POTENCY OF SOURSOP LEAF EXTRACT AND CURCUMIN WITH MAGNETIC AND MUCUS-PENETRATING NANOPARTICLE AS COLORECTAL CANCER ALTERNATIVE THERAPY by Faiza Rahma Ebnudesita, Ayik Rochyatul Jannah, Savira Butsainah Dienanta, Reny I'tishom

“…Curcumin works molecularly on cyclooxygenase-2 (COX-2) to prevent inflammation, thereby inhibit the growth of cancer cells and reducing the risk of metastasis. …”
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Associations between depressive and anxiety symptoms and incident kidney failure in patients with diabetic nephropathy by Chunmei Qin, Yucheng Wu, Yutong Zou, Yuancheng Zhao, Deying Kang, Fang Liu

“…The study endpoint was defined as progression to kidney failure. The cox proportional hazard analysis was performed to investigate the risk factors for progression to kidney failure in DN patients. …”
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High expression of SHP2 predicts a promising prognosis in colorectal cancer by Xibo Liu, Mengyao Li, Lirong Chen, Fei Wen, Shu Zheng, Weiting Ge

“…Kaplan–Meier survival curves and log-rank tests were used to analyze the relationships between SHP2 expression and the overall survival of patients. A Cox proportional hazard regression model was used for univariate and multivariate analyses of prognostic factors. …”
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Xanthomonas citri subsp. citri requires a polyketide cyclase to activate the type III secretion system for virulence by Shuying Zhu, Siyu Wu, Yanmin Liu, Zaibao Zhang, Huasong Zou

“…Results The PKC was determined to have a signal peptide, a START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) domain, and a GyrI-like small molecule binding domain. …”
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Clinical Outcomes in Patients with Cardiac Lupus: A Retrospective Study by K Maria Koshy, Tarun George, Sohini Das, J V Punitha, Sudha Jasmine Rajan, Bijesh Yadav, Thambu David Sudarsanam, Vijay Prakash Turaka

“…Disease manifestations, antibody associations, and clinical outcomes were studied. The Cox proportional hazards model was used to study factors associated with mortality. …”
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Investigating the impact of dioxins, furans, and coplanar polychlorinated biphenyls on mortality, inflammatory states, and chronic diseases: An integrative epidemiological analysis by Jiaxing Tan, Ying Gao, Yuanlin Xia, Peiyan Sun, Wei Qin

“…Statistical analyses employed multivariate Cox regression, multivariate logistic regression, restricted cubic splines and subgroup analysis. …”
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Significance of Baseline and Changes of Tumor Markers and Neutrophil-to-Lymphocyte Ratio in Predicting Overall Survival for Patients with Advanced Pancreatic Adenocarcinoma: A Retr... by Makoto Kadokura, Keisuke Tanaka, Fumitake Amemiya, Shinichi Takano, Mitsuharu Fukasawa, Nobuyuki Enomoto

“…Univariate and multivariate cox regression models were applied to investigate independent prognostic factors. …”
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Modifiable Risk Factors for Early Mortality on Hemodialysis by Rory McQuillan, Lilyanna Trpeski, Stanley Fenton, Charmaine E. Lok

“…Modifiable risk factors of early mortality were determined by a Cox model. In total, 876 of 4807 incident patients died during their first year on dialysis; 304 (34.7%) deaths occurred within the first 90 days of dialysis initiation. …”
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Effects of maximum dose on local control after stereotactic body radiotherapy for oligometastatic tumors of colorectal cancer. by Su Jin Kang, Jongmoo Park, Gyu-Seog Choi, Jong Gwang Kim, Jun Seok Park, Hye Jin Kim, Jin Ho Baek, Byung Woog Kang, An Na Seo, Shin-Hyung Park, Bong Kyung Bae, Min Kyu Kang, Soo Yeun Park

“…The significance of the planning target volume (PTV) biologically effective dose (BED) 10s (D2, D95, D98, Dmean) in LFFS was evaluated using Cox regression, considering sex, age, primary cancer, tumor site, oligometastatic status, multiplicity, and either tumor size or one of the volume parameters. …”
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Bmi-1在卵巢癌组织中的表达与临床病理意义

“…【目的】 探讨多梳基因家族成员Bmi-1在卵巢上皮性肿瘤中的表达及其临床病理意义65377; 【方法】 运用免疫组化SP法检测Bmi-1蛋白在12例正常卵巢65380;20例卵巢囊腺瘤65380;28例卵巢交界性肿瘤和124例卵巢癌患者中的表达情况65377;【结果】 免疫组化检测结果显示,分别有1/20 (5.0%)的卵巢良性囊腺瘤65380;4/28 (14.3%)的交界性肿瘤和49/124 (39.5%)的卵巢癌出现Bmi-1蛋白过表达,而12例正常卵巢组织均未见Bmi-1过表达;而且Bmi-1蛋白过表达与本组卵巢癌的临床FIGO分期,pT分期,pN分期以及组织学Silverberg分级均呈显著正相关(P < 0.05)65377;Kaplan-Meier生存分析显示Bmi-1蛋白高表达卵巢癌患者生存时间明显低于低表达组(104.0月:50.3月,P < 0.001)65377;多因素Cox回归分析结果显示:Bmi-1表达是影响卵巢癌预后的独立因素(P = 0.006)65377;【结论】 Bmi-1蛋白过度表达与卵巢癌的发展,淋巴结转移及预后密切相关,是卵巢癌患者独立的预后指标65377;…”
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High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease by Ming-Chun Chen, Bang-Gee Hsu, Chung-Jen Lee, Ji-Hung Wang

“…Kaplan–Meier analysis revealed higher cumulative incidence of CV events in the high ANGPTL3 group (median ANGPTL3 level ≥ 222.37 ng/mL) than in the low ANGPTL3 group (log-rank P=0.046). Multivariable Cox regression analysis demonstrated that ANGPTL3 levels were independently associated with MACEs in patients with CAD (hazard ratio: 1.003; 95% confidence interval: 1.000–1.005; P=0.026) after adjusted for age, gender, and body mass index, classical risk factors, and potential confounders. …”
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Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury by Mohammad Yassin Zamanian, Niloofar Taheri, Maria Jade Catalan Opulencia, Dmitry Olegovich Bokov, Sharif Y. Abdullaev, Mohammadreza Gholamrezapour, Mahsa Heidari, Gholamreza Bazmandegan

“…To achieve the protective impact of PG the following was required: (1) stimulating PPARγ; (2) decreasing oxidative stress; (3) decreasing nuclear factor kappa B (NF-κB), interleukin 6 (IL-6), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), and C-C motif chemokine ligand 20 (CCL20) expression; (4) limiting the increase in the number of activated microglia; and (5) reducing mitochondrial dysfunction. …”
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Predictors of hospitalization, death and incomplete/non-recovery from SARS-CoV-2 in an ambulatory global population by Sarah L. Pett

“…Risk factors for hospitalization, death, and failure to recover were identified using Cox and logistic models respectively. Results: 9817(ICOS) and 125(PCOS) participants, 46.7% male; median age 43 years; 24.5% with comorbidity(s); 0.8% pregnant; 9.3% SARS-CoV-2 vaccinated, were enrolled June-2020 and January-2022. …”
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Cardiovascular complications in vascular connective tissue disorders after COVID-19 infection and vaccination. by Anthony L Guerrerio, Allyson Mateja, Gretchen MacCarrick, Jonathan Fintzi, Erica Brittain, Pamela A Frischmeyer-Guerrerio, Harry C Dietz

“…The data were analyzed using a Cox proportional hazards model with time varying indicators for COVID-19 illness/vaccination in the preceding 30 days.…”
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Predictors of Onset of Wheezing in Grain Elevator Workers by Punam Pahwa, Ambikaipakan Senthilselvan, Helen H McDuffie, James A Dosman

“…Of the 1848 symptoms-free grain workers at cycle II, 203 (11.0%) subsequently reported wheezing during the study. Cox's proportional hazards model for analysis of survival data was used to determine significant predictors of first episode of wheezing. …”
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Factors Influencing Survival Status of HIV/AIDS after HAART in Huzhou City, Eastern China by Meihua Jin, Zhongrong Yang, Jing Li, Xiaoqi Liu, Zhenqian Wu

“…Bivariate and stepwise multivariate Cox proportional hazards regression model analyses were performed. …”
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广东Ⅰ型心脏生物瓣膜置换术后瓣膜生存分析

“…低(≤14岁)、中(15～40岁)、高(≥41岁)3个年龄组瓣膜累计生存率曲线比较,其中低与中,低与高年龄组间差异有统计学意义;低、中、高3个年龄组瓣膜6年累计生存率分别为34.3%、93.0%、90.6%%;10年累计生存率分别为0、47.8%、61.7%。Cox回归分析显示年龄每增加10岁,瓣膜生存概率增加到前一年龄组的1.415倍(95%CI=1.142,1.753)。…”
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Malnutrition in the Outcome of Wound Healing at Public Hospitals in Bahir Dar City, Northwest Ethiopia: A Prospective Cohort Study by Netsanet Fentahun, Yeabsira Anteneh, Yonatan Menber

“…Anthropometric and serum albumin measurements were used to measure nutritional status. A multivariable Cox-regression analyses model was fitted to show the association between malnutrition and wound healing and p value < 0.05 was used to declare statistical significance value. …”
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TMAO-Activated Hepatocyte-Derived Exosomes Are Widely Distributed in Mice with Different Patterns and Promote Vascular Inflammation by Xiang Liu, Jiazichao Tu, Ziqin Zhou, Bingxin Huang, Jianrong Zhou, Jimei Chen

“…Furthermore, TMAO-Exos, but not control-Exos, could significantly promote the mRNA expressions of Tnf, Icam1, Sele, and Cox-2 in the aorta. Conclusions. We provided clues about how TMAO may stimulate hepatocytes to produce Exos and further offered evidence that Exos secreted by TMAO-treated hepatocytes could be widely distributed in vivo and promote vascular inflammation.…”
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Predicting survival in malignant glioma using artificial intelligence by Wireko Andrew Awuah, Adam Ben-Jaafar, Subham Roy, Princess Afia Nkrumah-Boateng, Joecelyn Kirani Tan, Toufik Abdul-Rahman, Oday Atallah

“…However, predicting survival using traditional methods such as the Kaplan–Meier estimator and the Cox Proportional Hazards (CPH) model has faced many challenges and inaccuracies. …”
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