotherapy for patients with locally advanced or metastatic urothelial carcinoma: a single-center experience by Xing Huang, Chupeng Sun, Peng Zhang, Lei Wang

“…Kaplan–Meier curves were used to assess progression-free survival (PFS) and OS. A Cox regression analysis was conducted to explore the association of baseline variables with OS. …”
Get full text

Never mind the bug: no differences in infection-free survival after periprosthetic joint infections with Staphylococcus aureus, Coagulase-negative Staphylococcus, or Streptococcus by Anders Brüggemann, Nils P. Hailer

“…Infection-free survival was defined as the absence of (1) further surgery to the index joint due to PJI, (2) suppressive antibiotic therapy, and (3) death due to PJI and was assessed using the Kaplan–Meier method. Cox regression models were fitted to estimate the risk of infection relapse adjusted for relevant confounders.ResultsWe found no statistically or clinically significant difference in unadjusted survival between the three groups. …”
Get full text

Perspectives of Midwives and Nurse Practitioners in Kentucky on Exercise Counseling During Pregnancy: A Qualitative Study by Madhawa Perera, Taniya S. Nagpal, Maire M. Blankenship, Danilo V. Tolusso, Jordyn M. Cox, Dilini Prashadika, Mark Schafer, Rachel A. Tinius

Get full text

Copper homeostasis and neurodegenerative diseases by Yuanyuan Wang, Daidi Li, Kaifei Xu, Guoqing Wang, Feng Zhang

“…Copper homeostasis is meticulously maintained through a complex network of copper-dependent proteins, including copper transporters (CTR1 and CTR2), the two copper ion transporters the Cu -transporting ATPase 1 (ATP7A) and Cu-transporting beta (ATP7B), and the three copper chaperones ATOX1, CCS, and COX17. Disruptions in copper homeostasis can lead to either the deficiency or accumulation of copper in brain tissue. …”
Get full text

U-shaped relationship between uric acid levels and all-cause mortality in patients with hypertension by Yating Huang, Jie Li, Feifei Sun, Huining Zhou, Hua Jiang, Liang Chen

“…The correlation between UA and all-cause mortality was calculated by threshold and saturation effect analysis, along with Cox regression models. The stability of the results in the presence of different comorbidities was verified through stratified analysis for interaction testing. …”
Get full text

Uptake and safety of Sotrovimab for prevention of severe COVID-19 in a cohort and self-controlled case series study by Martina Patone, Andrew JHL Snelling, Holly Tibble, Carol Coupland, Aziz Sheikh, Julia Hippisley-Cox

Get full text

Co-occurring factors associated with suicidal ideation among individuals with parole involvement: A classification and regression tree analysis by Leah MCCOY, Javier F. BOYAS, Sung Seek MOON, Michael A. ROBINSON, Onick LEWIS, Amy E. COX

Get full text

Association of age-related macular degeneration on fracture risks among osteoporosis population: a nationwide population-based cohort study by Bing-Yu Chen, Chi Chin Sun, Ting-Shuo Huang, Tsai-Sheng Fu, Chia-Yi Lee, Fang-Ping Chen

“…A total of 13 584 and 54 336 patients with OS were enrolled in the AMD group and the non-AMD group, respectively.Intervention Patients with OS were included from the Taiwan’s NHIRD after exclusion, and each patient with AMD was matched for age, sex and comorbidities to four patients with non-AMD OS, who served as the control group. A Cox proportional hazard model was used for the multivariable analysis.Primary outcome measures Transitions for OS to spine fracture, OS to hip fracture, OS to humero-radio-ulnar fracture and OS to death.Results The risks of spine and hip fractures were significantly higher in the AMD group (HR=1.09, 95% CI=1.04 to 1.15, p<0.001; HR=1.18; 95% CI=1.08 to 1.30, p=0.001, respectively) than in the non-AMD group. …”
Get full text

Once-weekly semaglutide doubles the five-year risk of nonarteritic anterior ischemic optic neuropathy in a Danish cohort of 424,152 persons with type 2 diabetes by Jakob Grauslund, Andreas Abou Taha, Laleh Dehghani Molander, Ryo Kawasaki, Sören Möller, Kurt Højlund, Lonny Stokholm

“…Patients were stratified according to exposure (n = 106,454) or non-exposure (n = 317,698) to once-weekly semaglutide, and incidence rates and hazard ratios (HR) of NAION were estimated in a multivariable Cox proportional hazard regression model. Results At baseline, median age and hemoglobin A1c were 65 years and 50 mmol/mol, and 54·5% were male. …”
Get full text

Characterizing the pan-cancer role of exosomal miRNAs in metastasis across cancers by Piyush Agrawal, Gulden Olgun, Arashdeep Singh, Vishaka Gopalan, Sridhar Hannenhalli

“…Our analysis recapitulated exomiRs associated with M2 macrophage differentiation and chemoresistance, such as miR-21 and miR-222–3p, regulating signaling pathways like PTEN/PI3/Akt, NF-kB, etc. Additionally, Cox regression analysis in TCGA indicated that exomiR targets are significantly associated with better overall survival of patients. …”
Get full text