Bariatric Surgery as a Molecular Modulator: The Role of FSHR Polymorphisms in Enhancing eNOS Expression and Reproductive Hormone Dynamics in Women with Severe Obesity by Charalampos Voros, Despoina Mavrogianni, Kyriakos Bananis, Alexios Karakasis, Anthi-Maria Papahliou, Vasileios Topalis, Antonia Varthaliti, Raphail Mantzioros, Panagiota Kondili, Menelaos Darlas, Regina Sotiropoulou, Diamantis Athanasiou, Dimitris Mathiopoulos, Panagiotis Antsaklis, Dimitrios Loutradis, Georgios Daskalakis

“…Pre- and post-surgery levels of eNOS and reproductive hormones such as follicle-stimulating hormone (FSH), sex hormone-binding globulin (SHBG), anti-Müllerian hormone (AMH), and antral follicle count (AFC) were assessed. Patients were divided into three FSHR polymorphism groups (Ser/Ser, Asn/Asn, and Ser/Asn), and results were compared between them. …”
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Dream Recall Frequencies and Dream Content in Wilson’s Disease with and without REM Sleep Behaviour Disorder: A Neurooneirologic Study by Gotthard G. Tribl, Mateus C. Trindade, Michael Schredl, Joana Pires, Iris Reinhard, Thais Bittencourt, Geraldo Lorenzi-Filho, Rosana Cardoso Alves, Daniel Ciampi de Andrade, Erich T. Fonoff, Edson Bor-Seng-Shu, Alexandre A. Machado, Manoel J. Teixeira, Egberto R. Barbosa

“…WD patients showed a significantly lower dream word count and very few other differences in dream characteristics compared to age- and sex-matched healthy controls. …”
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Vegetable Crop Growth Modeling in Digital Twin Platform Based on Large Language Model Inference by ZHAO Chunjiang, LI Jingchen, WU Huarui, YANG Yusen

“…Over five years, the dataset collected included 4 300 detailed records, documenting parameters such as plant height, leaf count, soil conditions, irrigation schedules, fertilization practices, and pest management interventions. …”
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Unveiling chemical industry secrets: Insights gleaned from scientific literatures that examine internal chemical corporate documents-A scoping review. by Miaoran Dong, Marc-André Gagnon

“…In contrast to Gagnon and Dong's pharmaceutical corporate capture review, which identified 37 papers before 2022, our chemical industry findings reveal a lower count, with only 18 papers identified. Notably, the vast majority of the papers in both sectors shows an emphasis on analyzing strategies used for scientific capture. …”
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Iodine-131 Combined With Plasma Exchange Treatment in Graves’ Hyperthyroidism Patients With Severe Liver Injury Whose Average Model for End-Stage Liver Disease Scores >20 by Xin-Fang Zhu, Rong-Rong Ding, Bing-Yao Wang, Yun-hui Yang, Fu-Xia Ta, Yuan Wang, Qing-Mei Gao, Qi Zhang, Rong Xia, Xing-Guang Luo, Xuan Wang, Jian-Ming Zheng, Hui-Qing Zhu

“…The levels of hemoglobin, platelet count, alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, alkaline phosphatase, glutamyl transpeptidase, MELD scores, free triiodothyronine, free thyroxine, antithyroid peroxidase autoantibody and serum thyrotropin receptor antibodies after PE treatment were significantly lower than before PE treatment (P < .05). …”
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Predicting dupilumab effectiveness with Type-2 biomarkers: A real-world study of severe asthma by Kenji Mizumura, Yasuhiro Gon, Norihiro Harada, Shiho Yamada, Asami Fukuda, Ryosuke Ozoe, Shuichiro Maruoka, Sumiko Abe, Kazuhisa Takahashi, Akihiko Tanaka, Hironori Sagara, Taisuke Akamatsu, Toshihiro Shirai, Katsunori Masaki, Koichi Fukunaga, Konomi Kobayashi, Hiroyuki Nagase, Nobuaki Miyahara, Arihiko Kanehiro, Noboru Kitamura, Naruhiko Sugihara, Fumio Kumasawa, Junko Terada-Hirashima, Masayuki Hojo, Kazuyuki Chibana, Etsuko Tagaya

“…CASA-Q sputum domain scores were significantly higher in the group with elevated eosinophil counts. Regression analysis revealed that FeNO levels and blood eosinophil counts are significant predictors of FEV1 improvement, with blood eosinophil counts also predicting sputum improvement in patients treated with dupilumab. …”
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Examining the effect of direct-from-blood bacterial testing on antibiotic administration and clinical outcomes: a protocol and statistical analysis plan for a pragmatic randomised... by Li Wang, Wesley H Self, Todd W Rice, Matthew W Semler, Karen F Miller, Cheryl L Gatto, Andrea Fletcher, Romney M Humphries, Joanna L Stollings, Adrienne Baughman, Jakea Johnson, Edward T Qian, Mary Lynn Dear, David C Gaston, Ariel A Lewis, George E Nelson, Benjamin J Ereshefsky, Matthew A Christensen, Ritu Banerjee, Dan Albert, Alison Benton, Laura Bobbitt, Carleigh Burns, Timothy Duff, David C. Gaston, MLS Sharon Glover, Allyson Hobbie, Austin Ing, Gabriel Kemp, Sheryl Mangrum, Geoff Mavrak, Kelly Moser, David Mulherin, Shannon Pugh, Matthew Rodgers, Chrissie Schaeffer, Adam Turner, Sabrina Shipman, Halden Z VanCleave, Hamilton Wen Li Wang, LaKeysha Wiggins

“…Additional outcomes include highest stage of acute kidney injury, lowest platelet count and receipt of kidney replacement therapy within 14 days of randomisation, as well as hospital-free days, intensive care unit-free-days and all-cause, in-hospital mortality within 28 days of randomisation. …”
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Effect of Body Weight Supported Treadmill Training on Motor Function of Rats with Spinal Cord Injury Based on AMPK-Autophagy Signaling Pathway by CAI Jili, ZHAI Chenyuan, WANG Zun, WU Qi, FANG Lu, WANG Yu, WANG Tong

“…Nissl staining was used to observe the morphology and count of spinal cord neurons. Western blot method was used to detect the protein expression levels of p-AMPK, t-AMPK, LC3 and p62 in spinal cord tissue.Results(1) BBB score: compared with the sham operation group, the BBB score of the model group and the exercise group were significantly lower at the 1st, 7th, 14th, 21st and 28th days after modeling (<italic>P</italic>&lt;0.05). …”
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Grow-out of spiny lobster Panulirus sp. with high stocking density in controlled tanks by Rio Yusufi Subhan, Eddy Supriyono, Widanarni, Widanarni, Daniel Djokosetiyanto

“…The best stocking densities for spiny lobster was 18 ind/m3 (KT18) with 2.5‒3.5×106cells/mL total haemocyte counts, 24.6‒28.3 mg/dL haemolymph glucose, and 38.37 ± 3.20% frequency of molt. …”
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Analysis of stomatal characteristics of maize hybrids and their parental inbred lines during critical reproductive periods by Changyu Zhang, Changyu Zhang, Yu Jin, Yu Jin, Jinglu Wang, Jinglu Wang, Ying Zhang, Ying Zhang, Yanxin Zhao, Xianju Lu, Xianju Lu, Wei Song, Xinyu Guo, Xinyu Guo

“…Specifically, at the monocot scale, stomatal density increased from 74.35 to 87.19 Counts/mm2 from lower to upper leaf layers. Concurrently, the stomatal shape shifted from sub-circular (stomatal roundness = 0.64) to narrow and elongated (stomatal roundness = 0.63). …”
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Development of Multimorbidity Indexes Based on Common Mental Health Conditions by Junko Kose, Emmanuelle Kesse-Guyot, Pauline Duquenne, Serge Hercberg, Serge Hercberg, Pilar Galan, Mathilde Touvier, Valentina A. Andreeva, Léopold K. Fezeu

“…The new indexes had slightly better predictive performance than simple counts of mental disorders.ConclusionWe developed mental multimorbidity indexes as epidemiological research tools. …”
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Sickle Cell Anemia Patients Display an Intricate Cellular and Serum Biomarker Network Highlighted by TCD4+CD69+ Lymphocytes, IL-17/MIP-1β, IL-12/VEGF, and IL-10/IP-10 Axis by Nadja Pinto Garcia, Alexander Leonardo S. Júnior, Geyse Adriana S. Soares, Thainá Cristina C. Costa, Alicia Patrine C. dos Santos, Allyson Guimarães Costa, Andréa Monteiro Tarragô, Rejane Nina Martins, Flávia do Carmo Leão Pontes, Emerson Garcia de Almeida, Erich Vinícius de Paula, Olindo Assis Martins-Filho, Adriana Malheiro

“…Sickle cell anemia (SCA) is associated with a chronic proinflammatory state characterized by elevated leukocyte count, mortality from severe recurrent infections, and subsequent vasoocclusive complications with leukocyte adhesion to the endothelium and increased plasma levels of inflammatory cytokines. …”
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Pediatric bacterial meningitis in southern China: analysis of 838 cases by Lianfeng Chen, Wen-Lin Wu, Yuanyuan Gao, Xiaojing Li, Sida Yang, Huici Liang, Kelu Zheng, Yani Zhang, Haixia Zhu, Yang Tian, Bingwei Peng, Haisheng Lin, Xiuying Wang, Shuyao Ning, Yinyan Gan, Chi Hou, Yinting Liao, Huiling Sheng, Wen-Xiong Chen, Wen-Xiong Chen

“…Most patients initially exhibited typical cerebrospinal fluid (CSF) changes of BM, including elevated white blood cell count, increased protein levels, and decreased glucose concentration. …”
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Pilot clinical trial of neoadjuvant toll-like receptor 7 agonist (Imiquimod) immunotherapy in early-stage oral squamous cell carcinoma by Angela J. Yoon, Richard D. Carvajal, Evan M. Graboyes, John M. Kaczmar, William G. Albergotti, Alexandra E. Kejner, Scott H. Troob, Elizabeth Philipone, Jean-Sebastien Anoma, Kent E. Armeson, Elizabeth G. Hill, Mary S. Richardson, Tina R. Woods, Bhishamjit S. Chera, Farzad Nourollah-Zadeh, Byung J. Lee, Subramanya Pandruvada, Antonis Kourtidis, Christina Kingsley, Elizabeth C. O’Quinn, Stephanie Mills, Victoria C. Jordan, Mike Spencer, Danielle Fails, Trevor D. McKee, Mark Zaidi, Alan Brisendine, Shane Horn, Shikhar Mehrotra, Besim Ogretmen, Jason G. Newman

“…We report a single-arm, open-label, pilot clinical trial assessing the efficacy and safety of topical toll-like receptor-7 (TLR-7) agonist, imiquimod, utilized in a neoadjuvant setting in early-stage oral squamous cell carcinoma (OSCC).MethodsThe primary endpoint is reduction in tumor cell counts assessed by quantitative multiplex immunofluorescence and the immune-related pathologic response. …”
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A combined use of Panax ginseng extract and the probiotic, Lactobacillus plantarum in the diet of Asian seabass, Lates calcarifer: Effects on growth, immunity and survival after ba... by Xiaojie Hou, Jianfeng Zhang, Neda Behmagham, Hamed Ghafarifarsani

“…The intestinal lactic acid bacteria with maximum load of 4.1 ± 0.5, 3.9 ± 0.5 and 3.6 ± 0.4 log CFU/g intestine at LAC-P + GINS treatments, increased, following the probiotic administration, while total bacterial count remained unchanged (P < 0.01). The antioxidant enzyme activities in blood significantly increased in response to LAC-P, GINS (0.5–1 %) and their combinations compared to control (P < 0.01). …”
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Differences in the response to TNF inhibitors at distinct joint locations in patients with psoriatic arthritis: results from nine European registries by Adrian Ciurea, Seraphina Kissling, Andrea Götschi, Lykke Midtbøll Ørnbjerg, Simon Horskjær Rasmussen, Bálint Tamási, Burkhard Möller, Michael J. Nissen, Bente Glintborg, Anne Gitte Loft, Almut Scherer, René Bräm, Karel Pavelka, Jakub Závada, Joao Madruga Dias, Paula Valente, Bjorn Gudbjornsson, Olafur Palsson, Vappu Rantalaiho, Ritva Peltomaa, Catalin Codreanu, Corina Mogosan, Florenzo Iannone, Marco Sebastiani, Gareth T. Jones, Gary J. Macfarlane, Isabel Castrejon, Ziga Rotar, Brigitte Michelsen, Johan K. Wallman, Irene van der Horst-Bruinsma, Oliver Distler, Mikkel Østergaard, Merete Lund Hetland, Raphael Micheroli, Caroline Ospelt

“…Abstract Background Efficacy of tumour necrosis factor inhibitors (TNFi) for peripheral arthritis in patients with psoriatic arthritis (PsA) has been established in randomized clinical trials that have used improvement in summated joint counts as an outcome. Whether joints at different anatomical locations might respond differentially to TNFi remains unknown. …”
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Image Segmentation Method of Chinese Yam Leaves in Complex Background Based on Improved ENet by LU Bibo, LIANG Di, YANG Jie, SONG Aiqing, HUANGFU Shangwei

“…Although the real-time semantic segmentation algorithm LinkNet had a slightly higher mIoU, its FLOPs and parameters count were still far greater than the improved algorithm. …”
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ReluformerN: Lightweight High-Low Frequency Enhanced for Hyperspectral Agricultural Lancover Classification by LIU Yi, ZHANG Yanjun

“…The Reluformer achieved the highest classification accuracy and the lowest model parameter count among these models. This indicated that Reluformer not only effectively extracted global features but also reduced computational complexity. …”
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Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary Angiography by Zhubin Lun, Jin Liu, Liwei Liu, Jingjing Liang, Guanzhong Chen, Shiqun Chen, Bo Wang, Qiang Li, Haozhang Huang, Zhidong Huang, Danyuan Xu, Yunzhao Hu, Ning Tan, Jiyan Chen, Yong Liu, Jianfeng Ye

“…Kaplan–Meier analysis was used to count the cumulative mortality, and the log-rank test was used to assess differences between curves. …”
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Interaction of human gut microbiota and local immune system in progression of colorectal adenoma (MIMICA-1): a protocol for a prospective, observational cohort study by Jurate Valciukiene, Egle Lastauskiene, Aida Laurinaviciene, Aida Laurinaviciene, Matas Jakubauskas, Marius Kryzauskas, Ruta Barbora Valkiuniene, Ruta Barbora Valkiuniene, Renaldas Augulis, Renaldas Augulis, Ausra Garnelyte, Justinas Kavoliunas, Ugne Silinskaite, Tomas Poskus

“…The intestinal immune system response will be examined using digital image analysis where primarily immunohistochemistry procedures for CD3, CD8, CD20 and CD68 immune cell markers will be performed. Thereafter, the count, density and distribution of immunocompetent cells in epithelial and stromal tissue compartments will be evaluated using AI-based platform. …”
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