High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression by Jie Qi, Qichao Wu, Qian Cheng, Xiangyuan Chen, Minmin Zhu, Changhong Miao

“…Our previous study indicated that SET domain-containing protein 8 (SETD8) downregulation is involved in high glucose-mediated endothelial inflammation in human umbilical vein endothelial cells (HUVECs). …”
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Safety and Effectiveness of BPaL-Based Regimens to Treat Multidrug-Resistant TB: First Experience of an Italian Tuberculosis Referral Hospital by Gina Gualano, Maria Musso, Paola Mencarini, Silvia Mosti, Carlotta Cerva, Pietro Vittozzi, Antonio Mazzarelli, Angela Cannas, Assunta Navarra, Stefania Ianniello, Paolo Faccendini, Fabrizio Palmieri

“…<b>Conclusions</b>: BPaL-containing regimens also serve as promising options for patients with RR/MDR-TB in terms of real-life experience, but further multicentric studies are required in Europe to confirm the efficacy of shorter regimens to eliminate MDR TB.…”
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Acidity, sugar, and alcohol contents during the fermentation of Osmanthus-flavored sweet rice wine and microbial community dynamics by Ping Tian, Jiaqiong Wan, Tuo Yin, Li Liu, Hongbing Ren, Hanbing Cai, Xiaozhen Liu, Hanyao Zhang

“…Osmanthus flower petals contain various nutrients and have good medicinal value. …”
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The GWAS-MAP platform for aggregation of results of genome-wide association studies and the GWAS-MAP|homo database of 70 billion genetic associations of human traits by T. I. Shashkova, D. D. Gorev, E. D. Pakhomov, A. S. Shadrina, S. Zh. Sharapov, Y. A. Tsepilov, L. C. Karssen, Y. S. Aulchenko

“…The database currently contains information on more than 70 billion associations between genetic variants and human diseases, quantitative traits, and “omics” traits. …”
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Field-based evidence for the prevalence of soil antibiotic resistomes under long-term antibiotic-free fertilization by Yuhao Fu, Fang Hu, Fang Wang, Min Xu, Zhongjun Jia, Wulf Amelung, Zhi Mei, Xiaozeng Han, Marko Virta, Xin Jiang, James M. Tiedje

“…Growing evidence suggests that the use of manure containing residual antibiotics universally leads to an increase in soil antibiotic resistance genes (ARGs). …”
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Geochemistry and Genesis of Oil and Gas Seeps in the Junggar Basin, NW China: Implications for Hybrid Petroleum Systems by Jingkun Zhang, Jian Cao, Yan Wang, Jun Li, Guang Hu, Ni Zhou, Tianming Shi

“…The Junggar Basin of NW China is representative in containing oil and gas seeps worldwide as there are a wide variety of oil and gas seeps over a large area. …”
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Influence of aquaculture practices on microbiota composition and pathogen abundance in pond ecosystems in South China by Shuhui Niu, Chuanlong Li, Jun Xie, Zhifei Li, Kai Zhang, Guangjun Wang, Yun Xia, Jingjing Tian, Hongyan Li, Wenping Xie, Wangbao Gong

“…Higher nitrogen levels also increased the relative abundance of Mycobacterium in pond water, whereas the culture pattern (freshwater, seawater, brackish, modern captive culture, freshwater factory container aquaculture, or seawater factory culture) and species significantly influenced the relative abundances of Vibrio, Tenacibaculum, Pseudoalteromonas, and Francisella. …”
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Amphiphilic Ruthenium(II) Terpyridine Sensitizers with Long Alkyl Chain Substituted β-Diketonato Ligands: An Efficient Coadsorbent-Free Dye-Sensitized Solar Cells by Ashraful Islam, Surya Prakash Singh, Masatoshi Yanagida, Mohammad Rezaul Karim, Liyuan Han

“…Under standard AM 1.5 sunlight, the complex A3 containing long alkyl chain length of C16 yielded a short-circuit photocurrent density of 18.0 mA/cm2, an open-circuit voltage of 0.64 V, and a fill factor of 0.66, corresponding to an overall conversion efficiency of 7.6% in the absence of DCA. …”
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To Hemoadsorb or Not to Hemoadsorb—Do We Have the Answer Yet? An Updated Meta-Analysis on the Use of CytoSorb in Sepsis and Septic Shock by Carmen Orban, Angelica Bratu, Mihaela Agapie, Tudor Borjog, Mugurel Jafal, Romina-Marina Sima, Oana Clementina Dumitrașcu, Mihai Popescu

“…Methods: To better understand the clinical effectiveness of hemoadsorption in managing inflammation, we conducted an updated meta-analysis on the effects of CytoSorb in critically ill septic patients. Ten studies containing 715 patients (355 in the interventional group and 360 in the control group) have been included in the final analysis. …”
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A systematic investigation on microstructure evolution, phase transformation and dynamic recrystallization mechanisms of hot isostatic pressed Ti–45Al–2Mn–2Nb–1B alloy during hot d... by Meiyi Ba, Hongkui Tang, Lianxi Hu, Yu Sun, Fei Gao

“…The microstructure after thermal deformation contains true twins (TT) and pseudo twins (PT) and the DRX grains near twin boundaries (TBs) show a peak misorientation angle of 89 ± 3°, driven by high strain energy at twin intersections. …”
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A customizable multiplex protein microarray for antibody testing and its application for tick-borne and other infectious diseases by Hari Krishnan Krishnamurthy, Vasanth Jayaraman, Karthik Krishna, Tianhao Wang, Kang Bei, Chithra Changalath, Shiny Matilda, Alex J. Rai, Renata Welc-Falęciak, Agnieszka Pawełczyk, Lucas S. Blanton, Aleš Chrdle, Andrea Fořtová, Daniel Růžek, Gheyath K. Nasrallah, Laith J. Abu-Raddadi, Duaa W. Al-Sadeq, Marah Abed Alhakim Abdallah, Daniele Lilleri, Chiara Fornara, Piera D’Angelo, Milena Furione, Maria Söderlund-Venermo, Klaus Hedman, Dimosthenis Chochlakis, Eirini Makridaki, Artemis Ntoula, Anna Psaroulaki, Angélica Escárcega-Ávila, John J. Rajasekaran

“…Our microarray in its present form can accommodate 400 antigens (molecules that can bind to specific antibodies) and can multiplex across antigen types, whole cell lysates, recombinant proteins, and peptides. A designed array containing multiple antigens of several microbes including Borrelia burgdorferi, the Lyme disease spirochete, was manufactured and evaluated. …”
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Relationship between Ca2+ and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells by Masahiko Kutsukake, Naoko Kuwabara, Yoshikazu Miyate, Kenzo Kudo, Shoko Goto, Eiichi Taira, Eiichi Tachikawa

“…Incubation of the cells with 100 pM ACTH in Ca2+-containing (normal) medium for 1 h increased cortisol production without affecting cAMP content. …”
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Metabolically activated and highly polyfunctional intratumoral VISTA+ regulatory B cells are associated with tumor recurrence in early-stage NSCLC by Domenico Lo Tartaro, Beatrice Aramini, Valentina Masciale, Nikolaos Paschalidis, Francesco Demetrio Lofaro, Anita Neroni, Rebecca Borella, Elena Santacroce, Alin Liviu Ciobanu, Anna Valeria Samarelli, Federica Boraldi, Daniela Quaglino, Alessandra Dubini, Michele Gaudio, Gloria Manzotti, Francesca Reggiani, Federica Torricelli, Alessia Ciarrocchi, Antonino Neri, Federica Bertolini, Massimo Dominici, Pier Luigi Filosso, Franco Stella, Lara Gibellini, Sara De Biasi, Andrea Cossarizza

“…Our analysis revealed that TME contains diverse B cell clusters, including VISTA+ Bregs, with distinct metabolic and functional profiles. …”
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HPLC-MS/MS-Mediated Analysis of the Pharmacokinetics, Bioavailability, and Tissue Distribution of Schisandrol B in Rats by Dahu Liang, Zijing Wu, Yanhao Liu, Chao Li, Xianghong Li, Bin Yang, Haitang Xie, Hua Sun

“…A liquid-liquid extraction (LLE) approach was employed for the preparation of samples that were subsequently separated with an Agilent ZORBAX Eclipse XDB-C18 (4.6 × 150 mm, 5 μm) column with an isocratic mobile phase consisting of methanol and water containing 5 mM ammonium acetate and 0.1% formic acid (90 : 10, v/v). …”
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Aptamer-Conjugated Multi-Quantum Dot-Embedded Silica Nanoparticles for Lateral Flow Immunoassay by Kwanghee Yoo, Hye-Seong Cho, Jaehi Kim, Minsup Shin, Jun-Sik Chu, Sohyeon Jang, Han-Joo Bae, Heung Su Jung, Homan Kang, Bong-Hyun Jun

“…For LFIA optimization, we determined the optimal conditions as a 1.0:2.0 × 10⁻² ratio of polyethylene glycol (PEG) to aptamer by adjusting the amounts of PEG and aptamer, phosphate-buffered saline containing 0.5% Tween^® 20 as a developing solution, and 0.15 μg NPs by setting the NP weight during development. …”
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In Vitro Susceptibility and Florfenicol Resistance in Citrobacter Isolates and Whole-Genome Analysis of Multidrug-Resistant Citrobacter freundii by Wangxiao Zhou, Qianqian Chen, Changrui Qian, Kai Shen, Xinyi Zhu, Danying Zhou, Wei Lu, Zhewei Sun, Hongmao Liu, Kewei Li, Teng Xu, Qiyu Bao, Junwan Lu

“…Sequencing and comparative analysis of the plasmids from a multidrug-resistant C. freundii isolate named R47 showed that the floR-containing region in the plasmid pR47-54 was a truncated transposon-like structure and could be found on both plasmids and chromosomes of bacteria of either animal or human origin. …”
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Mapping QTLs for early leaf spot resistance and yield component traits using an interspecific AB-QTL population in peanut by J. Gomis, J. Gomis, A. Sambou, J. R. Nguepjop, J. R. Nguepjop, J. R. Nguepjop, H. A. Tossim, M. Seye, R. Djiboune, D. Sambakhe, D. Loko, D. Loko, S. Conde, S. Conde, M. H. Alyr, D. J. Bertioli, D. J. Bertioli, S. C. M. Leal-Bertioli, S. C. M. Leal-Bertioli, J. F. Rami, J. F. Rami, A. Kane, D. Fonceka, D. Fonceka, D. Fonceka

“…One genomic region on chromosome A02 contained several relevant QTLs, contributing to ELS resistance, earliness, and increased biomass yield, potentially allowing marker-assisted selection to introduce this region into elite cultivars. …”
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Structure and dynamics analysis of brain functional hypernetworks based on the null models by Chen Cheng, Yao Li, Chunyan Wang, Yanli Yang, Hao Guo

“…This indicates that the node degree is redundant with respect to other attributes, while the hyperedge degree, node degree-dependent redundancy coefficient, and hyperedge degree-dependent redundancy coefficient perhaps contain other topology information. In addition, there is redundancy between HCC2 and HCC3. …”
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Prevalence of antibiotic resistance genes in mining-impacted farmland environments by Hai-Yan Zou, Fang-Zhou Gao, Liang-Ying He, Min Zhang, You-Sheng Liu, Jun Qi, Guang-Guo Ying

“…Mining activities produce large quantities of tailings and acid mine drainage, which contain varieties of heavy metals, thereby affecting the downstream farmland soils and crops. …”
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Magnesium extraction of ferronickel slag processed by alkali fusion and hydrochloric acid leaching by Prasetyo A.B., Khaerul A., Mayangsari W., Febriana E., Maksum A., Andinie J., Firdiyono F., Soedarsono J.W.

“…Moreover, the accumulation due to increasing ferronickel demand as well as the environmental contamination due to various potentially toxic elements contained in the ferronickel slag could be prevented. …”
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