Characterization of Thirty Germplasms of Millet Pepper (<i>Capsicum frutescens</i> L.) in Terms of Fruit Morphology, Capsaicinoids, and Nutritional Components by Ruihao Zhang, Mengjuan Li, Junheng Lv, Pingping Li, Yunrong Mo, Xiang Zhang, Hong Cheng, Qiaoling Deng, Min Gui, Minghua Deng

“…The coefficient of variation (CV) for VE was as high as 94.943% and the highest diversity index (H’) was total soluble solid, at 1.988%. M5 and M18 contained rich and diverse fatty acids. At the same time, the content of capsaicinoids in M18 also ranks among the top, second only to M27 (with a total capsaicin content of 5623.96 μg/g). …”
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Annotation and characterization of immunoglobulin loci and CDR3 polymorphism in water buffalo (Bubalus bubalis) by Yunlan Deng, Fengli Wu, Fengli Wu, Qianqian Li, Lidie Yao, Chengzhi Yang, Long Ma, Xinsheng Yao, Jun Li

“…Repertoire diversity, gene usage, and clonal frequencies were analyzed using the Immunarch R package.ResultsThe IgH locus spans approximately 667 kb on chromosome 20, containing two D-J-C clusters, 54 VH genes, 10 DH genes, 8 JH genes, and 9 CH genes. …”
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Analysis of the Effect of Human Type I Collagen-Derived Peptide on Bone Regenerative Capacity and Comparison with Various Collagen Materials In Vivo by Tatsunori Asakura, Tran Thi Thuy Diep, Yuta Ueda, Aoi Yamada, Takahiro Tsuzuno, Naoki Takahashi, Masayuki Miyata, Koichi Tabeta, Masaki Nagata, Ken Matsuda

“…Cellnest is a xeno-free recombinant peptide based on human type I collagen, containing a rich Arg-Gly-Asp (RGD) motif related to cell adhesion. …”
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Computational and in vitro evaluation of sumac-derived ©Rutan compounds towards Sars-CoV-2 Mpro inhibition by Muzaffar Kayumov, Parthiban Marimuthu, Parthiban Marimuthu, Jamoliddin Razzokov, Jamoliddin Razzokov, Jamoliddin Razzokov, Nurkhodja Mukhamedov, Nurkhodja Mukhamedov, Akmal Asrorov, Nodir S. Berdiev, Jamolitdin F. Ziyavitdinov, Ansor Yashinov, Ansor Yashinov, Yuliya Oshchepkova, Shavkat Salikhov, Sharafitdin Mirzaakhmedov

“…Here, we evaluated the anti-SARS-CoV-2 main protease (Mpro) efficacy of ©Rutan, which contains five polyphenols (R5, R6, R7, R7’, and R8) extracted from sumac Rhus coriaria L. …”
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<i>Sambucus nigra</i>-Lyophilized Fruit Extract Attenuated Acute Redox–Homeostatic Imbalance via Mutagenic and Oxidative Stress Modulation in Mice Model on Gentamicin-Induced Nephr... by Kamelia Petkova-Parlapanska, Ivaylo Stefanov, Julian Ananiev, Tsvetelin Georgiev, Petya Hadzhibozheva, Veselina Petrova-Tacheva, Nikolay Kaloyanov, Ekaterina Georgieva, Galina Nikolova, Yanka Karamalakova

“…<i>Sambucus nigra</i> L., containing flavonoids, anthocyanins, and phytosterols, possesses antioxidant and anti-inflammatory potential. …”
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Transition metal-based MOFs for Fenton-like photocatalytic degradation of organic pollutants: Performance, stability, and biocompatibility by S.M. Tikhanova, Yu.A. Tishchenko, E.Yu. Stovpiaga, M. Timofeeva, D.V. Lipin, S.A. Povarov, V.A. Milichko, A.S. Timin, S.A. Shipilovskikh, V.I. Popkov

“…Photocatalytic performance was evaluated using methylene blue (MB) degradation under visible-light irradiation containing both conventional and Fenton-like processes. …”
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Developing an automatic treatment record review system for quality assurance of patient treatment delivery in radiation therapy by Peng Huang, Yingjie Xu, Fukui Huan, Yanxin Zhang, Min Ma, Kuo Men, Jianrong Dai

“…Abstract Background and purpose Treatment record contains most of information related to treatment plan delivery in radiation therapy. …”
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Monitoring Over Time of Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Patients Through an Ensemble Vision Transformers‐Based Model by Maria Colomba Comes, Annarita Fanizzi, Samantha Bove, Luca Boldrini, Agnese Latorre, Deniz Can Guven, Serena Iacovelli, Tiziana Talienti, Alessandro Rizzo, Francesco Alfredo Zito, Raffaella Massafra

“…Aims This study aimed to develop an ensemble deep learning‐based model, exploiting a Vision Transformer (ViT) architecture, which merges features automatically extracted from five segmented slices of both pre‐ and mid‐treatment exams containing the maximum tumor area, to predict and monitor pCR to NAC. …”
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Eco-friendly alginate/PCL-TiO2 hybrid biocomposites: Preparation, properties, and methylene blue photodegradation by Bunga Fisikanta Bukit, Agus Wedi Pratama, Erna Frida, Bakti Berlyanto Sedayu, Dina Fransiska, Deni Purnomo, Emma Rochima, Istiqomah Rahmawati, Sona Suhartana, Firda Aulya Syamani

“…Methylene blue solutions containing PA-Ti1, PA-Ti3, and PA-Ti5 composites exhibited a color change from blue to transparent after 24 h of irradiation, indicating MB degradation.…”
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Genome-wide association study of the antibody response to <i>Corynebacterium pseudotuberculosis</i> in sheep by J. Kyselová, L. Tichý, J. Marková, A. Gurgul, Z. Sztankóová, K. Vališ, S. Šlosárková, K. Kavanová, M. Beinhauerová, T. Szmatola, T. Szmatola

“…The study revealed two suggestive SNPs (single-nucleotide polymorphisms) on chromosomes 11 and 20, with the most significant SNP in the first exon of the <i>TRIM16</i> (tripartite-motif-containing 16) gene. By analysing genomic alterations and their context between positive and negative animals, including a gene ontology (GO) analysis of genes within <span class="inline-formula">±</span> 500 kb regions of the suggestive SNPs, we identified genes and immune-related processes and pathways potentially influencing CLA susceptibility. …”
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A study of the influence of the T2DL.2DS-2SS translocation and the 5S(5D) substitution from <i>Aegilops speltoides</i> on breeding-valuable traits of common wheat by R. O. Davoyan, I. V. Bebykina, E. R. Davoyan, A. N. Zinchenko, Y. S. Zubanova, D. M. Boldakov, V. I. Basov, E. D. Badaeva, I. G. Adonina, E. A. Salina

“…The results suggest that the genetic material of Ae. speltoides transferred to chromosomes 2D and 5D contains new resistance genes. To determine the effect of the T2DL.2DS-2SS translocation and the 5S(5D) substitution on the productivity and technological qualities of grain, the lines were assessed by weight of 1000 grains, grain weight and number of ears per 1 m2, by protein and gluten content, gluten quality and general baking evaluation. …”
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Identification and functional characterization of AsWRKY9, a WRKY transcription factor modulating alliin biosynthesis in garlic (Allium sativum L.) by Jiaying Wu, Min Li, Wanni Wang, Yiren Su, Jie Li, Jiaxin Gong, Xianfeng Meng, Chenyuan Lin, Qiantong Zhang, Yanyan Yang, Chunyan Xu, Limei Zeng, Jihong Jiang, Xuqin Yang

“…In transgenic callus overexpressing AsWRKY9, the transcription level of the key enzyme flavin-containing monooxygenase gene (AsFMO1) significantly higher, as did its enzymatic activity compared with the control. …”
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High Antimicrobial Susceptibility of Cloacal Enterococci and <i>Escherichia coli</i> from Free-Living Dalmatian and Great White Pelicans with Detection of Cefotaximase CTX-M-15 Pro... by Teresa Cardona-Cabrera, Sandra Martínez-Álvarez, Carmen González-Azcona, Carlos Javier Gijón-García, Olga Alexandrou, Giorgos Catsadorakis, Panagiotis Azmanis, Carmen Torres, Ursula Höfle

“…Three of the fifty-two samples (6%, all adults) contained ESBL-<i>E. coli</i> isolates (detected in chromogenic ESBL plates), all carrying the <i>bla</i>_CTX-M-15 gene and belonging to the lineage ST69. …”
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Metasilicate-based alkaline mineral water improves the growth performance of weaned piglets by maintaining gut-liver axis homeostasis through microbiota-mediated secondary bile aci... by Jian Chen, Kanwar K. Malhi, Xiaowei Li, Xiangwen Xu, Jianxun Kang, Bichen Zhao, Yaru Xu, Xuenan Li, Jinlong Li

“…This consequently improved weaning-induced colon and liver injury and dysfunction through the DCA-secondary bile acid (SBA) receptors (SBAR)-nuclear factor-kappaB (NF-κB)/NOD-like receptor family pyrin domain-containing 3 (NLRP3) pathways. Growth performance parameters, including final body weight (P = 0.034) and average daily gain (P < 0.001), in the SMS group were significantly higher than those in the Control group. …”
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Genome-wide identification and expression analysis of phytochrome gene family in Aikang58 wheat (Triticum aestivum L.) by Zhu Yang, Zhu Yang, Wenjie Kan, Wenjie Kan, Ziqi Wang, Caiguo Tang, Yuan Cheng, Yuan Cheng, Dacheng Wang, Dacheng Wang, Yameng Gao, Lifang Wu, Lifang Wu

“…The cis-acting element analysis indicates that the promoter regions of TaAkPHY genes contain a large number of CAT-box, CGTCA-motif, GC-motif, etc., which are mainly involved in plant development, hormone response, and stress response. …”
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Phase Transitions and Structural Evolution of Manganese Ores During High-Temperature Treatment by Ruslan Z. Safarov, Yerlan A. Baikenov, Assemgul K. Zhandildenova, Eldar E. Kopishev, Ruslan M. Kamatov, Jumat B. Kargin, H. Sanchez Cornejo, Crispin H. W. Barnes, Luis De Los Santos Valladares

“….%, while the Zhaksy ore contained manganese (44.88 wt.%), silicon (20.85 wt.%), and iron (6.14 wt.%) as its main components. …”
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Development of a latency model for HIV-1 subtype C and the impact of long terminal repeat element genetic variation on latency reversal by Shreyal Maikoo, Robert-Jan Palstra, Krista L. Dong, Tokameh Mahmoudi, Thumbi Ndung'u, Paradise Madlala

“…To address this scientific gap, we constructed a minimal genome retroviral vector expressing HIV-1C consensus transactivator of transcription protein (Tat) and green fluorescent protein (GFP) under the control of either HIV-1C consensus LTR (C731CC) or the transmitted/founder (T/F) LTRs derived from PLWH (CT/F731CC), produced corresponding LTR pseudotyped viruses using a vesicular stomatitis virus (VSV-G) pseudotyped Envelope vector and the pCMVΔR8.91 packaging vector containing HIV-1 accessory and rev genes. Viruses produced in this way were used to infect Jurkat E6 and primary CD4+ T cells in vitro. …”
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Genome assembly of an endemic butterfly (Minois aurata) shed light on the genetic mechanisms underlying ecological adaptation to arid valley habitat by Wenqian Hu, Yi Wang, Xiaoxiao Chen, Jialong Huang, Jingge Kuang, Lei Wang, Kangshan Mao, Liang Dou

“…Abstract Background The Hengduan Mountains, one of the global biodiversity hotspots with exceptional species richness and high endemism, contains numerous arid valleys that create a distinctive geographical and ecological landscape. …”
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Evaluating the effects of dietary glutamine on performance, carcass traits, blood biochemistry, and intestine morphology in laying quail by Ewa Tomaszewska, Kamil Drabik, Kornel Kasperek, Piotr Dobrowolski, Monika Hułas-Stasiak, Renata Pyz-Łukasik, Waldemar Paszkiewicz, Monika Ziomek, Janine Donaldson, Katarzyna Dobrowolska, Artur Burmaczuk, Justyna Batkowska, Marcin B. Arciszewski, Siemowit Muszyński

“…Seven-week-old dual-purpose female quails at the onset of laying were assigned to diets containing 0% (control), 0.5%, 1%, or 1.5% Gln. Performance metrics included laying rate, daily feed intake, and feed efficiency. …”
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Phase II randomised, double-blind, placebo-controlled trial to assess the efficacy and safety of MLC1501 in patients with stroke: the MLC1501 study Assessing Efficacy in post-STrOk... by Narayanaswamy Venketasubramanian, Deidre Anne De Silva, Christopher P L H Chen, Cyrus G Escabillas, John Harold Hiyadan, Johnny K Lokin, Romulo U Esagunde, Joel M Advincula, Christian Oliver C Co, Maria Epifania V Collantes, Annabelle Y Lao, Yeow-Hoay Koh, Carol Huilian Tham

“…Background MLC1501, consisting of four herbs, that is, Radix Astragali, Radix Angelicae sinensis, Rhizoma Chuanxiong, Radix Polygalae, has the same pharmacological properties as its precursors MLC601 and MLC901 which contain extracts of nine herbs and showed neuroprotective, anti-inflammatory and neurorestorative properties in non-clinical models, as well as clinical benefits in improving functional and neurological recovery after brain injuries.Aims To determine the efficacy of MLC1501 on motor recovery as measured by Fugl-Meyer motor Assessment (FMA) total score at 24 weeks in patients with ischaemic stroke (IS).Design A total of 300 patients aged &gt;18 years, diagnosed with IS in the prior 2–10 days, with National Institute of Health Stroke Scale (NIHSS) total score of 8–18 and a combined score of ≥3 on NIHSS motor items 5A, 5B, 6A and/or 6B, will be randomised in a 1:1:1 ratio to receive oral placebo, MLC1501 low dose or MLC1501 high dose for 6 months. …”
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