Single-chain variable fragment affinity tuning can optimize anti-AML CAR-NK cell functionality by Marianna Zahurak, Ravi Varadhan, Ilias Christodoulou, Ruyan Rahnama, Jun Choe, Huilin Yang, Monika Kizerwetter, Christian Guaraca, Natalie Jordan Holl, Stamatia C Vorri, Megan Zinsky, Danielle G Jones, Nikol Garcia Espinoza, Yun-Huai Kuo, Jamie B. Spangler, Challice L. Bonifant

“…Here, we study the functional consequences of CAR binding affinity and targeted epitope on CAR-NK cell activation, cytolytic synapse formation, and antitumor activity.Methods We characterized NK-92 and primary NK cell populations expressing variant affinity AML-specific CARs containing single-chain variable fragments (scFvs, 26292 or 7G3) targeting two epitopes on CD123. 26292 affinity variants were discovered through directed evolution of an error-prone mutagenic library, while 7G3 affinity variants were previously reported. …”
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Uncovering the Hidden Physical Structures and Protostellar Activities in the Low-metallicity S284-RE Region: Results from ALMA and JWST by O. R. Jadhav, L. K. Dewangan, Aayushi Verma, N. K. Bhadari, A. K. Maity, Saurabh Sharma, Mamta

“…ALMA continuum source #2 hosts at least three outflow-driving sources, whereas ALMA continuum source #3 contains two. The bipolar outflow olc1, driven by an embedded object within continuum source #2, is likely a massive protostar, as indicated by the Br- α and PAH emissions depicted in the JWST (F405N+F444W)/F356W ratio map. …”
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Increase in disturbance-induced canopy gaps leads to reorganization of Central European bird communities by Anne Graser, Claudia Frank, Friederike Kunz, Andreas Schuldt, Cornelius Senf, Christoph Sudfeldt, Sven Trautmann, Johannes Kamp

“…We harnessed a unique dataset from a nation-wide bird monitoring scheme containing richness and abundance data from 927 plots monitored annually from 2005 to 2019 across all of Germany (153,014 observations). …”
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Zipper Pattern: An Investigation into Psychotic Criminal Detection Using EEG Signals by Gulay Tasci, Prabal Datta Barua, Dahiru Tanko, Tugce Keles, Suat Tas, Ilknur Sercek, Suheda Kaya, Kubra Yildirim, Yunus Talu, Burak Tasci, Filiz Ozsoy, Nida Gonen, Irem Tasci, Sengul Dogan, Turker Tuncer

“…<b>Methods:</b> In this study, a new EEG psychotic criminal dataset was curated, containing EEG signals from psychotic criminal and control groups. …”
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High-speed centrifugation reduces immune rejection by removing bone marrow elements from fresh osteochondral allografts by Yongsheng Ma, Wenming Yang, Qitai Lin, Meiming Li, Zehao Li, Yugang Xing, Lei Wei, Wangping Duan, Xiaochun Wei

“…Background: Fresh osteochondral allografts (OCAs) contain numerous immunogenic components in the subchondral bone (SB). …”
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Metal Powder Production by Atomization of Free-Falling Melt Streams Using Pulsed Gaseous Shock and Detonation Waves by Sergey M. Frolov, Vladislav S. Ivanov, Viktor S. Aksenov, Igor O. Shamshin, Fedor S. Frolov, Alan E. Zangiev, Tatiana I. Eyvazova, Vera Ya. Popkova, Maksim V. Grishin, Andrey K. Gatin, Tatiana V. Dudareva

“…Zinc and aluminum powders contain agglomerates in the form of particles with fine satellites. …”
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Annotated image dataset with different stages of European pear rust for UAV-based automated symptom detection in orchardsMendeley Data by Virginia Maß, Pendar Alirezazadeh, Johannes Seidl-Schulz, Matthias Leipnitz, Eric Fritzsche, Rasheed Ali Adam Ibraheem, Martin Geyer, Michael Pflanz, Stefanie Reim

“…For data collection, ten UAV-flight campaigns were realized between 2021 and 2023 under various weather conditions and with different flight parameters in the experimental orchard of the Julius Kühn-Institute for Breeding Research on Fruit Crops in Dresden-Pillnitz (Germany). 1394 images were captured of different pear genotypes, including varieties, wild species and progeny from breeding. The dataset contains manually labelled images with a size of 768 × 768 pixels of leaves infected with pear rust at different stages of development, labelled as class GYMNSA, as well as background images without symptoms. …”
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Rapid Determination of Pemetrexed Concentration and Distribution in Human Breast Cancer Cells (McF-7) Based on UHPLC-MS/MS by Mengwei Zhang, Zhipeng Wang, Qiqiang Zhang, Qing Ye, Fengjing Xu, Lili Cui, Yanping Liu, Shouhong Gao, Wansheng Chen, Yan Liu

“…The column was equilibrated with initial mobile phase and eluted under gradient phases containing 0.1% formic acid in water (phase A) and in acetonitrile (phase B). …”
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Taxonomic composition and biodiversity of the gut microbiome from patients with irritable bowel syndrome, ulcerative colitis, and asthma by A. Y. Tikunov, A. N. Shvalov, V. V. Morozov, I. V. Babkin, G. V. Seledtsova, I. O. Voloshina, I. P. Ivanova, A. V. Bardasheva, V. V. Morozova, V. V. Vlasov, N. V. Tikunova

“…The third most common in all samples were sequences of the Proteobacteria type, which contains pathogenic and opportunistic bacteria. Sequences of the Actinobacteria type were, on average, the fourth most common. …”
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Antimicrobial susceptibilities of oral Neisseria from men on HIV pre-exposure prophylaxis in Hanoi, Vietnam by Huan Vinh Dong, Paul Adamson, Dieu Hoa Pham, Quynh Hoa Pham, Hai Ha Long Le, Loc Quang Pham, Hao Thi Minh Bui, Giang Minh Le, Jeffrey D. Klausner

“…Participants self-collected oral specimens using phosphate buffer solution, for culture on LB agar media containing sucrose, vancomycin, and trimethoprim (LBVT.SNR). …”
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Host-Induced Gene Silencing of the <i>Aspergillus flavus O</i>-Methyl Transferase Gene Enhanced Maize Aflatoxin Resistance by Olanike Omolehin, Yenjit Raruang, Dongfang Hu, Zhu-Qiang Han, Surassawadee Promyou, Robert L. Brown, Qijian Wei, Kanniah Rajasekaran, Jeffrey W. Cary, Kan Wang, Dan Jeffers, Zhi-Yuan Chen

“…Among the six transformation events that were positive for containing the <i>omtA</i> transgene, OmtA-6 and OmtA-10 were self-pollinated from T1 to T4, and OmtA-7 and OmtA-12 to the T6 generation. …”
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Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Co... by V. T. Ivashkin, T. L. Lapina, I. V. Maev, O. M. Drapkina, R. S. Kozlov, A. A. Sheptulin, A. S. Trukhmanov, S. R. Abdulkhakov, O. P. Alekseeva, S. A. Alekseenko, D. N. Andreev, D. S. Bordin, N. N. Dekhnich, I. L. Klyaritskaya, N. V. Korochanskaya, M. F. Osipenko, E. A. Poluektova, A. S. Sarsenbaeva, V. I. Simanenkov, A. V. Tkachev, A. I. Ulyanin, I. B. Khlynov, V. V. Tsukanov

“…Another second line therapy includes PPI, levofloxacin and amoxicillin, to which a bismuth-containing drug product may be added. The third line therapy is selected individually based on previously used treatment settings.Conclusion. …”
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Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1 by Cunru Zou, Yu Zhang, Chengyue Liu, Yaxin Li, Congjie Lin, Hao Chen, Jiangping Hou, Guojun Gao, Zheng Liu, Qiupeng Yan, Wenxia Su

“…Knockdown of CENPM inhibited proliferation, invasion, and migration of ACC cells and suppressed liver metastasis in xenograft NPG mice. Collagen‐containing extracellular matrix signalling was primarily downregulated when CENPM was knocked down. …”
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Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis by Meng Wang, Xing Huang, Tingbo Liang, Tianyu Tang, Gang Zhang, Minghao Lu, Zhengtao Hong, Junming Huang, Xiao Zhi

“…As regards the mechanism, ATP11B interacted with PD-L1 in a CKLF-like MARVEL transmembrane domain containing 6 (CMTM6)-dependent manner. The depletion of ATP11B promoted CMTM6-mediated lysosomal degradation of PD-L1, thus reactivating the immune microenvironment and inducing an antitumor immune response. …”
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Exosomes from LPS-Stimulated hDPSCs Activated the Angiogenic Potential of HUVECs In Vitro by Xiangyu Huang, Wei Qiu, Yuhua Pan, Jianjia Li, Zhao Chen, Kaiying Zhang, Yifei Luo, Buling Wu, Wenan Xu

“…The mRNA expression levels of vascular endothelial growth factor (VEGF) and kinase-insert domain-containing receptor (KDR) in the LPS-EXO group were significantly higher than those in the N-EXO group. …”
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The Role of Extracts of Edible Parts and Production Wastes of Globe Artichoke (<i>Cynara cardunculus</i> L. var. <i>scolymus</i> (L.)) in Counteracting Oxidative Stress by Valentina Laghezza Masci, Irene Mezzani, Enrica Alicandri, William Tomassi, Anna Rita Paolacci, Stefano Covino, Vittorio Vinciguerra, Elisabetta Catalani, Davide Cervia, Mario Ciaffi, Stefania Garzoli, Elisa Ovidi

“…Overall, the results indicated that the edible immature inflorescences of the “Carciofo Ortano” landrace, along with the byproducts of its cultivation, are sources of raw materials containing biomolecules whose properties can be exploited for further applications in the pharmaceutical and medical sectors.…”
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Controls on coastal saline groundwater across North America by Daniel V Kretschmer, Holly A Michael, Nils Moosdorf, Gualbert H P Oude Essink, Marc F P Bierkens, Thorsten Wagener, Robert Reinecke

“…We find that the coastal zone is particularly vulnerable to containing saline groundwater at low hydraulic gradients (<10 ^−4 ) and large hydraulic conductivities (>10 ^−2 m d ^−1 ). …”
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Bisphenol A attenuates testosterone synthesis via increasing apolipoprotein A1-mediated reverse cholesterol transport in mice by Tong Zhao, Tong Zhao, Wenzhe Yang, Wenzhe Yang, Feilong Pan, Feilong Pan, Jinhao Wang, Jinhao Wang, Wenqi Shao, Wenqi Shao, Fangfang Chen, Fangfang Chen, Kexiang Liu, Kexiang Liu, Shuchen Zhao, Shuchen Zhao, Lijia Zhao, Lijia Zhao

“…Adult male mice were treated by intraperitoneal injection of corn oil containing BPA (20 mg/kg) for 7 days. Testes were collected for protein extraction, RNA extraction, Oil red O staining or for Biochemical analysis. …”
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Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H2O2 by C.F. Pulliam, M.A. Fath, S. Sho, S.T. Johnson, B.A. Wagner, M. Singhania, A.L. Kalen, K. Bayanbold, S.R. Solst, B.G. Allen, B.N. George, J.M. Caster, G.R. Buettner, D.P. Riley, J.L. Keene, R.A. Beardsley, D.R. Spitz

“…Pentaazamacrocyclic Mn (II)-containing (MnPAM) superoxide dismutase (SOD) mimetics and pharmacological ascorbate given IV to achieve [mM] plasma levels (pharmacological ascorbate: P-AscH‾) have been shown to act individually as cancer cell radio- and chemosensitizers via the generation of H2O2 in vivo. …”
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Eco-friendly synthesis of silver nanoparticles: Enhancing optimization reaction, characterization, and antimicrobial properties with Lantana camara from geothermal area by Pati Kemala, Rinaldi Idroes, Khairan Khairan, Muliadi Ramli, Binawati Ginting, Zuchra Helwani, Rifki Aulia, Ghazi Mauer Idroes, Muhammad Yusuf, Rustam Efendi

“…The phytochemicals analysis revealed that the L. camara leaf extract contains flavonoids, phenolics, saponins, tannins, and steroids, lacking alkaloids and terpenoids, with total phenolic and flavonoid contents of 11.94 mg (GAE/g) and 6.70 mg (QE/g), respectively. …”
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