Significance of non-steroidal anti-inflammatory drugs in the prevention and treatment of cervical cancer by Xun Kan, Zhenhuan Zhou, Lianlian Liu, Reziwanguli Aiskikaer, Yinggang Zou

“…Chronic inflammation mediated by cyclooxygenase (COX) has been identified as a factor in cancer onset and progression, with HPV oncoproteins E6 and E7 inducing COX activation. …”
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Combination Therapy of PPAR𝛾 Ligands and Inhibitors of Arachidonic Acid in Lung Cancer by Jordi Tauler, James L. Mulshine

“…However, specific COX-inhibitors have been correlated with an increased cardiovascular risk. …”
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膀胱移行细胞癌环氧化酶2表达与淋巴管和血管生成的关系

“…【目的】 探讨环氧化酶2(COX-2)在膀胱移行细胞癌的表达与微血管65380;淋巴管生成的关系及其预后意义65377;【方法】 应用免疫组化方法检测81例膀胱移行细胞癌组织中COX-2的表达,同时应用CD34 65380;D2-40分别显色微血管和淋巴管进行微血管和淋巴管计数65377;并分析其与肿瘤临床病理特征和预后的关系65377;【结果】 COX-2表达阳性率为67.9%65377;COX-2表达与肿瘤分级呈正相关关系(P = 0.016),COX-2表达阳性组MVD和瘤内淋巴管(ITLVD)阳性的比例较阴性组高,两组差异有统计学意义(P = 0.046, P = 0.030)65377;瘤内淋巴管阳性与肿瘤分级(P = 0.001)和分期(P < 0.001)明显相关,瘤旁淋巴管(PTLVD)表达与肿瘤分期(P = 0.003)呈正相关65377;Kaplan-Meier 分析表明MVD和瘤内65380;瘤旁淋巴管阳性对疾病特异性生存有明显的影响(P < 0.001, P = 0.024和P = 0.004),COX-2和瘤内淋巴管阳性者无瘤生存时间较短(P = 0.013, P = 0.001)65377;多因素分析表明COX-2表达是膀胱移行细胞癌病人无瘤生存独立的预后因素65377;【结论】 COX-2可能参与膀胱移行细胞癌的发生并促进血管及淋巴管生成,影响肿瘤的复发65380;进展和预后65377;…”
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Exploration of cyclooxygenase-2 inhibitory peptides from walnut dreg proteins based on in silico and in vitro analysis by Zishan Hong, Jing Xie, Liang Tao, Jing-Jing Dai, Tingting Li, Li Zhang, Yuying Bai, Xia Hu, Jinlian Chen, Jun Sheng, Yang Tian

“…Walnut dreg protein hydrolysates (WDPHs) exhibit a variety of biological activities, however, the cyclooxygenase-2 (COX-2) inhibitory peptide of WDPHs remain unclear. …”
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Evaluation of the Anti-Cancer Efficacy of Cyclooxygenase Inhibition in Combination with Nutrient Starvation on Pancreatic Ductal Adenocarcinoma <em>In Vitro</em> by Ayşe Nur Çaldıran, Gizem Gürel, Başak Aru

“…Apoptosis, autophagy and cyclooxygenase (COX) levels were evaluated by flow cytometry. Results: Diclofenac decreased both COX isoforms compared to untreated cells. …”
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Integrated TWAS, GWAS, and RNAseq results identify candidate genes associated with reproductive traits in cows by Sevda Hosseinzadeh, Seyed Abbas Rafat, Lingzhao Fang

“…The identified genes include RPL12, FKBP1B, FZD10, COX10, COX7A2, GAA, ETFBKMT, ACSM5, NUDT9, TIGAR, PAIP2, and PSMB5. …”
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The Effect of Cyclooxygenase Inhibition on Tendon-Bone Healing in an In Vitro Coculture Model by Tim Schwarting, Sebastian Pretzsch, Florian Debus, Steffen Ruchholtz, Philipp Lechler

“…We examined the effects of selective COX-2 and nonselective COX inhibition on bone-tendon integration in an in vitro model. …”
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MOLECULAR STUDY OF THE RED-LEGGED HAM BEETLE NECROBIA RUFIPES (DE GEER, 1775) (COLEOPTERA: CLERIDAE) FROM THE ERBIL PROVINCE OF THE KURDISTAN REGION, IRAQ by H. M. Muhammad, P. A. Jalil, N. A. Mawlood, K. M. Taha

“…Parts of the COX gene were aligned with Clustal Omega and visualized and edited via Jalview software. …”
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Application of three statistical approaches to explore effects of dietary intake of multiple persistent organic pollutants on ER-positive breast cancer risk in the French E3N cohor... by Pauline Frenoy, Ismaïl Ahmed, Chloé Marques, Xuan Ren, Gianluca Severi, Vittorio Perduca, Francesca Romana Mancini

“…The second and third approaches applied in the present study were Principal component Cox regression (PCR-Cox) and partial least squares Cox regression (PLS-Cox) respectively, both being dimension-reduction methods (respectively unsupervised and supervised) coupled to a Cox model, used to identify principal components of POPs and to estimate their associations with ER-positive breast occurrence. …”
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In-Silico Evaluation of Binding Interaction and ADME Properties of Novel Pyrazoline and Pyrimidine Derivatives Targeting Cyclooxygenase-2 Enzyme by Sarmad Abbas Fadhil, Karima Fadhil Ali, Wesen Adel Mehde

“…This study aimed to design six new pyrazoline and pyrimidine derivatives and assess their potential anti-inflammatory activity by targeting the cyclooxygenase (COX) enzyme, a key mediator in the inflammation process. …”
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Cyclooxygenase Inhibition in Sepsis: Is There Life after Death? by David M. Aronoff

“…However, human studies have failed to show clinical utility of COX inhibitor treatment in severely septic patients. …”
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Analysis of Gene Expression in Cyclooxygenase-2-Overexpressed Human Osteosarcoma Cell Lines by Jeong A. Han, Ji-Yeon Kim, Jong-Il Kim

“…To understand the mechanism of action of COX-2 in the pathogenesis of osteosarcoma, we compared gene expression patterns between three stable COX-2-overexpressing cell lines and three control cell lines derived from U2OS human osteosarcoma cells. …”
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Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer by Kouji Banno, Miho Iida, Megumi Yanokura, Haruko Irie, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki

“…PGE2 is induced in the arachidonate cascade by COX-2. PGE2 maintains high expression of COX-2 and induces angiogenic factors including VEGF and bFGF, causing carcinogenesis. …”
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Bcl-2 and galectin-3 expression is associated with recurrence of ameloblastoma

“…Furthermore, in univariate analysis, high expression of Bcl-2 was associated with less recurrence-free survival (log-rank: P = 0.020-univariable Cox: P = 0.033), but in multiple Cox regression, there was no significant association (P = 0.471). …”
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颊癌模型中环氧合酶-2和诱导型一氧化氮合酶表达的意义 by 杨朝晖, 李劲松, 徐静, 陈伟良, 李海刚

“…[目的]研究环氧合酶-2（COX-2）和诱导型一氧化氮合酶（iNOS）在地鼠颊囊肿瘤发生发展中的表达,探讨两者可能的相关性。…”
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Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor 𝜅B Is a Steady Feature of Urinary Bladder Carcinogenesis by Stylianos Kontos, Georgia Sotiropoulou-Bonikou, Athina Kominea, Maria Melachrinou, Eleni Balampani, Dionysis Bonikos

“…A positive correlation between COX-2 and nuclear NF𝜅B immunoreactivity was observed. …”
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Genetic variation of the nuclear sequences of mitochondrial origin associated with retrotransposon Tv1 insertions in Drosophila species of the virilis group by B. V. Andrianov, D. A. Romanov, T. V. Gorelova

“…The Tv1 insertion into (AT)n, close to the atp6 or cox3 pseudogenes produces a unique sequence. This sequence is formed by retrotransposon Tv1 and pseudogenes atp6 or cox3. …”
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抗KCl盐水可提取多肽抗体测定在动物模型柯萨奇病毒性心肌炎诊断中意义

“…发现该抗体在感染ＣｏｘＢ伴心肌炎组鼠的阳性率远高于有ＣｏｘＢ感染而不伴有心肌炎组，揭示该抗体测定可能是一种很有前途的柯萨奇病毒性心肌炎实验诊断方法。…”
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Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell Lines by R. Sitarz, R. J. Leguit, W. W. J. de Leng, F. H. M. Morsink, W. P. Polkowski, R. Maciejewski, G. J. A. Offerhaus, A. N. Milne

“…Background: COX-2 and E-cadherin, involved in invasion and metastasis, are molecules critical for gastric carcinogenesis. …”
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β-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC by Ernst Fredericks, Gill Dealtry, Saartjie Roux

“…However, COX-2 protein expression was inverted with significant expression in the Normal and IBS groups and reduced levels in IBD and CRC. …”
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