CZYH Alleviates β-Amyloid-Induced Cognitive Impairment and Inflammation Response via Modulation of JNK and NF-κB Pathway in Rats by Yuanyuan Deng, Lianzhi Ye, Cheng Yu, Caixia Yin, Jingshan Shi, Qihai Gong

“…The protein expression levels of TNF-α, IL-1β, and COX-2 were also repressed by CZYH. Besides, CZYH treatment alleviated Aβ-induced IκB-α degradation and NF-κB p65 phosphorylation, as well as reduced the JNK phosphorylation level. …”
Get full text

Ferroptosis genes and ST-segment elevation myocardial infarction outcomes: A predictive signature by Xing-jie Wang, Lei Huang, Min Hou, Jie Guo, Xi-ming Li

“…We built an optimal model with least absolute shrinkage and selection operator (LASSO) penalized Cox proportional hazards regression. We tested the clinical value of the signature with survival analysis, ROC curve, decision curve analysis and a prognostic nomogram. …”
Get full text

Multimodal treatments and the risk of breast cancer-related lymphedema: insights from a nationally representative cohort in South Korea by Sung Hoon Jeong, Seong Min Chun, Miji Kim, Ye Seol Lee, Jisun Kim, Ja-Ho Leigh, Yoon-Hee Choi

“…Methods In this retrospective study conducted using National Health Insurance data and the Korea National Cancer Incidence Database (2006–2017), 114,638 participants who underwent Surgery (Surg) or Chemo within 6 months after breast cancer diagnosis were enrolled, and the effect of multimodality treatment on the risk of BCRL was analyzed using the Cox proportional-hazards model. Multimodality treatment administered through six months of treatment was grouped as only Surg; Surg/Chemo; Surg/ Chemo/Radio; Surg/Radio; only Chemo; and Chemo/Radio. …”
Get full text

Improving prognostic evaluations in patients with stage IIIb light chain cardiac amyloidosis: role of haemodynamic parameters by Jingyi Li, Yang Lu, Xiqi Xu, Zhuang Tian, Jian Li, Shuyang Zhang

“…Methods In this retrospective cohort study, we conducted invasive haemodynamic measurements concurrently with myocardial biopsies to diagnose AL-CA. We used Cox regression analysis and time-dependent receiver operating characteristic curve analysis to study the associations between these measurements and overall mortality. …”
Get full text

Morphological and molecular changes in renal tissue following experimental unilateral ureteral obstruction in rat kidneys by Tuncer KUTLU, Huseyin OZKAN, Ziya YURTAL, Ufuk KAYA, Mehmet GUVENC

“…These included the formation of cystic dilated tubules, a decrease in cyclooxygenase-2 (COX-2) gene expression, and a reduction in glutathione peroxidase (GSH-Px) levels. …”
Get full text

Quantitative Proteomics Analysis Reveals XDH Related with Ovarian Oxidative Stress Involved in Broodiness of Geese by Ning Zhou, Yaoyao Zhang, Youluan Jiang, Wang Gu, Shuai Zhao, Wanwipa Vongsangnak, Yang Zhang, Qi Xu, Yu Zhang

“…Antioxidant activity (GSH, CAT, SOD, T-AOC, and the content of H₂O₂) and the mRNA expression levels of antioxidant genes (GPX, SOD-1, SOD-2, CAT, COX-2, and Hsp70) were significantly higher in pre-broody geese compared to laying geese, while the expression of apoptosis-related genes (p53, Caspase-3, and Caspase-9) increased and the anti-apoptotic gene Bcl-2 decreased. …”
Get full text

Association of composite dietary antioxidant index with mortality risk among adults with chronic kidney disease in NHANES by Jun Sun, Haoyu Yang, Aru Sun, Huifang Guan, Weinan Xie, Lin Han, Yu Wei, Xiaoyu Zang, Pengfei Xie, Xiaolin Tong, Yiqun Lin

“…This study included 6379 adult CKD patients from the National Health and Nutrition Examination Survey (2001–2018). Use the Cox proportional hazards model, restricted cubic spline (RCS) model, and stratified and sensitivity analysis to evaluate the relationship between the Composite Dietary Antioxidant Index (CDAI) and mortality in patients with chronic kidney disease. …”
Get full text

Personalized treatment strategies for breast adenoid cystic carcinoma: A machine learning approach by Sakhr Alshwayyat, Mahmoud Bashar Abu Al Hawa, Mustafa Alshwayyat, Tala Abdulsalam Alshwayyat, Siya sawan, Ghaith Heilat, Hanan M. Hammouri, Sara Mheid, Batool Al Shweiat, Hamdah Hanifa

“…To identify the prognostic variables, we conducted Cox regression analysis and constructed prognostic models using five Machine Learning (ML) algorithms to predict the 5-year survival. …”
Get full text

Postoperative Morbidity and Mortality of Perforated Peptic Ulcer: Retrospective Cohort Study of Risk Factors among Black Africans in Côte d’Ivoire by Soro Kountele Gona, Mahassadi Kouamé Alassan, Koffi Gnangoran Marcellin, Kissi Ya Henriette, Coulibaly Adama, Assohoun Toussaint, Ehua Adjoba Manuela, Seu Gagon Sylvain, Afum-Adjei Awuah Anthony, Ehua Somian Francis

“…Variables were studied with Kaplan Meier and Cox proportional hazard models. Results. Among 161 patients operated on for PPU, 36 (27.5%) experienced complications and 31 (19.3%) died. …”
Get full text

18F-FDG-PET/CT can be used to predict distant metastasis in hypopharyngeal squamous cell carcinoma by Shinsuke Suzuki, Satoshi Toyoma, Tomoe Abe, Tentaro Endo, Teppei Kouga, Yohei Kaswasaki, Takechiyo Yamada

“…Univariate and multivariate Cox hazard regression analyses were used in identifying associations between the SUVmax and other clinicopathological factors with distant metastasis-free survival. …”
Get full text

Association between transarterial chemoembolization refractoriness and prognosis in Chinese patients with hepatocellular carcinoma: a large retrospective cohort study by Qinxue Sun, Ziliang Wu, Xi Yin, Feng Li, Ri Liu

“…Kaplan-Meier survival analysis and multivariate Cox regression models were performed to evaluate the association between TACE-Refractoriness and OS. …”
Get full text

Novel metabolic prognostic score for predicting survival in patients with cancer by Jinyu Shi, Chenan Liu, Xin Zheng, Yue Chen, Heyang Zhang, Tong Liu, Qi Zhang, Li Deng, Hanping Shi

“…The least absolute shrinkage and selection operator (LASSO) analysis was used to screen for indicators of metabolic disorders. Cox regression analysis was used to evaluate the independent association between indicators of metabolic disorders and mortality in patients. …”
Get full text

A Proposal of a Personalized Surveillance Strategy for Gastric Cancer: A Retrospective Analysis of 9191 Patients by Si-wei Pan, Peng-liang Wang, Han-wei Huang, Lei Luo, Xin Wang, Tao Wang, Fu-nan Liu, Hui-mian Xu

“…Disease-specific survival was analyzed by Kaplan-Meier method and the log-rank test. Cox proportional hazards regression analyses were used to confirm the independent prognostic factors. …”
Get full text

Prognostic prediction for inflammatory breast cancer patients using random survival forest modeling by Yiwei Jia, Chaofan Li, Cong Feng, Shiyu Sun, Yifan Cai, Peizhuo Yao, Xinyu Wei, Zeyao Feng, Yanbin Liu, Wei Lv, Huizi Wu, Fei Wu, Lu Zhang, Shuqun Zhang, Xingcong Ma

“…Methods: Clinical information of 1,230 IBC patients from 2010 to 2020 was extracted from the Surveillance, Epidemiology and End Results (SEER) database. Cox analysis was applied to identify clinicopathological characteristics associated with the overall survival (OS) of IBC patients. …”
Get full text

GNA15 predicts poor outcomes as a novel biomarker related to M2 macrophage infiltration in ovarian cancer by Qin Liu, Qin Liu, Yabing Sun, Yabing Sun, Tao Zhang, Wanrun Lin, Jing Zhang, Huijuan Zhang, Huijuan Zhang, Wenxin Zheng, Hong Xu, Hong Xu, Feng Zhou, Feng Zhou

“…This study aims to establish a novel prognostic signature and identify M2-like TAM-related biomarkers in OC using RNAseq-based transcriptome analysis.MethodsPrognostic M2-like TAM-related genes were identified through univariate Cox regression, consensus clustering, and LASSO regression. …”
Get full text

The Clinical Significance of HLA Compatibility Scores in Lung Transplantation by Liesbeth Daniëls, Liesbeth Daniëls, Hanne Beeckmans, Andrea Zajacova, Pieterjan Kerckhof, Saskia Bos, Maarten Naesens, Bart Vanaudenaerde, Frans Claas, Frans Claas, Robin Vos, Robin Vos

“…Since HLA disparity between donor and recipient plays a major role in rejection, we performed a single center, retrospective observational cohort analysis in our lung transplant cohort (n = 128) in which we calculated HLA compatibility scores for B-cell epitopes (HLAMatchmaker, HLA-EMMA), T-cell epitopes (PIRCHE-II) and missing self-induced NK cell activation (KIR Ligand Calculator). Adjusted Cox proportional hazards model was used to investigate the association between mismatched scores and time to development of donor-specific antibodies (DSA) post-transplant, time to first biopsy-proven acute rejection episode, freedom from CLAD, graft survival and overall survival. …”
Get full text

Comparative the impact intraoperative phrenic nerve sacrifice on prognosis patients with thymoma by Hongyun Ruan, Xuehui Shang, Dongjie Yan, Bin Liu, Fangchao Liu, Zhi Yang

“…A comparative analysis was conducted on postoperative complications, long-term survival recurrence between the two groups. Cox regression was used to analyze the factors related to the differences in short- and long-term prognosis between two groups. …”
Get full text

Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma by Yani Lu, Amr M. Abdou, James R. Cerhan, Lindsay M. Morton, Richard K. Severson, Scott Davis, Wendy Cozen, Nathaniel Rothman, Leslie Bernstein, Stephen Chanock, Patricia Hartge, Sophia S. Wang

“…During a median followup of 89 months, 31% (52 of 166) DLBCL and 28% (46 of 165) FL patients died. Using multivariate Cox regression models, we observed statistically significant associations between genetic variants and survival: HLA-Cw*07:01 was associated with poorer OS among DLBCL patients (Hazard ratio [HR] = 1.76, 95% confidence interval [CI] = 1.01–3.05); HLA-A*01:01 was associated with poorer OS (HR = 2.23, 95% CI = 1.24–4.01), and HLA-DRB1*13 (HR = 0.12, 95% CI = 0.02–0.90) and HLA-B Bw4 (HR = 0.36, 95% CI = 0.20–0.63) with better OS among FL patients. …”
Get full text

CD34 evaluation of microvasculature in lung adenocarcinoma and its microvascular density predicts postoperative tumor recurrence by Zijian Qiu, Jiaji Wu, Guanchao Pang, Xia Xu, Jun Lin, Pingli Wang

“…Survival analysis suggested that patients with high MVD had higher disease-free survival (log-rank P = 0.005) and overall survival (log-rank P = 0.004) compared to patients with low MVD. The Cox proportional hazards model showed that a high MVD (P = 0.022) reduced the risk of postoperative tumor recurrence in patients with LUAD.ConclusionDecreased intratumoral CD34 positive microvessels were associated with tumor development in patients with LUAD. …”
Get full text

Impact of thoracic radiotherapy on first‐line treatment outcomes in ES‐SCLC patients by Xiaoli Mu, Yixin Zhou, Qing Liu, Jiantao Wang, Feng Xu, Feng Luo, Ke Wang, Lu Li, Panwen Tian, Yalun Li, Jiewei Liu, Yan Zhang, Jiyan Liu, Yan Li

“…The primary outcomes were overall survival (OS) and progression‐free survival (PFS). Cox regression analysis was utilized to identify potential independent predictors of prognosis and to compare the treatment outcomes across various patient subgroups. …”
Get full text