A strategy for selective screening of dual-target bioactive compounds against hypertrophic scar through inhibiting angiotensin II type 1 receptor while stimulating type 2 receptor... by Lejing Qu, Meizhi Jiao, Zilong Zhang, Yuanyuan Ou, Xue Zhao, Yajun Zhang, Xinfeng Zhao

“…Methods To this end, we immobilized AT1R or AT2R onto the surface of silica gel from cell lysates through a specific covalent bond by bioorthogonal chemistry. The columns containing immobilized AT1R or AT2R were jointly utilized to pursue potential bioactive compounds simultaneously binding to AT1R and AT2R from the extract of Rhei Radix et Rhizoma. …”
Get full text

Effect of Acetyl tributyl citrate on bone metabolism based on network toxicology and molecular docking technology by Xuan Lin, Kun Lin, Yue Lai, Qingping Peng, Miao Xu, Yiting Xu, Jialin Yang, Huan Liu, Jianlin Shen

“…Collectively, our findings provide a theoretical scaffold for comprehending the intricate molecular mechanisms mediating ATBC’s effects on bone metabolism, and paves the way for the development of preventive and therapeutic strategies against orthopedic disorders that may arise from exposure to plastic products containing ATBC or excessive ATBC environments.…”
Get full text

Dynamic rationing using agent-based modeling of the assembly process of equipment for nuclear power plants by I. A. Loskutov, D. A. Skvortsova, V. G. Iskandarova

“…The agents of the model contain the workers and the technological process. …”
Get full text

MAMMOTH-Subaru. II. Diverse Populations of Circumgalactic Lyα Nebulae at Cosmic Noon by Mingyu Li, Haibin Zhang, Zheng Cai, Yongming Liang, Nobunari Kashikawa, Ke Ma, Xiaohui Fan, J. Xavier Prochaska, Bjorn H. C. Emonts, Xin Wang, Yunjing Wu, Shiwu Zhang, Qiong Li, Sean D. Johnson, Minghao Yue, Fabrizio Arrigoni Battaia, Sebastiano Cantalupo, Joseph F. Hennawi, Satoshi Kikuta, Yuanhang Ning, Masami Ouchi, Rhythm Shimakawa, Ben Wang, Weichen Wang, Zheng Zheng, Zhen-Ya Zheng

“…Utilizing the wide-field capability of Hyper Suprime-Cam, we present one of the largest blind Ly α nebula selections, including QSO nebulae, Ly α blobs, and radio galaxy nebulae down to the typical 2 σ Ly α surface brightness of $(5-10)\times {10}^{-18}\,\mathrm{erg}\,{{\rm{s}}}^{-1}\,{\mathrm{cm}}^{-2}\,{\mathrm{arcsec}}^{-2}$ . The sample contains 117 nebulae with Ly α sizes of 40–400 kpc, and the most gigantic one spans about 365 kpc, and is referred to as the Ivory Nebula. …”
Get full text

Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn’s disease by Lisa Budzinski, Gi-Ung Kang, René Riedel, Toni Sempert, Leonie Lietz, René Maier, Janine Büttner, Bettina Bochow, Marcell T. Tordai, Aayushi Shah, Amro Abbas, Tanisha Momtaz, Jannike L. Krause, Robin Kempkens, Katrin Lehman, Gitta A. Heinz, Anne E. Benken, Stefanie Bartsch, Kathleen Necke, Ute Hoffmann, Mir-Farzin Mashreghi, Robert Biesen, Tilmann Kallinich, Tobias Alexander, Bosse Jessen, Carl Weidinger, Britta Siegmund, Andreas Radbruch, Anja Schirbel, Benjamin Moser, Hyun-Dong Chang

“…IgA-coated fractions of the intestinal microbiota of Crohn’s disease (CD) patients have been shown to contain taxa that hallmark the compositional dysbiosis in CD microbiomes. …”
Get full text

Novel N-quaternary coumarin-3-yl-imidazo[1,2-a]pyridines as fluorescent hybrids: Their synthesis and biological evaluation in cancer cells by Karla Armendariz-Barrientos, Luis A. Pérez, Selene Lagunas-Rivera, Yolanda Alcaraz-Contreras, Marco A. García-Revilla, Heriberto Prado-Garcia, Rocío García-Becerra, Miguel A. Vazquez

“…Notably, most polar molecules contain an amino group at position 7, followed by those substituted with −OMe at position 6. …”
Get full text

Archeohandi: protocol for a national disabilities database in archaeology in France by Rozenn Colleter, Valérie Delattre, Cyrille Le Forestier, Alex Baiet, Philippe Blanchard, Fanny Chenal, Anne-Sophie Coupey, Stéphanie Desbrosse-Degobertière, Sylvie Duchesne, Cécile Durin, Jean-Luc Gisclon, Noémie Gryspeirt, Fanny La Rocca, Raphaëlle Lefebvre, Jérôme Livet, Cécile Paresys, Mikaël Rouzic, Isabelle Souquet, Florence Tane, Aminte Thomann, Ivy Thomson, Émilie Trébuchet, Marie-Cécile Truc, Jean-Baptiste Barreau

“…The database, whose administrative interface can be accessed at archeohandi.huma-num.fr, contains so far 211 existing operations with a total of 1232 registered subjects spread throughout metropolitan France. …”
Get full text

Hybrid peptides inspired by the RWQWRWQWR sequence inhibit cervical cancer cells growth in vitro by Natalia Ardila-Chantré, Claudia Marcela Parra-Giraldo, Yerly Vargas-Casanova, Andrea Carolina Barragán-Cardenas, Ricardo Fierro-Medina, Zuly Jenny Rivera-Monroy, Jhon Erick Rivera-Monroy, Javier Eduardo García-Castañeda

“…Some hybrid peptides exhibited significant, fast, and selective cytotoxic activity against the cancerous cells evaluated, specifically those containing sequences of anticancer peptides and cell-penetrating peptides. …”
Get full text

Hyssopus cuspidatus volatile oil: a potential treatment for steroid-resistant asthma via inhibition of neutrophil extracellular traps by Xu Wang, Hui-Ming Peng, Meng-Ru Zhang, Jing-Jing Li, Chuan-Peng Zhao, Ya-Li Zhang, Si-Yu Wang, Si-Ying Zhu, Jian-Kang Lu, Hai-Long Yin, Qiang Yin, Jin-Bo Fang

“…Results HVO could significantly ameliorate OVA/LPS-induced SRA symptoms, including airway hyperresponsiveness, airway inflammation, mucus overproduction and airway remodeling. 41 prototype compounds, 65 Phase I metabolites and 50 Phase II metabolites were identified in serum-containing HVO. The integration of network pharmacology with experimental validation revealed that HVO can inhibit the formation of NETs by targeting neutrophil elastase, thereby exerting a therapeutic influence on SRA. …”
Get full text

Electronic cigarette use in relation to changes in smoking status and respiratory symptoms by Linnéa Hedman<sup>+<sup>, Gustaf Lyytinen<sup>+<sup>, Helena Backman, Magnus Lundbäck, Caroline Stridsman, Anne Lindberg, Hannu Kankaanranta, Lina Rönnebjerg, Eva Rönmark, Linda Ekerljung

“…A validated postal questionnaire containing identical questions was used in OLIN and WSAS at baseline in 2006–2008 and at follow-up in 2016. …”
Get full text

Hepatic Abnormal Secretion of Apolipoprotein C3 Promotes Inflammation in Aortic Dissection by Xinghui Zhuang, Mohammad Zarif, Yue Shen, Zhaofeng Zhang, Jian He, Linfeng Xie, Qingsong Wu, Xinfan Lin, Keyuan Chen, Yue Tian, Yong Lin, Yuling Zhang, Ziwen Cai, Zhihuang Qiu, Liangwan Chen

“…In vitro, recombinant apo C3 protein promoted M1 polarization and matrix metalloproteinase secretion in macrophages by activating the Toll‐like receptor 2/NLR family pyrin domain containing 3 pathway. Additionally, apo C3 increased adhesion molecule expression in endothelial cells and induced inflammation, chemotaxis, and apoptosis in vascular smooth muscle cells. …”
Get full text

Comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysm by Marcos Vinícius Melo de Oliveira, MD, PhD, Alexandre Malta Brandão, MD, PhD, Gina Camillo Rocha Silvestre, BS, Alexandre Queiroz Silva, BS, Michele Alberto Marques, BS, Marcia Martins Reis, PhD, Maria de Lourdes Higuchi, MD, PhD, Erasmo Simão da Silva, MD, PhD

“…In contrast, AAA walls contain a greater number of B lymphocytes within the adventitia compared with PAA walls. …”
Get full text

Development and validation of predictive models of early immune effector cell–associated hematotoxicity by Emily C. Liang, Jennifer J. Huang, Andrew J. Portuguese, Valentín Ortiz-Maldonado, Aya Albittar, Natalie Wuliji, Ryan Basom, Yein Jeon, Qian Wu, Aiko Torkelson, Delaney Kirchmeier, Abigail Chutnik, Barbara Pender, Mohamed Sorror, Joshua A. Hill, Noam E. Kopmar, Rahul Banerjee, Andrew J. Cowan, Damian Green, Ajay K. Gopal, Christina Poh, Mazyar Shadman, Alexandre V. Hirayama, Brian G. Till, Erik L. Kimble, Lorenzo Iovino, Aude G. Chapuis, Folashade Otegbeye, Ryan D. Cassaday, Filippo Milano, Cameron J. Turtle, David G. Maloney, Jordan Gauthier

“…We trained (n = 483) and validated (n = 208) 2 eICAHT prediction models (eIPMs): eIPMPre including preinfusion factors only (disease type and pre-LD ANC, platelet count, LDH, and ferritin) and eIPMPost containing both preinfusion (disease type and pre-LD ANC, platelet count, and LDH) and early postinfusion (day +3 ferritin) factors. …”
Get full text

Reinvestigation into the role of lipopolysaccharide Glycosyltransferases in Helicobacter pylori protein glycosylation by Hong Li, Xiaoqiong Tang, Tiandi Yang, Tingting Liao, Aleksandra W. Debowski, Tiankuo Yang, Yalin Shen, Hans-Olof Nilsson, Stuart M. Haslam, Barbara Mulloy, Anne Dell, Keith A. Stubbs, Wolfgang Fischer, Rainer Haas, Hong Tang, Barry J. Marshall, Mohammed Benghezal

“…Moreover, using LPS-protein reconstitution experiments, we demonstrate that the presence of O-antigen containing full-length LPS interferes with the electrophoretic mobility of H. pylori RecA and many other proteins including AlpA/B on SDS-PAGE. …”
Get full text

Residual ciprofloxacin in chicken manure inhibits methane production in an anaerobic digestion system by Yiting Wang, Qing Liu, Hongli Ran, Pingcai Peng, Yan Wang, Guoliang Peng, Yinbao Wu, Xin Wen

“…Here, the effects of three types of veterinary antibiotics commonly used in laying hen breeding on AD were explored. Manures containing antibiotics at two different concentrations were continuously added during AD for 5 days: amoxicillin (HAMX: 145.06 mg/kg, LAMX: 57.88 mg/kg), doxycycline (HDOC: 183.61 mg/kg, LDOC: 98.00 mg/kg), and ciprofloxacin (HCIP: 96.34 mg/kg, LCIP: 40.43 mg/kg). …”
Get full text

Humic Acid Enhances Antioxidant and Glyoxalase Systems to Combat Copper Toxicity in Citrus by Wei-Tao Huang, Xu-Feng Chen, Wei-Lin Huang, Qian Shen, Fei Lu, Ning-Wei Lai, Jiuxin Guo, Lin-Tong Yang, Xin Ye, Li-Song Chen

“…The addition of HA reduced the Cu400-induced production and accumulation of reactive oxygen species and methylglyoxal and alleviated the impairment of Cu400 to the antioxidant defense system (ascorbate-glutathione cycle, antioxidant enzymes, sulfur-containing compounds, and sulfur-metabolizing enzymes) and glyoxalase system in roots and leaves. …”
Get full text

Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue by Sara Nava, Valeria Sordi, Luisa Pascucci, Carlo Tremolada, Emilio Ciusani, Offer Zeira, Moris Cadei, Gianni Soldati, Augusto Pessina, Eugenio Parati, Mark Slevin, Giulio Alessandri

“…Over the last few years, human microfragmented adipose tissue (MFAT), containing significant levels of mesenchymal stromal cells (MSCs) and obtained from fat lipoaspirate (LP) through a minimal manipulation in a closed system device, has been successfully used in aesthetic medicine as well as in orthopedic and general surgery. …”
Get full text

Genomic insights into the specialisation and selection of the Jinding duck by H. Chen, Y. Huang, J. Xue, K. luo, H. Tang, S. Zheng, Y. Xiong, Y. Wu, J. Li, R. Xuan, R. Xiong, Y. Gong, X. Fang, L. Wang, J. Miao, J. Zhou, H. Tan, Y. Wang, L. Wu, J. Ouyang, Y. Shen, X. Yan

“…A salient discovery was a 200 kb genomic interval containing three genes (NCF2, SMG7, and ARPC5) with almost exclusive haplotypes, which were inherited from Anas platyrhynchos or Anas zonorhyncha, impacting the morphological attributes of JDD. …”
Get full text

Synthesis of Mg-, Al- and Mg/Al-date palm fronds modified biochars: characterization and investigations on phosphorus adsorption characteristics by Jellali, Salah, Hadroug, Samar, Al-Wardy, Malik, Hamdi, Helmi,  Al-Sabahi, Jamal, Bekri, Imene, Al-Raeesi, Ahmed, Hamdi, Wissem,  Jeguirim, Mejdi

“…In this study, three biochars were synthesized at 500 °C from pre-impregnated date palm fronds (DPFs) with 1 M solutions containing either MgCl2 (DPF-Mg-B), AlCl3 (DPF-Al-B) or a combination of MgCl2/AlCl3 (DPF-Mg/Al-B). …”
Get full text

Antioxidant Potential, Subacute Toxicity, and Beneficiary Effects of Methanolic Extract of Pomelo (Citrus grandis L. Osbeck) in Long Evan Rats by Md. Yousuf Ali, Nur-E Noushin Rumpa, Sudip Paul, Md. Sakib Hossen, E. M. Tanvir, Tareq Hossan, Moumoni Saha, Nadia Alam, Nurul Karim, Md. Ibrahim Khalil, Siew Hua Gan

“…The rats were orally treated with three doses of pomelo (250, 500, and 1000 mg/kg) once daily for 21 days. Pomelo extract contained high concentrations of polyphenols, flavonoids, and ascorbic acid while exhibiting high 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and ferric reducing antioxidant power values. …”
Get full text