Clinical characteristics and prognosis of amyopathic dermatomyositis patients with interstitial lung disease: insights from a retrospective cohort by Yanan Ying, Tingting Wu, Long Wang, Yun Zhang, Yiming Yu, Zaichun Deng, Qunli Ding

“…Cox multivariate analysis revealed that age (p = 0.002), smoking status (p = 0.011), anti-melanoma differentiation-associated gene 5 (MDA5) antibody (p = 0.017), and white blood cell count (p = 0.004) were independent predictors of shorter survival. …”
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Strength Training Session Induces Important Changes on Physiological, Immunological, and Inflammatory Biomarkers by Ayla Karine Fortunato, Washington Martins Pontes, Débora Maria Soares De Souza, Jéssica Santos Ferreira Prazeres, Lucas Soares Marcucci-Barbosa, Júlia Miranda Mól Santos, Érica Leandro Marciano Veira, Eduardo Bearzoti, Kelerson Mauro De Castro Pinto, André Talvani, Albená Nunes Da Silva

“…This protocol changed the count/total number of circulating immune cells in both groups (UTG and TG) and also increased the level of plasmatic apelin, BDNF, and FLTS1 only in TG and FABP3 myokines in both groups.…”
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A novel approach to digital characterisation of Tertiary Lymphoid Structures in colorectal cancer by Luis Munoz-Erazo, Luis Munoz-Erazo, Saem Mul Park, Saem Mul Park, Shelly Lin, Shelly Lin, Chun-Jen J. Chen, Chun-Jen J. Chen, Lisa Y. Y. Zhou, Lisa Y. Y. Zhou, Janet L. Rhodes, Janet L. Rhodes, Taesung Jeon, Sonya Fenton, John L. McCall, Roslyn A. Kemp, Roslyn A. Kemp, P. Rod Dunbar, P. Rod Dunbar

“…TLS domains varied substantially between samples in size, morphology, cellular constituents, count (from 4 to 100), and proportion of total section area they occupied (0.2%-7.8%). …”
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Clinical risk score to predict in-hospital mortality in COVID-19 patients: a retrospective cohort study by Adriano Peris, Andrea Ungar, Niccolò Marchionni, Federico Lavorini, Alessandro Bartoloni, Stefano Fumagalli, Rossella Marcucci, Giulia Cesaroni, Riccardo Pini, Carlo Nozzoli, Carlo Fumagalli, Renzo Rozzini, Matteo Vannini, Flaminia Coccia, Francesca Mazzeo, Maria Cola, Paolo Fontanari, Alessandro Morettini, Filippo Pieralli, Loredana Poggesi

“…Using Cox regression analysis, tertiles of increasing age (≥75, upper vs <62 years, lower: HR 7.92; p<0.001) and number of chronic diseases (≥4 vs 0–1: HR 2.09; p=0.007), respiratory rate (HR 1.04 per unit increase; p=0.001), PaO2/FiO2 (HR 0.995 per unit increase; p<0.001), serum creatinine (HR 1.34 per unit increase; p<0.001) and platelet count (HR 0.995 per unit increase; p=0.001) were predictors of mortality. …”
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Structural safety assessment procedure of plastic single-span greenhouses considering semi-rigid clamp joints by Byung-Hun Seo, Sangik Lee, Do-Kyung Kim, Jong-Hyuk Lee, Dong-Su Kim, Dong-Woo Kim, Yerim Jo, Won Choi

“…Among design parameters, rafter pipe diameter had the greatest impact on FS, while purlin count had minimal influence. These results emphasize the necessity of considering semi-rigid joint behavior in greenhouse design to ensure structural safety under extreme weather conditions. …”
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Diminished ovarian reserve is associated to euploidy rate: a single center study by Edoardo Carnesi, Stefano Castellano, Stefano Castellano, Elena Albani, Andrea Busnelli, Andrea Busnelli, Antonella Smeraldi, Ozgur Bulbul, Emanuela Morenghi, Valentina Immediata, Paolo Emanuele Levi-Setti, Paolo Emanuele Levi-Setti

“…While ovarian reserve markers such as Anti-Müllerian Hormone (AMH) and Antral Follicle Count (AFC) traditionally serve as quantitative predictors of fertility, emerging evidence suggests they may also reflect oocyte quality, particularly in patients with Diminished Ovarian Reserve (DOR). …”
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Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasticity after ischemic stroke in rats by transcranial direct current stimulation by Yu Chen, Lin Mao, Qinxiang Zhou, Dingqun Bai, Yuhan Kong

“…HE and Nissl staining helped observe the morphological changes and count of nerve cells. We tested the expression of growth-associated protein-43(Gap-43) and microtubule-associated protein-2(Map-2), K+-Cl- co-transporter 2(KCC2), γ-aminobutyric acid(GABA), and key BDNF-TrkB downstream signaling, the phospholipase C gamma(PLCγ) / CaMK IV / cAMP response element binding protein(CREB), and extracellular signal-regulated protein kinase(ERK1/2) / ribosomal S6 kinase(RSK) using western blotting. …”
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The influence of exercise modality and intensity on ventricular arrhythmia burden and perception of effort in patients with Arrhythmogenic Right Ventricular Cardiomyopathy with pla... by Fernando G. Beltrami, Kyle G. P. J. M. Boyle, Guan Fu, Corinna Brunckhorst, Firat Duru, Christina M. Spengler, Ardan M. Saguner

“…Peak PVC burden during the different activities (highest PVC count in 1 min) ranged between 0–57% among participants and it was lower during the activities (5 ± 8%) than the subsequent 5-min recovery (8 ± 8%, p = 0.006). but no differences were detected between activities. …”
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Implications of prognostic nutritional index in predicting adverse outcomes of uncontrolled diabetic patients: a cohort study of the national health and nutrition examination surve... by Fei Liu, Zhili Jiang, Wei Luo, Yunxiao Yang, Shuai Guo, Jiayi Yi, Geng Shen, Wei Li, Lin Wang, Xiuhuan Chen, Zhaogong Zhi, Tian Liu, Xuedong Zhao, Chen Li, Hai Gao

“…PNI was calculated as 5×lymphocyte count (109/L)+ 10×serum albumin (g/L). The endpoints were DM-related and cardiovascular mortality, which were obtained from National Death Index. …”
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Late-stage diversification strategy for the synthesis of peptide acids and amides using hydrazides by Shoko Tanaka, Mizuki Kanno, Yosuke Tashiro, Tetsuo Narumi, Nobuyuki Mase, Kohei Sato

“…The antimicrobial activity of modelin-5 derivatives synthesized from the corresponding hydrazides was evaluated by the colony count of Escherichia coli (E. coli) after treatment with the peptides. …”
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Intracranial complications in adult patients with severe pneumococcal meningitis: a retrospective multicenter cohort study by Camille Legouy, Renaud Cornic, Keyvan Razazi, Damien Contou, Stéphane Legriel, Eve Garrigues, Pauline Buiche, Maxens Decavèle, Sarah Benghanem, Thomas Rambaud, Jérôme Aboab, Marina Esposito-Farèse, Jean-François Timsit, Camille Couffignal, Romain Sonneville

“…Through multivariable analysis, we found that intracranial complications (adjusted odds ratio (aOR) 2.88, 95%CI 1.37–6.21) were associated with unfavorable outcome, along with chronic alcohol consumption (aOR 3.10, 95%CI 1.27–7.90), chronic vascular disease (aOR 4.41, 95%CI 1.58–13.63), focal neurological sign(s) (aOR 2.38, 95%CI 1.11–5.23), and cerebrospinal fluid leukocyte count < 1000 cell/microL (aOR 4.24, 95%CI 2.11–8.83). …”
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A phase Ia study of a novel anti-HER2 antibody–drug conjugate GQ1001 in patients with previously treated HER2 positive advanced solid tumors by Chenfei Zhou, Bin Wang, Christina Teng, Hui Yang, Sarina A. Piha-Paul, Gary Richardson, Ashanya Malalasekera, Yajun Sun, Wei Wang, Jieqiong Liu, Yan Shi, Xianbao Zhan, Charlotte Lemech

“…Grade ≥ 3 treatment-related adverse events rate was 28.1% (9/32) and platelet count decreased (4/32, 12.5%) was the most common one. …”
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Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study by Rolando Barrios, Julio S G Montaner, Silvia Guillemi, Ni Gusti Ayu Nanditha, Viviane D Lima, Thomas L Patterson, Fidel Vila-Rodriguez, William G Honer, Jason Trigg, Hasan Nathani, Sara Shayegi-Nik, Weijia Yin, Alejandra Fonseca, Bronhilda T Takeh

“…Among the adjusted covariates, CD4 cell count&lt;50 cells/mm3 (adjusted CSH (aCSH) 8.61, 95% CI: 4.75 to 15.60), uncontrolled viremia (aCSH 1.95, 95% CI: 1.20 to 3.17), 10-year increase in age (aCSH 2.41, 95% CI: 1.89 to 3.07), schizophrenia (aCSH 2.85, 95% CI: 1.69 to 4.80), traumatic brain injury (aCSH 2.43, 95% CI: 1.59 to 3.71), delirium (aCSH 2.27, 95% CI: 1.45 to 3.55), substance use disorder (SUD) (aCSH 1.94, 95% CI: 1.18 to 3.21) and mood/anxiety disorders (aCSH 1.80, 95% CI: 1.13 to 2.86) were associated with an increased hazard for dementia. …”
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Kajian patogenisitas bakteri Edwardsiella ictaluri pada ikan patin Pangasionodon hypophthalmus by Wiwik Susanti, Agustin Indrawati, Fachriyan H Pasaribu

“…Internal organ sample were taken on the 5th day for histopatologic test while blood sample was on the 1st, 3rd, and 5th day after infection. Mortality rate was count to reach LD50. Clinical signs and pathology anatomy of co-infection fish showed vertical swim, petechial hemorrhage in the skin, dropsy, ascites in the abdominal cavity, pale liver and the kidney was dark red. …”
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Influencing factors of IgA nephropathy combined with hyperuricemia and a nomogram to predict the risk of hyperuricemia in IgA nephropathy patients by Zhou Jie, Xian Wei-ying, Li Ji-tian, Zeng Jin-cheng

“…There were significant differences in the male proportion （65.82% vs 47.40%）， body mass index ［BMI， （24.67 ± 4.52）kg/m2 vs （22.28 ± 3.17）kg/m2］， hypertension （43.04% vs 23.38%）， triglyceride ［TG， （2.16 ± 0.61）mmol/L vs （1.72 ± 0.30）mmol/L］， white blood cell count ［WBC， （7.28 ± 2.06）×109L vs （5.75 ± 1.52）×109L］， estimated glomerular filtration rate ［eGFR，（66.93 ± 19.85）mL·min-1·（1.73 m2）-1 vs （86.42 ± 22.37）mL·min-1·（1.73 m2）-1］ and IgA/C3 ［（3.07 ± 0.96） vs （2.35 ± 0.62）］ between HUA group and non-HUA group （P<0.05）. …”
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Combining Charlson comorbidity and VACS indices improves prognostic accuracy for all-cause mortality for patients with and without HIV in the Veterans Health Administration by Kathleen A. McGinnis, Amy C. Justice, Amy C. Justice, Vincent C. Marconi, Vincent C. Marconi, Maria C. Rodriguez-Barradas, Maria C. Rodriguez-Barradas, Ronald G. Hauser, Ronald G. Hauser, Krisann K. Oursler, Krisann K. Oursler, Sheldon T. Brown, Kendall J. Bryant, Janet P. Tate, Janet P. Tate, for the Veterans Aging Cohort Study

“…Baseline predictors included age, and components of CCI and VACS Index (excluding CD4 count and HIV RNA). Patients were followed until December 31, 2021. …”
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Virological and serological outcomes in people with HIV-HBV coinfection who had discontinued tenofovir-containing antiretroviral therapy: Results from a prospective cohort study by Amir M. Mohareb, Patrick Miailhes, Julie Bottero, Caroline Lascoux-Combe, Julie Chas, Sarah Maylin, Audrey Gabassi, Hayette Rougier, Emily P. Hyle, Constance Delaugerre, Karine Lacombe, Anders Boyd

“…Determinants of HBV DNA >2000 IU/mL while people were off tenofovir were detectable HIV RNA (p = 0.041), lower CD4+ T-cell count (p = 0.027), HBeAg positive serology (p = 0.004) and positive hepatitis D serology (p = 0.001). …”
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Construction of a C-reactive protein-albumin-lymphocyte index-based prediction model for all-cause mortality in patients on maintenance hemodialysis by Junmin Huang, Junfeng Hao, Huasheng Luo, Lu Chen, Hongying Luo, Huafeng Liu, Yongzhi Xu, Peng Wang

“…In the study, stratification analysis and covariate adjustment were conducted to explore the correlation between the CALLY index and the mortality of MHD patients.Results In the final model, logistic regression showed that the CALLY index, creatinine, triglycerides, dialysis duration, absolute neutrophil count, blood urea nitrogen, sodium and ferritin were variables associated with mortality in MHD patients. …”
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Dual inhibition of LAG-3 and PD-1 with IBI110 and sintilimab in advanced solid tumors: the first-in-human phase Ia/Ib study by Chenyu Mao, Anwen Xiong, Jiong Qian, Wenxiang Wang, Ying Liu, Tao Zhang, Zhihai Wu, Haiqing Ni, Jia Lu, Sixiang Long, Li Zhao, Yuling Chen, Caicun Zhou, Nong Xu

“…The most common TRAE was anemia (17.9%, including 3.6% ≥ G3) in phase Ia dose escalation of IBI110 monotherapy (n = 28), aspartate aminotransferase increased (28.9%, all G1-G2) in phase Ib dose escalation of IBI110 plus sintilimab (n = 45), anemia (70.0%, all G1-G2) in phase Ib dose expansion in sqNSCLC (n = 20), and neutrophil count decreased (64.7%, including 17.6%≥ G3) in phase Ib dose expansion in GC (n = 17). …”
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Characterization of a Natural Accession of <i>Elymus sibiricus</i> with <i>In Situ</i> Hybridization and Agronomic Evaluation by Yizhuo Liu, Jiarui Ding, Chunfei Wu, Weiwei Song, Xinyu Zhao, Haibin Zhao, Yunfeng Qu, Hui Jin, Rui Zhang, Mingyao Li, Xinyu Yan, Liangyu Zhu, Yaqi Bao, Dianhao Liu, Xinling Li, Lei Cui, Hongjie Li, Yanming Zhang

“…Morphologically, 20HSC-Z9 had an average tiller count ranging from 56 to 74, similar to that of the control accession 20HSC-ES, and its plant height was significantly lower than that of 20HSC-IWG. …”
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