Do Increased Doses to Stem-Cell Niches during Radiation Therapy Improve Glioblastoma Survival? by Sebastian Adeberg, Semi Ben Harrabi, Nina Bougatf, Denise Bernhardt, Angela Mohr, Juliane Rieber, Christian Koelsche, Stefan Rieken, Juergen Debus

“…The relationship of dosimetry data and survival was evaluated using the Cox regression analysis. Results. Conventionally fractionated patients (n=54) who received higher doses (Dmean ≥ 40 Gy) to the IL SVZ showed improved PFS (8.5 versus 5.2 months; p=0.013). …”
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Application of a targeted amplicon sequencing panel to screen for insecticide resistance mutations in Anopheles darlingi populations from Brazil by Holly Acford-Palmer, Alice O. Andrade, Jody E. Phelan, Rosa A. Santana, Stefanie C. P. Lopes, Jansen F. Medeiros, Taane G. Clark, Maisa S. Araujo, Susana Campino

“…In this study, we developed a low-cost, high throughput amplicon sequencing (“amp-seq”) panel, consisting of 11 amplicons targeting genes linked to mosquito species identification (cox-1 and its2) and insecticide resistance (ace-1, GSTe2, vgsc and rdl). …”
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Nutritional assessment using subjective global assessment identifies energy malnutrition and predicts mortality in patients with liver cirrhosis by Takao Miwa, Tatsunori Hanai, Kayoko Nishimura, Sachiyo Hirata, Shinji Unome, Yuki Nakahata, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu

“…The usefulness of the SGA in identifying energy malnutrition and predicting mortality was assessed by the logistic regression and Cox proportional hazards models, respectively. Out of the 230 patients analyzed, 43% were found to have energy malnutrition. …”
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Risk of second primary malignancies among survivors of cutaneous melanoma: A nationwide population-based study in the Republic of Korea by Joon Min Jung, Do Hyung Kim, Ye-Jee Kim, Ik Jun Moon, Woo Jin Lee, Sung Eun Chang, Mi Woo Lee, Chong Hyun Won

“…The risk factor for overall SPM development was analyzed using a multivariable Cox regression model. A total of 10,070 patients with melanoma were included in the study. …”
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Overexpression of metalloproteinase PAPPA accelerates cancer progression and correlates with immune cell infiltration in gastric cancer: insights from bioinformatics and in vitro i... by Shiya Yu, Shiyao Zheng, Jinwei Qiu, Hongming Lin, Xiaojuan Yu, Huiyan Chen, Junhong Wu, Weihang Wu, Jiong Chen, Yongyuan Chen, Jianwei Chen, Hu Zhao, Yu Wang

“…Results Bioinformatics analysis has demonstrated that the expression of PAPPA is upregulated in GC and correlates with poor prognosis. Correlation and Cox regression analyses have revealed that TNM staging, pathological staging, age, outcome assessment, postoperative tumor residue, and PAPPA expression are prognostic determinants in GC. …”
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THE EFFECT OF ABDOMINAL MASSAGE AND KUNYIT ASAM HERBS TO REDUCE PRIMARY MENSTRUAL PAIN (DYSMENORRHEA) by Dwi Setiani Sumardiko, Alyaa’ Maulida Rizki Roswandi, Neny Purwitasari, Rini Hamsidi

“…Result: Turmeric and tamarind contain active compounds curcumin and anthocyanin which work together to inhibit cyclooxygenase (COX) reactions so that they can inhibit or reduce inflammation and uterine contractions which cause menstrual pain. …”
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Advanced glycation end products and risk of mortality in patients with cirrhosis: a prospective cohort study by Mohsen Shaygan Tabar, Maryam Nilghaz, Azita Hekmatdoost, Fereshteh Pashayee-Khamene, Zeinab Mokhtari, Sara Karimi, Saleheh Ahmadzadeh, Mehdi Saberifiroozi, Behzad Hatami, Zahra Yari

“…To determine the incidence of mortality in the quartiles of dietary AGEs, cox regression models were used with the adjustment of potential confounding variables. …”
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Elevated Serum Total Bilirubin Level Is Associated with Poor Outcomes in Pediatric Patients with Sepsis-Associated Liver Injury by Yun Cui, Yijun Shan, Rongxin Chen, Chunxia Wang, Yucai Zhang

“…The serum levels of TBIL of patients were significantly higher in the nonsurvivor group than the survivor group. Cox regression analysis indicated that the elevated serum TBIL level within 72 hours after admission was an independent risk factor of mortality in patients with SALI. …”
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Long-Term Prospective Study of the Influence of Estrone Levels on Events in Postmenopausal Women with or at High Risk for Coronary Artery Disease by Antonio de Padua Mansur, Tereza Cristina B. F. Silva, Julio Yoshio Takada, Solange Desirée Avakian, Célia Maria C. Strunz, Luiz Antonio Machado César, José Mendes Aldrighi, José Antonio F. Ramires

“…The Kaplan-Meier survival curve showed a significant trend (P=0.039) of greater all-cause mortality in women with low estrone levels (<15 pg/mL). Cox multivariate regression analysis model adjusted for body mass index, diabetes, dyslipidemia, family history, and estrone showed estrone (OR=0.45; P=0.038) as the only independent variable for all-cause mortality. …”
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Impact of heteroresistance on treatment outcomes of people with drug-resistant TB by R. Crowder, M. Kato-Maeda, B. Schwem, A. dela Tonga, D.M. Geocaniga-Gaviola, E. Lopez, C.L. Valdez, A.R. Lim, N. Hunat, A.G. Sedusta, C.A. Sacopon, G.A.M. Atienza, E. Bulag, D. Lim, J. Bascuña, K. Shah, R.P. Basillio, C.A. Berger, M.C.D.P. Lopez, S. Sen, C. Allender, M. Folkerts, U. Karaoz, E. Brodie, S. Mitarai, A.M.C. Garfin, M.C. Ama, D.M. Engelthaler, A. Cattamanchi, R. Destura

“…We evaluated the association between heteroresistance and time to unfavorable treatment outcome using Cox proportional hazards regression. RESULTS: The proportion of drug-resistant isolates with a known mutation conferring resistance was lower for streptomycin (45.2%) and second-line injectables (79.1%) than for fluoroquinolones (86.7%), isoniazid (93.2%) and rifampin (96.5%). …”
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Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress by Chikako Sumi, Naoto Hirose, Makoto Yanoshita, Mami Takano, Sayuri Nishiyama, Yuki Okamoto, Yuki Asakawa, Kotaro Tanimoto

“…Gene expression of IL-1β, TNF-ɑ, COX-2, MMP-3, and MMP-13 was examined by qPCR analysis. …”
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Beneficial Effects of Poplar Buds on Hyperglycemia, Dyslipidemia, Oxidative Stress, and Inflammation in Streptozotocin-Induced Type-2 Diabetes by Shiqin Peng, Ping Wei, Qun Lu, Rui Liu, Yue Ding, Jiuliang Zhang

“…For inflammatory factors, feeding of 50% fraction could also reduce the levels of interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), monocyte chemotactic protein 1 (MCP-1), and cyclooxygenase-2 (COX-2) in liver homogenate. Taken together, our results suggest that crude extract and 50% fraction of poplar buds, particularly the latter, can decrease blood glucose levels and insulin resistance, and 50% fraction can significantly relieve dyslipidemia, oxidative stress, and inflammation caused by type-2 diabetes.…”
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Oxidized LDL Induces Alternative Macrophage Phenotype through Activation of CD36 and PAFR by Francisco J. Rios, Marianna M. Koga, Mateus Pecenin, Matheus Ferracini, Magnus Gidlund, S. Jancar

“…In murine TG-elicited macrophages, this protocol significantly reduced NO, iNOS and COX2 expression. Thus, oxLDL induced macrophage differentiation and activation towards the alternatively activated M2-phenotype. …”
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Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages by Qi Wang, Juqing Huang, Yafeng Zheng, Xuefang Guan, Chenchun Lai, Huiying Gao, Chi-Tang Ho, Bin Lin

“…Se-TE treatments (50 and 150 μg/mL) significantly suppressed the over-production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated macrophages via downregulating the expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, Se-TEs also effectively inhibited the productions of inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β). …”
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Effects of a flavonoid-enriched orange peel extract against type 2 diabetes in the obese ZDF rat model by Alexander Gosslau, Emmanuel Zachariah, Shiming Li, Chi-Tang Ho

“…The analysis of inflammatory mediators revealed a significant down-regulation of COX-2, ICAM-1, and TNF-α in epididymal adipose tissue in response to OPE to a higher degree as compared to ibuprofen. …”
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Prognostic impact of chronic obstructive pulmonary disease on short-term and long-term outcomes following coronary artery bypass grafting by Mohammad Sadeq Najafi, Arash Jalali, Zahra Karimi, Mohadese Dashtkoohi, Kimia Moradi, Mojgan Ghavami, Saeed Davoodi, Seyed Hossein Ahmadi Tafti, Rasoul Aliannejad

“…Data were collected on patient demographics, intraoperative factors, and postoperative outcomes. Cox proportional hazard with inverse probability weighting (IPW) and propensity score matching (PSM) were conducted to assess the adjusted effect of COPD on 30-day and long-term mortality and major adverse cardiac and cerebrovascular events (MACCE). …”
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Association of hypertension and plant-based dietary patterns on cognitive impairment: a nationwide cohort study in China by Fang Liang, Jialin Fu, Gabrielle Turner-McGrievy, Yechuang Wang, Kai Ding, Jing Zeng, Justin B Moore, Rui Li

“…Blood pressure was measured through physical examination. Cox proportional hazard regression and restricted cubic spline were performed. …”
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Calculated Tumor Volume Is an Independent Predictor of Biochemical Recurrence in Patients Who Underwent Retropubic Radical Prostatectomy by Nobumichi Tanaka, Kiyohide Fujimoto, Akihide Hirayama, Yasushi Nakai, Yoshitomo Chihara, Satoshi Anai, Atsushi Tomioka, Keiji Shimada, Noboru Konishi, Yoshihiko Hirao

“…Multivariate analysis using the Cox proportional hazards model showed that calculated cancer volume was an independent predictor among the preoperative clinicopathological parameters (𝑃<0.05). …”
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Impact of Mediterranean Diet Adherence on the Incidence of New‐Onset Hypertension in Adults With Obesity in Korea: A Nationwide Cohort Study by Jung‐Hwan Kim, Ji‐Won Lee, Yaeji Lee, Chung‐Mo Nam, Yu‐Jin Kwon

“…The primary endpoint was the incidence of new‐onset HTN. Cox proportional hazard models were used to estimate the hazard ratio (HR) and 95% confidence interval for HTN incidence with increasing MD adherence. …”
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18F-FDG PET/CT assessment of metabolic tumor burden predicts survival in patients with metastatic posterior uveal melanoma by Tine Gadegaard Hindso, Torben Martinussen, Camilla Wium Bjerrum, Sune Høgild Keller, Annika Loft, Mette Bagger Sjøl, Kristoffer Nissen, Carsten Faber, Marco Donia, Inge Marie Svane, Eva Ellebaek, Steffen Heegaard, Jens Folke Kiilgaard, Karine Madsen

“…The three parameters were also independent predictors in the multivariate Cox model, while the AJCC staging turned insignificant. …”
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