Hepatorenal Syndrome: Outcome of Response to Therapy and Predictors of Survival by Jan Heidemann, Christoph Bartels, Christoph Berssenbrügge, Hartmut Schmidt, Tobias Meister

“…Univariate analysis of factors influencing the success of terlipressin therapy and Cox regression analysis of factors influencing survival was carried out. …”
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Neuroprotective Effect of DAHP via Antiapoptosis in Cerebral Ischemia by Yanhua Qin, Weiming Hu, Yang Yang, Zhiying Hu, Weiyun Li, Marong Fang

“…Western blotting and immunohistochemistry were performed to detect iNOS, caspase-3, Bcl-2, COX-2, and TNF-α protein expressions. Apoptosis was determined by TUNEL staining. …”
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Integrative description of two new species of the Xenylla maritima species complex (Collembola: Hypogastruridae) from Crete (Greece), with notes on the high intraspecific genetic d... by Dariusz Skarżyński, Barbara Valle, Dariusz J. Gwiazdowicz, David Porco

“… A classical taxonomic analysis of materials from several European museums as well as our own collection along with the analysis of DNA barcoding data (cox1) allowed us to determine the taxonomic status of Cretan forms included in the recently revised Xenylla maritima complex. …”
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Multiscale Analysis of the Interfacial Mechanical Behavior for Composite of Carbon Nanotube and α-Alumina by Tingting Yan, Gaofeng Wei

“…The stress distribution of the interface is obtained by improved COX model. The strain rate of nanotube-composite is presented when the interfacial slip occurs through the van der Waals interaction.…”
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Molecular Docking Study of Conformational Polymorph: Building Block of Crystal Chemistry by Rashmi Dubey, Ashish Kumar Tewari, Ved Prakash Singh, Praveen Singh, Jawahar Singh Dangi, Carmen Puerta, Pedro Valerga, Rajni Kant

“…Polymorph 1b has a better binding affinity with the cyclooxygenase (COX-2) receptor than the standard (Nimesulide).…”
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A Nomogram Based on Circulating Inflammatory Factors for Predicting Prognosis of Newly Diagnosed Multiple Myeloma Patients by Wang M, Yue X, Ding Y, Cai Z, Xiao H, Huang H, He J

“…We established a nomogram model after LASSO Cox and multivariate Cox regression analysis. The nomogram model exhibited acceptable discrimination, with C-index values of 0.777, 0.714, and 0.71 in the training cohort, validation cohort, and entire cohort, respectively, which was significantly higher than the C-indices of the three most extensively used staging systems for NDMM (D-S, ISS, and R-ISS). …”
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Allogeneic Adipose-Derived Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Self-Reactive T Cell Responses and Dendritic Cell Function by Per Anderson, Elena Gonzalez-Rey, Francisco O’Valle, Francisco Martin, F. Javier Oliver, Mario Delgado

“…The addition of the COX-1/2 inhibitor indomethacin, but not the iNOS inhibitor L-NAME, reversed the block in DC maturation implicating prostaglandin (PG) E2 in this process. …”
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Prognostic Value of Concomitant Bronchiectasis in Newly Diagnosed Diffuse Panbronchiolitis Patients on a Maintenance Therapy with Macrolides by Benyong Xu, Yanhua Mao, Xiaoyu Wan, Jianhui Chen, Meiping Ye, Mengling Zhan, Liyun Xu, Lan Zhao, Bing Li, Zhemin Zhang, Yang Liu, Haiqing Chu

“…The survival curve and Cox regression analysis models were additionally constructed to further demonstrate the predicting role of bronchiectasis in DPB exacerbation. …”
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Anti-Inflammatory Effects of Artemisia Leaf Extract in Mice with Contact Dermatitis In Vitro and In Vivo by Chanyong Yun, Youngchul Jung, Wonjoo Chun, Beodeul Yang, Junghyun Ryu, Chiyeon Lim, Jung-Hoon Kim, Hyungwoo Kim, Su-In Cho

“…In addition, ALE inhibited expression of COX-2 and iNOS and production of NO and PGE2 in Raw 264.7 cells. …”
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Red blood cell distribution width is an independent predictor of mortality following amputation for diabetic foot by Yeo Kwon Yoon, Jae Han Park, Hang Hwan Cho, Dong Woo Shim, Wonwoo Lee, Seung Hwan Han, Jin Woo Lee, Kwang Hwan Park

“…After establishing an optimal cutoff value of preoperative RDW for all-cause mortality, univariable and multivariable analyses with Cox proportional hazard model for survivorship and logistic regression analysis for prolonged hospital length of stay (> 30 days) were performed to identify significant prognostic factors. …”
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Triglyceride-glucose index and mortality risks in Helicobacter pylori-infected patients: a national cohort study by Yue Cao, Lingxiao Li, Feipeng Qiu, Weixing Wen, Hao Zhang, Yangxin Chen, Xiaoyan Cai, Yuli Huang

“…Methods This study analyzed NHANES 1999–2000 data to assess the association between the TyG index and all-cause and cardiovascular mortality in H. pylori-infected patients using weighted Cox models and restricted cubic spline analysis. …”
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Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women: A 15-Year Population-Based Study by Joonas Sirola, Anna-Kaisa Koistinen, Kari Salovaara, Toni Rikkonen, Marjo Tuppurainen, Jukka S. Jurvelin, Risto Honkanen, Esko Alhava, Heikki Kröger

“…There were no differences in FR between BL tertiles in Cox regression model. Factors predicting lower FR in Cox model were in high tertile: high T-score (HR 0.71; 95% CI 0.54–0.93, P=.012), no sister's fracture (HR 0.35; 0.19–0.64, P=.001), no mother's fracture (HR 0.52; 0.31–0.88, P=.015), in moderate tertile: high T-score (HR 0.69;0.53–0.91, P=.008) and good grip strength (HR 0.98; 0.97–0.99, P=.022). …”
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Exploring the prognostic role of microbial and genetic markers in lung squamous cell carcinoma by Fan Yang, Xiaodong Jia, Zihuan Ma, Siyao Liu, Chunzi Liu, Dan Chen, Xiuju Wang, Niansong Qian, Hui Ma

“…Furthermore, hub mRNA between high- and low-risk groups were selected by XGBOOST and intersect with mRNAs screened by univariate Cox regression analysis, finally identifying four mRNA significantly associated with LUSC prognosis. …”
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Prostanoid Receptor Subtypes and Its Endogenous Ligands with Processing Enzymes within Various Types of Inflammatory Joint Diseases by Mohammed A. Al-Madol, Mohammed Shaqura, Thilo John, Rudolf Likar, Reham Said Ebied, Magdi M. Salih, Sascha Treskatsch, Michael Schäfer, Shaaban A. Mousa

“…Our results demonstrated that PGE2 and its processing enzymes COX-2 and mPGES-1 were highest in the synovial tissue of RA, followed by the synovial tissue of OA and JT patients. …”
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The effect of NLRP3 inflammasome on cardiovascular prognosis in patients with acute coronary syndrome by De-Gang Mo, Ming-Ting Liang, Li Xu, Tai Li, Qian-Feng Han, Chen Chen, Heng-Chen Yao

“…The NLRP3 inflammasome was quantified using enzyme-linked immunosorbent assays, with the Gensini score used to assess disease severity. A Cox regression model evaluated whether NLRP3 inflammasome levels were independent predictors of MACEs. …”
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Challenges of healthcare financing in the world’s largest refugee camp: a mixed-method study among healthcare stakeholders for Rohingya refugees in Bangladesh by Isabel Smith, Imdadul Haque Talukdar, Sayeeda Tarannum, M A Rifat, Priyanka Boga, Jubayer Mumin, Pablo André Veronés, Ziba Mahdi, Syeda Saima Alam, Arif Faysal Khan

“…Objectives This study aimed to increase the understanding of healthcare stakeholders’ viewpoints on the challenges and potential solutions regarding healthcare financing for the Rohingya refugees in Cox’s Bazar.Design A mixed-method approach, containing semi-structured interviews with healthcare stakeholders and review of financial documents, was employed. …”
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Chinese Medicine Huzhen Tongfeng Formula Effectively Attenuates Gouty Arthritis by Inhibiting Arachidonic Acid Metabolism and Inflammatory Mediators by Jianping Deng, Zicong Wu, Chen Chen, Zhenling Zhao, Yifei Li, Zhengquan Su, Yiguang Lin, Yifei Wang, Zhiping Wang

“…In particular, cyclooxygenase (COX)-1, COX-2, and 5-lipoxygenase were simultaneously downregulated. …”
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Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with He... by Ning Pan, Jie Qiu, Hang Sun, Fengqin Miao, Qian Shi, Jinhuan Xu, Wei Jiang, Hui Jin, Wei Xie, Youji He, Jianqiong Zhang

“…The effect of each KIR locus, HLA ligand, and HLA-KIR combination was examined individually by Kaplan-Meier (KM) analysis. Multivariate Cox hazard regression model was also applied. We identified C1C1-KIR2DS2/2DL2 as an independent risk factor for earlier onset age of HCC (median onset age was 44 for C1C1-KIR2DS2/2DL2 positive patients compared to 50 for negative patients, P=0.04 for KM analysis; HR = 1.70, P=0.004 for multivariate Cox model). …”
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PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1/PGE2 Pathway in db/db Mice by Ying Sun, Zhanjun Jia, Gang Liu, Li Zhou, Mi Liu, Baoxue Yang, Tianxin Yang

“…Strikingly, urinary PGE2 was remarkably elevated in db/db mice paralleled with the increased protein expressions of COX-2 and mPGES-1. In contrast, the protein expressions of COX-1, mPGES-2, cPGES, and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) were not altered. …”
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A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis by Elbio Leiguez, Karina Cristina Giannotti, Mariana do Nascimento Viana, Márcio Hideki Matsubara, Cristina Maria Fernandes, José Maria Gutiérrez, Bruno Lomonte, Catarina Teixeira

“…Moreover, PPAR-β/δ, but not PPAR-γ, is involved in MT-III-induced PLIN2 protein expression, and both PPAR-β/δ and PPAR-γ upregulated CD36 protein expression, which contributes to MT-III-induced COX-2 expression. Furthermore, production of 15-d-PGJ2, an activator of PPARs, induced by MT-III, was dependent on COX-1 being LDs an important platform for generation of this mediator.…”
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