Occipital bone fractures in two-wheeler road traffic accidents: Understanding contrecoup brain injuries and implications for prevention by Robert Mark Wallang, R Giridharan, T. Arunan

“…The most common diagnoses were frontal hemorrhagic contusion (56.7%) and subdural hematoma (30%). Conservative management was more common among survivors (68.2%), while a higher proportion of nonsurvivors underwent surgical intervention (60.0%), though these differences were not statistically significant. …”
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Non-operative approaches to major blunt hepatic (Grade IV): a case report by Amirreza Salehi, Mansoor Kodori, Mohammad Sohrabi

“…Case presentation An 8-year-old Iranian child presented with a Grade IV liver laceration and contusion, pneumothorax, and rib fractures after a 1.5 m fall. …”
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Traumatic Asphyxia due to Automobile Accident. A Case Report by Elona Markeci, Admir Mustafa

“…In our case, we found associated injuries such as a fracture of the right 7th rib, displaced fracture of the right tibia, and bilateral pulmonary contusion. In our case, supportive therapy and specific treatment for the right tibial fracture were performed. …”
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Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Brain TNF-α Contents and by Stimulating Newly Formed Neurogenesis by Chong-Un Cheong, Ching-Ping Chang, Chien-Ming Chao, Bor-Chih Cheng, Chung-Zhing Yang, Chung-Ching Chio

“…It remains unclear whether etanercept penetrates directly into the contused brain and improves the outcomes of TBI by attenuating brain contents of TNF-α and/or stimulating newly formed neurogenesis. …”
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AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury by Wen-Yuan Li, Ying Wang, Feng-Guo Zhai, Ping Sun, Yong-Xia Cheng, Ling-Xiao Deng, Zhen-Yu Wang

“…In vivo, young adult C57BL/6 mice received a T10 contusion followed by an AAV-KLF7 injection at the T7–9 levels above the lesion. …”
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Temporal and spatial pattern of DNA damage in neurons following spinal cord Injury in mice by Elle EM Scheijen, Naomi Veeningen, Sam Duwé, Anna Ivanova, Jana Van Broeckhoven, Sven Hendrix, David M Wilson

“…Nevertheless, the pathophysiological mechanisms leading to neuronal loss following SCI remain incompletely defined. Methods: Using a contusion model, a severe SCI was induced at the L1 spinal level in C57Bl/6J mice. …”
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Single-Port Laparoscopic Surgery Is Feasible and Safe for Hepatic Left Lateral Sectionectomy for Benign Liver Lesions by Yuan Cheng, Ze-sheng Jiang, Xiao-ping Xu, Wen-fa Huang, Guo-lin He, Chen-jie Zhou, Jia-sheng Qin, Yi Gao, Ming-xin Pan

“…There was no significant difference in the operative time, estimated intraoperative blood loss, length of hospital stay, and incidences of postoperative complications (biliary leakage, hemorrhage, and contusion at incision) between groups (all P>0.05). …”
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Local Inflammation in Fracture Hematoma: Results from a Combined Trauma Model in Pigs by K. Horst, D. Eschbach, R. Pfeifer, S. Hübenthal, M. Sassen, T. Steinfeldt, H. Wulf, S. Ruchholtz, H. C. Pape, F. Hildebrand

“…Combined trauma consisted of tibial fracture, lung contusion, liver laceration, and controlled hemorrhage. …”
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Spinal cord injury induces transient activation of hepatic stellate cells in rat liver by Inmaculada Fernandez-Canadas, Alejandro Badajoz, Jesús Jimenez-Gonzalez, Martin Wirenfeldt, Beatriz Paniagua-Torija, Clara Bravo-Jimenez, Mar Del Cerro, Angel Arevalo-Martin, Daniel Garcia-Ovejero

“…Here, we describe the transient activation of HSCs after a thoracic contusion in rats, considered a clinically relevant model of experimental SCI. …”
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Epidemiology of Pediatric Traumatic Brain Injury at Sylvanus Olympio University Hospital of Lomé in Togo by Pilakimwe Egbohou, Tabana Mouzou, Pikabalo Tchetike, Hamza Doles Sama, Sarakawabalo Assenouwe, Gnimdou Akala-Yoba, Lonlongnon Randolph, Kadjika Tomta

“…The most common brain injuries found in the CT scan were brain edema (72.9%), skull fracture (69.5%), and brain contusion (55.9%). The average duration under mechanical ventilation was 2.1 ± 2.9 days, and the mean ICU stay was 4.9 ± 4.4 days. …”
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Comportamiento clínico epidemiológico del trauma ocular grave según clasificación estandarizada, Cienfuegos, 2009 -2011 by Joselito Cruz Martínez, Bárbara Teresa Ríos Araujo, Liuset Damayansi Díaz Pérez, Inés Zamora Galindo

“…El hifema y la catarata traumática fueron las complicaciones más frecuentes del trauma cerrado (69,57 %) y del abierto (41,18 %), respectivamente. La contusión predominó en el trauma cerrado (95,45 %) y la herida penetrante en el trauma abierto (78,13 %). …”
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Acute portal vein thrombosis in an isolated, blunt, minor liver injury near the porta hepatis by Onchuda Wongweerakit, Osaree Akaraborworn, Burapat Sangthong, Komet Thongkhao

“…His secondary survey showed a large contusion (7 × 7 cm2) at the epigastrium with marked tenderness and localized guarding. …”
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Formulated citrus peel extract gold lotion improves cognitive and functional recovery from traumatic brain injury (TBI) in rats by Cheng Guang, Yue Zhiwei, Wang Liwen, Miyauchi Yutaka, Suzawa Michiko, Li Shiming, Ho Chi‐Tang, Zhao Hui, Chen Naiyao

“…TBI rat model was prepared by the electric Cortical Contusion Impactor (eCCI) device. Prevention against TBI by GL was assessed by the behavioral, organizational of rats and the molecular markers in the brain injury area. …”
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LIPS and PaO2/FiO2 Combined Plasma Biomarkers Predict Onset of Acute Respiratory Distress Syndrome in Patients of High Risks in SICU: A Prospective Exploratory Study by Ziyuan Shen, Zhongnan Yin, Senhao Wei, Zhukai Cong, Feng Zhao, Hua Zhang, Xi Zhu

“…Univariate analysis found 15 risk factors showed differences between ARDS and non-ARDS, namely, interleukin 6, interleukin 8 (IL-8), angiopoietin Ⅱ, LIPS, APACHEⅡ, SOFA, PaO2/FiO2, age, sex, shock, sepsis, acute abdomen, pulmonary contusion, pneumonia, hepatic dysfunction. We included factors with p <0.2 in multivariate analysis and showed LIPS, PaO2/FiO2, IL-8, and receptor for advanced glycation end-products (RAGE) of the first day were independent risk factors for ARDS in SICU, a model combining them was good in predicting ARDS (C-index was 0.864 in total patients of high risks). …”
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Stem cell-derived exosome treatment for acute spinal cord injury: a systematic review and meta-analysis based on preclinical evidence by Chunlin Mou, Ziyao Xia, Ziyao Xia, Ziyao Xia, Xiujuan Wang, Xunan Dai, Jiaxian Wang, Chun Zhang, Chun Zhang, Yongsheng Xu, Yongsheng Xu, Yongsheng Xu

“…BackgroundThe study aims were to systematically review and analyze preclinical research on the efficacy of exosomes derived from various mesenchymal stem cell sources (MSC-exos) for the treatment of spinal cord contusion injury (SCI) in small animal models.MethodsWe conducted a systematic search of PubMed, Embase and Google Scholar databases from their inception through February 29, 2024, to identify eligible English-language studies based on predefined inclusion and exclusion criteria. …”
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The Morphofunctional Effect of the Transplantation of Bone Marrow Stromal Cells and Predegenerated Peripheral Nerve in Chronic Paraplegic Rat Model via Spinal Cord Transection by Vinnitsa Buzoianu-Anguiano, Sandra Orozco-Suárez, Elisa García-Vences, Sara Caballero-Chacón, Gabriel Guizar-Sahagún, Luis Chavez-Sanchez, Israel Grijalva

“…Employed separately, both the transplantation of the predegenerated peripheral nerve (PPN) and the transplantation of bone marrow stromal cells (BMSCs) have been shown to promote the regrowth and remyelination of the damaged central axons in SCI models of hemisection, transection, and contusion injury. With the aim to test the effects of the combined transplantation of PPN and BMSC on regrowth, remyelination, and locomotor function in an adult rat model of spinal cord (SC) transection, 39 Fischer 344 rats underwent SC transection at T9 level. …”
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Evaluation of the Expression of Infection-Related Long Noncoding RNAs among COVID-19 Patients: A Case-Control Study by Zahra Firoozi, Elham Mohammadisoleimani, Farzaneh Bagheri, Atefeh Taheri, Babak Pezeshki, Mohammad Mehdi Naghizadeh, Abdolreza Daraei, Jalal Karimi, Yousef Gholampour, Yaser Mansoori, Zahra Montaseri

“…The most prevalent symptoms were as follows: cough, general weakness, contusion, headache, and sore throat. The results showed that three lncRNAs, including lnc ISR, lnc ATV, and lnc HEAL, were expressed dramatically higher in the case group compared to healthy controls. …”
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Establishment and validation of predictive model of ARDS in critically ill patients by Senhao Wei, Hua Zhang, Hao Li, Chao Li, Ziyuan Shen, Yiyuan Yin, Zhukai Cong, Zhaojin Zeng, Qinggang Ge, Dongfeng Li, Xi Zhu

“…The final model included gender, Lung Injury Prediction Score (LIPS), Hepatic Disease, Shock, and combined Lung Contusion. Based on the AUC and DCA in the validation group, the logistic model demonstrated excellent performance, achieving an AUC of 0.836 (95% CI: 0.762–0.910). …”
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Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects by Rodrigo Moraga-Amaro, Oscar Moreno, Jordi Llop, Marion Bankstahl, Marion Bankstahl, Jens P. Bankstahl

“…In addition, male rats showed significantly increased florzolotau binding in the brain after 12 weeks, suggesting brain contusion causes increased tau aggregation. Interestingly, brain neurofibrillary tangles (NFTs) at 12 weeks after rmTBI showed a strong correlation with the neurological state at 1 day after rmTBI.DiscussionTaken together, our findings suggest that male rats may be more susceptible to short-and long-term consequences of rmTBI in the applied model. …”
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Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult... by Stuart I. Hodgetts, Jun Han Yoon, Alysia Fogliani, Emmanuel A. Akinpelu, Danii Baron-Heeris, Imke G. J. Houwers, Lachlan P. G. Wheeler, Bernadette T. Majda, Sreya Santhakumar, Sarah J. Lovett, Emma Duce, Margaret A. Pollett, Tylie M. Wiseman, Brooke Fehily, Alan R. Harvey

“…Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the cerebral cortex promotes plasticity and regrowth of axons projecting into the female adult F344 rat spinal cord after moderate thoracic (T10) contusion injury (SCI). Cortical neurons were transduced with a bicistronic adeno-associated viral vector (AAV1) expressing a secretory form of CNTF coupled to mCHERRY (AAV-CNTFmCherry) or with control AAV only (AAV-GFP) two weeks prior to SCI. …”
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