Complete mitochondrial genomes of Culicoides brevitarsis and Culicoides imicola biting midge vectors of Bluetongue Virus by Khandaker Asif Ahmed, Anjana Karawita, Melissa J. Klein, Luana Fiorella Mincarelli, Barbara Secondini, Giuseppe Satta, Massimo Ancora, Cipriano Foxi, Marco Di Domenico, Michela Quaglia, Maria Goffredo, Alessio Lorusso, Cesare Cammà, Leon Court, Rahul V. Rane, Tom K. Walsh, Prasad N. Paradkar, Debbie Eagles, Gunjan Pandey, Christopher M. Hardy

“…Eleven protein-coding genes encode a full TAA stop codon, while two (ND5, COX3) are completed by mRNA polyadenylation. Phylogenetic analysis of the mitogenomes showed C. brevitarsis and C. imicola form a monophyletic group. …”
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Mechanistic insights into the role of traditional Chinese medicine in treating gastric cancer by Ziqiang Chen, Ting Yu, Yunhe Wang, Jiaxin Li, Bo Zhang, Liya Zhou

“…We examine how TCM suppresses angiogenesis by targeting the vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) pathways, effectively starving tumors of nutrients and oxygen required for growth and metastasis. …”
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Influence of Age at Diagnosis and Time-Dependent Risk Factors on the Development of Diabetic Retinopathy in Patients with Type 1 Diabetes by Luis Forga, María José Goñi, Berta Ibáñez, Koldo Cambra, Marta García-Mouriz, Ana Iriarte

“…The influence of age at diagnosis, glycemic control, duration of diabetes, sex, blood pressure, lipids, BMI, and smoking is analyzed using Cox univariate and multivariate models with fixed and time-dependent variables. …”
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Weightbearing in Select Geriatric Ankle Fractures Following Open Reduction Internal Fixation: Short Scientific Report by Atticus Coscia MD, Michal Jandzinski MD, Paul Talusan MD, Jaimo Ahn MD PhD

“…Complication-free survival and hardware failure–free survival were compared using the log-rank (Mantel-Cox) test. Results: There were no hardware failures in the WBAT group and 1 hardware failure in the NWB group; the difference was not statistically significant. …”
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Anti-Inflammatory Activity of Phyllanthus niruri L. Leaf Extract: In Vitro Study on RAW 264.7 Macrophage Cells and In Silico Analysis by Ngurah Intan Wiratmini, Made Pharmawati, Anak Agung Sagung Alit Sukmaningsih, Sentot Joko Raharjo, Wahyu Widowati

“…Molecular docking studies further supported the anti-inflammatory potential of the extract by demonstrating its ability to inhibit COX-2 and TNF-alpha. These findings suggest that P. niruri leaf extract has promising anti-inflammatory properties and needs further investigation as a potential treatment for inflammatory diseases. …”
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No Obesity Paradox—BMI Incapable of Adequately Capturing the Relation of Obesity with All-Cause Mortality: An Inception Diabetes Cohort Study by Mohammadreza Bozorgmanesh, Banafsheh Arshi, Farhad Sheikholeslami, Fereidoun Azizi, Farzad Hadaegh

“…In the mortality analysis, anthropometric measures—body mass index (BMI), waist, and hip circumference—were assessed using Cox models incorporating cubic spline functions. …”
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Younger Age Is Associated with Poorer Survival in Patients with Signet-Ring Cell Carcinoma of the Colon without Distant Metastasis by Ben Huang, Mengdong Ni, Chen Chen, Yang Feng, Sanjun Cai

“…A higher percentage of stage III disease and a higher percentage of N2 disease were observed in patients ≤ 35 years of age. The multivariate Cox proportional model demonstrated that patients ≤ 35 years of age were more likely to have a poorer survival outcome compared with patients aged >35 years (HR 1.411, 95% CI 1.032–1.929, and P=0.031). …”
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MCL Plays an Anti-Inflammatory Role in Mycobacterium tuberculosis-Induced Immune Response by Inhibiting NF-κB and NLRP3 Inflammasome Activation by Qingwen Zhang, Xinru Jiang, Weigang He, Kailin Wei, Jinxia Sun, Xiangyang Qin, Yuejuan Zheng, Xin Jiang

“…Meanwhile, MCL dramatically suppressed Mtb-induced activation of iNOS and COX2 as well as subsequent production of NO. Furthermore, MCL inhibited Mtb-induced phosphorylation of Akt (Ser 473) in Raw264.7. …”
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Cyclooxygenase Inhibitor Associated with Carboplatin in Treatment of Metastatic Nasal Carcinoma in Dog by Carlos Eduardo Fonseca-Alves, Aline Gonçalves Corrêa, Fabiana Elias, Sabryna Gouveia Calazans

“…Immunohistochemical staining for cytokeratin (AE1/AE3), vimentin, and COX-2 was performed. After histopathological evaluation nasal carcinoma diagnosis was obtained. …”
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The Obesity Paradox and Cardiorespiratory Fitness by Paul A. McAuley, Nancy S. Smith, Brian T. Emerson, Jonathan N. Myers

“…Associations of baseline fitness and adiposity measures with all-cause mortality were determined by Cox proportional hazards analysis adjusted for age, ethnicity, hypertension, hypercholesterolemia, family history of coronary artery disease, and cardiovascular medication use. …”
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Eosinophil as a Protective Cell in S. aureus Ventilator-Associated Pneumonia by Ana Rodriguez-Fernandez, David Andaluz-Ojeda, Raquel Almansa, Mar Justel, Jose Maria Eiros, Raul Ortiz de Lejarazu

“…Our results showed that nonsurvivors had significant lower eosinophil counts at VAP diagnosis. Multivariate Cox regression analysis performed by the Wald test for forward selection showed that eosinophil increments from ICU admission to VAP diagnosis and total eosinophil counts at VAP diagnosis were protective factors against mortality in the first 28 days following diagnosis: (HR [CI 95%], P): (0.996 [0.993–0.999], 0.010); (0.370 [0.180–0.750], 0.006). …”
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Patients Hospitalized in General Wards via the Emergency Department: Early Identification of Predisposing Factors for Death or Unexpected Intensive Care Unit Admission—A Historical... by Thierry Boulain, Isabelle Runge, Nathalie Delorme, Angèle Bouju, Antoine Valéry

“…Prospective cohort study in a medical-surgical adult ED in a teaching hospital, including consecutive patients hospitalized on regular wards after ED visit, and identification of predictors by logistic regression and Cox proportional hazards model. Results. Among 4,619 included patients, 77 (1.67%) target events were observed: 32 unexpected deaths and 45 unplanned transfers to an ICU/HDU. …”
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Morphometric Analysis of Human Embryonic Stem Cell-Derived Ventricular Cardiomyocytes: Determining the Maturation State of a Population by Quantifying Parameters in Individual Cell... by Harvey Y. S. Chan, Wendy Keung, Ronald A. Li, Andrew L. Miller, Sarah E. Webb

“…Cells were double-immunolabeled with α-actinin and COX IV antibodies, to label the myofibrils and mitochondria, respectively, after which images were acquired via confocal microscopy. …”
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Clinical characteristics and prognosis of patients treated as invasive pulmonary aspergillosis outside of severe immunosuppression by Furui Liu, Wenling Chen, Honglei Qi, Yonghong Yang, Ying Yang, Zhaojun Wang, Jinyuan Zhu

“…Clinical data, including demographics, laboratory tests, and imaging, were collected. Multivariate Cox regression analysis identified glucocorticoid use (odds ratio [OR] = 30.223, 95% confidence interval [CI]: 2.676–341.306), intensive care unit admission (OR = 0.133, 95% CI: 0.023–0.758), and the arterial oxygen partial pressure/fractional inspired oxygen ratio (OR = 0.994, 95% CI: 0.990–0.999) as significant predictors of 28-day mortality. …”
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OPN Polymorphism Is Related to the Chemotherapy Response and Prognosis in Advanced NSCLC by Yanzhang Hao, Jianwei Liu, Ping Wang, Feng Wang, Zeshun Yu, Mianli Li, Shaoshui Chen, Fangling Ning

“…The median overall survival time for patients with −443CC, −443CT, and −443TT genotype carriers was significantly different. Multivariate Cox proportional hazards regression models showed that OPN −443C>T gene polymorphisms were closely correlated to poor NSCLC prognosis. …”
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Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice by Hongxing Zhang, Chi Shang, Zhao Tian, Hatem K. Amin, Rami B. Kassab, Ahmed E. Abdel Moneim, Yingang Zhang

“…Carrageenan injection potentiated an inflammatory reaction as presented by the elevated serological C-reactive protein (CRP) levels and transcription of tumor necrosis factor-alpha (TNF-α, Tnfα), interleukin-1 beta (IL-1β, Il1b), interleukin-2 (IL-2, Il2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase-2 (COX-2, Ptgs2), prostaglandin E2 (PGE2), monocyte chemoattractant protein-1 (MCP-1, Ccl1), nuclear factor kappa B (NF-κB), and myeloperoxidase (MPO) activity, while interleukin-10 (IL-10) was declined in the injured paw tissue. …”
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Association of serum high-sensitivity C reactive protein with risk of mortality in an Asian population: the Health Examinees cohort by Jong-Koo Lee, Daehee Kang, Sang-Ah Lee, Xiao-Ou Shu, Sung Ok Kwon, Hyerim Park

“…We conducted advanced analysis after stratification by NCDhistory and sensitivity analysis after excluding death before 1 or 2 years from recruitment. Cox proportional hazard and restricted cubic spline models were used to assess the association.Results The association between serum hsCRP and risk of all-cause mortality was observed with strong linearity in both genders and was not influenced by NCDhistory. …”
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Identification and validation of a prognostic risk model based on radiosensitivity-related genes in nasopharyngeal carcinoma by Yi Li, Xinyi Hong, Wenqian Xu, Jinhong Guo, Yongyuan Su, Haolan Li, Yingjie Xie, Xing Chen, Xiong Zheng, Sufang Qiu

“…Machine learning algorithms and Cox regression were used to construct a prognostic risk model, validated in the GSE102349 dataset. …”
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Clinical and Epidemiological Factors Associated with Mortality in Parkinson’s Disease in a Brazilian Cohort by Gustavo Costa Fernandes, Mariana Peixoto Socal, Artur Francisco Schumacher Schuh, Carlos R. M. Rieder

“…In the univariate analysis, age at baseline was associated with decreased survival. In the adjusted Cox proportional hazards model, age at disease onset and race/ethnicity were predictors of mortality. …”
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Matrix Metalloproteinase-9 is associated with tumor microenvironment remodeling of bladder cancer by Fang Fang, Tiange Wu, Mengxue Wang, Wenchao Li, Zonghao You, Ming Chen, Han Guan

“…We utilized these two algorithms to analyze the immune components of 433 bladder cancer cases from The Cancer Genome Atlas database, aiming to compensate for the current lack of large-sample single-cell information. Then we used Cox regression to analyze the prognostic value of differentially expressed genes, and the protein–protein interaction network was constructed. …”
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