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  1. 1161
  2. 1162

    Indirect determination of hemoglobin A2 reference intervals in Pakistani infants using data mining by Muhammad Shariq Shaikh, Sibtain Ahmed, Saba Farrukh, Shahnawaz Bayunus

    Published 2025-01-01
    “…RIs were computed using an indirect KOSMIC algorithm, which assumes non-pathologic samples follow a Gaussian distribution after Box-Cox transformation. Results A total of 88,690 specimens were analyzed for HbA2. …”
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  3. 1163

    Long-Term Use of Antibiotics and Risk of Parkinson’s Disease in the Nurses’ Health Study by Natalia Palacios, Éilis J O’Reilly, Michael A. Schwarzschild, Alberto Ascherio

    Published 2020-01-01
    “…We conducted a prospective study of 59,637 women in the Nurses’ Health Study who reported total duration of antibiotic use at ages 20–39, 40–59, 60 +, or during the past 4 years. We used Cox Proportional Hazard regression to estimate hazard ratios and 95% confidence intervals for the association between categories of antibiotic use and risk of PD. …”
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  4. 1164

    Long-Term Mortality following Acute Noninvasive Ventilation for Obesity-Related Respiratory Failure: A Retrospective Single-Centre Study by Aditya Krishnan, Paul Ellis, Pearlene Antoine-Pitterson, Amy Oakes, Bethany Jones, Alice Turner, Rahul Mukherjee

    Published 2023-01-01
    “…Adults with hypercapnic ORRF requiring acute NIV were included. pH data were grouped by threshold (pH≤ and >7.25) and correlated with time from presentation to death; multivariable analysis was performed using Cox proportional hazards. Results. A total of 277 acute NIV episodes were included. …”
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  5. 1165

    The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis by Ying He, Ying He, Yongqing Liu, Min Zhang

    Published 2025-01-01
    “…Furthermore, curcumin has a potent inhibitory effect on the activity of nuclear factor kappa B (NF-κB) and cyclooxygenase-2 (COX-2), which are involved in the overexpression of antiapoptosis genes such as Bcl-2. …”
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  6. 1166

    LncRNA HOTAIR: A Novel Biomarker for the Diagnosis of Asymptomatic Carotid Artery Stenosis and Prediction of the Onset of Cerebral Ischemic Events by Pengcheng Feng, Chenguang Tong, Yuan Li, Li Liu

    Published 2024-07-01
    “…Predictive value of serum HOTAIR levels for the occurrence of CIE was assessed by Kaplan–Meier curves and Cox regression. Results Serum HOTAIR was markedly lower in ACAS patients than in controls (P < 0.001). …”
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  7. 1167
  8. 1168

    Associations between the Global Diet Quality Score and risk of type 2 diabetes: Tehran lipid and glucose study. by Shahrzad Daei, Firoozeh Hosseini-Esfahani, Azam Ildarabadi, Parvin Mirmiran, Fereidoun Azizi

    Published 2025-01-01
    “…Biochemical and anthropometric characteristics were assessed during the first and follow-up surveys. Multivariable Cox proportional hazards regression models were used to estimate the progression of T2D in association with the GDQS.…”
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  9. 1169

    Stromal Expression of Hypoxia Regulated Proteins Is an Adverse Prognostic Factor in Colorectal Carcinomas by Arjen H. G. Cleven, Manon van Engeland, Bradly G. Wouters, Adriaan P. de Bruïne

    Published 2007-01-01
    “…Furthermore expression of HIF-2α and CA9 in tumor-associated stroma were both associated with a significantly reduced overall survival. In the Cox proportional hazard model, stromal HIF-2α expression was an independent prognostic factor for survival. …”
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  10. 1170
  11. 1171

    Moringa oleifera Flower Extract Suppresses the Activation of Inflammatory Mediators in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages via NF-κB Pathway by Woan Sean Tan, Palanisamy Arulselvan, Govindarajan Karthivashan, Sharida Fakurazi

    Published 2015-01-01
    “…Hydroethanolic extract of M. oleifera flower significantly suppressed the secretion and expression of NO, prostaglandin E2 (PGE2), interleukin- (IL-) 6, IL-1β, tumor necrosis factor-alpha (TNF-α), nuclear factor-kappa B (NF-κB), inducible NO synthase (iNOS), and cyclooxygenase-2 (COX-2). However, it significantly increased the production of IL-10 and IκB-α (inhibitor of κB) in a concentration dependent manner (100 μg/mL and 200 μg/mL). …”
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  12. 1172

    Improving HIV testing and retention among adolescents and youths: Lessons from a quasi-experimental study of the Red-Carpet Program in Malawi. by Rachel Chamanga, Tessa Musukwa, Cosima Lenz, Louiser Kalitera, Geoffrey Singini, Felix Gent, Harrid Nkhoma, Godfrey Woelk, Judith Kose, Thulani Maphosa

    Published 2024-01-01
    “…Kaplan-Meier curves were employed to assess longitudinal outcomes, and Cox regression analysis was used to estimate the hazard of non-retention in care. …”
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  13. 1173

    EGFR as a biomarker of smoking status and survival in oropharyngeal squamous cell carcinoma by Shanmugappiriya Sivarajah, Morris Kostiuk, Cameron Lindsay, Lakshmi Puttagunta, Daniel A. O’Connell, Jeffrey Harris, Hadi Seikaly, Vincent L. Biron

    Published 2019-01-01
    “…Results A total of 249 patients were included retrospectively and 64 patients were enrolled prospectively. p16 status (p < 0.001), smoking above 10 pack years (p = 0.04), smoking above 20 pack years (p < 0.001), total EGFR tumor levels (p = 0.016), and high EGFR within high or low Ki67 tumor nuclear staining (p = 0.03) were found to be significant predictors of 5-year disease specific survival (DSS). A Cox proportional hazard model of DSS showed smoking status and eGFR expression to be dependent of each other on predicting 5-year DSS. ddPCR analysis showed a significant association between smoking status and EGFR levels. …”
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  14. 1174

    Interaction between sleep duration and physical activity on mortality among cancer survivors: findings from National Health and Nutrition Examination Surveys 2007–2018 by Ruyan Chen, Jianglong Han, Si Li, Haiyu Deng, Tingting Jian, Zheyu Huang, Yuxuan Wei, Zhenming Fu

    Published 2025-01-01
    “…However, the interaction between sleep duration and PA with mortality risk among cancer survivors has not been well explored.MethodsThis cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007–2018. Multivariable Cox regression analysis and restricted cubic splines were employed to evaluate the hazard ratios (HRs) and 95% confidence intervals (CIs) of the association of sleep duration and PA with mortality risk in cancer survivors. …”
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  15. 1175

    Smoking is associated with higher risk of contracting bacterial infection and pneumonia, intensive care unit admission and death. by Karl Stattin, Mikael Eriksson, Robert Frithiof, Rafael Kawati, Douglas Crockett, Michael Hultström, Miklos Lipcsey

    Published 2024-01-01
    “…The risks of contracting infection and pneumonia or dying in infection and pneumonia were assessed using Cox regression. Of 62,902 cohort participants, 25,297 contracted an infection of which 4,505 died; and 10,471 contracted pneumonia of which 2,851 died. …”
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  16. 1176

    A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer by Xin Zhang, Xingda Zhang, Guozheng Li, Yi Hao, Lei Liu, Lei Zhang, Yihai Chen, Jiale Wu, Xinheng Wang, Shuai Yang, Shouping Xu

    Published 2022-01-01
    “…Kaplan-Meier curves all showed an adverse prognosis for patients in the high-risk group. Cox assays confirmed that risk score was an independent prognostic factor for BRCA patients. …”
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  17. 1177

    Interference in Macrophage Balance (M1/M2): The Mechanism of Action Responsible for the Anti-Inflammatory Effect of a Fluorophenyl-Substituted Imidazole by Julia Salvan da Rosa, Eduarda Talita Bramorski Mohr, Tainá Larissa Lubschinski, Guilherme Nicácio Vieira, Thais Andreia Rossa, Marcus Mandolesi Sá, Eduardo Monguilhott Dalmarco

    Published 2024-01-01
    “…We also evaluated the anti-inflammatory effect of the compound, and the macrophage repolarization to M2 was confirmed by the ability of the compound to reduce the M1 markers TNF-α, IL-6, MCP-1, IL-12p70, IFN-γ, and TLR4, the high levels of p65 phosphorylated, iNOS and COX-2 mRNA expression, and the fact that the compound was not able to induce the production of M1 markers when used in macrophages without lipopolysaccharide (LPS) stimulation. …”
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  18. 1178

    Tamsulosin use in benign prostatic hyperplasia and risks of Parkinson's disease, Alzheimer's disease and mortality: An observational cohort study of elderly Medicare enrollees. by Kin Wah Fung, Fitsum Baye, Seo H Baik, Clement J McDonald

    Published 2024-01-01
    “…<h4>Materials and methods</h4>All male Medicare enrollees aged 65 or above who were diagnosed with benign prostatic hyperplasia and received one of the study drugs between 2007-2020 were followed-up for the three outcomes. We used Cox regression analysis to assess the relative risk of each of the outcomes for each study drug compared to the most prescribed drug, tamsulosin, while controlling for demographic, socioeconomic and comorbidity factors.…”
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  19. 1179

    Prognostic impact of psychoeducation program completion on inpatients with schizophrenia: a pilot cohort study by Hiroki Noguchi, Seiichiro Tarutani, Yoshiki Takei, Koichi Matsumoto, Takehiko Okamura, Hiroshi Yoneda

    Published 2025-01-01
    “…Results DOT was significantly longer in the program completion group than in the noncompletion group (918.2 (174.3) days vs. 225.5 (35.7) days, p = 0.001), and multivariate Cox proportional hazards regression analysis revealed that program noncompliance was associated with a 4.450-fold (p = 0.002) greater risk of discontinuation of outpatient treatment according to multivariate analysis. …”
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  20. 1180

    Incidence and Predictors of Outcome in the Treatment of In-Stent Restenosis with Drug-Eluting Balloons, a Real-Life Single-Centre Study by Kyle Murnaghan, Helen Bishop, Navjot Sandila, Bakhtiar Kidwai, Lawrence Title, Ata Ur Rehman Quraishi, Catherine Kells, Hussein Beydoun, Osama Elkhateeb

    Published 2022-01-01
    “…The one-year TLR rate was 4.3%, and the five-year rate was 18.7%. The univariable-Cox proportional hazard models for TLR showed lesion length, and the number of DEBs per vessel is associated with adverse outcomes with H.R. of 1.038 (1.007–1.069) and 4.7 (1.6–13.8), respectively. …”
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