Associations of Abnormal Sleep Duration and Chronotype with Higher Risk of Incident Amyotrophic Lateral Sclerosis: A UK Biobank Prospective Cohort Study by Gan Zhang, Wen Cao, Zhuoya Wang, Kailin Xia, Binbin Deng, Dongsheng Fan

“…All sleep traits were analyzed in relation to the subsequent incidence of ALS using Cox proportional hazards models. <b>Results:</b> Multivariate analysis showed that 6–7 h of sleep was related to the lowest risk for ALS. …”
Get full text

New model to predict survival in advanced pancreatic ductal adenocarcinoma patients by measuring GGT and LDH levels and monocyte count by Rocío del Campo-Pedrosa, Rocío del Campo-Pedrosa, Alfonso Martín-Carnicero, Ana González-Marcos, Alfredo Martínez

“…Cut-off points for hematological parameters were calculated and correlated with overall survival (OS) using Kaplan-Meier, log-rank test, robust Cox proportional hazards and logistic regressions.ResultsIn univariate analysis, individuals with low levels of GGT, LDH, ALP, leukocyte-, neutrophil- and monocyte counts showed significantly longer survival than patients with higher levels. …”
Get full text

Treatment Interruption and Regimen Change in Firstgeneration versus Second-generation Tyrosine Kinase Inhibitors used as First-line Therapy for Chronic Myeloid Leukemia by Melea A. Ward, Gang Fang, Kristy L. Richards, Christine M. Walko, Stephanie R. Earnshaw, Laura E. Happe, Susan J. Blalock

“…Treatment interruption and regimen change were compared using multivariable Cox proportional hazard regression models. Treatment interruption was defined as a gap in any TKI pharmacy claim that was longer than an allowable refill gap plus days’ supply from the previous TKI medication claim. …”
Get full text

The Diagnostic Journey of Dysautonomia Patients: Insights from a Patient-Reported Outcome Study by John A. O’Dell MSN, MBA, Ash Walker DHSc, Andrew J. Latham PhD, Daniel J. Parisian PhD, Lindsay E. Branch BS, Dreena D. Vanderburg, Ava A. Cox, Shelley Chavis, Silvia E. Smith PhD

Get full text

Association between the depressive symptom trajectories and all-cause mortality in Chinese middle-aged and elderly adults by Yayun Fan, Dingliu He, Lin Chen, Chunxia Ge

“…Group-based trajectory modeling was used to identify the different trajectories of depressive symptoms. The multivariable Cox regression model was used to examine the association between long-term depressive symptom trajectories and all-cause mortality. …”
Get full text

Association of oxidative balance score with all-cause and cardiovascular mortality in overweight and obese by Shuxin Ying, Hongyan Ding, Yanjin Chen, Su Zheng

“…Kaplan–Meier survival analysis, along with multivariate Cox regression and restricted cubic spline (RCS) modeling, were utilized to explore the link between OBS and mortality risks. …”
Get full text

Predicting pain and its association with mortality in patients with stroke by Adam Viktorisson, Aref Haj Hashem, Katharina S Sunnerhagen, Tamar Abzhandadze

“…The association between PSP and one-year poststroke mortality was examined using Cox proportional hazards models. Results Among 4,160 stroke patients participating in the three-month follow-up, 54.7% reported PSP. …”
Get full text

A Prediction Model for Prediabetes Risk in Middle-Aged and Elderly Populations: A Prospective Cohort Study in China by Jiahua Wu, Jiaqiang Zhou, Xueyao Yin, Yixin Chen, Xihua Lin, Zhiye Xu, Hong Li

“…The associations between possible indicators and prediabetes were assessed by the Cox proportional-hazards model. The predictive values were evaluated by the area under the receiver operating characteristic (ROC) curve (AUC). …”
Get full text

喉癌切缘中eIF4E、p53、ras和c-myc表达与预后的研究 by 雷文斌, 苏振忠, 文卫平, 柴丽萍, 蒋爱云, 廖冰

“…【结果】喉癌原发灶eIF4E、p53、ras和c-myc阳性率分别是100%（42/42）,57.1%（24/42）,40.5%（17/42）和33.3%（14/42）;手术切缘eIF4E、p53、ras、c-myc和两个以上基因阳性率分别是42.8%（18/42）、14.3%（6/42）、9.5%（4/42）,9.5%（4/42）和21.4%（9/42）,生存分析提示切缘eIF4E、p53或两个以上基因阳性组复发率高,5年生存率低;COX回归分析提示切缘eIF4E表达阳性与预后相关。【结论】喉癌切缘eIF4E阳性的患者复发率高,预后不良。…”
Get full text

Association between red blood cell distribution width-to-albumin ratio at admission and all-cause mortality in patients with acute pancreatitis based on the MIMIC-III database. by Qingsong Wu, Lianyi Liao, Qingjun Deng

“…Multivariate analysis indicated that potassium levels, total bilirubin, blood urea nitrogen, lactate, partial thromboplastin time, neutrophil and RAR were independently associated with the 28-day mortality. Multivariate Cox regression analysis confirmed that an elevated RAR was independently associated with increased mortality at 28 day (HR, 2.72; 95% CI, 1.64-4.52; p < 0.001).…”
Get full text

Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells by Marta Buzzetti, Sonia Morlando, Dimitrios Solomos, Ammara Mehmood, Alexander W. I. Cox, Mattia Chiesa, Yuri D’Alessandra, Michela Garofalo, Caroline H. Topham, Gianpiero Di Leva

Get full text

Outcomes of Pembrolizumab plus chemotherapy for patients with metastatic non-squamous NSCLC: Real-world evidence by Irina Surovtsova, Felix J. F. Herth, Daria B. Kokh, Philipp Morakis

“…OS was assessed using Kaplan-Meier and multivariable Cox models, adjusted for major clinical parameters. …”
Get full text

Impact of Visit-to-Visit Triglyceride-Glucose Index Variability on the Risk of Cardiovascular Disease in the Elderly by Fei Chen, Ying Pan, Ziqing Liu, Rong Huang, Jing Wang, Jian Shao, Yaqin Gong, Xiyi Sun, Xiaobo Jiang, Weihao Wang, Zhaoqiang Li, Shao Zhong, Qi Pan, Kaixin Zhou

“…CVD events were identified from the chronic disease registry or follow-up database and included myocardial infarction, angina, coronary, and stroke. Multivariate Cox regression was used to examine the correlation between TyG variability and incident CVD. …”
Get full text

MRI对局部晚期直肠癌新辅助放化疗中无瘤生存期的评估价值

“…用Kaplan-Meier 法比较DFS,进行log-rank 检验,多因素分析采用Cox比例风险模型进行?【结果】 121例患者,新辅助放化疗后病理上有淋巴结转移的31例?有癌残留的有93例(76.86%);肿瘤完全消退的有28例(23.14%)?…”
Get full text

Cardiac events and procedures following COVID-19 compared with other pneumonias: a national register study by Knut Stavem, Peder Langeland Myhre, Kristian Berge, Tarjei Øvrebotten, Birgitte Tholin

“…We defined outcomes using ICD-10 codes for incident myocarditis, acute myocardial infarction, atrial fibrillation/flutter, heart failure, ischaemic heart disease, other cardiac disease and total cardiac disease (any heart condition). We used Cox regression and logistic regression for analysis.Results Patients with COVID-19 had a mean (SD) age of 60 (18) years, compared with 69 (19) years for viral and 72 (17) years for bacterial pneumonia. …”
Get full text

The impact of gender-affirming interventions on eating disorder diagnosis risk among transgender and gender-diverse individuals by Matthew Loria, Tomasz Tabernacki, Elad Fraiman, Jaime Perez, Jessica Abou Zeki, Julia Palozzi, Carly Goldblatt, Shubham Gupta, Kirtishri Mishra, Megan McNamara, Swagata Banik

“…To assess the risk of eating disorder diagnoses across groups, we applied a Cox proportional hazards model with gender-affirming care as a time-varying covariate. …”
Get full text

Study protocol for an epidemiological study ‘Multimorbidity − identifying the most burdensome patterns, risk factors and potentials to reduce future burden (MOLTO)’ based on the Fi... by Annamari Lundqvist, Seppo Koskinen, Päivikki Koponen, Tuija Jääskeläinen, Jaana Suvisaari, Jutta Järvelin

“…The burden caused by multimorbidity as well as risk and protective factors for multimorbidity will be analysed by survival analysis methods such as Cox proportional hazards and Poisson regression models.Ethics and dissemination The survey data have been collected following the legislation at the time of the survey. …”
Get full text

Weight-Adjusted Waist Index, Psoriasis, and All-Cause Mortality: Findings from the NHANES 2003&ndash;2006 and 2009&ndash;2014 by Zhou T, Wu J, Wang Y, Gao Y, Cheng K

“…Survival probabilities were assessed employing Kaplan-Meier curves and Cox regression analyses.Results: Out of the 19,919 subjects that we eventually included, 522 had psoriasis. …”
Get full text

Role of the Kaiso gene in the development of inflammation in Mucin-2 defcient mice by E. A. Litvinova, K. M. Achasova, M. A. Borisova, S. V. Zhenilo, E. B. Prokhortchouk, E. N. Kozhevnikova

“…The defciency of the Kaiso transcription factor in Mucin-2 knockout mice causes a decrease in the expression level of only the Cox2 and Tff3 genes. Perhaps a decline in the expression of the gene encoding cyclooxygenase-2 can lead to a decrease in the expression of the antibacterial factor Trefoil factor 3. …”
Get full text

Loss of H2A.Z Is Not Sufficient to Determine Transcriptional Activity of Snf2-Related CBP Activator Protein or p400 Complexes by Tamara A. Bowman, Madeline M. Wong, Linda K. Cox, Joseph J. Baldassare, John C. Chrivia

Get full text