Machine learning based on blood test biomarkers predicts fast progression in advanced NSCLC patients treated with immunotherapy by Jie Yang, Jian-Guo Zhou, Benjamin Frey, Hu Ma, Haitao Wang, Markus Hecht, Rainer Fietkau, Udo Gaipl, Xiaofei Chen, Ada Hang-Heng Wong, Fangya Tan, Si-Si He, Gang Shen, Yun-Jia Wang, Wenzhao Zhong

“…The most important variables for the prediction model were: C reactive protein, neutrophil count, lactate dehydrogenase and alanine transaminase. …”
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Aetiology and Outcomes of Thrombocytopenia in Pregnancy: A Cross-Sectional Study in a University Hospital, India by Sudha V. Hooli, Neelima Shah, Prashant Shah, Shrradha Suresh, Bali Sukeshani Sunil

“…Methodology: The authors included a total of 133 patients in their third trimester (>32 weeks), with a platelet count <149,000 /mm3, admitted to the authors’ institution from 1st January 2021 to 31st December 2021. …”
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In vivo evidence for cell body loss in cortical lesions in people with multiple sclerosis by Eva A. Krijnen, Hansol Lee, Samantha Noteboom, Florence L. Chiang, Martijn D. Steenwijk, Menno M. Schoonheim, Eric C. Klawiter, Susie Y. Huang

“…Results Cortical lesions were present in all people with multiple sclerosis with a median count of 8 [IQR 5–18] and total volume of 0.16 [0.09–0.46 mL]. …”
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The Efficacy of Moxibustion on the Serum Levels of CXCL1 and β-EP in Patients with Rheumatoid Arthritis by Siyu Tao, Xue Wang, Chenxi Liao, Yan Xiong, Jie Tang, Nannan Jiang, Yuan Li, Xinyue Hu, Rouxian Shuai, Yueyue Wang, Ping Wu

“…Trial endpoints were change (∆) in symptoms, measured by Ritchie’s articular index (RAI), swollen joint count (SJC), and laboratory indicators, measured by the level of CXCL1, β-EP, tumor necrosis factor-a (TNF-α), and interleukin-1β (IL-1β). …”
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Personalized prediction of glycemic responses to food in women with diet-treated gestational diabetes: the role of the gut microbiota by Polina V. Popova, Artem O. Isakov, Anastasiia N. Rusanova, Stanislav I. Sitkin, Anna D. Anopova, Elena A. Vasukova, Alexandra S. Tkachuk, Irina S. Nemikina, Elizaveta A. Stepanova, Angelina I. Eriskovskaya, Ekaterina A. Stepanova, Evgenii A. Pustozerov, Maria A. Kokina, Elena Y. Vasilieva, Lyudmila B. Vasilyeva, Soha Zgairy, Elad Rubin, Carmel Even, Sondra Turjeman, Tatiana M. Pervunina, Elena N. Grineva, Omry Koren, Evgeny V. Shlyakhto

“…The final model showed better correlation with measured PPGRs than one based only on carbohydrate count (r = 0.72 vs. r = 0.51 for iAUC120). Although microbiome features were important, their contribution to model performance was modest.…”
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Fixed-Point Grover Adaptive Search for Quadratic Binary Optimization Problems by Akos Nagy, Jaime Park, Cindy Zhang, Atithi Acharya, Alex Khan

“…For all values of <inline-formula><tex-math notation="LaTeX">$\Lambda$</tex-math></inline-formula>, the non-Clifford gate count of these oracles is strictly lower (at least by a factor of <inline-formula><tex-math notation="LaTeX">$\sim 2$</tex-math></inline-formula>) than previous constructions. …”
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Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation by Wei Yan, Yi-si Zhao, Ke Xie, Yu Xing, Fang Xu

“…The fungal load in the lung tissue was determined by the plate colony count. ELISA kit was used to detect the lung tissue homogenate proinflammatory cytokines TNF-α, IL-6, CCL2, and VEGF. …”
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Clinical Profile and Outcome in Patients with Coronary Slow Flow Phenomenon by Xiaogang Zhu, Hua Shen, Fei Gao, Sijing Wu, Qian Ma, Shuo Jia, Ziwei Zhao, Shan Tong, Zhihao Zhang, Yujie Zhou

“…Two teams (clinical center and core lab) were blind to patient data for the assessment of coronary angiograph using corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC). The study cohort consisted of 429 patients (294 men, 68.5%), aged from 30 to 78 years (mean, 54 years). …”
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Development and validation of a nomogram for predicting immune-mediated colitis in lung cancer patients treated with immune checkpoint inhibitors: a retrospective cohort study in C... by Qianjie Xu, Xiaosheng Li, Yuliang Yuan, Guangzhong Liang, Zuhai Hu, Wei Zhang, Ying Wang, Haike Lei

“…Conversely, a higher white blood cell (WBC) count, CD4/CD8 ratio, and platelet−lymphocyte ratio (PLR) were identified as factors associated with a reduced risk of IMC development (all P &lt; 0.05). …”
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The clinical implication of CD45RA+ naïve T cells and CD45RO+ memory T cells in advanced pancreatic cancer: a proxy for tumor biology and outcome prediction by Junjie Hang, Junjie Huang, Siyuan Zhou, Lixia Wu, Yingwei Zhu, Lina Zhu, Hanyu Zhou, Kequn Xu, Hua Jiang, Xuguang Yang

“…CD4+ naïve/memory ratio showed close correlations with hemoglobin, red blood cell (RBC), absolute neutrophil count (ANC) and platelet while CD8+ naïve/memory ratio was correlated with hemoglobin, RBC and CEA. …”
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Development of antibacterial magnetic clay-based nanocomposites for water treatment by Horue, Manuel, Barraqué, Facundo, Montes, María Luciana, Zelaya-Soulé, María Emilia, Morantes, César Fernández, Urruchua, Florencia Camila, Correa, Hilda Edith, Castro, Guillermo Raul, Fernandez, Mariela Alejandra

“…Those results were more precisely investigated using the viable plate count method. The magnetic materials had a similar antimicrobial effect to those without magnetic properties, indicating that Fe oxides can be nucleated to impart a magnetic response without affecting the biocide properties. …”
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Tofacitinib Efficacy/Safety in Patients with Ankylosing Spondylitis by Baseline Body Mass Index: A Post Hoc Analysis of Phase 2/3 Trials by Hillary Norton, Paula Sliwinska-Stanczyk, Tomas Hala, Bassel El-Zorkany, Lori Stockert, Rajiv Mundayat, Lisy Wang, Christopher T. Ritchlin

“…At baseline, patients with BMI < 25 kg/m2 were younger and more likely to be current smokers/Asian, and patients with BMI ≥ 30 kg/m2 had higher mean waist circumference/swollen joint count (SJC) and were more likely to have enthesitis, high-sensitivity C-reactive protein (hsCRP) > 5 mg/L, an inadequate response to tumor necrosis factor inhibitors (TNFi), and prior biologic disease-modifying anti-rheumatic drug (bDMARD) use versus other categories. …”
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Machine learning for predicting severe dengue in Puerto Rico by Zachary J. Madewell, Dania M. Rodriguez, Maile B. Thayer, Vanessa Rivera-Amill, Gabriela Paz-Bailey, Laura E. Adams, Joshua M. Wong

“…Feature importance analysis identified hemoconcentration (≥ 20% increase during illness or ≥ 20% above baseline for age and sex), leukopenia (white blood cell count < 4000/mm3), and timing of presentation at 4–6 days post-symptom onset as key predictors. …”
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An early lung cancer diagnosis model for non-smokers incorporating ct imaging analysis and circulating genetically abnormal cells (CACs) by Ran Ni, Yongjie Huang, Lei Wang, Hongjie Chen, Guorui Zhang, Yali Yu, Yinglan Kuang, Yuyan Tang, Xing Lu, Hong Liu

“…Furthermore, our results indicated that the model built using random forest (RF) method, which integrates clinical characteristics (age, extra-thoracic cancer history, gender), radiological characteristics of pulmonary nodules (nodule diameter, nodule count, upper lobe location, malignant sign at the nodule edge, subsolid status), the artificial intelligence analysis of LDCT data, and liquid biopsy achieved the best diagnostic performance in the independent external non-smokers validation cohort (sensitivity 92%, specificity 97%, area under the curve [AUC] = 0.99). …”
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General immunologic reactivity of patients with COVID-19 and its relation to gene polymorphism, severity of clinical course of the disease and combination with comorbidities by M.O. Sokolenko, L.P. Sydorchuk, L.S. Sokolenko, A.A. Sokolenko

“…The overall immunological reactivity was detected and evaluated based on the analysis of 14 integral leukocyte indices: leukocyte shift index, absolute leukocyte count/erythrocyte sedimentation rate (ESR) ratio index, lymphocyte-granulocyte index, lymphocyte index, immunological resistance and reactivity index, and others. …”
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Double-Blind Clinical Trial of Arginine Supplementation in the Treatment of Adult Patients with Sickle Cell Anaemia by Renata M. N. Eleutério, Francisco O. Nascimento, Tamara G. Araújo, Marilena F. Castro, Tarcísio P. Almeida Filho, Pedro A. Maia Filho, José Eleutério, Darcielle B. D. Elias, Romélia P. G. Lemes

“…Laboratory tests were performed to determine the levels of the following: (1) complete blood count; (2) nitrite + nitrate; (3) HbF; and (4) reticulocytes. …”
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Molecular, Cytogenetic, and Hematological Analysis of Chronic Myeloid Leukemia Patients and Discovery of Two Novel Translocations by Muhammad Asif, Abrar Hussain, Abdul Wali, Nazeer Ahmed, Irfan Ali, Zafar Iqbal, Muhammad Amir, Muhammad Shafiq, Mahmood Rasool

“…In this study, 131 CML patients were enrolled. Complete blood cell count was performed at the time of diagnosis for all the patients. …”
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In vivo pharmacokinetic and pharmacodynamic study and cutoff of florfenicol against Riemerella anatipestifer in ducks by Hui-Lin Zhang, Fa-Lei Li, Hui-Yang Chen, Ding-Mei Qin, Shu-Jun Sun, Meng-Meng Zhang, Huan-Zhong Ding, Yong Liu

“…The magnitudes of AUC24h/MIC and Cmax/MIC required to produce a drop of 3 Log10CFU/mL in the bacterial count were 58.56 h and 15.10, respectively. The MIC distribution of 164 R. anatipestifer strains for FF ranged from 0.25 to 16 μg/mL. …”
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The Effect of Temperature over the Growth and Biofilm Formation of the Thermotolerant <i>Aspergillus flavus</i> by José Alejandro Hernández-Benítez, Brenda Nallely Santos-Ocampo, Daniel Genaro Rosas-Ramírez, Luis Antonio Bautista-Hernández, Víctor Manuel Bautista-de Lucio, Néstor Octavio Pérez, Aída Verónica Rodríguez-Tovar

“…Radial growth was highest at 28 °C, while the conidial count and density were favored at higher temperatures. …”
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Acute therapeutic effects and pathophysiology of eosinophilic granulomatosis with polyangiitis neuropathy by Fumitaka Shimizu, Mariko Oishi, Toshihiko Maeda, Yukio Takeshita, Hideaki Nishihara, Ryota Sato, Takashi Kanda, Masayuki Nakamori, Michiaki Koga, Miwako Fujisawa, Yuki Mizumoto, Nanami Yamanaka, Takashi Nawata, Tatsuya Okafuji, Susumu Fujikawa, Kinya Matsuo, Joe Nemoto, Masaya Honda

“…Peripheral nerve recovery rates were evaluated after early treatment by identifying the damaged peripheral nerve through detailed neurological findings.Results The eosinophil count at onset was significantly correlated with the total number of damaged nerves. …”
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