Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature by Sandra Maria Barbalho, Beatriz Leme Boaro, Jéssica da Silva Camarinha Oliveira, Jiří Patočka, Caroline Barbalho Lamas, Masaru Tanaka, Lucas Fornari Laurindo

“…The key findings highlight that plants like <i>Cleistocalyx nervosum</i> var. paniala, <i>Curcuma longa</i>, <i>Cannabis sativa</i>, and <i>Dioscorea nipponica</i> reduce pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), inhibit enzymes (COX-2 and iNOS), and activate antioxidant pathways, particularly Nrf2. …”
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Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank by Jaegyun Jung, Sangyeon Lee, Jeong Ho Lee, Doheon Lee

“…After the genetic stratification of the depression phenotype cohort using hierarchical clustering, multivariable logistic regression models and Cox proportional hazards models were built to investigate the associations between physical activity and the risk of self-harm behaviour. …”
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Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries by Hui-shan Wang, Xian-xiu Ge, Quan-peng Li, Jun-jie Nie, Lin Miao

“…The relationship between PT and survival times was analyzed through univariate and multivariate analyses (Cox proportional hazards model). Kaplan–Meier curves and log-rank test were used to assess the effects of PT on overall survival (OS) and tumor recurrence-free survival (RFS). …”
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Urinary Sodium Concentration Is an Independent Predictor of All-Cause and Cardiovascular Mortality in a Type 2 Diabetes Cohort Population by Pierre-Jean Saulnier, Elise Gand, Stéphanie Ragot, Lise Bankir, Xavier Piguel, Frédéric Fumeron, Vincent Rigalleau, Jean-Michel Halimi, Richard Marechaud, Ronan Roussel, Samy Hadjadj, SURDIAGENE Study group

“…Baseline UNa was measured from second morning spot urinary sample. We used Cox proportional hazard models to identify independent predictors of mortality. …”
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Sleep Pattern, Lifestyle Pattern, and Risks of Overall and 20 Types of Cancers: Findings From the UK Biobank Cohort by Yue-Ze Zhao, Yue-Ze Zhao, Wen-Li Zhang, Kai-Wen Zhang, Yong-Qiao He, Wen-Qiong Xue, Da-Wei Yang, Da-Wei Yang, Hua Diao, Hua Diao, Ruo-Wen Xiao, Ying Liao, Qiao-Ling Wang, Qiao-Ling Wang, Wei-Hua Jia, Wei-Hua Jia, Tong-Min Wang

“…The effect of healthy sleep and lifestyle on cancer risk was examined by Cox proportional hazard models.ResultsBoth healthy sleep and lifestyle patterns were significantly associated with a reduced risk of overall cancer and specific cancer sites. …”
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Downregulation of the immunoproteasome subunit PSMB8 attenuates sepsis-associated acute kidney injury through the NF-κB pathway by Min Li, Wenjia Tong, Chao Dai, Guoping Lu, Danqun Jin, Fang Deng

“…PSMB8 knockdown inhibited renal expression of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α) and COX-2 to improve inflammatory response. Mechanistic studies demonstrated that downregulation of PSMB8 blocked LPS-induced S-AKI phosphorylation and nuclear translocation of NF-κB P65. …”
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Evaluation of the Costs and Outcomes of COVID-19 Therapeutic Protocols in Critically Ill Patients in Alzahra Hospital, Isfahan, Iran by Majid Davari, Sarah Mousavi, Mohammad Reza Maracy, Elahe Khorasani, Masih Zamani, Mohammadreza Amirsadri

“…Statistical analysis included Cox-Regression analysis and Kaplan-Meier survival curve. …”
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Comparison of air-liquid interface transwell and airway organoid models for human respiratory virus infection studies by Camilla T. Ekanger, Camilla T. Ekanger, Camilla T. Ekanger, Nilima Dinesh Kumar, Rosanne W. Koutstaal, Fan Zhou, Martin Beukema, Joanna Waldock, Simon P. Jochems, Noa Mulder, Cécile A. C. M. van Els, Cécile A. C. M. van Els, Othmar G. Engelhardt, Nathalie Mantel, Kevin P. Buno, Karl Albert Brokstad, Karl Albert Brokstad, Agnete S. T. Engelsen, Agnete S. T. Engelsen, Rebecca J. Cox, Rebecca J. Cox, Barbro N. Melgert, Barbro N. Melgert, Anke L. W. Huckriede, Puck B. van Kasteren

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Construction of a prognostic model for gastric cancer based on immune infiltration and microenvironment, and exploration of MEF2C gene function by Si-yu Wang, Yu-xin Wang, Lu-shun Guan, Ao Shen, Run-jie Huang, Shu-qiang Yuan, Yu-long Xiao, Li-shuai Wang, Dan Lei, Yin Zhao, Chuan Lin, Chang-ping Wang, Zhi-ping Yuan

“…As a result, based on univariate and multivariate Cox regression, ICI Score was considered to be an independent prognostic factor for GC. …”
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All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES III by C. M. Durward, T. J. Hartman, S. M. Nickols-Richardson

“…Hazard ratios (HR) for all-cause mortality were estimated with Cox regression models. Nonpregnant women and men were included (n=4373, mean ± SD, age 37.1±10.9 years, BMI 27.3±5.8 kg/m2, 49.4% female). …”
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The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of Diabetic Kidney Disease by Hongtu Hu, Wei Liang, Zongwei Zhang, Zikang Liu, Fan Chu, Yan Bao, Jialu Ran, Guohua Ding

“…Kaplan–Meier survival curve analysis showed that H-PFT was associated with a higher incidence of albuminuria than L-PFT (log-rank test, χ2 = 4.522, P = 0.033). Cox regression analysis showed that PFT was a risk factor for the earlier onset of albuminuria (hazard ratio 2.83, 95% CI: 1.34–4.88, P < 0.001). …”
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Residual β-Cell Function in Type 1 Diabetes Followed for 2 Years after 3C Study by Kun Lin, Xiaoping Yang, Yixi Wu, Shuru Chen, Qiong Zeng

“…Results. 36.8% of patients had residual β-cell function, and the percentage was 68.2% in newly diagnosed diabetic patients. COX regression analysis indicated that the age of diagnosis, HbA1C level, and duration were independent factors of residual β-cell function in individuals with ≤5 years duration, but in those with duration ≥5 years, only the age of diagnosis was a predictor. …”
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Childhood peer status and circulatory disease in adulthood: a prospective cohort study in Stockholm, Sweden by Alexander Miething, Ylva Brännström Almquist

“…The survey material was linked to inpatient care registers that contained information about circulatory diseases (n=1668) across ages 20–63. Cox proportional hazard models were used for the analysis.Outcome measure Circulatory disease.Results Peer marginalisation at age 13 resulted in significantly higher risks of circulatory disease in adulthood among males (HR 1.34; 95% CI 1.09 to 1.64) and females (HR 1.33; 95% CI 1.04 to 1.70) alike. …”
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Gender differences in the prognostic impact of uric acid in patients with heart failure and preserved ejection fraction by Xuefeng Wu, Jianming Li, Zhaoyan Xu, Yingqing Feng

“…Kaplan–Meier survival analysis and stratified Cox regression examined the combined effect of gender and uric acid on the composite endpoint, and restricted cubic spline curves were applied to visualize the relationship. …”
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Association of expedited review programmes with postmarketing safety events of new drugs approved by the US food and drug administration between 2007 and 2017 by Bao Liu, Xingyue Zhu

“…The duration from marketing approval to the occurrence of a safety event was measured.Method Cox models were performed to determine the factors related to the time-to-safety event.Results The FDA approved 338 new drugs between 2007 and 2017, among which 53.6% (181) were under expedited review and 32.2% (109) received two or more expedited programmes. …”
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Therapeutic potential of Garlic (Allium sativum L.) on new models of asthma immune pathobiology: A review by VR Bataduwaarachchi, DCJ Liyanage, SMN Hansanie, HDSM Perera, LG D'Cruz

“…It also reduces vital key proinflammatory mediators, including IL-6, PGE2, and COX2, which are vital in asthma pathogenesis. Garlic (Allium sativum L.) compounds further suppress inflammatory response via modulation of NF-κB/IκB expression. …”
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Association between lactate dehydrogenase levels and all-cause mortality in ICU patients with heart failure: a retrospective analysis of the MIMIC-IV database by Panxu Guo, Hongfu Ding, Xiaowan Li, Danying Xie, Ke Wang, Wanmin Su, XiaoJuan Yang, Fang Nie, Peixi Wang

“…We utilized the restricted cubic spline (RCS) method, Kaplan-Meier (K-M) survival curves, and Cox regression analysis to assess the association between lactate dehydrogenase (LDH) levels and all-cause mortality in HF patients. …”
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Association Between Resting Heart Rate and the Risk of Incident Hypertension Among Older Chinese Adults: A Prospective Cohort Study by Shiyu Lou, Zihan Yu, Yizhu Song, Dechen Liu

“…A total of 3836 participants from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) were included in this prospective study. Using Cox proportional hazard models, the association between RHR and the risk of incident hypertension was evaluated, with results expressed as hazard ratios (HRs) and 95% confidence intervals (CIs). …”
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Associations Between Frailty and Risk of All-Cause and Cardiovascular Mortality in Patients with Prediabetes: A Population-Based Study by Zhao C, Wang K

“…Kaplan-Meier curves and weighted Cox proportional hazards regression were used to assess the association between frailty and mortality.Results: The weighted prevalence of frailty was 28.21% in this cohort of 7845 prediabetic participants with a mean age of 62.89 years. …”
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Clinical trial participation, clinical care, and patient outcomes by practice setting: a real-world database analysis of patients with Chronic Lymphocytic Leukemia or Mantle Cell L... by Debora S. Bruno, Manoj Khanal, Xiaohong Li, Maricer P. Escalon, Katherine Winfree, Lisa M. Hess

“…Overall survival (OS) was analyzed using Kaplan Meier method, censoring patients without events at last observation in the database. Cox proportional hazards regression model was used to adjust for baseline covariates.Results A total of 6,372 patients with CLL and 3,411 with MCL met eligibility criteria for this analysis; 13.9% and 22.2%, respectively, were treated in academic settings. …”
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