Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer by Fahad M. Aldakheel, Hadeel Alnajran, Ayesha Mateen, Shatha A. Alduraywish, Mohammed S. Alqahtani, Rabbani Syed

“…Finally, a network depicting miRNA-mRNA interactions was constructed using Cytoscape software to analyze the regulatory network of prostate cancer. …”
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Hypothyroidism is Not Associated with Keratoconus Disease: Analysis of 626 Subjects by Zsuzsa Flaskó, Elena Zemova, Timo Eppig, László Módis, Achim Langenbucher, Stefan Wagenpfeil, Berthold Seitz, Nóra Szentmáry

“…A multiple logistic linear regression model was constructed to determine the effects of age (covariate), gender, and hypothyroidism (effect sizes) on “TKC-positive” disease. …”
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Spatial delineation on marine environmental characteristics using fuzzy c-means clustering method by E.D. Lusiana, S. Astutik, N. Nurjannah, A.B. Sambah

“…This study aimed to construct geophysical and chemical environmental delineation of the Lesser Sunda Islands which are located in Indonesia. …”
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Conflict Management and Organisational Performance of Nongovernmental Organizations: A Case Study of Compassion International in Greater Kabale District by Laban, Biryomumeisho

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Cathepsin G promotes arteriovenous fistula maturation by positively regulating the MMP2/MMP9 pathway by Lemei Hu, Changqing Zheng, Ying Kong, Zhiqing Luo, Fengzhang Huang, Zhigang Zhu, Quhuan Li, Ming Liang

“…The results of Masson’s trichrome and collagen I IHC staining demonstrated a higher extent of collagen deposition in the media of immature AVF veins compared to the mature. By constructing an in vitro CTSG overexpression model in VSMCs, we found that CTSG upregulated the expression of MMP2 and MMP9 while downregulating the expression of collagen I and collagen III. …”
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Children with autoimmune hepatitis receiving standard-of-care therapy demonstrate long-term obesity and linear growth delay by Or Steg Saban, Shannon M. Vandriel, Syeda Aiman Fatima, Celine Bourdon, Amrita Mundh, Vicky L. Ng, Simon C. Ling, Robert H.J. Bandsma, Binita M. Kamath

“…A time-dependent Cox proportional hazards model was constructed to determine predictors for growth impairments. …”
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The role of inflammatory system genes in individual differences in nonverbal intelligence by R. F. Enikeeva, A. V. Kazantseva, Yu. D. Davydova, R. N. Mustafin, Z. R. Takhirova, S. B. Malykh, Y. V. Kovas, E. K. Khusnutdinova

“…Gene-by-environment interaction models, which determined interindividual differences in nonverbal intelligence, have been constructed: sibship size (number of children in a family) and smoking demonstrated a modulating effect on association of the TNF/LTA (rs1041981) (β = 2.08; βST = 0.16; p = 0.001) and P2RX7 (rs2230912) (β = –1.70; βST = –0.10; p = 0.022) gene polymorphisms with nonverbal intelligence. …”
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Simplified Outcome Prediction in Patients Undergoing Transcatheter Tricuspid Valve Intervention by Survival Tree-Based Modelling by Vera Fortmeier, MD, Mark Lachmann, MD, Lukas Stolz, MD, Jennifer von Stein, MD, Karl-Philipp Rommel, MD, Mohammad Kassar, MD, Muhammed Gerçek, MD, Anne R. Schöber, MD, Thomas J. Stocker, MD, Hazem Omran, MD, Michelle Fett, Jule Tervooren, Maria I. Körber, MD, Amelie Hesse, Gerhard Harmsen, PhD, Kai Peter Friedrichs, MD, Shinsuke Yuasa, MD, PhD, Tanja K. Rudolph, MD, Michael Joner, MD, Roman Pfister, MD, Stephan Baldus, MD, Karl-Ludwig Laugwitz, MD, Stephan Windecker, MD, Fabien Praz, MD, Philipp Lurz, MD, Jörg Hausleiter, MD, Volker Rudolph, MD

“…Results: Following univariate regression analysis to pre-select candidate variables for 2-year mortality prediction, a survival tree-based model was constructed using 4 key parameters. Three distinct cluster-related risk categories were identified, which differed significantly in survival after TTVI. …”
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Annotation and characterization of immunoglobulin loci and CDR3 polymorphism in water buffalo (Bubalus bubalis) by Yunlan Deng, Fengli Wu, Fengli Wu, Qianqian Li, Lidie Yao, Chengzhi Yang, Long Ma, Xinsheng Yao, Jun Li

“…The CDR3 repertoires were constructed using genomic DNA extracted from spleen samples of five healthy buffaloes. …”
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3D synergistic tumor-liver analysis further improves the efficacy prediction in hepatocellular carcinoma: a multi-center study by Yurong Jiang, Jiawei Zhang, Zhaochen Liu, Jinxiong Zhang, Xiangrong Yu, Danyan Lin, Dandan Dong, Mingyue Cai, Chongyang Duan, Shuyi Liu, Wenhui Wang, Yuan Chen, Qiyang Li, Weiguo Xu, Meiyan Huang, Sirui Fu

“…Besides tumor, we also performed automatic 3D assessment of liver parenchyma by extracting morphological and high-dimensional data, respectively. Subsequently, we constructed a tumor model, a tumor-liver model, a clinical model and an integrated model combining information from clinical factors, tumor and liver parenchyma. …”
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Do community-based digital health inclusion programmes contribute to tackling health inequalities in disadvantaged population groups?: a qualitative study of experiences of a city-... by Shoba Poduval, Lily Arnold, Emma Carta, Danielle Nimmons, Irene Stratton, Michael Shaw, Katherine Bradbury, Fiona Stevenson

“…Results Inductive thematic analysis was used to identify four major themes and mapped to ‘Consolidated Framework for Implementation Research’ constructs. These were: programme components, recipient-centred support, impacts on service-users and system-level barriers to digital health services. …”
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Identifying health risk determinants and molecular targets in patients with idiopathic pulmonary fibrosis via combined differential and weighted gene co-expression analysis by Abu Tayab Moin, Md. Asad Ullah, Jannatul Ferdous Nipa, Mohammad Sheikh Farider Rahman, Afsana Emran, Md. Minhazul Islam, Swapnil Das, Tawsif Al Arian, Mohammad Mahfuz Enam Elahi, Mukta Akter, Umme Sadea Rahman, Arnab Halder, Shoaib Saikat, Mohammad Jakir Hosen

“…Protein-protein interaction (PPI) networks and co-expression modules were constructed to identify hub genes and their associations with disease severity. …”
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Individualized diagnosis of Parkinson’s disease based on multivariate magnetic resonance imaging radiomics and clinical indexes by Qianqian Ye, Chenhui Lin, Fangyi Xiao, Tao Jiang, Jialong Hou, Yi Zheng, Jiaxue Xu, Jiani Huang, Keke Chen, Jinlai Cai, Jingjing Qian, Weiwei Quan, Yanyan Chen

“…The clinical-radiomics model was constructed by integrating clinical variables, including UPDRS, Hoehn-Yahr stage, age, sex, and MMSE scores. …”
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Integrative Omics Analysis Reveals Mechanisms of Anthocyanin Biosynthesis in Djulis Spikes by Chunmei Zheng, Wenxuan Ge, Xueying Li, Xiuzhang Wang, Yanxia Sun, Xiaoyong Wu

“…A possible regulatory pathway for anthocyanin biosynthesis during the spike maturation was constructed based on the analysis results. The results provide a reference and theoretical basis for further studying the molecular mechanism of anthocyanin regulation of color changes in <i>Amaranthaceae</i> plants.…”
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Computer-guided identification of novel inhibitors of apoptosis-signaling kinase 1 from Spondia mombim bioactive compounds against colorectal cancer by Olusola Olalekan Elekofehinti, Hannah Oluwaseun Popoola, Adedotun Olayemi Oluwatuyi, Opeyemi Iwaloye, Moses Orimoloye Akinjiyan, Oluwamodupe Cecilia, Frank Abimbola Ogundolie, Olalekan Isaac Olatunde, Oussama Abchir, Samir Chtita, Joao Batista Texeira Rocha

“…The oral bioavailability and toxicities of these compounds are promising as compounds obeyed the Lipinski rule of five. The constructed quantitative structure–activity relationship model with a trustworthy R 2 coefficient value supports the inhibition prowess of these compounds. …”
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Multimodal data-based longitudinal prognostic model for predicting atrial fibrillation recurrence after catheter ablation in patients with patent foramen ovale and paroxysmal atria... by Shoupeng Duan, Xujun Li, Jun Wang, Yuhong Wang, Tianyou Xu, Fuding Guo, Yijun Wang, Lingpeng Song, Zeyan Li, Xiaomeng Yang, Xiaoyu Shi, Hengyang Liu, Liping Zhou, Yueyi Wang, Hong Jiang, Lilei Yu

“…Results The dataset was partitioned into the development cohort (n = 102) and the validation cohort (n = 43) using a 7:3 ratio. The constructed nomogram included four clinical variables: age, diabetes mellitus, lipoprotein (a), and right ventricular diameter. …”
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Psychometric evaluation of the exercise-related cognitive errors questionnaire among Chinese emerging adults by Mengyao Guo, Jin Kuang, Ting Wang, Fabian Herold, Alyx Taylor, Jonathan Leo Ng, Jonathan Leo Ng, M. Mahbub Hossain, M. Mahbub Hossain, Arthur F. Kramer, Arthur F. Kramer, Robert Schinke, Zhihui Cheng, Liye Zou

“…In accordance with the literature, we also observed positive associations between the six dimensions of E-CEQ-C and the constructs of the CD-Quest-C, which provided concurrent validity evidence for the E-CEQ-C.ConclusionThis study showed that E-CEQ-C is a psychometrically sound measure to assess exercise-related cognitive errors in Chinese-speaking populations.…”
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T-cell receptor beta variable gene polymorphism predicts immune-related adverse events during checkpoint blockade immunotherapy by Linghua Wang, Siqing Fu, Aung Naing, Funda Meric-Bernstam, Carl Morrison, Joud Hajjar, Mingxuan Xu, Anas Alshawa, Bettzy Stephen, Ying Yuan, Jordi Rodon Ahnert, Abdulrazzak Zarifa, Shrutii Sarda, Timothy Looney, Sapna P Patel, Geoffrey M Lowman, Dzifa Yawa Duose, Jeffrey M Conroy, Evan Kwiatkowski

“…Resultant amplicons were sequenced via the Ion Torrent and TRBV allele profiles constructed for each individual was correlated with irAE annotations to identify haplotypes associated with severe irAEs (≥ grade 3).Results Our study included 81 patients who had irAEs when treated with immunotherapy for cancer. …”
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Fecal microbiome change in patients with ulcerative colitis after fecal microbiota transplantation by A. Y. Tikunov, V. V. Morozov, A. N. Shvalov, A. V. Bardasheva, E. V. Shrayner, O. A. Maksimova, I. O. Voloshina, V. V. Morozova, V. V. Vlasov, N. V. Tikunova

“…The main method is a comparative analysis of 16S ribosomal RNA sequence libraries constructed using fecal samples obtained from patients with ulcerative colitis before and after FT and sequenced on the Illumina MiSeq platform. …”
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Inferior outcome of stand-alone short versus long tibial stem in revision total knee arthroplasty. A retrospective comparative study with minimum 2 year follow-up by Abdelatif Elsayed Ahmed, Abu Mukh Assala, Elsaid Ahmed Nady Saleh, Youssef Ahmed Omar, Foissey Constant, Servien Elvire, Lustig Sebastien

“…To obtain the benefits of short stem and improve the longevity of the construct; adjuvant zone II (metaphyseal) fixation might be the clue.…”
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