Clinical and genetic drivers of oligo-metastatic disease in colon cancer by Alessandro Ottaiano, Mariachiara Santorsola, Roberto Sirica, Annabella Di Mauro, Antonella Di Carlo, Monica Ianniello, Francesco Sabbatino, Rosa Castiello, Francesca Del Peschio, Marco Cascella, Francesco Perri, Maurizio Capuozzo, Nicola Martucci, Edoardo Mercadante, Valentina Borzillo, Rossella Di Franco, Francesco Izzo, Vincenza Granata, Carmine Picone, Antonella Petrillo, Massimiliano Berretta, Salvatore Stilo, Luca Tarotto, Anna Chiara Carratù, Gerardo Ferrara, Madhura Tathode, Alessia Maria Cossu, Marco Bocchetti, Michele Caraglia, Guglielmo Nasti, Giovanni Savarese

“…Overall survival (OS) was determined from metastasis diagnosis until death using Kaplan–Meier analysis. Multivariate Cox regression examined prognostic links between clinicopathological and genetic factors. …”
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Integrating deep learning in public health: a novel approach to PICC-RVT risk assessment by Yue Li, Yue Li, Shengxiao Nie, Lei Wang, Dongsheng Li, Shengmiao Ma, Ting Li, Hong Sun

“…Stability varied with the number of predictive factors, with Cox-Time showing the highest ICC (0.974) with 16 predictive factors, and DeepSurv the most stable with 26 predictive factors (ICC: 0.983). …”
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Single-cell RNA sequencing and immune microenvironment analysis reveal PLOD2-driven malignant transformation in cervical cancer by Zhiheng Lin, Fengxin Wang, Renwu Yin, Shengnan Li, Yuquan Bai, Baofang Zhang, Chenlin Sui, Hengjie Cao, Dune Su, Lianwei Xu, Honghong Wang

“…The CIBERSORT and ESTIMATE R packages were used to evaluate the immune microenvironment characteristics, and univariate and multivariate Cox regression analyses were used to extract prognostic features. …”
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Association between forced expiratory volume in 1 s and relapse-free survival in operable non-small cell lung cancer: a prospective cohort study with propensity score overlap weigh... by Jing Cheng, Yang Du, Karl Sylvester, Shaoping Wu, Suixin Liu, Yaoshan Dun, Baiyang You, Siqian Fu, Ning Xu, Jeffrey William Ripley-Gonzalez, Ni Cui

“…Results revealed 110 and 71 relapses and deaths per 1000 person-years for patients with FEV1 values of <82%pred and ≥82%pred, respectively. Cox proportional hazards models, adjusted for demographics, medical history and surgery characteristics with propensity score overlap weighting, revealed the significant impact of lower FEV1%pred on decreased RFS and OS. …”
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Implications of prognostic nutritional index in predicting adverse outcomes of uncontrolled diabetic patients: a cohort study of the national health and nutrition examination surve... by Fei Liu, Zhili Jiang, Wei Luo, Yunxiao Yang, Shuai Guo, Jiayi Yi, Geng Shen, Wei Li, Lin Wang, Xiuhuan Chen, Zhaogong Zhi, Tian Liu, Xuedong Zhao, Chen Li, Hai Gao

“…Univariable and multivariable cox proportional hazard regression were performed to investigate prognostic value of PNI. …”
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Pharmacological modulation of Sigma-1 receptor ameliorates pathological neuroinflammation in rats with diabetic neuropathic pain via the AKT/GSK-3β/NF-κB pathway by Yuyu An, Shanshan Cao, Leilei Shi, Yuhan Zhang, Xin Wang, Shiyu Yuan, Yongheng Shi, Bin Wang, Jiping Liu, Chao-jun Han

“…The mRNA levels of TNF-α, IL-1β, and cyclooxygenase 2 (COX-2) were reduced. Pharmacological inhibition of Sig-1R with BD1047 (10 μM) abolished Sig-1R-mediated activation of lipopolysaccharide-treated BV-2 microglial cells. …”
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Biochemical recurrence prediction after robot-assited radical prostatectomy (BCR-PRARP) by Tanan Bejrananda, Kiyoshi Takahara, Dutsadee Sowanthip, Tomonari Motonaga, Kota Yagi, Wataru Nakamura, Masanobu Saruta, Takuhisa Nukaya, Masashi Takenaka, Kenji Zennami, Manabu Ichino, Hitomi Sasaki, Makoto Sumitomo, Ryoichi Shiroki

“…BCR was defined as two consecutive PSA levels exceeding 0.2 ng/mL post-radical prostatectomy. Cox proportional hazards regression identified predictive variables for BCR. …”
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Chronic kidney disease progression in patients with previous type 2 diabetes and/or hypertension: a population-based cohort study from primary care in Spain by David Vizcaya, Betlem Salvador-González, Oriol Cunillera-Puértolas, Sílvia Cobo-Guerrero, José Romano-Sánchez, Daniel Bundó-Luque, Ariadna Arbiol-Roca

“…Subdistributional hazard ratios (sHRs) were estimated using Cox regression adjusted for confounders.Results Compared with the CKD without hypertension and T2D group, adjusted sHRs (95% CIs) for SKI/kidney failure were 1.77 (1.65 to 1.89) for CKD with hypertension and T2D, 1.50 (1.41 to 1.59) for CKD with hypertension and 1.21 (1.09 to 1.34) for CKD with T2D, and for kidney failure were 1.24 (1.10 to 1.39) for CKD with hypertension, 0.74 (0.61 to 0.90) for CKD with T2D and 1.09 (0.96 to 1.24) for CKD with hypertension and T2D. …”
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Survival and Its Predictors Among Patients Receiving Transarterial Chemoembolization for Hepatocellular Carcinoma in Ethiopia: A 6-Year Follow-Up Study by Abigia Ashenafi, Soliyana Demelash, Efrata Melaku, Haymanot Abe, Meron Yitna, Fisseha Tekle, Jiksa Dabessa, Biniam Araya, Yared Nigussie, Wondmagegn Demsiss, Ashenafi Zelalem, Song Jung Kim, Nebiyu Dereje

“…Predictors of survival were identified using a multivariable Cox proportional hazards regression model as expressed by adjusted hazard ratio (aHR).RESULTSOf the total 257 patients included in the study, 68.9% were male, with a mean age of 56.5 (±14.06) years, and 86% were diagnosed at the advanced stage of the cancer (Barcelona Clinic Liver Cancer-C). …”
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Risk Factors for Fracture in Patients with Coexisting Chronic Kidney Disease and Type 2 Diabetes: An Observational Analysis from the CREDENCE Trial by Tamara K. Young, Nigel D. Toussaint, Gian Luca Di Tanna, Clare Arnott, Carinna Hockham, Amy Kang, Aletta E. Schutte, Vlado Perkovic, Kenneth W. Mahaffey, Rajiv Agarwal, George L. Bakris, David M. Charytan, Hiddo J. L. Heerspink, Adeera Levin, Carol Pollock, David C. Wheeler, Hong Zhang, Meg J. Jardine

“…Within the CREDENCE cohort with adjudicated fracture outcomes, we assessed the association of individual factors with fracture using Cox regression models. We used the Akaike information criteria (AIC) and Schwartz Bayes Criterion (SBC) to assess six separate variable sets based on hypothesized associations with fracture, namely, traditional osteoporosis, exploratory general population findings, cardiovascular risk, CKD-mineral and bone disorder, diabetic osteodystrophy, and an all-inclusive set containing all variables. …”
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Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth by Hao Wang, Ruixue Huo, Kexin He, Weihan Li, Yuan Gao, Wei He, Minhao Yu, Shu-Heng Jiang, Junli Xue

“…Kaplan-Meier survival analysis and Cox regression models were used to identify prognostic factors. …”
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Machine learning-based plasma metabolomics for improved cirrhosis risk stratification by Jingru Song, Ziwei Gao, Liqun Lai, Jie Zhang, Binbin Liu, Yi Sang, Siqi Chen, Jiachen Qi, Yujun Zhang, Huang Kai, Wei Ye

“…Methods This study used proton nuclear magnetic resonance (1 H-NMR) serum metabolomics data from the UK Biobank (UKB) and employed elastic net-regularized Cox proportional hazards models to explore the role of metabolomics in cirrhosis risk stratification in patients with CLD. …”
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Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NF-κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways by Nami Lee, Yu Jung Heo, Sung-E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim

“…Empagliflozin and gemigliptin (individually and combined) inhibited prostaglandin E2 (PGE2) release and COX-2, iNOS gene expression in LPS-stimulated RAW 264.7 macrophages. …”
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Prognosis and factors related to severe secondary hyperparathyroidism in long-term peritoneal dialysis patients by Yanmei Li, Xiaonan Feng, Na Chen, Shuhua Song, Min Yu, Yan Wang, Hongxia Zhang, Li Wang, Menghua Chen, Na Tian

“…The influence of sSHPT on the prognosis of and risk factors for sSHPT progression were evaluated using logistic and Cox regression analyses. After adjusting for confounding factors, higher (each 100-pg/mL increase) baseline PTH levels (95% confidence interval (CI) 1.206–1.649, p < .001), longer (each 1-year increase) dialysis vintages (95% CI 1.013–1.060, p = .002), higher concomitant diabetes rates (95% CI 1.375–10.374, p = .010), and lower (each 1-absolute unit decrease) Kt/V values (95% CI 0.859–0.984, p = .015) were independent risk factors for progression to sSHPT in patients on PD. …”
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Postpartum depression in relation to chronic diseases and multimorbidity in women’s mid-late life: a prospective cohort study of UK Biobank by Yue Zhang, Yangyang Cheng, Rodrigo M. Carrillo-Larco, Yaguan Zhou, Hui Wang, Xiaolin Xu

“…Logistic regression models, Cox proportional hazard models, quasi-Poisson mixed effects models, and linear mixed models were conducted to examine the association of PPD with chronic diseases and multimorbidity at baseline and during follow-up. …”
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Inferior vena cava diameter in patients with chronic heart failure and chronic kidney disease: a retrospective study by Jianan Li, Chi Wang, Hui wu Dong, Jing Qi, Chongyou Rao, Qiuyang Li, Kunlun He

“…Information on all-cause mortality was collected by telephone interview and medical records review. We used Cox regression to evaluate the risk of all-cause mortality among groups, and used mediation analysis to examine the mediation role of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) and serum albumin in the association between IVC and all-cause mortality. …”
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Are noise and air pollution related to the incidence of dementia? A cohort study in London, England by Derek G Cook, Frank J Kelly, Iain M Carey, H Ross Anderson, David P Strachan, Richard W Atkinson, Sean D Beevers, David Dajnak, John Gulliver

“…All exposure measures were linked anonymously to clinical data via residential postcode. HRs from Cox models were adjusted for age, sex, ethnicity, smoking and body mass index, with further adjustments explored for area deprivation and comorbidity.Results 2181 subjects (1.7%) received an incident diagnosis of dementia (39% mentioning Alzheimer’s disease, 29% vascular dementia). …”
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Construction and validation of prognosis and treatment outcome models based on plasma membrane tension characteristics in bladder cancer by Zhipeng Wang, Sheng Li, Fuchun Zheng, Situ Xiong, Lei Zhang, Liangwei Wan, Chen Wang, Xiaoqiang Liu, Jun Deng

“…Patients were then randomly divided into training and validation groups, and MTRG scores were constructed by logistic minimum absolute contraction and selection operator (LASSO) and Cox regression analysis. We assessed changes in clinical outcomes and immune-related factors between different patient groups. …”
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Effectiveness of HPV vaccination in reducing infection among young Brazilian women by Ana Carolina da Silva Santos, Nayara Nascimento Toledo Silva, Ismael Dale Cotrim Guerreiro da Silva, Mariângela Carneiro, Wendel Coura-Vital, Angélica Alves Lima

“…The prevalence of HPV infection was analyzed using the compare proportions test. Poisson and Cox multivariate regression models were used to estimate vaccine effectiveness. …”
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LncRNAs in serum-derived extracellular vesicles are potential biomarker and correlated with immune infiltration in gastric cancer by Juan Ding, Yunyan Teng, Rongshu Cui, Jin Liu, Ke Xiao, Zhaogang Dong, Yi Zhang, Xiaofei Xu

“…Univariate and multivariate Cox regression analyses confirmed that linc-ROR was the only independent prognostic factor for GC. …”
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