Prognostic Impact of the Postoperative Carcinoembryonic Antigen Level after Curative Resection of Locally Advanced Rectal Cancer by Ryoichi Tsukamoto, Kiichi Sugimoto, Yuki Ii, Takahiro Irie, Megumi Kawaguchi, Aya Kobari, Yuki Tsuchiya, Kumpei Honjo, Masaya Kawai, Shun Ishiyama, Makoto Takahashi, Kazuhiro Sakamoto

“…In comparison of superiority between pre- and post- CEA levels, Akaike's information criterion (AIC) was used in the Cox proportional-hazard regression model. Results: The subjects were 323 patients who underwent curative surgical treatment for Stage II/III rectal cancer. …”
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Clinical calculator based on clinicopathological characteristics predicts local recurrence and overall survival following radical resection of stage II-III colorectal cancer by Fei Huang, Ran Wei, Shiwen Mei, Tixian Xiao, Wei Zhao, Zhaoxu Zheng, Qian Liu

“…Multivariate nomograms and a clinical risk calculator based on Cox regression were developed. Discrimination was measured with an area under curve (AUC) and variability in individual predictions was assessed with calibration curves. …”
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Treatment and Outcomes of Pancreatic Cancer in Armenia: A Retrospective Study From Resource-Limited Settings by Elen Baloyan, Davit Zohrabyan, Liana Safaryan, Armen Avagyan, Lilit Harutyunyan, Vardan Bardakhchyan, Jemma Arakelyan, Amalya Sargsyan, Martin Harutyunyan, Mariam Mailyan, Gevorg Tamamyan, Samvel Bardakhchyan

“…Log-rank test and Kaplan-Meier curves were used for survival analysis. Cox regression analysis was performed for identification of main prognostic factors.RESULTSOf 70 patients involved in the final analysis, 45.7% was female. …”
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Concomitant Usage of H1‐Antihistamines and Immune Checkpoint Inhibitors on Cancer Patient Survival by Yin Leung, Terry Cheuk‐Fung Yip, Grace Lai‐Hung Wong, Vincent Wai‐Sun Wong, Vicki Wing‐Ki Hui, Tony Shu‐Kam Mok, Henry Lik‐Yuen Chan, Stephen Lam Chan, Rashid Nok‐Shun Lui

“…Results A total of 1740 (65.1% male, mean age 61.9 years) were included in the landmark analysis, of which 529 (30.4%) and 307 (17.6%) had primary lung and liver malignancies. The multivariable Cox regression model estimated statistically significant improvement in overall survival of intermediate use in patients with primary lung malignancies (adjusted hazard ratio [aHR] 0.223, 95% confidence interval [CI] 0.052–0.958, p = 0.044), but not with primary liver maligancies. …”
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Joint exposure to multiple air pollutants and residual cardiovascular risk in hypertension by Yalan Li, Wei Hong, Jingjing Wu, Jie Wang, Shiqi Liu, Hong Yuan, Jingjing Cai, Rujia Miao, Jiangang Wang, Yao Lu

“…The relationships between individual and multiple air pollutants with the residual cardiovascular risk were assessed by Cox proportional hazards models, air pollution score analyses and Bayesian Kernel Machine Regression model. …”
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Heat-not-burn technology affects plasma testosterone levels and markers of inflammation, oxidative stress in the testes of rats by Silvia Granata, Camilla Morosini, Maria Chiara Valerii, Ivan Fagiolino, Stefano Sangiorgi, Severino Ghini, Enzo Spisni, Fabio Vivarelli, Lucy C. Fairclough, Moreno Paolini, Donatella Canistro

“…On the other hand, an increase in oxidative stress markers, including those associated with DNA damage, was observed in exposed animals, along with the induction of NF-kB dependent pro-inflammatory mediators: TNF-α, IL-1β, IL-6 and COX-2. Furthermore, inactivation of key androgenic enzymes, such as 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase, together with decreased testosterone synthesis suggest a potential impairment of male gonadal function.DiscussionThe results indicate that animals exposed to HnB smoke show higher levels of oxidative stress markers, including those associated with DNA damage, as well as higher levels of pro-inflammatory cytokines. …”
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Psoriasis increases the risk of Sjögren’s syndrome: evidence from a propensity score-matched cohort study and transcriptomic analysis by Zijian Kang, Yu Du, Ran Cui, Qian Wang, Miao Chen, Yu-Hsun Wang, James Cheng‐Chung Wei, Sheng-Ming Dai

“…Methods A retrospective cohort study using TriNetX data compared SS development in patients with psoriasis and controls using propensity score matching, Kaplan–Meier curves, and Cox models. Transcriptome data were analyzed to identify shared differentially expressed genes and pathways between the two diseases. …”
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Prognostic Utility of the Combination of Platelet Count with Neutrophil-to-Lymphocyte Ratio in Aged Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Inter... by Xiao-Qing Quan, Hong-Yan Ji, Jie Jiang, Jia-Bao Huang, Cun-Tai Zhang

“…The prognostic role of the combination of platelet count and neutrophil-to-lymphocyte ratio on mortality was assessed by the univariate and multivariate Cox regression analysis. Result. Our study population was divided into three parts according to the median values of platelet count and neutrophil-to-lymphocyte ratio. …”
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Nonlinear effect of body mass index on postoperative survival following isolated heart transplantation by Reid Dale, PhD, Nataliya Bahatyrevich, MD, MS, Matthew Leipzig, BSc, Maria Elizabeth Currie, MD, PhD

“…Overall survival was the primary outcome. A multivariate Cox proportional hazards model was applied and included a penalized smoothing spline term for recipient BMI and risk factors such as diabetes. …”
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Risk of depression in glaucoma patients with vision impairment: A nationwide cohort study by Sheng-Min Wang, Younhea Jung, Kyungdo Han, Kyoung Ohn, Hae-young Lopilly Park, Chan Kee Park, Jung Il Moon

“…Depression risk in relation to glaucoma and vision impairment was analyzed using a multivariable-adjusted Cox proportional hazard model. Results: Among 3,680,570 individuals screened through the Korean National Health Screening Program in 2009, 681,515 were newly diagnosed with depression during follow-up. …”
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Necessity of applying anatomical unit resection surgery in suspected posterior oral squamous cell carcinoma by Bowen Dai, Hongyu Tan, Zhimin Yang, Zhaojian Gong, Kun Wu, Hanjiang Wu

“…Univariable and multivariable cox analysis were conducted to identify independent prognostic factors of the patients. …”
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Negative Expression of DSG1 and DSG2, as Prognostic Biomarkers, Impacts on the Overall Survival in Patients with Extrahepatic Cholangiocarcinoma by Shu Xu, Shengfu Huang, Daiqiang Li, Qiong Zou, Yuan Yuan, Zhulin Yang

“…In comparison to patients with negative DSG1 and/or DSG2 expression, the average overall survival time of those with positive expression was significantly longer (P=0.000). Cox multivariate analysis revealed that negative DSG1 and DSG2 expressions were independent of poor prognosis factors in EHCC patients. …”
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Surgical margins of the oral cavity: is 5 mm really necessary? by James Fowler, Yael Campanile, Andrew Warner, Francisco Laxague, Naif Fnais, Kevin Fung, Adrian Mendez, Danielle MacNeil, John Yoo, David Palma, Anthony Nichols

“…Descriptive statistics, as well as univariable and multivariable Cox proportional hazards regression modelling were performed for all patients. …”
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Microbial diversity, functional attributes, and nutritional proficiency of yogurts produced in Bangladesh by Md. Tanvir Islam, M. Shaminur Rahman, Susmita Roy Chowdhury, Tanay Chakrovarty, S. M. Kador, Md. Mazharul Islam, Khondoker Tanjim Islam, Mohammad Imtiaj Uddin Bhuiyan, Ovinu Kibria Islam

“…Among the samples, those from Cox's Bazar exhibited the greatest bacterial diversity. …”
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Impact of handgrip strength on cardiovascular, cancer and all-cause mortality in the Korean longitudinal study of ageing by Gyu Ri Kim, Jiyu Sun, Minkyung Han, Sohee Park, Chung Mo Nam

“…Estimates of handgrip strength were collected using a handheld dynamometer. Cox proportional hazard models with time-varying covariates were used to estimate HRs and their 95% CIs for all-cause mortality. …”
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Targeting EP2 Receptor Improves Muscle and Bone Health in Dystrophin^−/−/Utrophin^−/− Double-Knockout Mice by Xueqin Gao, Yan Cui, Greg Zhang, Joseph J. Ruzbarsky, Bing Wang, Jonathan E. Layne, Xiang Xiao, Johnny Huard

“…We found that Ep2, Ep4, Cox-2, 15-Pgdh mRNA, and PGE2 were significantly increased in DKO-Hom mice compared to wild-type (WT) mice. …”
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Predicting the Development of Gastric Neoplasms in a Healthcare Cohort by Combining Helicobacter pylori Antibodies and Serum Pepsinogen: A 5-Year Longitudinal Study by Min-Sun Kwak, Goh Eun Chung, Su Jin Chung, Seung Joo Kang, Jong In Yang, Joo Sung Kim

“…During the 5.6 years of mean follow-up period, the annual incidence of gastric neoplasms increased gradually by 0.06% in group A, 0.16% in group B, 0.38% in group C, and 0.49% in group D. A Cox proportional hazard model showed increased development of gastric neoplasms according to group (P for trend = 0.025). …”
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Lebanese Cannabis sativa L. extract protects from cisplatin-induced nephrotoxicity in mice by inhibiting podocytes apoptosis by Alia Khalil, Sahar Al Toufaily, Wassim Shebaby, Marissa El Hage, Dima Mroue, Wissam Faour, Mohamad Mroueh

“…Western blot analysis showed that COE inhibited COX-2 protein induction as well as apoptosis marker production (Bax/Bcl2 ratio) in cisplatin-treated mice when compared to mice treated with cisplatin alone. …”
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Association between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort study by Zhen Guo, Zhenyu Xiong, Lixiang He, Shaozhao Zhang, Xinghao Xu, Guanzhong Chen, Mengjie Xie, Wenjing Zhang, Ziwen Hui, Jiaying Li, Xinxue Liao, Xiaodong Zhuang

“…Patients were divided into two groups according to the cut-off value of TyG-BMI index (Ln[triglycerides (mg/dL)* glucose (mg/dL)/2]*BMI). Cox regression and restricted subgroup analysis were used to evaluate the association of TyG-BMI index and progression of non-severe AS. …”
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Surgical treatment of obesity and excess risk of developing heart failure in a controlled cohort study by Christina E. Lundberg, Shabbar Jamaly, Martin Adiels, Jesper Lagergren, Carl Johan Svensson, Lena Björck, Annika Rosengren

“…These groups were compared with 55 149 and 78 004 matched population controls, respectively. Cox regression provided hazard ratios (HR) with 95% confidence intervals (CI), adjusted for age, education, and sex. …”
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