A phase Ia study of a novel anti-HER2 antibody–drug conjugate GQ1001 in patients with previously treated HER2 positive advanced solid tumors by Chenfei Zhou, Bin Wang, Christina Teng, Hui Yang, Sarina A. Piha-Paul, Gary Richardson, Ashanya Malalasekera, Yajun Sun, Wei Wang, Jieqiong Liu, Yan Shi, Xianbao Zhan, Charlotte Lemech

“…Grade ≥ 3 treatment-related adverse events rate was 28.1% (9/32) and platelet count decreased (4/32, 12.5%) was the most common one. …”
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Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study by Rolando Barrios, Julio S G Montaner, Silvia Guillemi, Ni Gusti Ayu Nanditha, Viviane D Lima, Thomas L Patterson, Fidel Vila-Rodriguez, William G Honer, Jason Trigg, Hasan Nathani, Sara Shayegi-Nik, Weijia Yin, Alejandra Fonseca, Bronhilda T Takeh

“…Among the adjusted covariates, CD4 cell count<50 cells/mm3 (adjusted CSH (aCSH) 8.61, 95% CI: 4.75 to 15.60), uncontrolled viremia (aCSH 1.95, 95% CI: 1.20 to 3.17), 10-year increase in age (aCSH 2.41, 95% CI: 1.89 to 3.07), schizophrenia (aCSH 2.85, 95% CI: 1.69 to 4.80), traumatic brain injury (aCSH 2.43, 95% CI: 1.59 to 3.71), delirium (aCSH 2.27, 95% CI: 1.45 to 3.55), substance use disorder (SUD) (aCSH 1.94, 95% CI: 1.18 to 3.21) and mood/anxiety disorders (aCSH 1.80, 95% CI: 1.13 to 2.86) were associated with an increased hazard for dementia. …”
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Sex differences in epigenetic ageing for older people living with HIVResearch in context by Carrie D. Johnston, Alina P.S. Pang, Eugenia L. Siegler, Charlene Thomas, Chelsie O. Burchett, Mia Crowley, Rochelle O'Brien, Lishomwa C. Ndhlovu, Marshall J. Glesby, Michael J. Corley

“…Higher epigenetic frailty risk scores were associated with lower CD4 T cell counts (p = 0.0072) and lower CD4/CD8 ratio (p = 0.0017). …”
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Methodology for the Positive Voices 2022 Survey of People With HIV Accessing Care in England, Wales, and Scotland: Cross-Sectional Questionnaire Study by Janey Sewell, Carole Kelly, Adamma Aghaizu, Hannah Kitt, Annegret Pelchen-Matthews, Veronique Martin, Amal Farah, Colette Smith, Alison Brown, Clare Humphreys, Alex Sparrowhawk, Valerie Delpech, Alison Rodger, Fiona Lampe, Meaghan Kall

“…Data linkage to HARS enabled the extraction of clinical information on antiretroviral therapy (ART), HIV viral load, and CD4 lymphocyte counts. Probabilistic sampling was used to provide a randomly selected, representative sample of people attending HIV care who could be invited to complete a paper or online questionnaire 'on the web' to online. …”
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Exploring Mortality and Prognostic Factors of Heart Failure with In-Hospital and Emergency Patients by Electronic Medical Records: A Machine Learning Approach by Yu CS, Wu JL, Shih CM, Chiu KL, Chen YD, Chang TH

“…We aimed to investigate the relationship between morality and potential prognostic factors among in-patient and emergency patients with HF.Patients and Methods: A case series study: Data are collected from in-hospital and emergency care patients from 2014 to 2021, including their international classification of disease at admission, and laboratory data such as blood count, liver and renal functions, lipid profile, and other biochemistry from the hospital’s electrical medical records. …”
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AN INTEGRATED INFORMATION SYSTEM ON BIORESOURCE COLLECTIONS OF THE FASO OF RUSSIA by S. A. Lashin, D. A. Afonnikov, M. A. Genaev, F. V. Kazantsev, E. G. Komyshev, E. A. Oschepkova, А. V. Petrov, D. A. Rasskazov, A. A. Smirnova, N. A. Kolchanov

“…Collection materials have generally been formed over hundreds of years and may describe a vast number of samples counted by billions. Great efforts are made to preserve these materials, as well as to obtain more and more samples. …”
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Predictive Value of Urinary KIM-1, TIMP-2 and sTREM-1 for Contrast-Induced Acute Kidney Injury in Elderly Patients After Percutaneous Coronary Intervention by Huang W, Wang R, Zhang P

“…Serum creatinine (Scr) levels were tested and an estimated glomerular filtration rate (eGFR) was counted. Urinary KIM-1, TIMP-2 and sTREM-1 levels were assessed and the preoperative and general data as well as postoperative urinary KIM-1, TIMP-2 and sTREM-1 levels were compared. …”
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A novel nomogram based on the patient’s clinical data and CT signs to predict poor outcomes in AIS patients by Jingyao Yang, Fangfang Deng, Qian Zhang, Zhuyin Zhang, Qinghua Luo, Yeyu Xiao

“…Results Multivariate logistic regression analysis showed that hyperdense middle cerebral artery sign (HMCAS) (OR 9.113; 95% CI [1.945–42.708]; P = 0.005), the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) > 6 (OR 7.707; 95% CI [2.201–26.991]; P = 0.001), NIHSS score (OR 1.085; 95% CI [1.009–1.166]; P = 0.027), age (OR 1.077; 95% CI [1.020–1.138]; P = 0.008) and white blood cell count (WBC) (OR 1.200; 95% CI [1.008–1.428]; P = 0.040) were independent risk factors for early poor outcomes after mechanical thrombectomy. …”
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Serum hsa-miR-22-3p, hsa-miR-885-5p, Lipase-to-Amylase Ratio, C-Reactive Protein, CA19-9, and Neutrophil-to-Lymphocyte Ratio as Prognostic Factors in Advanced Pancreatic Ductal Ade... by Jakub Wnuk, Dorota Hudy, Joanna Katarzyna Strzelczyk, Łukasz Michalecki, Kamil Dybek, Iwona Gisterek-Grocholska

“…All patients underwent a complete medical history, physical examination, and routine laboratory tests including a complete blood count, C-reactive protein (CRP), CA19-9, lipase, and amylase. …”
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Efficacy of Transcutaneous Electrical Acupoint Stimulation on Modulating Upper Extremity Sympathetic Skin Response in Alleviating Cancer Survivors With Chemotherapy-Induced Periphe... by Xu Y, Wu J, Jiang Q, Lv Y, Zhou J, Wang Z, Zhao H, Du D

“…The procedure was considered a clinically effective relief if the patients’ NRS scores were reduced by 50% or more, and overall patients with effective relief were all counted after treatment. Furthermore, a multivariable logistic regression model was utilized to evaluate the predictors of effective relief following CIPN treatment.Results: : A total of 102 cancer survivors with CIPN were analyzed after PSM (51 in each group). …”
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Adverse events associated with the delivery of telerehabilitation across rehabilitation populations: A scoping review. by Thomas Yau, Josh Chan, McKyla McIntyre, Damanveer Bhogal, Angie Andreoli, Carl Froilan D Leochico, Mark Bayley, Ailene Kua, Meiqi Guo, Sarah Munce

“…For synthesis, data were summarized quantitatively using numerical counts and qualitatively via content analysis. The data were grouped by intervention type and by type of adverse event.…”
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Seaweed extract of Gracilaria verrucosa as an antibacterial and treatment against Vibrio harveyi infection of Litopenaeus vannamei by Mad Rudi, Sukenda Sukenda, Dinamella Wahjuningrum, Wesly Pasaribu, Dendi Hidayatullah

“…ABSTRACT The objectives of this study were to investigate the antibacterial activity of G. verrucosa extract in test inhibitory zone with different concentrations (500, 1000, 1500, and 2000 mg/L) and  to examine G. verrucosa extract with different dosage (0.5, 1.0, 1.5, 2.0 g/kg) in feed on immune responses (total hemocytes count, phagocytic activity, phenoloxidase activity, respiratory burst) and survival rate in the Litopenaeus vannamei against the pathogenic Vibrio harveyi. …”
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Development of a new data management system for the study of the gut microbiome of children who are small for their gestational age by Felix Manske, Magdalena Durda-Masny, Norbert Grundmann, Jan Mazela, Monika Englert-Golon, Marta Szymankiewicz-Bręborowicz, Joanna Ciomborowska-Basheer, Izabela Makałowska, Anita Szwed, Wojciech Makałowski

“…Without restrictions caused by the level of programming proficiency, our team members could explore the study data and optionally filter them using the graphical interface, before exporting the data in a format directly suitable for external normalization of read counts and statistical analyses. Study results could be conveniently and transparently shared with the public, as demonstrated here. …”
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Machine learning derivation of two cardiac arrest subphenotypes with distinct responses to treatment by Weidong Zhang, Chenxi Wu, Peifeng Ni, Sheng Zhang, Hongwei Zhang, Ying Zhu, Wei Hu, Mengyuan Diao

“…After an extensive literature review and expert consultations, key factors such as temperature (T), sodium (Na), creatinine (CR), glucose (GLU), heart rate (HR), PaO2/FiO2 ratio (P/F), hemoglobin (HB), mean arterial pressure (MAP), platelets (PLT), and white blood cell count (WBC) were identified as the most significant for cluster analysis. …”
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Results of replacing fish meal with insect protein in carp feeds by O. Deren, O. Bernakevych, L. Bobeliak, N. Hrytsyshyna, M. Koryliak

“…At the same time, a tendency for an increase in hemoglobin content and the count of erythrocytes in the blood of the experimental group compared to the control group was recorded. …”
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Dietary citral increase growth and health performance of shrimp Penaeus vannamei by Ricky Hadi Pratama, Julie Ekasari, Muhammad Agus Suprayudi, Ichsan Achmad Fauzi, Wiyoto Wiyoto

“…The shrimp immune response was also higher in the shrimp fed with dietary citral diets as shown by the higher total hemocyte count, respiratory burst, and phenoloxidase activity compared to those of the control. …”
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Effects of biologic therapy on novel indices of lung inhomogeneity in patients with severe type-2 high asthma by Nayia Petousi, Nick P Talbot, Ian Pavord, Peter A Robbins, Nicholas M J Smith, Graham Richmond, Asma Alamoudi, Lorenzo Petralia, Haopeng Xu, Dominic Sandhu, Grant AD Ritchie

“…Assessments included prebronchodilator and postbronchodilator CCP and spirometry, and measurements of blood eosinophil count (BEC), fractional exhaled nitric oxide and Asthma-Symptom Questionnaire (ACQ-5).Results Bronchodilation significantly reduced σlnCl, a novel CCP-derived ventilation inhomogeneity index, (ΔσlnCl −0.08, 95% CI (−0.10 to –0.05), p<0.001). …”
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Research Status and Direction of Chronic Obstructive Pulmonary Disease Complicated with Coronary Heart Disease: A Bibliometric Analysis from 2005 to 2024 by Bian H, Zhu S, Xing W, Qi L, Xue J, Peng X, Jin Z, Zhao H

“…The United States emerged as the leading country by publication count; Lin Cheng-li ranked first among authors, while China Medical University topped institutional contributions. …”
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Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

“…Following a single 0.08 mg/kg dose of Pegmolesatide in BALB/c mice, reticulocyte count, red blood cells, hemoglobin, and hematocrit persisted at elevated levels 4-6 days after administration. …”
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Evaluation of CellerateRX Surgical Powder utility in reducing groin complications after femoral exposure by Vy C. Dang, BS, Eric K. Peden, MD, Trisha Roy, MD, PhD, Alan B. Lumsden, MD, Linda Le, MD, Charudatta S. Bavare, MD, Sohaib K. Mhaidi, MD, Maham Rahimi, MD, PhD

“…Bilateral groin incisions were counted as two separate constituents in the overall sample. …”
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