Predictive value of preoperative pan-immune-inflammation value index in the prognosis of oral cancer patients undergoing radical resection by Weihai Huang, Yulan Lin, Enling Xu, Yanmei Ji, Jing Wang, Fengqiong Liu, Fa Chen, Yu Qiu, Bin Shi, Lisong Lin, Baochang He

“…Univariate and multivariate Cox regression was used to assess the prognostic value of PIV, and propensity score matching (PSM) analysis was used to adjust for potential confounders. …”
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Renal Dysfunction, Metabolic Syndrome and Cardiovascular Disease Mortality by David Martins, Chizobam Ani, Deyu Pan, Omolola Ogunyemi, Keith Norris

“…A sample of 13115 non-pregnant individuals aged ≥35 years, with available follow-up mortality assessment was selected. Multivariable Cox Proportional hazard regression analysis techniques explored the relationship between co-clustered CKD, MetS and CVD mortality. …”
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Natriuretic Peptide System Activation in Acute Heart Failure Patients with Diabetes by Filipe M. Cunha, Joana Pereira, Pedro Marques, Helena Moreira, Pedro Rodrigues, Maria João Pinto, Patrícia Lourenço, Paulo Bettencourt

“…Diabetics and nondiabetics were compared. Cox-regression analysis was used to analyse the prognostic impact of diabetes. …”
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Methyl Canthin-6-one-2-carboxylate Inhibits the Activation of the NLRP3 Inflammasome in Synovial Macrophages by Upregulating Nrf2 Expression by Yuanyuan Chen, Zongying Zhang, Yuan Yao, Xiaorong Zhou, Yong Ling, Liming Mao, Zhifeng Gu

“…Our data reveal that exposure to Cant significantly suppressed the transcription and secretion of multiple pro-inflammatory mediators, including IL-1β, IL-6, IL-18, TNF-α, NO, and COX2, in a dose-dependent manner. These alterations were associated with changes in the activation of various signaling pathways, including NF-kB, MAPK, and PI3K-AKT pathways. …”
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PD-L1 Expression and CD8+ T Cell Infiltration Predict a Favorable Prognosis in Advanced Gastric Cancer by Yangyang Wang, Chunchao Zhu, Wei Song, Jun Li, Gang Zhao, Hui Cao

“…In contrast, a high density of FOXP3+ T cells in AGCs indicated a poor prognosis. Multivariate Cox regression analysis revealed that CD8+ T cell density acts as an independent predictor of overall survival (OS) in AGC patients. …”
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Impact of Centralisation of Radical Prostatectomy Driven by the Introduction of Robotic Systems on Positive Surgical Margin and Biochemical Recurrence in pT2 Prostate Cancer by Ibrahim Ibrahim, Omar Kouli, Sanjana Ilangovan, Melanie Sneddon, Sarika Nalagatla, Carol Marshall, Lorenzo Dutto, Hing Y. Leung, Imran Ahmad

“…Propensity score matching and Cox regression models were performed using R. Results A total of, 907 patients were included; 662 robot assisted radical prostatectomy (RARP), 245 open RP. …”
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Lonicera caerulea polyphenols inhibit fat absorption by regulating Nrf2-ARE pathway mediated epithelial barrier dysfunction and special microbiota by Yuehua Wang, Ningxuan Gao, Andrea Nieto-Veloza, Lingxi Zhou, Xiyun Sun, Xu Si, Jinlong Tian, Yang Lin, Xinyao Jiao, Bin Li

“…LCP also inhibited the dysfunction of the small intestine epithelial barrier, via alleviating the oxidative stress activated by Nrf2-ARE pathway, and by modulating the expressions of pro-inflammatory factors such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2), nuclear factor kappa-B p65 (NF-κB p65) and inducible nitric oxide synthase (iNOS) in the small intestine. …”
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Characterization of stem cell landscape and identification of stemness-relevant prognostic gene signature to aid immunotherapy in breast cancer by Xiaozhou Yang, Xiaojun Yang, Haili Tang, Xin Chen, Jiangang Wang, Huadong Zhao

“…Prognosis, tumor microenvironment (TME) elements, and treatment responses varied across subtypes. Using LASSO, Cox regression, and differential expression analysis, we developed a stemness-risk model. …”
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Incidence and Predictors of Antiretroviral Treatment Modification in HIV-Infected Adults: A Brazilian Historical Cohort from 2001 to 2010 by Letícia Penna Braga, Cássia Cristina Pinto Mendicino, Edna Afonso Reis, Ricardo Andrade Carmo, Cristiane Menezes de Pádua

“…Kaplan-Meier inverse survival curves were employed to describe the probability of ART modification and Cox proportional hazard regression was used to estimate the adjusted hazard ratio (aHR) of ART modification. …”
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Associations of daily step count with all-cause mortality and cardiovascular mortality in hypertensive US adults: a cohort study from NHANES 2005–2006 by Tuo Guo, Yang Zhou, Guifang Yang, Aifang Zhong, Xiaogao Pan, Yuting Pu, Michael Simons, Lijuan Sheng, Xiangping Chai

“…Methods We used data from the National Health and Nutrition Examination Survey 2005–2006, including 1,629 hypertensive participants with accelerometer-measured step counts. Cox proportional hazards models and restricted cubic spline regression were employed to assess the associations between daily step count and mortality outcomes. …”
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Residual Dyslipidemia Leads to Unfavorable Outcomes in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention by Bin Que, Chunmei Wang, Hui Ai, Xinyong Zhang, Mei Wang, Shaoping Nie

“…Of all 3,047 patients, those with a suboptimal goal were 67.75%, 85.85%, and 33.64% for LDL-C, HDL-C, and TG levels, respectively. Multiple Cox regression analysis revealed there were significant increases in cumulative MACCE of 41% (HR = 1.41, 95% CI [1.09–1.82], p=0.008), and revascularization of 48% (HR = 1.48, 95% CI [1.10–1.99], p=0.01) in low HDL-C patients with ACS after PCI, but not the high TG group at the end of study. …”
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Choroidal and Retinal Thickness of Highly Myopic Eyes with Early Stage of Myopic Chorioretinopathy: Tessellation by Yanping Zhou, Minlu Song, Minwen Zhou, Yiming Liu, Fenghua Wang, Xiaodong Sun

“…The odds ratio (OR) and 95% confidence interval (CI) was 0.975 (0.960–0.990, P=0.001, binary logistics regression) and 0.991 (0.984–0.999, P=0.022, Cox regression). The area under the curve (AUC) of SFCT was the greatest for detecting tessellation (AUC = 0.824, P<0.001). …”
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General obesity, abdominal obesity, and the risk of cardiovascular disease including stroke in 5-year breast cancer survivors by Ji Soo Kim, Jihun Song, Seulggie Choi, Sang Min Park

“…Among 72,174 5-year breast cancer survivors aged 40 years and above, body mass index (BMI) and waist circumference (WC) were used to determine obesity status. Cox proportional hazards models were used to evaluate the association of obesity and risk of CVD, including stroke. …”
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Healthcare workers safety: a cohort study using healthcare utilisation databases on vaccination and vaccine timeliness impact against SARS-CoV-2 infection by Edlira Skrami, Andrea Faragalli, Marica Iommi, Marco Morbidoni, Cristina Mancini, Antonella Guidi, Annalisa Cardone, Marco Pompili, Pietro Serafini, Remo Appignanesi, Luigi Ferrante, Flavia Carle

“…The impact of vaccination status, time to vaccination, occupational role, age, gender, and health status on infection risk was analysed with a multiple Cox regression model, adjusting for vaccination coverage velocity, swabbing probability, and monthly intensive care unit admissions rate in each LHA. …”
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Nanostructured, Self-Assembling Peptide K5 Blocks TNF-α and PGE2 Production by Suppression of the AP-1/p38 Pathway by Woo Seok Yang, Yung Chul Park, Ji Hye Kim, Hye Ri Kim, Tao Yu, Se Eun Byeon, Larry D. Unsworth, Jaehwi Lee, Jae Youl Cho

“…Similarly, there was inhibition of cyclooxygenase- (COX-) 2 mRNA expression assessed by real-time PCR, indicating that the inhibition is at the transcriptional level. …”
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A lower atherogenic index of plasma was associated with a higher incidence of sarcopenia by Zhiping Duan, Yunda Huang, Xiaoling Liu, Huiyu Tang, Guihua Jiang, Wei Huang, Runfen Du, Dan Zhou, Hong Yang

“…Longitudinal associations between AIP and sarcopenia and its components were assessed using Cox proportional risk regression modeling. The results showed that AIP was negatively associated with sarcopenia [HR and 95% CI: 0.73 (0.62–0.86)]; with muscle mass [β and 95%CI: 0.49 (0.4–0.57)], skeletal muscle mass index [β and 95%CI: 0.17 (0.15–0.2)], and grip strength [β and 95% CI: 0.17 (0.15–0.2)] being positively correlated. …”
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Socioeconomic status correlates with clinical outcomes in patients with acral melanoma by Rong Huang, Jiayu Wang, Kelin Zheng, Mengke Zhao, Zhengyun Zou, Zhengyun Zou, Zhengyun Zou

“…ObjectivesThis study aimed to investigate the impact of socioeconomic status on survival in Chinese patients with acral melanoma.MethodsWe collected clinical and socioeconomic information of 298 primary acral melanoma patients and performed Kaplan–Meier curves, log-rank tests, Cox proportional hazards models, and Pearson’s chi-squared tests to evaluate the relationships between clinical characteristics, socioeconomic factors, and survival outcomes.ResultsAmong the clinical characteristics, age, gender, stage, Breslow thickness, and primary tumor site significantly impacted survival in acral melanoma patients (p = 0.01, p = 0.05, p &lt; 0.01, p &lt; 0.01, p &lt; 0.01, respectively). …”
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Key oncogenes and candidate drugs for hepatitis-B-driven hepatocellular carcinoma progression by Liqin Ruan, Ningbo Fang, Xinhua Zhao, Weili Chen, Zhaoping Wu, Xiaoyong Wu

“…Based on these genes, prognostic cox regression models for OS and DFS were constructed. …”
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Predictors of oral anticoagulant-associated adverse events in seniors transitioning from hospital to home: a retrospective cohort study protocol by Lehana Thabane, James Douketis, Anne Holbrook, Gary Foster, Harsukh Benipal, J. Michael Paterson

“…The primary outcome is a composite of the first hospitalisation or emergency department visit for a haemorrhage or thromboembolic event or mortality within 30 days of hospital discharge. A Cox proportional hazards model will be used to determine the association between the composite outcome and a set of prespecified covariates. …”
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Socioeconomic status and delayed surgery: impact on non-metastatic papillary thyroid carcinoma outcomes by Kun Zhang, Xinyi Wang, Jianyong Lei, Anping Su, Tao Wei, Zhihui Li, Ya-Wen Chen, Ya-Wen Chen, Ya-Wen Chen, Ya-Wen Chen, Ya-Wen Chen

“…Kaplan–Meier survival curve, Cox proportional hazard regression, competing risk hazard regression, and multinomial logistic regression were applied.ResultsReceiving neck dissection or radioactive iodine therapy, being married at diagnosis, living in an urban area, being richer, and being of other minority ethnicity were estimated to be independent predictors for better overall survival. …”
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