p300/Sp1-Mediated High Expression of p16 Promotes Endothelial Progenitor Cell Senescence Leading to the Occurrence of Chronic Obstructive Pulmonary Disease by Zhihui He, Huaihuai Peng, Min Gao, Guibin Liang, Menghao Zeng, Xuefeng Zhang

“…Then, we knocked down or overexpressed Sp1 and p300 and used the ChIP assay to detect the histone H4 acetylation level in the promoter region of p16, CCK8 to detect cell proliferation, flow cytometry to detect the cell cycle, and β-galactosidase staining to count the proportion of senescent cells. Results. …”
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Protocol for a multicentre randomised controlled trial examining the effects of temporarily pausing Bruton tyrosine kinase inhibitor therapy to coincide with SARS-CoV-2 vaccination... by Abhishek Abhishek, Jonathan A Cook, Helen M Parry, Anne Francis, Lelia Duley, Vicki S Barber, Paul Moss, Nicholas Peckham

“…Secondary outcomes are RBD antibody levels at 12 weeks postbooster vaccination, participant global assessments of disease activity, blood films, full blood count and lactate dehydrogenase levels, impact on quality of life, self-reported adherence with request to temporarily pause or continue BTKi, T cell response against spike protein and relative neutralising antibody titre against SARS-CoV-2 viral variants. …”
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Prognostic Value of Endothelial Progenitor Cells in Acute Myocardial Infarction Patients by Gongjie Ye, Xiaodan Chen, Yinchao Zhou, Jianqing Zhou, Yongfei Song, Xiaoyong Yang, Lei Yang

“…Among these patients, 23 (25.3%) died from various causes during the follow-up period. The counts of EPCs were found to be significantly higher in the survival group compared to the death group (P<0.05). …”
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The potential of aloe vera gel utilization for skin wound healing in rats based on GC–MS and HPLC chemical profile by Nadia Mohamed Said Arafa, Huda Mohammad Ahmad Hummadi, Gehan Moustafa Badr

“…The evaluation was through the assessment of the wound contraction and complete blood count, serum interleukin-4 and skin tissue proline, hydroxyproline, glycine, malondialdehyde, nitric oxide contents and skin histopathology investigation at tested intervals. …”
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Occurrence and assessment of chronic pain fatigue and sleep disturbance in axial spondyloarthritis patients by Eman Abdel Ghani Sayed, Samer Samy, Faruk Ali Abdi, Anna Abou-Raya

“…Patients with rheumatoid arthritis, cancer, liver disease, and severe sleep or psychiatric disorders were excluded.Methods Complete blood count, erythrocyte sedimentation rate, C-reactive protein (CRP), human leucocyticantigen-B27, plain x-ray, and magnetic resonance imaging of the sacroiliac joints were performed. …”
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Assessing the Impact of Social Media Usage and Performance of the Selected Small and Medium Businesses in Ntungamo District. by Nyamwija, Bonitah

“…The collected data was analyzed manually using tallies and the responses of the subjects were then categorized in frequency counts and score tables with varying percentages calculated and later tabulation method was used to present data. …”
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A novel sustained-release agent based on disulfide-induced recombinant collagen hydrogels for the prevention and treatment of Schistosoma infections by Jie Wang, Lijun Song, Yuntian Xing, Yang Dai, Jinyuan Hu, Guoli Qu, Yongliang Xu, Xuren Yin, Derong Hang, Jianfeng Zhang, Chunrong Xiong, Liang Shi, Fei Xu

“…The subcutaneous injection of praziquantel after 28 days of infection showed 95.19% and 80.12% reduction of worm and egg counts, respectively, and the development of larvae was significantly slowed down. …”
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Microbiome of <i>Hyalomma dromedarii</i> (Ixodida: Ixodidae) Ticks: Variation in Community Structure with Regard to Sex and Host Habitat by Nighat Perveen, Alejandro Cabezas-Cruz, Daniil Iliashevich, Lianet Abuin-Denis, Olivier Andre Sparagano, Arve Lee Willingham

“…We obtained 151,168 read counts, and these formed 237 operational taxonomic units representing 11 phyla, 22 classes, 77 families, and 164 genera. …”
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Neopterin and Beta-2 Microglobulin Relations to Immunity and Inflammatory Status in Nonischemic Dilated Cardiomyopathy Patients by Celina Wojciechowska, Jan Wodniecki, Romuald Wojnicz, Ewa Romuk, Wojciech Jacheć, Andrzej Tomasik, Bronisława Skrzep-Poloczek, Beata Spinczyk, Ewa Nowalany-Kozielska

“…The cryostat biopsy specimens were assessed using histology, immunohistology, and immunochemistry methods (HLA ABC, HLA DR expression, CD3 + lymphocytes, and macrophages counts). Results. The strong increase of HLA ABC or HLA DR expression was detected in 27.2% patients—group A—being low in 72.8% patients—group B. …”
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Circulating MicroRNAs in Patients with Psoriasis Treated with Anti-IL-23: A Cohort Study by Federico Diotallevi, Giulia Matacchione, Anna Campanati, Elena Marinelli Busilacchi, Nadia Viola, Ilaria Pace, Beatrice Fontana, Roberta Roncarati, Massimiliano Bonafè, Manuela Ferracin, Jacopo Sabbatinelli, Fabiola Olivieri

“…Results Significant clinical improvement was observed in all patients after 1 year of treatment, accompanied by increased Treg counts and reduced levels of pro-inflammatory cytokines. …”
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Age-specific reference ranges and variation of anti-mülerian hormone in healthy Chinese women of reproductive and perimenopausal age: a nationwide population-based prospective mult... by Linli Hu, Hongyi Yang, Haining Luo, Yuexiang Zhang, Xiaohong Wang, Sanhua Wei, Qiongfang Wu, Ying Jiang, Xiaoyan Liang, Jianhui Chen, Yingpu Sun†

“…Multivariable linear regressions were undertaken to analyze the association of serum AMH with different demographic and clinical variables, including antral follicle count (AFC).Results 1113 healthy Chinese women were enrolled, including 614 of premenopausal age and others of reproductive age. …”
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Returning to the emergency department: a retrospective analysis of mental health re-presentations among young people in New South Wales, Australia by Rebecca Ivers, Michael Dinh, Patricia Cullen, Bette Liu, Katharine Steinbeck, Natasha Walker, Robert Neil Leong

“…Objectives This study aimed to describe mental health emergency department (ED) presentations among young people aged 8–26 years in New South Wales, Australia, and to identify key characteristics associated with higher risk of ED mental health re-presentation.Design, setting and participants Retrospective analysis of linked ED data records for mental health presentations between 1 January 2015 and 30 June 2018.Main outcome measures The main outcome was the total number of mental health ED re-presentations within 1 year, following initial presentation. Count regression models were fitted to estimate factors associated with higher likelihood of re-presentations.Results Forty thousand two hundred and ninety patients were included in the analyses, and 9713 (~25%) re-presented during the following year; 1831 (20%) presented at least three times. …”
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Liver Transplantation without Perioperative Transfusions Single-Center Experience Showing Better Early Outcome and Shorter Hospital Stay by Nicolás Goldaracena, Patricio Méndez, Emilio Quiñonez, Gustavo Devetach, Lucio Koo, Carlos Jeanes, Margarita Anders, Federico Orozco, Pablo D. Comignani, Ricardo C. Mastai, Lucas McCormack

“…While median MELD was significantly higher in Yes-Transfusion (11 versus 21; P=0.0001) group, platelet count, prothrombin time, and hemoglobin were significantly lower. …”
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The Influence of Ficus deltoidea in Preserving Alveolar Bone in Ovariectomized Rats by N. I. Omar, B. Baharin, S. F. Lau, N. Ibrahim, N. Mohd, A. Ahmad Fauzi, N. Muhammad, N. M. Fernandez

“…In conclusion, F. deltoidea has the capacity to prevent alveolar bone loss in ovariectomy-induced osteoporosis rats by potentially preserving trabecular bone microarchitecture and to decrease osteoclast and increase osteoblast cell count.…”
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A nonactivating ITGB3 mutation in the β3 cytoplasmic region causes macrothrombocytopenia with an impaired αIIbβ3/RhoA pathway by Keiichi Nakata, Keigo Akuta, Takaya Endo, Midori Koike, Daisuke Motooka, Daisuke Okuzaki, Hisashi Kato, Yoshiaki Tomiyama, Naoki Hosen, Hirokazu Kashiwagi

“…Macrothrombocytopenia was decreased to 76% and 40% of platelet counts in heterozygous (Hetero) and homozygous (Homo) KI mice, respectively, when compared with the wild-type mice. …”
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Comparison of Tick Control and Antibiotic Use Practices at Farm Level in Regions of High and Low Acaricide Resistance in Uganda by Joseph Byaruhanga, Fred Odua, Yvette Ssebunya, Olivia Aketch, Dickson Stuart Tayebwa, Innocent B. Rwego, Patrick Vudriko

“…Delvotest SP-NT® test kit was used to detect antibiotic residues in milk. Half-body tick counts and acaricide efficacy tests were performed. …”
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Efficacy of double filtration plasmapheresis in hyperlipidemia acute pancreatitis: a retrospective observational study by Rong Qin, Yibei Liu, Rui Ding, Minhui Yang, Yun Huang, Xujia Chen, Feng Zhang, Yanting Liu, Hongping Jia, Yiyao Duan, Lifang Zhou, Hui Wang

“…Within-group analysis revealed significant pre- and post-treatment changes in total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), white blood cell count (WBC), neutrophil percentage (N%), systemic immune-inflammation index (SII), mean arterial pressure (MAP), bedside index for severity in acute pancreatitis (BISAP), and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores in the DFPP group (P < 0.05). …”
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Human Papillomavirus, Human Immunodeficiency Virus, and Oral Microbiota Interplay in Nigerian Youth (HOMINY): A Prospective Cohort Study Protocol by Jia Liu, Esosa Osagie, Paul Akhigbe, Nosakhare Idemudia, Ozoemene Obuekwe, Ruxton Adebiyi, Nicolas Schlecht, Yana Bromberg, Fidelis E Eki-Udoko, Nosayaba Osazuwa-Peters, Modupe Oluseun Coker

“…Blood samples are tested for HIV, Hepatitis B virus (HBV) and Hepatitis C virus (HCV), with CD4, CD8 and full blood counts performed. Oral HPV is assessed for incidence, persistence, and clearance. …”
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Characterization of a Natural Accession of <i>Elymus sibiricus</i> with <i>In Situ</i> Hybridization and Agronomic Evaluation by Yizhuo Liu, Jiarui Ding, Chunfei Wu, Weiwei Song, Xinyu Zhao, Haibin Zhao, Yunfeng Qu, Hui Jin, Rui Zhang, Mingyao Li, Xinyu Yan, Liangyu Zhu, Yaqi Bao, Dianhao Liu, Xinling Li, Lei Cui, Hongjie Li, Yanming Zhang

“…Morphologically, 20HSC-Z9 had an average tiller count ranging from 56 to 74, similar to that of the control accession 20HSC-ES, and its plant height was significantly lower than that of 20HSC-IWG. …”
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Environmental DNA metabarcoding shows potential for monitoring meiofauna and marine nematodes diversity in mangrove ecosystems in China by Mingcheng Hu, Yuqing Guo, Fenfen Ji, Yijia Shih, Kai Liu, Xiangxiang Yi, Yuanxin Fan

“…The appropriate specific primers, a comprehensive database, and the definitive correlation between individual counts and sequences are crucial for the further widespread implementation of eDNA metabarcoding in monitoring meiofauna and marine nematodes diversity.…”
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